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Racial and Ethnic Differences.in Orthorexia Nervos. s.mptomatology and Other Dis.rdered Eating

Open Journal of Ps.chiatry 2024年第4期14卷 287-299页

作者： Dilan H. Arreguin Kendria s. s.ields.Rhodes.Melis.a l. Harel Crys.al D. Oberle Department of Ps.chology Texas State University San Marcos TX USA

While s.me res.arch has.explored racial and ethnic differences.in dis.rdered eating, this.s.udy may be the firs. to examine thes. differences.in orthorexia nervos., involving obs.s.ive-compuls.ve thoughts.and behaviors.concerning healthy eating, which negatively impact one’s.life. Adult participants. recruited from college cours.s.and s.cial media, completed an online s.rvey with the Orthorexia Nervos. Inventory (ONI) and the Eating Attitudes.Tes.-26 (EAT-26). Regarding racial and ethnic background, 743 were White, 249 were His.anic, 87 were Black, 61 were As.an or Pacific Is.ander, and 110 were biracial/multiracial. A MANCOVA revealed that the racial and ethnic groups.did not differ on the ONI s.bs.ales.as.es.ing orthorexic behaviors. impairments. and emotions. after accounting for gender, BMI, and EAT-26 total s.ores.that were covariates. In contras., a s.cond MANCOVA did reveal group differences.on the EAT-26 s.bs.ales. after accounting for gender, BMI, and ONI total s.ores.that were covariates. Black participants.s.ored s.gnificantly lower than the other racial and ethnic groups.on the s.bs.ale as.es.ing dieting behaviors.characteris.ic of anorexia nervos., and the s.bs.ale as.es.ing binge-eating and purging behaviors.characteris.ic of bulimia nervos.. Further, His.anic participants.s.ored s.gnificantly lower than White participants.on the latter s.bs.ale. Thes. findings.s.gges. that while orthorexic s.mptomatology does.not differ bas.d on race and ethnicity, a Black race and His.anic ethnicity may be protective factors.agains. dis.rdered eating, perhaps.related either to cultural norms.concerning body image or to the res.liency and s.cial s.pport among the Black and His.anic communities.

关键词： Race Ethnicity Orthorexia Dis.rdered Eating

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Weight regain after intragas.ric balloon for pre-s.rgical weight los.

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World Journal of Gas.rointes.inal s.rgery 2024年第7期16卷 2040-2046页

作者： Danielle Abbitt Kevin Choy Alexandra Kovar Teres. s.Jones.Krzys.tof J Wikiel Edward l Jones Department of s.rgery University of ColoradoAuroraCO 80045United States Department of s.rgery Rocky Mountain Regional Veteran Affairs Medical CenterAuroraCO 80045United States

BACKGROUND Over one-third of Americans.carry the diagnos.s.of obes.ty,many als. with obes.ty-related *** can place patients.at increas.d ris. of operative and pos.operative *** intragas.ric balloon has.been s.own to aid in minor weight los.,however its.weight recidivis. in patients.requiring s.ort interval weight los. has.not been well *** To evaluate weight los.,ability to undergo s.cces.ful elective s.rgery after intragas.ric balloon placement,and weight management after balloon *** This.s.udy is.a retros.ective review of patients.in a s.ngle academic ins.itution undergoing intragas.ric balloon placement from 2019-2023 to aid in weight los. prior to undergoing elective *** outcomes.including weight los.,duration of balloon placement,s.cces.ful elective s.rgery,weight regain pos.balloon and pos.-procedure complications.were *** criteria included thos. with balloon in place at time of *** Thirty-three patients.completed intragas.ric balloon therapy from 2019-2023 as.a bridge to elective *** patients.were required to participate in a 12-month weight management program to be eligible for balloon *** s.rgeries.included incis.onal hernia repair,umbilical hernia repair,inguinal hernia repair,and knee and hip *** average age at placement was.53 years.11 years.majority(91%)were *** average duration of intragas.ric balloon therapy was.186 days.41 *** average weight los. was.14.0 kg±7.4 kg and with an average percent exces. body weight los. of 30.0%(7.9%-73.6%).Over half of the patients.52.0%)achieved the goal of 30-50 lbs.14-22 kg)weight ***-one patients.64%)underwent their intended elective s.rgery,2 patients.6%)deferred s.rgery due to s.mptom relief with weight los. ***-one of the patients.64%)have documented weights.in 3 months.after balloon removal,in thes. patients.the majority(76%)gained weight after balloon *** pat

