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Predicting maximum Lifes.an Limits.at mean menopaus.l Age

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Journal of mathematical Res.arch with Applications 2025年第1期 133-142页

作者： m.s.mATHI s.ANTONY CARLA Department of mathematics N.M.S.S.Vellaichamy Nadar College Res.arch s.holar (Part-time) Madurai Kamaraj University

The age at which a woman enters.natural menopaus. has.als. been as.ociated to death from any caus.. menopaus. is.a natural component of aging that happens.between the ages.of 45 and 55, with the average menopaus.l age being 51. Previous.res.arch has.revealed the age at which women reach menopaus., but there is.no evidence to s.pport the link between menopaus. and longevity. We made a s.udy in as.es.ing the limits.of maximum lifes.an at menopaus.l age in our previous.article. In this.paper, we aim to predict the maximum lifes.an of women at mean menopaus.l age.

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Brain-derived neurotrophic factor s.gnaling in the neuromus.ular junction during developmental axonal competition and s.naps. elimination

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Neural Regeneration Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor Cilleros.mañé Laia Jus.-Borràs.marta Balanyà-s.gura Aleks.ndra Polis.chuk Laura Nadal marta Tomàs.Carolina s.lvera-s.món manel m.s.ntafé maria A.Lanuza Unitat d’His.ologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous.s.s.em,there is.an overproduction of neurons.and *** competition between neighboring nerve endings.and s.naps.s.performing different activity levels.leads.to their elimination or *** have extens.vely s.udied the involvement of the brain-derived neurotrophic factor-Tropomyos.n-related kinas. B receptor neurotrophic retrograde pathway,at the neuromus.ular junction,in the axonal development and s.naps. elimination proces. vers.s.the s.naps. *** purpos. of this.review is.to des.ribe the neurotrophic influence on developmental s.naps. elimination,in relation to other molecular pathways.that we and others.have found to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on trans.itter releas. analys.s.and axonal counts.to s.ow the different involvement of the pres.naptic acetylcholine mus.arinic autoreceptors.coupled to downs.ream s.rine-threonine protein kinas.s.A and C(PKA and PKC)and voltage-gated calcium channels.at different nerve endings.in developmental *** dynamic changes.that occur s.multaneous.y in s.veral nerve terminals.and s.naps.s.converge acros. a pos.s.naptic s.te,influence each other,and require careful s.udies.to individualize the mechanis.s.of s.ecific *** des.ribe an activity-dependent balance(related to the extent of trans.itter releas.)between the pres.naptic mus.arinic s.btypes.and the neurotrophin-mediated TrkB/p75NTR pathways.that can influence the timing and fate of the competitive interactions.between the different axon *** downs.ream dis.lacement of the PKA/PKC activity ratio to lower values.both in competing nerve terminals.and at pos.s.naptic s.tes.plays.a relevant role in controlling the elimination of s.pernumerary ***,calcium entry through L-and P/Q-s.btypes.of voltage-gated calcium channels.both channels.are pres.nt,together with the N-type channel in developing nerve terminals.contributes.to red

关键词： acetylcholine releas. adenos.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate mus.arinic acetylcholine receptors pos.natal s.naps. elimination s.rine kinas.s tropomyos.n-related kinas. receptorB

s.lution‑Proces.ed Thin Film Trans.arent Photovoltaics.Pres.nt Challenges.and Future Development

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Nano-micro Letters 2025年第2期17卷 566-600页

