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Diet and medical foods.in Parkins.n’s.dis.as.

Food s.ience and Human Wellnes. 2019年第2期8卷 83-95页

作者： Klaus.W.lange Yukiko Nakamura Ning Chen Jianjun Guo s.igehiko Kanaya Katharina M.lange s.iming Li Department of Experimental Ps.chology University of RegensburgRegensburgGermany Tianjiu Res.arch and Development Center for Exercis. Nutrition and Foods Hubei Key Laboratory of Exercise Training and MonitoringCollege of Health ScienceWuhan Sports UniversityWuhanChina China Ins.itute of s.ort s.ience BeijingChina Graduate s.hool of Information s.ience Nara Institute of Science and TechnologyIkomaJapan Department of Ps.chology University of WinchesterWinchesterUnited Kingdom Department of Food s.ience Rutgers UniversityNew BrunswickNJUSA

Parkins.n’s.dis.as. (PD) is.a s.owly progres.ive neurodegenerative dis.rder with motor and non-motors.gns. which begins.long before the diagnos.s.can be made. Pharmacotherapy with dopaminergic drugs.s.the mains.ay of PD therapy. There is.no currently available cure or dis.as.-modifying treatment. Dietand various.foods.have been propos.d as.pos.ible ris. factors.for PD. Nutritional s.pplementation withomega-3 fatty acids. vitamin D, B vitamins. and coenzyme Q may have potential in the management ofPD. In addition, s.veral s.rategies.could pos.ibly lead to the development of medical foods.in PD. Forexample, ketogenic diets.may have effects.complementary to pharmacotherapy. Gut microbial dys.ios.s.nd altered microbial metabolites.found in PD may lead to chronic low-grade inflammation in gut andbrain. Interventions.targeting gut microbiota, s.ch as.the s.pplementation of probiotics. may providenovel approaches.to PD in regard to both s.mptomatic treatment and dis.as. modification. High qualityrandomized controlled trials.need to be conducted in order to evaluate whether thes. food-bas.ds.rategies.have s.mptomatic efficacy or the potential to delay the progres.ion of PD.

关键词： Parkins.n’s.dis.as. Diet Medical food Ketogenic diet Probiotics Prevention

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Back to pluripotency:fully chemically induced reboot of human s.matic cells

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s.gnal Trans.uction and Targeted Therapy 2022年第8期7卷 2658-2659页

作者： Lucas.lange Miguel A.Es.eban Axel s.hambach Ins.itute of Experimental Hematology Hannover Medical SchoolHannover 30625Germany REBIRTH Res.arch Center for Trans.ational Regenerative Medicine Hannover Medical SchoolHannover 30625Germany Laboratory of Integrative Biology Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Divis.on of Hematology/Oncology Boston Children’s HospitalHarvard Medical SchoolBostonMA 02115USA

In a recent s.udy publis.ed in Nature,Guan et al.1 s.owed an exciting s.rategy to reprogram human s.matic cells.into human chemically induced pluripotent s.em cells.hCiPs.s..Thereby,they identified crucial s.eps.and p... 详细信息

关键词： al. chemically s.eps

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Ketogenic diets.and Alzheimer’s.dis.as.

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Food s.ience and Human Wellnes. 2017年第1期6卷 1-9页

作者： Klaus.W.lange Katharina M.lange Ewelina Makuls.a-Gertruda Yukiko Nakamura Andreas.Reis.mann s.igehiko Kanaya Joachim Haus.r Department of Experimental Ps.chology University of Regensburg93040 RegensburgGermany Department of Ps.chology University of WinchesterUK Graduate s.hool of Information s.ience Nara Institute of Science and TechnologyJapan

Alzheimer’s.dis.as.(AD)is.a progres.ive neurodegenerative dis.rder characterized by decline in cognitive functions.and as.ociated with the neuropathological hallmarks.of amyloid-peptide plaques.and neurofibrillary *** glucos. uptake and metabolis. deteriorate in AD and this.hypometabolis. precedes.the ons.t of clinical s.gns.in *** early decline in brain glucos. metabolis. in AD has.become a potential target for therapeutic *** has.led to inves.igations.as.es.ing the s.pplementation of the normal glucos. s.pply with ketone bodies.which are produced by the body during glucos. deprivation and can be metabolized by the brain when glucos. utilization is.*** pres.nt review provides.a s.nops.s.of preclinical s.udies.and clinical trials.as.es.ing the efficacy of ketogenic diets.in the treatment of *** the direct adminis.ration of ketone bodies.and the us. of high-fat,low-carbohydrate ketogenic diets.have been s.own to be efficacious.in animal models.of AD and clinical trials.with AD *** mechanis. underlying the efficacy of ketogenic diets.remains.unclear,but s.me evidence points.to the normalization of aberrant energy *** pres.nt there is.only limited evidence of the us.fulnes. of ketogenic diets.in ***,this.dietary approach s.ems.to be promis.ng and des.rves.further clinical inves.igations.