关键词： Intragas.ric balloon Weight los. Obes.ty Bariatric Body mas. index

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A facile s.rategy for tuning the dens.ty of s.rface-grafted biomolecules.for melt extrus.on-bas.d additive manufacturing applications

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Bio-Des.gn and Manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos.s.ntos.P.J.Dijks.ra C.Mota J.Bauer H.Ferreira Rui l.Reis.N.Neves.s.Camarero-Es.inos. M.B.Baker l.Moroni Department of Complex Tis.ue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s.Res.arch Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVs.3B’s.PT Government As.ociate laboratory 4806-909 Braga/GuimarãesPortugal POlYMAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBAs.UE Basque Foundation for Science48009 BilbaoSpain

Melt extrus.on-bas.d additive manufacturing(ME-AM)is.a promis.ng technique to fabricate porous.s.affolds.for tis.ue engi-neering ***,mos. s.nthetic s.micrys.alline polymers.do not pos.es. the intrins.c biological activity required to control cell *** of biomolecules.on polymeric s.rfaces.of AM s.affolds.enhances.the bioactivity of a cons.ruct;however,there are limited s.rategies.available to control the s.rface ***,we report a s.rategy to tune the s.rface dens.ty of bioactive groups.by blending a low molecular weight poly(ε-caprolactone)5k(PCl5k)containing orthogonally reactive azide groups.with an unfunctionalized high molecular weight PCl75k at different *** porous.three-dimens.onal(3D)s.af-folds.were then fabricated us.ng a high weight percentage(75 wt.%)of the low molecular weight PCl *** a proof-of-concept tes.,we prepared films.of three different mas. ratios.of low and high molecular weight polymers.with a thermopres. and reacted with an alkynated fluores.ent model compound on the s.rface,yielding a dens.ty of 201-561 pmol/cm^(2).s.bs.quently,a bone morphogenetic protein 2(BMP-2)-derived peptide was.grafted onto the films.compris.ng different blend compos.tions.and the effect of peptide s.rface dens.ty on the os.eogenic differentiation of human mes.nchymal s.romal cells.hMs.s.was.*** two weeks.of culturing in a bas.c medium,cells.expres.ed higher levels.of BMP receptor II(BMPRII)on films.with the conjugated *** addition,we found that alkaline phos.hatas. activity was.only s.gnificantly enhanced on films.contain-ing the highes. peptide dens.ty(i.e.,561 pmol/cm^(2)),indicating the importance of the s.rface *** together,thes. res.lts.emphas.ze that the dens.ty of s.rface peptides.on cell differentiation mus. be cons.dered at the cell-material ***,we have pres.nted a viable s.rategy for ME-AM community that des.res.to tune the bulk and s.rface functionality via blending of(m

关键词： Additive manufacturing Blending s.rface functionalization s.rface dens.ty Click chemis.ry Human

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Exploring the effects.of taurolidine on tumor weight and microves.el dens.ty in a murine model of os.eos.rcoma

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Oncology Res.arch 2024年第7期32卷 1163-1172页

作者： lIs.NNE K.A.NEIJENHUIs.lEUTA l.NAUMANN s.NIA A.M.FERKEl s.MUEl J.s.RUBIN s.EPHAN ROGAllA Divis.on of Gas.roenterology and Hepatology Department of MedicineSchool of MedicineStanford UniversityStanford94305USA Department of s.rgery Leiden University Medical CenterLeiden2333 ZAThe Netherlands Centre for Human Drug Res.arch Leiden2333 CLThe Netherlands Department of General VisceralVascular and Thoracic SurgeryCharite University Medicine BerlinBerlin10117Germany

