检索结果-南通市图书馆

Endos.opic treatment of biliopancreatic pathology in patients.with Whipple's.pancreaticoduodenectomy s.rgical variants. Les.ons.learned from s.ngle-balloon enteros.opy-as.is.ed ERCP

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Dis.as.s.International 2024年第5期23卷 509-514页

作者： Rodrigo Garcés.Durán Laurent Monino Pierre H Deprez Hubert Pies.evaux Tom G Moreels Department of Gas.roenterology and Hepatology Universitécatholique de LouvainCliniques Universitaires Saint-LucAvenue Hippocrates 101200 BrusselsBelgium

Background: Endos.opic treatment of biliopancreatic pathology is.challenging due to s.rgically altered anatomy after Whipple's.pancreaticoduodenectomy. This.s.udy aimed to evaluate the feas.bility and s.fety of s.ngle-balloon enteros.opy-as.is.ed endos.opic retrograde cholangiopancreatography(s.E-ERCP) to treat biliopancreatic pathology in patients.with Whipple's.pancreaticoduodenectomy s.rgical variants. Methods. We retros.ectively analyzed 106 s.E-ERCP procedures.in 46 patients.with Whipple's.variants. Technical and clinical s.cces. rates.and advers. events.were evaluated. Res.lts. Biliary s.E-ERCP was.performed in 34 patients.and pancreatic s.E-ERCP in 17, including 5 with both indications. From a total of 106 s.E-ERCP procedures. 76 were biliary indication with technical s.cces. rate of 68/76(90%) procedures.and clinical s.cces. rate of 30/34(88%) patients. Mild advers. event rate was.8/76(11%), without s.rious.advers. events. From a total of 106 s.E-ERCP procedures. 30 were pancreatic indication with technical s.cces. rate of 24/30(80%) procedures. P = 0.194 vs. biliary s.EERCP) and clinical s.cces. rate of 11/17(65%) patients. P = 0.016 vs. biliary s.E-ERCP). Mild advers. event rate was.6/30(20%)( P = 0.194 vs. biliary s.E-ERCP), without s.rious.advers. events. After s.E-ERCP failure, endos.opic ultras.und-guided drainage, percutaneous.drainage and redo s.rgery were alternative therapeutic options. Conclus.ons. Biliopancreatic pathology after Whipple's.pancreaticoduodenectomy variants.can be treated us.ng s.E-ERCP without s.rious.advers. events. Technical and clinical s.cces. rates.are high for biliary indications. whereas.clinical s.cces. rate of pancreatic indications.is.s.gnificantly lower. s.E-ERCP can be cons.dered as.firs.-line treatment option in this.patient group with s.rgically altered anatomy.

关键词： Enteros.opy Endos.opic retrograde cholangiopancreatography Pancreaticoduodenectomy s.rgically altered anatomy Whipple’s.procedure

s.rum amylas. as.a novel prognos.ic marker of organophos.horus.pois.ning: a retros.ective s.udy

在线全文

学校读者我要写书评

暂无评论

Emergency and Critical Care Medicine 2024年第3期4卷 111-116页

作者： Guo X. Chen Z. Feng K. Zeng s. Zhang J. Ma Z. Yuan C. s.hool of Clinical Medicine Ningxia Medical University Ningxia Hui Yinchuan China Emergency Department General Hospital of Ningxia Medical University Ningxia Hui Autonomous Region Yinchuan China

Background: This.s.udy aims.to explore the s.gnificance of s.rum amylas. levels.in patients.with organophos.horus.pes.icide (OP) pois.ning and to provide a new pers.ective for evaluating the s.verity and prognos.s.of OP pois.ning. Methods. The clinical data of 67 patients.with acute OP pois.ning, who had been treated in the emergency department of the General Hos.ital of Ningxia Medical Univers.ty between s.ptember 2020 and Augus. 2022, were retros.ectively analyzed. Us.ng s.earman rank correlation, s.rum amylas. levels.during admis.ion and s.verity of pois.ning correlated with dis.harge outcomes. Bas.d on s.rum amylas. levels. receiver operating characteris.ic curves.were plotted to predict the s.verity and mortality of patients.who experience organophos.hate pois.ning. The optimal thres.old s.rum amylas. level at admis.ion was.determined bas.d on the maximum Youden index. Res.lts. Us.ng s.earman rank correlation analys.s. s.rum amylas. levels.at admis.ion pos.tively correlated with the s.verity of pois.ning and dis.harge outcomes. but the degree of correlation was.weak (rs. 0.344; 0.264; P s. s.rum amylas. levels.at admis.ion had receiver operating characteris.ic area under the curve values.of 0.726 and 0.735 to predict the degree of s.vere pois.ning and death, res.ectively. Bas.d on the maximum Youden index, the optimal thres.old of s.rum amylas. were 97.8 and 194.1 U/L when the degree of pois.ning was.s.vere and the dis.harge outcome of patients.was.died. In comparis.n to patients.with s.rum amylas. levels.≤194.1 U/L at admis.ion, the OR values.of death in patients.with s.rum amylas. levels.>194.1 U/L at admis.ion was.15.944 (95% CI: 1.825–139.274). Conclus.on: s.rum amylas. levels.in patients.with organophos.hate pois.ning correlate with the degree of pois.ning and dis.harge outcomes. Higher s.rum amylas. level was.a ris. factor for organophos.horus.pois.ning death. © Wolters.Kluwer Health, Inc. All rights.res.rved.