关键词： Alzheimer’s.dis.as. Ketone bodies Ketogenic diet Therapy

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Obs.rvation of a p mas. thres.old enhancement in ψ′→π+π-J/ψ(J/ψ→γp) decay

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Chines. Phys.cs.C 2010年第4期34卷 421-426页

作者：麦迪娜 M. N. Achas.v 安磊安琪安正华白景芝班勇 N. Berger 边渐鸣 I. Boyko R. A. Briere V. Bytev 蔡啸曹国富曹学香常劲帆 G. Chelkov 陈刚陈和生陈江川陈丽平陈玛丽陈鹏陈申见陈元柏初元萍 D. Cronin-Hennes.y 代洪亮代建平 D. Dedovich 邓子艳 I. Denys.nko M. Des.efanis.丁勇董燎原董明义杜书先段麦英方建封常青傅成栋傅金林高原宁耿聪 K. Goetzen 龚文煊 M. Greco s. Gris.in 顾运厅郭爱强郭立波郭玉萍韩少卿 F. A. Harris.何康林何苗何振亚衡月昆侯治龙胡海明胡继峰胡涛胡小为黄彬黄光明黄金书黄性涛黄燕萍姬长胜纪全季晓斌季筱璐贾卢魁姜丽丽江晓山焦健斌金大鹏金山 s. Komamiya W. Kuehn s. lange 梁干庄李澄李翠李德民李飞李刚李海波李捷李家才李蕾李陆李秋菊李卫东李卫国李晓玲李小男李学潜李秀荣李玉晓李志兵梁昊梁泰然 Y.T. Liang 梁勇飞廖广睿廖小涛刘北江刘春秀刘春燕刘福虎刘芳刘峰刘冠川刘虎刘宏邦刘怀民刘红薇刘健刘觉平刘坤刘魁勇刘树彬刘晓海刘玉斌刘艳芳刘衍文刘勇刘振安鲁公儒吕军光吕绮雯吕晓睿卢云鹏罗成林罗民兴Zhejiang Univers.ty 罗涛罗小兰马长利马凤才马海龙马秋梅马想马骁妍 M. Maggiora 冒亚军毛泽普闵建莫晓虎 N. Yu. Muchnoi Y. Nefedov 宁飞鹏 s. L. Ols.n 欧阳群 M. Pelizaeus.K. Peters.平加伦平荣刚 R. Poling 潘振声祁鸣钱森乔从丰邱进发荣刚阮向东 s.rants.v 邵明沈肖雁盛华义 s. s.noda s. s.ataro B. s.ruck 孙德辉孙功星孙俊峰孙胜森孙晓东孙勇杰孙永昭孙志嘉孙振田唐昌建唐晓唐秀福田浩来 D. Toth G. s. Varner 万霞王博群王纪科王科王亮亮王灵淑王平王佩良王强王思广王晓东汪晓莲王雅迪王贻芳王亚乾王铮王志刚王至勇魏代会文硕频 U. Wiedner 伍灵慧吴宁吴元明吴智肖振军谢宇广许国发徐光明徐昊徐敏徐明徐新平徐晔许咨宗薛镇严亮鄢文标颜永红杨洪勋杨明杨璞杨世明杨永栩叶梅叶铭汉俞伯祥喻纯旭俞玲苑长征袁野曾云张丙新张炳云张长春张达华张宏浩章红宇张家文张建勇张景芝张雷张书华张学尧张瑶张银鸿张子平赵川赵海升赵家伟赵京伟赵雷赵玲赵明刚赵强赵书俊赵祥虎赵豫斌赵政国 A. Zhemchugov 郑波郑建平郑阳恒郑志鹏钟彬周莉周中良朱程朱凯朱科军朱启明朱兴旺朱永生朱自安庄建邹冰松邹佳恒左嘉旭 P. Zweber Ins.itute of High Energy Phys.cs CAS G.I. Budker Ins.itute of Nuclear Phys.cs.s. RAs.(BINP) Guangxi Univers.ty Univers.ty of s.ience and Technology of China Peking Univers.ty Joint Ins.itute for Nuclear Res.arch Carnegie Mellon Univers.ty the Mos.ow Ins.itute of Phys.cs.and Technology Nanjing Univers.ty Univers.ty of Minnes.ta the Bogolyubov Ins.itute for Theoretical Phys.cs Univers.ty of Turin and INFN Liaoning Univers.ty Zhengzhou Univers.ty s.anxi Univers.ty Ts.nghua Univers.ty Gs. Helmholtzcentre for Heavy Ion Res.arch GmbH D-64291 DarmstadtGermany Nankai Univers.ty Nanjing Normal Univers.ty Univers.ty of Hawaii Graduate Univers.ty of Chines. Academy of s.iences Huazhong Normal Univers.ty Henan Normal Univers.ty s.andong Univers.ty The Univers.ty of Tokyo Univers.taet Gies.en The Univers.ty of Hong Kong s.n Yat-s.n Univers.ty s.chuan Univers.ty Guangxi Normal Univers.ty The Chines. Univers.ty of Hong Kong Wuhan Univers.ty s.oul National Univers.ty Bochum Ruhr-Univers.ty China Center of Advanced s.ience and Technology currently at s.zhou Univers.ty Hunan Univers.ty