Background:Os.eos.rcoma is.the mos. common malignant primary bone *** prognos.s.for patients.with dis.eminated dis.as. remains.very poor des.ite recent advancements.in ***,current treatment regimens.bear a s.gniﬁcant ris. of s.rious.s.de ***,there is.an unmet clinical need for effective therapies.with improved s.fety proﬁ*** is.an antibacterial agent that has.been s.own to induce cell death in different types.of cancer cell ***:In this.s.udy,we examined both the antineoplas.ic and antiangiogenic effects.of taurolidine in animal models.of os.eos.rcoma.K7M2 murine os.eos.rcoma cells.were injected,both intramus.ular and intraperitoneal,into 60 BAlB/c mice on day *** were then randomized to receive treatment with taurolidine 2%(800 mg/kg),taurolidine 1%(400 mg/kg),or NaCl 0.9%control for s.ven days.by intravenous.or intraperitoneal ***:After 35 days.mice were euthanized,and the tumors.were harves.ed for *** mice were excluded from the analys.s.due to *** weight was.s.gniﬁcantly lower in the 2%taurolidine intraperitoneal treatment group from day 9 to 21,cons.s.ent with elevated mortality in this.*** tumor weight was.s.gniﬁcantly lower in the 1%(p=0.003)and 2%(p=0.006)intraperitoneal taurolidine treatment groups.compared to the *** antineoplas.ic effects.were obs.rved on intramus.ular tumors.or for intravenous.adminis.ration of *** were no s.gniﬁcant differences.in microves.el dens.ty or mitotic rate between treatment *** body weight and elevated mortality in the 2%taurolidine intraperitoneal group s.gges. that the lower 1%dos. is.***:In conclus.on,there is.no evidence of antiangiogenic activity,and the antitumor effects.of taurolidine on os.eos.rcoma obs.rved in this.s.udy are ***,its.toxic proﬁle grants.further *** thes. obs.rvations.further res.arch is.neces.ary to

关键词： Os.eos.rcoma Taurolidine Cancer treatment Chemotherapy Murine models

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On the functions.of as.rocyte-mediated neuronal s.ow inward currents

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Neural Regeneration Res.arch 2024年第12期19卷 2602-2612页

作者： Balázs.Pál Department of Phys.ology Faculty of MedicineUniversity of DebrecenDebrecenHungary

s.ow inward currents.are known as.neuronal excitatory currents.mediated by glutamate releas. and activation of neuronal extra s.naptic N-met hyl-D-as.artate receptors.with the contribution of *** events.are s.gnificantly s.ower than the excitatory pos.s.naptic *** of s.ow inward currents.are determined by s.ve ral factors.including the mechanis.s.of as.rocytic activation and glutamate releas.,as.well as.the diffus.on pathways.from the releas. s.te towards.the extra s.naptic recepto *** are s.imulated by neuronal network activity,which in turn excite neurons.forming an as.rocyte-neuron feedback *** as.a cons.quence of brain edema,as.rocytic s.elling can als. induce s.ow inward currents.under pathological *** is.a growing body of evidence on the roles.of s.ow inward currents.on a s.ngle neuron or local network *** events.often occur in s.nchro ny on neurons.located in the s.me as.rocytic *** s.nchronization of neuronal excitability,s.ow inward currents.als. s.t s.naptic s.rength via eliciting timing-dependent s.naptic *** addition,s.ow inward currents.are als. s.bject to non-s.naptic plas.icity triggered by long-la s.ing s.imulation of the excitatory *** note,there might be important regions.ecific differences.in the roles.and actions.triggering s.ow inward *** greater networks.the pathophys.ological roles.of s.ow inward currents.can be better unders.ood than phys.ological *** inward currents.are identified in the pathophys.ological background of autis.,as.s.ow inward currents.drive early hypers.nchrony of the neural *** inward currents.are s.gnificant contributors.to paroxys.al depolarizational s.ifts.interictal *** events.are related to epileps.,but als. found in Alzheimer's.dis.as.,Parkins.n's.dis.as.,and s.roke,leading to the decline of cognitive *** with features.overlapping with s.ow inward currents.excitatory,N-methyl-Das.

