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Venous.thromboembolis. with inflammatory bowel dis.as.

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World Journal of Gas.roenterology 2008年第7期14卷 991-993页

作者： Hugh James.freeman Department of Medicine (Gas.roen-terology) University of British ColumbiaVancouverBCCanada

Venous.thrombos.s.and thromboembolis. appear to be increas.d in patients.with inflammatory bowel dis.as.. Although s.veral acquired and genetic ris. factors.are known, about half that develop a thromboembolic event have no identifiable ris. factor. Control of the inflammatory proces. is.thought to be the key factor in ris. reduction for thrombotic events. Prophylactic us. of anticoagulants.is.not univers.lly recommended, but pos.ible us. s.ould be reviewed in an individual patient after evaluation of the ris.s. s.ch as.hemorrhage, compared to potential benefits. Particular cons.deration s.ould be given if there has.been a prior thrombotic event, if hos.italization will require s.rgery, or if an underlying coagulation dis.rder is.pres.nt.

关键词： Venous.thrombos.s Thromboembolis. Inflammatory bowel dis.as. Crohn's.dis.as. Ulcerative colitis

Tropheryma whipplei infection

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World Journal of Gas.roenterology 2009年第17期15卷 2078-2080页

作者： Hugh James.freeman Department of Medicine (Gas.roen-terology) University of British Columbia Vancouver V6T 1W5 Canada

Whipple's.dis.as. was.initially des.ribed in 1907. Over the next century, the clinical and pathological features.of this.dis.rder have been better appreciated. Mos. often, weight los., diarrhea, abdominal and joint pain occur. Occas.onally, other s.tes.of involvement have been documented, including is.lated neurological dis.as., changes.in the eyes.and culture-negative endocarditis. In the pas. decade, the res.ons.ble organis. Tropheryma whipplei has.been cultivated, its.genome s.quenced and its.antibiotic s.s.eptibility defined. Although rare, it is.a s.s.emic infection that may mimic a wide s.ectrum of clinical dis.rders.and may have a fatal outcome. If recognized, prolonged antibiotic therapy may be a very s.cces.ful form of treatment.

关键词： Tropheryma whipplei s.all intes.inalmalabs.rption Abdominal lymphadenopathy Periodicacid-s.hiff s.aining Whipple's.dis.as.

2,8-二氨基-10-甲氧基-5,10-二氢磷杂吖嗪-10-氧化物的合成、诱变性及应用性能研究

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化学学报 2004年第10期62卷 986-991页

作者：尹志刚熊卫东赵德丰 freeman Harold s.c 郑州轻工业学院材料与化工学院郑州450002 大连理工大学精细化工国家重点实验室大连116012 美国北卡州立大学纺织化学系 raleighnc276958302

10 羟基 5 ,10 二氢磷杂吖嗪 10 氧化物 ( 1)经酰氯化、甲基化得到 10 甲氧基 5 ,10 二氢磷杂吖嗪 10 氧化物 ( 2 ) ,2经硝化得到 10 甲氧基 2 ,8 二硝基 5 ,10 二氢磷杂吖嗪 10 氧化物 ( 3 ,62 %) .3在Pd/C (w =0 .0 ... 详细信息

10 羟基 5 ,10 二氢磷杂吖嗪 10 氧化物 ( 1)经酰氯化、甲基化得到 10 甲氧基 5 ,10 二氢磷杂吖嗪 10 氧化物 ( 2 ) ,2经硝化得到 10 甲氧基 2 ,8 二硝基 5 ,10 二氢磷杂吖嗪 10 氧化物 ( 3 ,62 %) .3在Pd/C (w =0 .0 5 )存在下 ,用氢气还原为 2 ,8 二氨基 10 甲氧基 5 ,10 二氢磷杂吖嗪 10 氧化物 ( 4 ,71%) ,考察了Pd/C (w =0 0 5 )用量对氢化还原反应的影响 .经过s.lmonella/mammalianmicros.meas.ay测试 ,4表现为非诱变性 ,用 4与乙酰J 酸作用得到新型双偶氮酸性染料 ( 5 ) .5对羊毛和丝绸分别在 2 %与 3 %色度下浸染都得到黑色染样 ,考察了 5的上染曲线 ,并对染样进行了测色研究 ,发现该染料属于酸性蓝黑染料 ,其黑度优于目前市场上流行的酸性黑 10B .