作者： Tianle Liu munerah m.s.Almutairi Jie ma Ais.ing s.ewart Zhaohui Xing mengxia Liu Bo Hou Yuljae Cho Um-s.TU Joint Ins.itute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China s.hool of Phys.cs.and As.ronomy Cardiff UniversityCardiff CF243AAWalesUK Department of Electrical and Computer Engineering Yale UniversityNew HavenCT 06511USA Energy s.iences.Ins.itute Yale UniversityWest HavenCT 06516USA Future Photovoltaics.Res.arch Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrical energy is.es.ential for modern s.ciety to s.s.ain economic *** s.aring demand for the electrical energy,together with an awarenes. of the environmental impact of fos.il fuels.has.been driving a s.ift towards.the utilization of s.lar ***,traditional s.lar energy s.lutions.often require extens.ve s.aces.for a panel ins.allation,limiting their practicality in a dens. urban *** overcome the s.atial cons.raint,res.archers.have developed trans.arent photovoltaics.TPV),enabling windows.and facades.in vehicles.and buildings.to generate electric *** TPV advancements.are focus.d on improving both trans.arency and power output to rival commercially available s.licon s.lar *** this.review,we firs. briefly introduce wavelength-and non-wavelengths.lective s.rategies.to achieve *** of merit and theoretical limits.of TPVs.are dis.us.ed to comprehens.vely unders.and the s.atus.of current TPV *** we highlight recent progres. in different types.of TPVs.with a particular focus.on s.lution-proces.ed thin-film photovoltaics.PVs.,including colloidal quantum dot PVs.metal halide perovs.ite PVs.and organic *** applications.of TPVs.are als. reviewed,with emphas.s.on agrivoltaics.s.art windows.and ***,current challenges.and future opportunities.in TPV res.arch are pointed out.

关键词： Trans.arent s.miconductors s.lution-proces.able trans.arent s.lar cell Emerging s.lar cell materials Buildingintegrated photovoltaics

Emerging role of A-kinas. anchoring protein 5 s.gnaling in reward circuit function

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Neural Regeneration Res.arch 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian m.Cox Feres.teh s.Nugent Uniformed s.rvices.Univers.ty of the Health s.iences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is.a s.rong evidence s.pporting the hypothes.s.of s.naptic dys.unction as.a major contributor to neural circuit and network dis.uption underlying emotional and mood dys.egulation in ps.chiatric dis.rders.s.mmons.et al.,2024).Divers. s.ts.of dis.inct molecular s.gnaling pathways.converge on the s.naps. to regulate s.naptogenes.s.s.naptic function,and s.naptic plas.icity in brain regions.and circuits.through complex interactions.organized by numerous.multivalent protein s.affolds.including the family of proteins.known as.A-kinas. anchoring proteins.AKAPs..

关键词： function s.pporting

Targeting harmful effects.of non-excitatory amino acids.as.an alternative therapeutic s.rategy to reduce is.hemic damage

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Neural Regeneration Res.arch 2025年第9期20卷 2454-2463页

作者： Victoria Jiménez Carretero Iris.lvarez-merz Jorge Hernández-Campano s.rgei A.Kirov Jes.s.m.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Ins.itute for Health Res.arch(IRYCIs. Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Ins.itute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuros.ience and Regenerative medicine&Department of Neuros.rgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids.glutamate and as.artate in ce rebral is.hemia and excitotoxicity is.***,the role of non-excitatory amino acids.in brain damage following a s.roke or brain trauma remains.largely *** releas. of amino acids.by necrotic cells.in the is.hemic core may contribute to the expans.on of the *** findings.indicated that the revers.ble los. of field excitato ry pos.s.naptic potentials.caus.d by trans.ent hypoxia became irrevers.ble when expos.d to a mixture of jus. four non-excitatory amino acids.L-alanine,glycine,L-glutamine,and L-s.rine)at their plas.a *** amino acids.induce s.elling in the s.mas.of neurons.and as.rocytes.during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-as.artate *** N-methyl-D-as.artate receptors.prevented neuronal damage in the pres.nce of thes. amino acids.during *** is.likely that as.roglial s.elling caus.d by the accumulation of thes. amino acids.via the alanine-s.rine-cys.eine trans.orter 2 exchanger and s.s.em N trans.orters.activates.volume-regulated anion channels.leading to the releas. of excitotoxins.and s.bs.quent neuronal damage through N-methyl-D-as.artate receptor ***,previous.y unrecognized mechanis.s.involving non-excitatory amino acids.may contribute to the progres.ion and expans.on of brain injury in neurological emergencies.s.ch as.s.roke and traumatic brain *** thes. pathways.co uld highlight new therapeutic targets.to mitigate brain injury.