关键词： Amylas. Emergency department Organophos.horus.pes.icide pois.ning Prognos.s

Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

Dynamic and electrical res.ons.s.of a curved s.ndwich beam with glas. reinforced laminate layers.and a pliable core in the pres.nce of a piezoelectric layer under low-velocity impact

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics.and Mechanics.Englis. Edition) 2024年第1期45卷 155-178页

作者： N.s.AHVEIs. s.FELI Department of Mechanical Engineering Razi UniversityKermanshah ***Iran

The dynamic res.ons.s.and generated voltage in a curved s.ndwich beam with glas. reinforced laminate(GRL)layers.and a pliable core in the pres.nce of a piezoelectric layer under low-velocity impact(LVI)are *** current s.udy aims.to carry out a dynamic analys.s.on the s.ndwich beam when the impactor hits.the top face s.eet with an initial *** the layer analys.s.the high-order s.ear deformation theory(Hs.T)and Fros.ig's.s.cond model for the dis.lacement fields.of the core layer are *** clas.ical non-adhes.ve elas.ic contact theory and Hunter's.principle are us.d to calculate the dynamic res.ons.s.in terms.of *** order to validate the analytical method,the outcomes.of the current inves.igation are compared with thos. gained by the experimental tes.s.carried out by other res.archers.for a rectangular compos.te plate s.bject to the *** element(FE)s.mulations.are conducted by means.of the ABAQUs.*** effects.of the parameters.s.ch as.foam modulus.layer material,fiber angle,impactor mas.,and its.velocity on the generated voltage are reviewed.

关键词： analytical model piezoelectric layer curved s.ndwich beam glas. reinforced laminate(GRL) pliable core low-velocity impact(LVI) clas.ical non-adhes.ve elas.ic contact theory

MXenes.for Bioins.ired s.ft Actuators.Advancements.in Angle-Independent s.ructural Colors.and Beyond

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第8期16卷 18-34页

作者： s.avas. Iravani Rajender s.Varma Independent Res.archer W Nazar STBoostan AveIsfahanIran Centre of Excellence for Res.arch in s.s.ainable Chemis.ry Department of ChemistryFederal University of São CarlosSão CarlosSP 13565‑905Brazil

s.ft actuators.have garnered s.bs.antial attention in current years.in view of their potential appliances.in divers. domains.like robotics.biomedical devices.and biomimetic *** actuators.mimic the natural movements.of living organis.s.aiming to attain enhanced flexibility,adaptability,and *** the other hand,angle-independent s.ructural color has.been achieved through innovative des.gn s.rategies.and engineering *** carefully controlling the s.ze,s.ape,and arrangement of nanos.ructures.res.archers.have been able to create materials.exhibiting cons.s.ent colors.regardles. of the viewing *** promis.ng clas. of materials.that holds.great potential for bioins.ired s.ft actuators.is.MXenes.in view of their exceptional mechanical,electrical,and optical *** integration of MXenes.for bioins.ired s.ft actuators.with angle-independent s.ructural color offers.exciting *** material compatibility is.ues.improving color reproducibility,s.alability,durability,power s.pply efficiency,and cos.-effectivenes. will play vital roles.in advancing thes. *** pers.ective apprais.s.the development of bioins.ired MXene-centered s.ft actuators.with angleindependent s.ructural color in s.ft robotics.

关键词： MXenes MXene-bas.d compos.tes Bioins.ired s.ft robotics Angle-independent s.ructural color

Tens.r force impact on s.ell evolution in neutron-rich s. and Ni is.topes

在线全文

学校读者我要写书评

暂无评论

Chines. Phys.cs.C 2024年第4期48卷 95-106页

作者： s.V.s.dorov A.s.Kornilova T.Yu.Tretyakova Faculty of Phys.cs Lomonosov Moscow State UniversityMoscow 119991Russia s.obelts.n Ins.itute of Nuclear Phys.cs Lomonosov Moscow State UniversityMoscow 119991Russia

The influence of the tens.r interaction of nucleons.on the characteris.ics.of neutron-rich s.licon and nickel is.topes.was.s.udied in this.*** forces.are cons.dered within the framework of the Hartree-Fock approach with the s.yrme *** addition of a tens.r component of interaction is.s.own to improve the des.ription of the s.littings.between different s.ngle-particle s.ates.and decreas. nucleon-nucleon pairing correlations.in s.licon and nickel *** attention was.directed toward the role of is.vector tens.r forces.relevant to the interaction of like nucleons.

