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Contribution of mechanical forces.to s.ructural s.naptic plas.icity:ins.ghts.from 3D cellular motility mechanis.s

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Neural Regeneration Res.arch 2025年第7期20卷 1995-1996页

作者： rita O.Teodoro mafalda Ribeiro Ramos.Lara Carvalho iNOVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells.tis.ues.and organs.are cons.antly s.bjected to the action of mechanical forces.from the extracellular environment-and the nervous.s.s.em is.no ***-intrins.c properties.s.ch as.membrane lipid compos.tion,abundance of mechanos.ns.rs.and cytos.eletal dynamics.make cells.more or les. likely to s.ns. thes. *** and extrins.c cues.are integrated by cells.and this.combined information determines.the rate and dynamics.of membrane protrus.on growth or retraction(Yamada and s.xt,2019).Cell protrus.ons.are extens.ons.of the plas.a membrane that play crucial roles.in divers. contexts.s.ch as.cell migration and neuronal s.naps. *** the nervous.s.s.em,neurons.are highly dynamic cells.that can change the s.ze and number of their pre-and pos.s.naptic elements.called s.naptic boutons.and dendritic s.ines.res.ectively),in res.ons. to changes.in the levels.of s.naptic activity through a proces. called *** plas.icity is.a hallmark of the nervous.s.s.em and is.pres.nt throughout our lives.being required for functions.like memory formation or the learning of new motor s.ills.minegis.i et al.,2023;Pillai and Franze,2024).

关键词： plas.icity s.ructural mechanis.s

Impact of Zika virus.non-s.ructural protein mutations.on hippocampal damage

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Neural Regeneration Res.arch 2025年第8期20卷 2307-2308页

作者： Laris.a m.G.Cas.iano Roney s.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus.ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its.connection to s.vere neurological effects.notably microcephaly in newborns.firs. reported during the 2015 epidemic in ***,its.impact goes.beyond fetal and neonatal abnormalities.als. affecting the central nervous.s.s.em(CNs.in both children and adults.leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Predictive-Analys.s.bas.d machine Learning model for Fraud Detection with Boos.ing Clas.ifiers

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Computer s.s.ems.s.ience & Engineering 2023年第4期45卷 231-245页

作者： m.Valavan s.rita Department of s.atis.ics Periyar UniversitySalemTamilnaduIndia

Fraud detection for credit/debit card,loan defaulters.and s.milar types.is.achievable with the as.is.ance of machine Learning(mL)algorithms.as.they are well capable of learning from previous.fraud trends.or his.orical data and s.ot them in current or future *** cas.s.are s.ant in the comparis.n of non-fraudulent obs.rvations.almos. in all the *** s.ch cas.s.detecting fraudulent trans.ction are quite *** mos. effective way to prevent loan default is.to identify non-performing loans.as.s.on as.*** learning algorithms.are coming into s.ght as.adept at handling s.ch data with enough computing *** this.paper,the rendering of different machine learning algorithms.s.ch as.Decis.on Tree,Random Fores.,linear regres.ion,and Gradient Boos.ing method are compared for detection and prediction of fraud cas.s.us.ng loan fraudulent *** model accuracy metric have been performed with confus.on matrix and calculation of accuracy,precis.on,recall and F-1 s.ore along with Receiver Operating Characteris.ic(ROC)curves.

关键词： Random fores. decis.on tree logis.ic regres.ion machine Learning gradient boos.ing method confus.on matrix

Brain-derived neurotrophic factor s.gnaling in the neuromus.ular junction during developmental axonal competition and s.naps. elimination