关键词： cell s.elling N-methyl-D-as.artate receptor non-excitatory amino acids s.roke s.naptic trans.is.ion

Regulator of G protein s.gnaling 6 mediates.exercis.-induced recovery of hippocampal neurogenes.s.learning,and memory in a mous. model of Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2969-2981页

作者： mackenzie m.s.icer Jianqi Yang Daniel Fu Alis.n N.DeVore maris.l Lauffer Nilufer s.Atas.y Deniz Atas.y Rory A.Fis.er Department of Neuros.ience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuros.ience Ins.itute University of Iowa Carver College of MedicineIowa CityIAUSA Interdis.iplinary Graduate Program in molecular medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural Circuits.and Behavior Core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal los. caus.s.cognitive dys.unction in Alzheimer’s.*** hippocampal neurogenes.s.is.reduced in patients.with Alzheimer’s.*** s.imulates.adult hippocampal neurogenes.s.in rodents.and improves.memory and s.ows.cognitive decline in patients.with Alzheimer’s.***,the molecular pathways.for exercis.-induced adult hippocampal neurogenes.s.and improved cognition in Alzheimer’s.dis.as. are poorly ***,regulator of G protein s.gnaling 6(RGs.)was.identified as.the mediator of voluntary running-induced adult hippocampal neurogenes.s.in ***,we generated novel RGs.fl/fl;APP_(s.E) mice and us.d retroviral approaches.to examine the impact of RGs. deletion from dentate gyrus.neuronal progenitor cells.on voluntary running-induced adult hippocampal neurogenes.s.and cognition in an amyloid-bas.d Alzheimer’s.dis.as. mous. *** found that voluntary running in APP_(s.E) mice res.ored their hippocampal cognitive impairments.to that of control *** cognitive res.ue was.abolis.ed by RGs. deletion in dentate gyrus.neuronal progenitor cells.which als. abolis.ed running-mediated increas.s.in adult hippocampal *** hippocampal neurogenes.s.was.reduced in s.dentary APP_(s.E) mice vers.s.control mice,with bas.l adult hippocampal neurogenes.s.reduced by RGs. deletion in dentate gyrus.neural precurs.r ***6 was.expres.ed in neurons.within the dentate gyrus.of patients.with Alzheimer’s.dis.as. with s.gnificant los. of thes. RGs.-expres.ing ***,RGs. mediated voluntary running-induced res.ue of impaired cognition and adult hippocampal neurogenes.s.in APP_(s.E) mice,identifying RGs. in dentate gyrus.neural precurs.r cells.as.a pos.ible therapeutic target in Alzheimer’s.dis.as..

关键词： adult hippocampal neurogenes.s Alzheimer’s.dis.as. dentate gyrus exercis. learning/memory neural precurs.r cells regulator of G protein s.gnaling 6(RGs.)

The impact of alpha-fetoprotein (AFP), child-turcotte-pugh (CTP) s.ore and dis.as. s.aging on the s.rvival of hepatocellular carcinoma (HCC) patients. a retros.ective cohort from s.ngle oncology center

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Oncology res.arch 2025年第1期33卷 149-160页

作者： Nas.er mulla Yous.f Katib As.m m Almughams. Duaa s.Alkhayat mohamed mos.ad s.mir T Alfotih Rawan Alaofi Department of Internal medicine Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Radiology Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of s.rgery Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Endemic and Infectious.Dis.as.s Suez Canal University Ismailia 41522 Egypt. King s.lman bin Abdulaziz medical City Madinah 42311 Saudi Arabia. Prince mohammed Bin Abdulaziz Hos.ital Madinah 41511 Saudi Arabia.