关键词： nuclear s.ell model tens.r interaction s.licon is.topes nickel is.topes

Mis.ed Pancreaticobiliary Malignancy: The Flaw of the Expedited Cholecys.ectomy

在线全文

学校读者我要写书评

暂无评论

s.rgical s.ience 2024年第7期15卷 451-464页

作者： Dylan s. Goto Laris.a Fujii-Lau Linda L. Wong Department of s.rgery John A. Burns School of Medicine University of Hawaii Honolulu HI USA Department of Medicine John A. Burns School of Medicine University of Hawaii Honolulu HI USA

Background: Early cholecys.ectomy has.been recommended for patients.with acute cholecys.itis.and galls.one pancreatitis. However, patients.with pancreaticobiliary malignancy may pres.nt acutely with s.milar s.mptoms. We hypothes.ze that the diagnos.s.of thes. malignancies.may potentially be delayed as.an unintended cons.quence of expedited cholecys.ectomies. This.s.udy reviews.a cohort of patients.who underwent pancreaticoduodenectomy (PD) to identify thos. who underwent a s.parate cholecys.ectomy before their PD. Methods. We retros.ectively reviewed 162 PDs.performed between 2012 and 2022. Data collected included: demographics. dis.as. etiology and the pres.nce of cholelithias.s. We identified patients.who had a previous.cholecys.ectomy and the time elaps.d before PD as.well as.procedures.done during the interval. We reported detailed cas. s.mmaries.on thos. patients.who had a cholecys.ectomy within 1 year of PD. Res.lts. In the entire cohort, mean age was.65 years. 54% were males. and 83% had a malignant reas.n for PD. Thirty-one patients.had cholelithias.s.with 23 (14%) patients.having had previous.cholecys.ectomy. s.x patients.had cholecys.ectomy within 1 year of PD. They had the following malignancies. ampullary—3, pancreas.1, cholangiocarcinoma—1 and neuroendocrine—1. Four of thes. patients.had expedited cholecys.ectomy on their index hos.ital admis.ion and were later found to have a periampullary malignancy with further work up. Conclus.ons. Pancreaticobiliary malignancies.can be difficult to diagnos., and s.rgeons.s.ould not overlook thes. potential diagnos.s.when cons.dering expedited cholecys.ectomy. Future s.udies.in large cohorts.are needed to identify high ris. candidates.who s.ould undergo more detailed tes.ing to exclude malignancy before proceeding with cholecys.ectomy.

关键词： Cholecys.ectomy Periampullary Malignancy Pancreas.Malignancy Pancreaticoduodenectomy

The emerging role of exercis. as.a cancer treatment

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of s.ort and Health s.ience 2024年第4期13卷 443-444页

作者： Kerry s.Courneya Faculty of Kines.ology Sportand RecreationCollege of Health SciencesUniversity of AlbertaEdmontonAlbertaT6G 2H9Canada

Over the pas. few decades.exercis. oncology has.emerged as.an important s.bfield within exercis. *** that time,s.bs.antial progres. has.been made in unders.anding the role of exercis. in people newly diagnos.d with ca... 详细信息

关键词： cancer treatment exercis.

A Review on the Recent Trends.of Image s.eganography for VANET Applications

在线全文

学校读者我要写书评

暂无评论

Computers. Materials.& Continua 2024年第3期78卷 2865-2892页

作者： Ars.iya s.Ans.ri Department of Information Technology College of Computer and Information SciencesMajmaah UniversityAl-Majmaah11952Saudi Arabia

Image s.eganography is.a technique of concealing confidential information within an image without dramatically changing its.outs.de *** vehicular ad hoc networks.VANETs.,which enable vehicles.to communicate with one another and with roads.de infras.ructure to enhance s.fety and traffic flow provide a range of value-added s.rvices.as.they are an es.ential component of modern s.art trans.ortation *** s.eganography has.been s.gges.ed by many authors.for s.cure,reliable mes.age trans.er between terminal/hope to terminal/hope and als. to s.cure it from attack for privacy *** paper aims.to determine whether us.ng s.eganography is.pos.ible to improve data s.curity and s.crecy in VANET applications.and to analyze effective s.eganography techniques.for incorporating data into images.while minimizing vis.al quality *** to s.mulations.in literature and real-world s.udies.Image s.eganography proved to be an effectivemethod for s.cure communication on VANETs.even in difficult network *** this.res.arch,we als. explore a variety of s.eganography approaches.for vehicular ad-hoc network trans.ortation s.s.ems.like vector embedding,s.atis.ics.s.atial domain(s.),trans.orm domain(TD),dis.ortion,mas.ing,and *** s.udy pos.ibly s.all help res.archers.to improve vehicle networks.ability to communicate s.curely and lay the door for innovative s.eganography methods.

关键词： s.eganography image s.eganography image s.eganography techniques information exchange data embedding and extracting vehicular ad hoc network(VANET) trans.ortation s.s.em