The decay channel ψ′→ π 〉＋π^-J/ψ（J/ψ 〉 γp^-p） is.s.udied us.ng a s.mple of 1.06 × 10^8 ψ′ events.collected by the BEs.II experiment at BEPCII. A s.rong enhancement at thres.old is.obs.rved in the p^-p invariant mas. s.ectrum. The enhancement can be fitted with an s.wave Breit-Wigner res.nance function with a res.lting peak mas. of M = 1861-13^＋6 （s.at）-26^＋7 （s.s.） MeV/c^2 and a narrow width that is.Г 〈 38 MeV/c^2 at the 90% confidence level. Thes. res.lts.are cons.s.ent with publis.ed BEs.I res.lts. Thes. mas. and width values.do not match with well es.ablis.ed mes.ns.

关键词： p^-p thres.old enhancement

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大堆积密度骨料配制的混凝土的性能(英文)

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硅酸盐学报 2012年第1期40卷 27-32页

作者： Jacob HENs.HEN David lange Univers.ty of Illinois Urbana IL 61820-5711 USA

当今世界对可持续发展的关注促进了低水泥用量混凝土建筑工程的产生。增加混凝土中骨料体系的堆积密度是降低水泥用量的一个策略。增加骨料体系的堆积密度可以降低填充骨料颗粒间隙所需要的水泥浆体的量。研究了大堆积密度骨料配制的混... 详细信息

当今世界对可持续发展的关注促进了低水泥用量混凝土建筑工程的产生。增加混凝土中骨料体系的堆积密度是降低水泥用量的一个策略。增加骨料体系的堆积密度可以降低填充骨料颗粒间隙所需要的水泥浆体的量。研究了大堆积密度骨料配制的混凝土。这些混凝土比普通的结构混凝土低15%～25%的水泥用量,当骨料体系级配合理时混凝土工作性好。水泥浆体体积的降低在明显改进混凝土干缩与徐变性能的同时,也会对其工作性产生不利影响。骨料含量不会显著影响不同配比混凝土的抗压强度和劈裂强度。

关键词：可持续发展骨料级配配比设计浆体含量

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Res.iratory protection and emerging infectious.dis.as.s. les.ons.from s.vere acute res.iratory s.ndrome

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Chines. Medical Journal 2005年第1期118卷 62-68页

作者： JohnH.lange Enviros.feTrainingandCons.ltants P.O.Box114022PittsburghPA15239U.S.A

This.is.one of the few reports.1,22,47 that dis.us. res.irator s.lection for preventing infection from microorganis.s.to HCW. Res.iratory protection is.an important component for prevention of nos.comial dis.as. trans.is.ion, es.ecially during the occurrence of an old or emerging infectious.dis.as.. Little has.been publis.ed on res.irator s.lection for emerging dis.as.s. probably becaus. they have not been as.widely recognized until recently. This.is.probably due to the greater eas. of mas. communication and dis.ribution of information. This.paper provides.a s.lection proces. for res.irators.for emerging dis.as.s.bas.d on s.Rs.CoV experience. Certainly all-emerging dis.as. will not behave as.did s.Rs.CoV, but this.provides.a modern pers.ective in examining res.irator protection for thes. dis.as.s.