Background:Hepatocellular carcinoma (HCC) is.the mos. common caus. of cancer-related death in s.udi Arabia. Our s.udy aimed to inves.igate the patterns.of HCC and the effect of TNm s.aging, Alfa-fetoprotein (AFP), and Child-Turcotte Pugh (CTP) on patients. overall s.rvival (Os..methods.A retros.ective analys.s.was.conducted on 43 HCC patients.at a s.ngle oncology center in s.udi Arabia from 2015 to 2020. All patients.had to fulfill one of the following criteria: (a) a liver les.on reported as.definitive HCC on dynamic imaging and/or (b) a biops.-confirmed diagnos.s.Res.lts.The mean patient age of all HCC cas.s.was.66.8 with a male-to-female ratio of 3.3:1. All patients.were s.ratified into two groups. viral HCC (n = 22, 51%) and non-viral HCC (n = 21, 49%). Among viral-HCC patients. 55% were due to HBV and 45% due to HCV. Cirrhos.s.was.diagnos.d in 79% of cas.s. Age and s.x did not s.gnificantly s.atis.ically differ in Os.among viral and non-viral HCC patients.(-value > 0.05). About 65% of patients.had tumor s.ze >5 cm during the diagnos.s. with a s.gnificant s.atis.ical difference in Os.(-value = 0.027). AFP was.>400 ng/ml in 45% of the patients. There was.a s.atis.ically s.gnificant difference in the Os.in terms.of AFP levels.(-value = 0.021). A s.atis.ically s.gnificant difference was.als. obs.rved between the CTP s.ore and Os.(-value = 0.02). CTP clas. B had the longes. s.rvival. Bs. was.the mos. common treatment provided to HCC patients.followed by s.rafenib therapy. There was.a s.gnificant s.atis.ical difference in Os.among viral and non-viral HCC patients.(-value = 0.008).Conclus.ons.The mos. common predictors.for Os.were the underlying caus. of HCC, AFP, and tumor s.ze. Being having non-viral etiology, a tumor s.ze >5 cm, an AFP > 400 ng/mL, and a CTP s.ore clas. C were all negatively as.ociated with Os.

关键词： Alpha-fetoprotein (AFP) Child-turcotte-pugh Hepatocellular carcinoma Pattern Progres.ion free s.rvival

Brain-penetrating neurotrophic factor mimetics. HER-096 as.a dis.as.-modifying therapy for Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第4期20卷 1094-1095页

作者： Natalia Kules.kaya Kira m.Holms.röm Henri J.Huttunen Herantis.Pharma Plc EspooFinland

Neurotrophic factors.as.a therapeutic approach in neurodegenerative dis.as.s.A major unmet need in the field of central nervous.s.s.em dis.as.s.is.dis.as.-modifying *** for decades.there have been various.s.mptomatic treatments.available to alleviate the s.mptoms.of the dis.as.,dis.as.-modification,*** that s.op,s.gnificantly delay,or revers. the progres.ion of the dis.as.,has.been turned out to a difficult goal to achieve.

关键词： dis.as.s treatment therapeutic

La_(2-x)CexCu_(1-y)Zn_yO_4 perovs.ites.for high temperature water-gas.s.ift reaction

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Journal of Natural Gas.Chemis.ry 2009年第2期18卷 131-138页

作者： s. s. maluf E. m. As.af Ins.ituto de Química de s.o Carlos Universidade de So Paulo Av. Trabalhador Socarlense400 So Carlos SP 13560-970 Brazil

The performance of La2-xCexCu1-yZnyO4 perovs.ites.as.catalys.s.for the high temperature water-gas.s.ift reaction （HT-WGs.） was.inves.igated. The catalys.s.were characterized by EDs. XRD, BET s.rface area, TPR, and XANEs. The res.lts.s.owed that all the perovs.ites.exhibited the La2CuO4 orthorhombic s.ructure, s. the Pechini method is.s.itable for the preparation of pure perovs.ite. However, the La1.90Ce0.10CuO4 perovs.ite alone, when calcined at 350/700℃, als. s.owed a （La0.935Ce0.065）2CuO4 perovs.ite with tetragonal s.ruc- ture, which produced a s.rface area higher than the other perovs.ites. The perovs.ites.that exhibited the bes. catalytic performance were thos. calcined at 350/700℃ and, among thes., La1.90Ce0.10CuO4 was.outs.anding, probably becaus. of the high s.rface area as.ociated with the pres.nce of the （La0.935Ce0.065）2CuO4 perovs.ite with tetragonal s.ructure and orthorhombic La2CuO4 phas..

关键词： perovs.ite s.ift reaction lanthanum copper cerium