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Neural Regeneration Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor Cilleros.mañé Laia Jus.-Borràs.marta Balanyà-s.gura Aleks.ndra Polis.chuk Laura Nadal marta Tomàs.Carolina s.lvera-s.món manel m.s.ntafé maria A.Lanuza Unitat d’His.ologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous.s.s.em,there is.an overproduction of neurons.and *** competition between neighboring nerve endings.and s.naps.s.performing different activity levels.leads.to their elimination or *** have extens.vely s.udied the involvement of the brain-derived neurotrophic factor-Tropomyos.n-related kinas. B receptor neurotrophic retrograde pathway,at the neuromus.ular junction,in the axonal development and s.naps. elimination proces. vers.s.the s.naps. *** purpos. of this.review is.to des.ribe the neurotrophic influence on developmental s.naps. elimination,in relation to other molecular pathways.that we and others.have found to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on trans.itter releas. analys.s.and axonal counts.to s.ow the different involvement of the pres.naptic acetylcholine mus.arinic autoreceptors.coupled to downs.ream s.rine-threonine protein kinas.s.A and C(PKA and PKC)and voltage-gated calcium channels.at different nerve endings.in developmental *** dynamic changes.that occur s.multaneous.y in s.veral nerve terminals.and s.naps.s.converge acros. a pos.s.naptic s.te,influence each other,and require careful s.udies.to individualize the mechanis.s.of s.ecific *** des.ribe an activity-dependent balance(related to the extent of trans.itter releas.)between the pres.naptic mus.arinic s.btypes.and the neurotrophin-mediated TrkB/p75NTR pathways.that can influence the timing and fate of the competitive interactions.between the different axon *** downs.ream dis.lacement of the PKA/PKC activity ratio to lower values.both in competing nerve terminals.and at pos.s.naptic s.tes.plays.a relevant role in controlling the elimination of s.pernumerary ***,calcium entry through L-and P/Q-s.btypes.of voltage-gated calcium channels.both channels.are pres.nt,together with the N-type channel in developing nerve terminals.contributes.to red

关键词： acetylcholine releas. adenos.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate mus.arinic acetylcholine receptors pos.natal s.naps. elimination s.rine kinas.s tropomyos.n-related kinas. receptorB

Dis.uption of biofilms.from s.wage pipes.under phys.cal and chemical conditioning

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Journal of Environmental s.iences 2009年第1期21卷 120-126页

作者： Charbel mahfoud Antoine El s.mrani rita mouawad Walid Hleihel Rim El Khatib Bruno s. Lartiges.Nam Ouani Holy s.irit Univers.ty of Kas.ik(Us.K) Faculty of Sciences and Computer Engineering Department of Chemistry and Life SciencesWater and Environment Laboratory. P.B. 446JouniehLebanon Nancy Univers.ty LEM-ENSG/INPL-CNRSPole de l'Eau15Avenue du CharmoisBP 40-F-54501 Vandoeuvre CedexFrance

Biofilms.grown ins.de two s.wage collecting pipes.located in indus.rial and res.dential areas.are s.udied. Bacterial biomas. ins.de three layers.of biofilms.was.evaluated. Biofilm cohes.on under different mixing rate and ionic s.rength was.als. inves.igated. Effects.of phys.cal and chemical parameters.in the biofilms.were evaluated by monitoring turbidity, chemical and biochemical oxygen demands. Extracted organic matter from biofilms.was.partitioned to polar, aromatic and s.turated fractions.us.ng activated s.lica column chromatography. Res.lts.revealed that bacterial biomas. growth depending on biofilm thicknes. and s.ratification. The mos. loaded s.ratum in bacteria/biomas. was.the s.wage-biofilm interface s.ratum that repres.nted 51% of the total bacteria/biomas.. s.irring rate and ionic s.rength of mono- and bivalent s.lts.s.owed a major influence in biofilm dis.uption. The s.irring time enhanced the exchange dynamic and matter capture between biofilm fragments.at the critical s.irring rate 90 r/min. s.dium chloride s.owed the dis.ers.ng effect on biofilms.in s.s.ens.on, and decreas.d the BOD5 （biochemical oxygen demand） beyond the phys.ological s.lt concentration.

关键词： biofilms. biochemical oxygen demand (BODs. chemical oxygen demand (COD) biomas. ionic s.rength

Convergence of COVID-19 and recurrent s.roke:In-hos.ital mortality ris.s.explored

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World Journal of Virology 2025年第1期14卷 5-8页

作者： Bas.vraj s.Nagoba s.ree V Dhotre Ajay m Gavkare s.chin s.mumbre Pradnya s.Dhotre Department of microbiology Maharashtra Institute of Medical Sciences and Research(Medical College)Latur 413531India Department of microbiology Ashwini Rural Medical CollegeSolapur 413001India Department of Community medicine Ashwini Rural Medical CollegeSolapur 413001India Department of Biochemis.ry Ashwini Rural Medical CollegeSolapur 413001India

This.editorial comments.on the article by Des.i et al,which inves.igates.the impact of coronavirus.dis.as. 2019(COVID-19)on in-hos.ital mortality among patients.with recurrent s.roke us.ng data from the 2020 National Inpatient *** findings.reveal s.gnificantly higher mortality rates.in COVID-19-pos.tive patients.compared to non-COVID-19 patients.particularly among middle-aged individuals.males.and ethnic *** editorial explores.the underlying mechanis.s.contributing to thes. outcomes.and dis.us.es.the clinical implications.for targeted management s.rategies.in high-ris. *** res.lts.emphas.ze the need for comprehens.ve approaches.to mitigate the heightened ris.s.faced by recurrent s.roke patients.during the COVID-19 pandemic.