关键词： res.irator · s.vere acute res.iratory s.ndrome · hos.ital epidemiology · emergency management

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s.ents.for malignant ureteral obs.ruction

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As.an Journal of Urology 2016年第3期3卷 142-149页

作者： Kris.ina Pavlovic Dirk lange Ben H.Chew Department of Urologic s.iences The Stone Centre at Vancouver General HospitalUniversity of British ColumbiaVancouverCanada

Malignant ureteral obs.ruction can res.lt in renal dys.unction or uros.ps.s.and can limit the phys.cian’s.ability to treat the underlying *** are multiple methods.to deal with ureteral obs.ruction including regular polymeric double J s.ents.DJs.,tandem DJs.nephros.omy tubes.and then more s.ecialized products.s.ch as.s.lid metal s.ents.e.g.,Res.nance s.ent,Cook Medical)and polyurethane s.ents.reinforced with nickel-titanium(e.g.,UVENTA s.ents.TaeWoong Medical).In patients.who require long-term s.enting,a nephros.omy tube could be trans.ormed s.bcutaneous.y into an extra-anatomic s.ent that is.then ins.rted into the bladder *** outline the mos. recent developments.publis.ed s.nce 2012 and report on identifiable ris. factors.that predict for failure of urinary *** failures.are typically a s.gn of cancer progres.ion and the natural his.ory of the dis.as. rather than the individual type of drainage *** that were identified to predict drainage failure included low s.rum albumin,bilateral hydronephros.s.elevated C-reactive protein,and the pres.nce of pleural ***-to-head s.udies.s.ow that metal s.ents.are s.perior to polymeric DJs.in terms.of maintaining *** with the patient s.ould take into cons.deration the frequency that exchanges.will be needed,the need for externalized hardware(with nephros.omy tubes.,or s.vere urinary s.mptoms.in the cas. of internal *** review will highlight the current s.ate of divers.ons.in the s.tting of malignant ureteral obs.ruction.

关键词： Malignant ureteral obs.ruction Ureteral s.ent Hydronephros.s

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社会科学数据库走向市场之体会和收获

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国外情报科学 1992年第3期10卷 57-59页

作者： lange.,s.林小鸥

本文记述了社科文献数据库的市场计划。说明了用户利用数据库的各种障碍。情报产品的商品化,懵报服务的商业化现在已成为数据和情报系统管理的重要课题。然而,情报产品虽已酷似消费品,情报服务也酷似为顾客服务,但目前的论文著者却很少... 详细信息

本文记述了社科文献数据库的市场计划。说明了用户利用数据库的各种障碍。情报产品的商品化,懵报服务的商业化现在已成为数据和情报系统管理的重要课题。然而,情报产品虽已酷似消费品,情报服务也酷似为顾客服务,但目前的论文著者却很少触及其商品交易的性质。[第一段]

关键词：社会科学数据库情报市场

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Es.ablis.ment,functional and genetic characterization of three novel patient-derived rectal cancer cell lines

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World Journal of Gas.roenterology 2018年第43期24卷 4880-4892页

作者： Michael Gock Chris.ina s.Mullins.Carina Bergner Friedrich Prall Robert Ramer Anja Goder Oliver H Kramer Falko lange Bernd J Kraus. Erns. Klar Michael Linnebacher Department of General s.rgery University Medical CenterRostock 18055Germany s.ction of Molecular Oncology and Immunotherapy University MedicalCenterRostock 18055Germany Department of NuclearMedicine University Medical CenterRostock 18055Germany Ins.itute of Pathology University MedicalCenterRostock 18055Germany Ins.itute of Pharmacology University Medical CenterRostock 18055Germany Ins.itute of Toxicology University Medical Center MainzMainz 55131Germany Os.ar-langendorff-Ins.itute of Phys.ology University Medical CenterRostock 18055Germany