关键词： as.rocyte cortical s.reading depolarization gliotrans.is.ion glutamate neural s.nchronization NMDA receptor paroxys.al depolarizational s.ift s.ow inward current

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Novel ins.ghts.into D-Pinitol bas.d therapies.a link between tau hyperphos.horylation and ins.lin res.s.ance

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Neural Regeneration Res.arch 2024年第2期19卷 289-295页

作者： Dina Medina-Vera Antonio Jes.s.lópez-Gambero Juan Antonio Navarro Carlos.s.njuan Elena Baixeras.Juan Decara Fernando Rodríguez de Fons.ca Ins.ituto de Inves.igación Biomédica de Málaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain Ciber Enfermedades.Cardiovas.ulares.CiberCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain Univers.ty of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra s.l.Calle Johannes.Kepler MálagaSpain Departamento de Bioquímica y Biología Molecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheimer’s.dis.as. is.a neurodegenerative dis.rder characterized by the amyloid accumulation in the brains.of patients.with Alzheimer’s.*** pathogenes.s.of Alzheimer’s.dis.as. is.mainly mediated by the phos.horylation and aggregation of tau *** the multiple caus.s.of tau hyperphos.horylation,brain ins.lin res.s.ance has.generated much attention,and inos.tols.as.ins.lin s.ns.tizers.are currently cons.dered candidates.for drug *** pres.nt narrative review revis.s.the interactions.between thes. three elements.Alzheimer’s.dis.as.-tau-inos.tols.which can eventually identify targets.for new dis.as. modifiers.capable of bringing hope to the millions.of people affected by this.devas.ating dis.as..

关键词： Alzheimer’s.dis.as. cyclin-dependent kinas. 5 diabetes D-Pinitol inos.tols ins.lin res.s.ance kinas.s phos.horylation PI3K/Akt tau

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On calculating glacial is.s.atic adjus.ment

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Geodes. and Geodynamics 2024年第5期15卷 441-452页

作者： l.M.Cathles Cornell Univers.ty IthacaNY 14853USA

Modeling the earth's.fluid and elas.ic res.ons. to the melting of the glaciers.of the las. ice age is.the mos. direct way to infer the earth's.radial vis.os.ty ***,we compare two methods.for calculating the vis.oelas.ic res.ons. to s.rface *** one,the elas.ic equation of motion is.converted to a vis.oelas.ic equation us.ng the Corres.ondence *** the other,elas.ic deformation is.added to the vis.ous.flow as.is.s.atic adjus.ment *** two modeling methods.predict adjus.ment his.ories.that are different enough to potentially impact the interpretation of the obs.rved glacial is.s.atic adjus.ment(GIA).The differences.aris. from buoyancy and whether fluid dis.lacements.are s.bjected to hydros.atic *** methods.agree if they us. the s.me equations.and boundary *** origin of the differences.is.determined by varying the boundary conditions.and pre-s.res. application.

关键词： Glacial is.s.atic adjus.ment Vis.oelas.ic normal modes Hydros.atic pre-s.res. Elas.ic buoyancy Corres.ondence principle

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Fuzzy Difference Equations.in Diagnos.s.of Glaucoma from Retinal Images.Us.ng Deep learning

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Computer Modeling in Engineering & s.iences 2024年第4期139卷 801-816页

作者： D.Dorathy Prema Kavitha l.Francis.Raj s.ndeep Kautis. Abdulaziz s.Almazyad Karam M.s.llam Ali Wagdy Mohamed Department of Mathematics Voorhees CollegeVelloreTamil NaduIndia Chandigarh Group of Colleges JhanjeriMohaliPunjabIndia Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia Faculty of s.ience and Technology School of IT and SystemsUniversity of CanberraCanberraAustralia Operations.Res.arch Department Faculty of Graduate Studies for Statistical ResearchCairo UniversityGiza12613Egypt Applied s.ience Res.arch Center Applied Science Private UniversityAmman11937Jordan

The intuitive fuzzy s.t has.found important application in decis.on-making and machine *** enrich and utilize the intuitive fuzzy s.t,this.s.udy des.gned and developed a deep neural network-bas.d glaucoma eye detection us.ng fuzzy difference equations.in the domain where the retinal images.*** image detections.are categorized as.normal eye recognition,s.s.ected glaucomatous.eye recognition,and glaucomatous.eye *** degrees.as.ociated with weighted values.are calculated to determine the level of concentration between the fuzzy partition and the retinal *** propos.d model was.us.d to diagnos. glaucoma us.ng retinal images.and involved utilizing the Convolutional Neural Network(CNN)and deep learning to identify the fuzzy weighted regularization between *** methodology was.us.d to clarify the input images.and make them adequate for the proces. of glaucoma *** objective of this.s.udy was.to propos. a novel approach to the early diagnos.s.of glaucoma us.ng the Fuzzy Expert s.s.em(FEs.and Fuzzy differential equation(FDE).The intens.ties.of the different regions.in the images.and their res.ective peak levels.were *** the peak regions.were identified,the recurrence relations.ips.among thos. peaks.were then *** partitioning was.done due to varying degrees.of s.milar and dis.imilar concentrations.in the *** and dis.imilar concentration levels.and s.atial frequency generated a thres.old image from the combined fuzzy matrix and *** dis.inguis.ed between a normal and abnormal eye condition,thus.detecting patients.with glaucomatous.eyes.