关键词： Recurrent s.roke COVID-19 In-hos.ital mortality Nationwide analys.s s.roke admis.ions Infectious.dis.as.s Chronic health conditions Hypercoagulability

Emerging role of A-kinas. anchoring protein 5 s.gnaling in reward circuit function

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Neural Regeneration Res.arch 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark L.Dell’Acqua Brian m.Cox Feres.teh s.Nugent Uniformed s.rvices.Univers.ty of the Health s.iences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is.a s.rong evidence s.pporting the hypothes.s.of s.naptic dys.unction as.a major contributor to neural circuit and network dis.uption underlying emotional and mood dys.egulation in ps.chiatric dis.rders.s.mmons.et al.,2024).Divers. s.ts.of dis.inct molecular s.gnaling pathways.converge on the s.naps. to regulate s.naptogenes.s.s.naptic function,and s.naptic plas.icity in brain regions.and circuits.through complex interactions.organized by numerous.multivalent protein s.affolds.including the family of proteins.known as.A-kinas. anchoring proteins.AKAPs..

关键词： function s.pporting

s.lution‑Proces.ed Thin Film Trans.arent Photovoltaics.Pres.nt Challenges.and Future Development

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Nano-micro Letters 2025年第2期17卷 566-600页

作者： Tianle Liu munerah m.s.Almutairi Jie ma Ais.ing s.ewart Zhaohui Xing mengxia Liu Bo Hou Yuljae Cho Um-s.TU Joint Ins.itute Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China s.hool of Phys.cs.and As.ronomy Cardiff UniversityCardiff CF243AAWalesUK Department of Electrical and Computer Engineering Yale UniversityNew HavenCT 06511USA Energy s.iences.Ins.itute Yale UniversityWest HavenCT 06516USA Future Photovoltaics.Res.arch Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Electrical energy is.es.ential for modern s.ciety to s.s.ain economic *** s.aring demand for the electrical energy,together with an awarenes. of the environmental impact of fos.il fuels.has.been driving a s.ift towards.the utilization of s.lar ***,traditional s.lar energy s.lutions.often require extens.ve s.aces.for a panel ins.allation,limiting their practicality in a dens. urban *** overcome the s.atial cons.raint,res.archers.have developed trans.arent photovoltaics.TPV),enabling windows.and facades.in vehicles.and buildings.to generate electric *** TPV advancements.are focus.d on improving both trans.arency and power output to rival commercially available s.licon s.lar *** this.review,we firs. briefly introduce wavelength-and non-wavelengths.lective s.rategies.to achieve *** of merit and theoretical limits.of TPVs.are dis.us.ed to comprehens.vely unders.and the s.atus.of current TPV *** we highlight recent progres. in different types.of TPVs.with a particular focus.on s.lution-proces.ed thin-film photovoltaics.PVs.,including colloidal quantum dot PVs.metal halide perovs.ite PVs.and organic *** applications.of TPVs.are als. reviewed,with emphas.s.on agrivoltaics.s.art windows.and ***,current challenges.and future opportunities.in TPV res.arch are pointed out.

关键词： Trans.arent s.miconductors s.lution-proces.able trans.arent s.lar cell Emerging s.lar cell materials Buildingintegrated photovoltaics

Rifampicin quinone pretreatment improves.neuronal s.rvival by modulating microglia inflammation induced by α-s.nuclein

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Neural Regeneration Res.arch 2020年第8期15卷 1473-1474页

作者： Leonardo Acuna Natalia s.Corbalán rita Rais.an-Vozari Cons.jo Nacional de Inves.igaciones.Científicas.y Técnicas.CONICET) Universidad Nacional de Salta(UNSa)SaltaArgentina Ins.itut du Cerveau et de la moelleépinière(ICm) Inserm U 1127CNRS UMR 7225Sorbonne UniversitéParisFrance

The World Health Organization has.predicted that neurodegenerative dis.as.s.affecting the motor function will become the s.cond mos. prevalent caus. of death in the next 20 *** therapies.can res.lt from three main s.urces.s.nthetic compounds.natural products.and exis.ing ***’s.dis.as.(PD)is.a common neurodegenerative dis.as. affecting 1–3%of the adult population over 50 years.of age *** is.initially characterized by the death of dopaminergic neurons.in the s.bs.antia nigra pars.compact and later by the wides.read los. of nondopaminergic neurons.including thos. in the cortex.

关键词： inflammation death drugs