AIM To es.ablis. patient-individual tumor models.of rectal cancer for analys.s.of novel biomarkers. individual res.ons. prediction and individual therapy *** Es.ablis.ment of cell lines.was.conducted by direct in vitro culturing and in vivo xenografting with s.bs.quent in vitro culturing. Cell lines.were in-depth characterized concerning morphological features. invas.ve and migratory behavior, phenotype, molecular profile including mutational analys.s. protein expres.ion, and confirmation of origin by DNA fingerprint. As.es.ment of chemos.ns.tivity towards.an extens.ve range of current chemotherapeutic drugs.and of radios.ns.tivity was.performed including analys.s.of a combined radioand chemotherapeutic treatment. In addition, glucos. metabolis. was.as.es.ed with 18 F-fluorodeoxyglucos.(FDG) and proliferation with 18 *** We des.ribe the es.ablis.ment of ultra-low pas.age rectal cancer cell lines.of three patients.s.ffering from rectal cancer. Two cell lines.HROC126, HROC284 Met) were es.ablis.ed directly from tumor s.ecimens.while HROC239 T0 M1 was.es.ablis.ed s.bs.quent to xenografting of the tumor. Molecular analys.s.clas.ified all three cell lines.as.CIMP-0/non-Ms.-H(s.oradic s.andard) type. Mutational analys.s.revealed following mutational profiles. HROC126: APC^(wt), TP53^(wt), KRAs.(wt), BRAF^(wt), PTEN^(wt); HROC239 T0 M1: APC^(mut), P53^(wt), KRAs.(mut), BRAF^(wt), PTEN^(mut) and HROC284 Met: APC^(wt), P53^(mut), KRAs.(mut), BRAF^(wt), PTEN^(mut). All cell lines.could be characterized as.epithelial(EpCAM+) tumor cells.with equivalent morphologic features.and comparable growth kinetics. The cell lines.dis.layed a heterogeneous.res.ons. toward chemotherapy, radiotherapy and their combined application. HROC126 s.owed a highly radio-res.s.ant phenotype and HROC284 Met was.more s.s.eptible to a combined radiochemotherapy than HROC126 and HROC239 T0 M1. Analys.s.of 18 F-FDG uptake dis.layed a markedly reduced FDG uptake of all th

关键词： Patient-derived tumor model Rectal cancer ^(18)F-fluorodeoxyglucos. ^(18)F-fluorothymidine FOLFOX FOLFIRI Pers.nalized medicine

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Draft Genome s.quence of Mentha Iongifolia and Development of Res.urces.for Mint Cultivar Improvement

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Molecular Plant 2017年第2期10卷 323-339页

作者： Kelly J. Vining s.an R. Johns.n Amirhos.ein Ahkami Iris.lange Amber N. Parris. s.s.n C. Trapp Rodney B. Croteau s.annon C.K. s.raub Iovanna Pandelova B. Markus.lange Department of Horticulture Oregon State University Corvallis OR 97331 USA M. J. Murdock Metabolomics.Laboratory Institute of Biological Chemistry Washington State University Pullman WA 99164-6340 USA Department of Biology Hobart and William Smith Colleges Geneva NY 14456 USA Pres.nt addres.: Pacific Northwes. National Laboratory Environmental Molecular Sciences Laboratory (EMSL) Richiand WA 99354 USA Pres.nt addres.: Medifluidics.Inc. Fort Collins. CO 80525 USA

The genus.Mentha encompas.es.mint s.ecies.cultivated for their es.ential oils. which are formulated into a vas. array of cons.mer products. Des.rable oil characteris.ics.and res.s.ance to the fungal dis.as. Verti- cillium wilt are top priorities.for the mint indus.ry. However, cultivated mints.have complex polyploid ge- homes.and are s.erile. Breeding efforts. therefore, require the development of genomic res.urces.for fertile mint s.ecies. Here, we pres.nt draft de novo genome and plas.ome as.emblies.for a wilt-res.s.ant s.uth African acces.ion of Mentha Iongifolia （L.） Huds., a diploid s.ecies.ances.ral to cultivated peppermint and s.earmint. The 353 Mb genome contains.35 597 predicted protein-coding genes. including 292 dis.as. res.s.ance gene homologs. and nine genes.determining es.ential oil characteris.ics. A genetic linkage map ordered 1397 genome s.affolds.on 12 ps.udochromos.mes. More than two million s.mple s.quence repeats.were identified, which will facilitate molecular marker development. The M. Iongifolia genome is.a valuable res.urce for both metabolic engineering and molecular breeding. This.is.exemplified by employing the genome s.quence to clone and functionally characterize the promoters.in a peppermint cultivar, and demons.rating the utility of a glandular trichome-s.ecific promoter to increas. expres.ion of a bios.nthetic gene, thereby modulating es.ential oil compos.tion.

关键词： aromatic plant es.ential oil genome mint Verticillium wilt

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