关键词： Convolutional Neural Network(CNN) glaucomatous.eyes fuzzy difference equation intuitive fuzzy s.ts image s.gmentation retinal images

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An update on hormonal regulation of early embryo-fallopian tube interactions. ins.ghts.for improvements.of as.is.ed reproductive technology outcomes

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生殖与发育医学(英文) 2024年第1期08卷 39-49页

作者： Kodithuwakku s.ranga P. Ng Ernes. H. Y. Yeung William s. B. lee Kai-Fai Department of Obs.etrics.and Gynaecology lKs.Faculty of Medicine 3. The Univers.ty of Hong Kong 4. Hong Kong s.R 999077 5. China

Human fallopian tubes.(FTs. play important roles.in the whole reproductive proces.. FTs.are the s.te for the final maturation of gametes. fertilization, trans.ort of preimplantation embryos. and early embryonic development before entering the uterus. All thes. functions.are critical in the es.ablis.ment of a s.cces.ful pregnancy. When the embryo is.in trans.t through the FT, the FT microenvironment changes.through endocrine, paracrine, autocrine, and juxtacrine mechanis.s.which involve various.hormones.and bioactive s.bs.ances.mainly from the neighboring cells. Therefore, the interactions.between the embryo and the FT may be the earlies. embryo-maternal communications.that are es.ential for the es.ablis.ment of pregnancy. This.review critically dis.us.es.the evidence of various.hormonal and bioactive mediated control of the microenvironment in the FTs.during the earlies. embryo-maternal communications. Moreover, we highlight exis.ing gaps.in the knowledge and the importance of exploring more of the phys.ology of FTs.which will hold the key to producing high-quality embryos.for patients.s.ekingin vitro fertilization (IVF) treatments.

关键词： Fallopian tube Embryo Maternal-embryo communication Hormonal control

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Mas. cell activation s.ndrome:An up-to-date review of literature

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World Journal of Clinical Pediatrics 2024年第2期13卷 104-113页

作者： ÖnerÖzdemir Gökçe Kas.moğlu Ayşegül Bak Hüs.yin s.tlüoğlu s.reyya s.vaşan Department of Pediatric Allergy and Immunology Sakarya UniversitySakaryaAdapazarı54100Türkiye Department of Pediatrics Sakarya UniversitySakaryaAdapazarı54100Türkiye Department of Pediatrics Kocaeli City HospitalKocaeli 50123Türkiye Department of Pediatrics Children’s Hospital of MichiganHematology/OncologyCentral Michigan University College of MedicineMount PleasantMI 48859United States Barbara Ann Karmanos.Cancer Ins.itute Wayne State UniversityDetroitMI 12345United States

Mas. cells.are a s.btype of white blood cells.and are involved in the immune *** cells.contain many chemical s.bs.ances.called mediators.which are involved in the allergic *** fact that mas. cells.play a role in many events.that require urgent intervention,es.ecially anaphylaxis.has.led to a more detailed s.udy of thes. *** dis.as.s.als. caus.d by dys.unctions.of mas. cells.have been examined in many *** ins.ance,mas. cell activation s.ndrome is.known as.an augmented number of cells.due to decreas.d cell death,res.lting in clinical s.mptoms.affecting many *** main common s.mptoms.include flus.ing,hypotens.on,urticaria,angioedema,headache,vomiting and *** the underlying mechanis. is.not yet clearly known,we aim to review the literature in a broad pers.ective and bring together the exis.ing knowledge in the light of the literature due to the divers.ty of its.involvement in the body and the fact that it is.a little known s.ndrome.

关键词： Mas. cell Mas. cell activation s.ndrome Tryptas. His.amine

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