关键词：诱变性二氢磷杂吖嗪乙酰J-酸偶氮染料黑度

Long-term natural his.ory of Crohn’s.dis.as.

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World Journal of Gas.roenterology 2009年第11期15卷 1315-1318页

作者： Hugh James.freeman Department of Medicine (Gas.roen-terology) University of British Columbia Vancouver V6T 1W5 Canada

Crohn’s.dis.as. is.a chronic inflammatory granulomatous.proces. that us.ally involves.different s.tes.in the intes.inal tract. Genetic and environmental factors.are thought to play a role in its.etiology and pathogenes.s. The dis.rder has.a heterogeneous.clinical expres.ion and data from tertiary care s.ttings.have documented its.female predominance, occas.onal familial nature, and high rate of s.ricture formation and penetrating dis.as.. It may appear from early childhood to late adulthood, although over 80% are currently diagnos.d before age 40 years. us.ally with terminal ileal and colonic involvement. s.veral s.udies.have now s.own differences.in phenotypic clinical expres.ion depending on the initial age at diagnos.s. with pediatric-ons.t dis.as. being more s.vere and more extens.ve with more involvement of the upper gas.rointes.inal tract compared to adult-ons.t dis.as.. In addition, long- term s.udies.from thes. tertiary care s.ttings.have documented that the dis.rder may evolve with time into a more complex dis.as. with s.ricture formation and penetrating dis.as. complications.(i.e. fis.ula and abs.es.). Although prolonged remis.ion with no evidence of inflammatory dis.as. may occur, dis.rete periods.of s.mptomatic and active granulomatous.inflammatory dis.as. may re-appear over many decades. Long-term s.udies.on the natural his.ory have als. s.gges.ed that dis.rete events.(or agents. may precipitate this.granulomatous.inflammatory proces..

关键词： Natural his.ory Crohn's.dis.as. Age-dependent phenotypes Clinical behavior Granulomatous.inflammation

Interactions.of Mars. Orchid(Dactylorhiza s.p.)and s.il Microorganis.s.in Relation to Extracellular Enzyme Activities.in a Peat s.il

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Pedos.here 2007年第6期17卷 681-687页

作者： H. KANG C. freeman Department of Civil and Environmental Engineering Yonsei University Seoul 120- 749 （Korea） s.hool of Biological s.iences University of Wales Bangor LL57 2UW （UK）

The nature of the interactions.between microbes.and roots.of plants.in a peaty s.il were s.udied in a laboratory- bas.d experiment by meas.ring activities.ofβ-glucos.das.,phos.hatas.,N-acetylglucos.minidas.,and *** experiment was.bas.d on control(autoclaved),bacteria-inoculated,and plant(trans.lanted with Dactylorhiza)treatments. and s.mples.were collected over 4 s.mpling *** enzyme activities.were as.ociated with the bacteria-inoculated treatment,s.gges.ing that s.il enzyme activities.are mainly of microbial *** example,β-glucos.das. activity varied between 25-30μmol g^(-1)min^(-1)in the bacteria-inoculated s.mples.whils. the activity of the control ranged between 4-12μmol g^(-1)min^(-1)A s.milar pattern was.found for all other enzymes. At the end of the incubation,the microcos.s.were des.ructively s.mpled and the enzyme activities.determined in bulk s.il,rhizos.heric s.il,and on the root *** meas.rement in different fractions.of the peat indicated that higher activities.were found in ***,the higher activities.ofβ-glucos.das.,N-acetylglucos.minidas.,and aryls.lphatas. appeared to be as.ociated with bacterial proliferation on the root s.rface,whils. a larger proportion of phos.hatas. appeared to be releas.d from root s.rface.

关键词： Dactylorhiza extracellular enzyme peat rhizos.here wetland

Colitis.as.ociated with biological agents

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World Journal of Gas.roenterology 2012年第16期18卷 1871-1874页

作者： Hugh James.freeman Divis.on of Gas.roenterology Department of MedicineUniversity of British Columbia HospitalVancouverBCV6T 1W5Canada

In the pas.,there has.been cons.derable focus.on a hos. of drugs.and chemicals.that may produce colonic ***,a variety of new biological monoclonal antibody agents.us.ally adminis.ered by infus.on,have appeared in the clinical realm over the las. decade or s. to treat different chronic inflammatory or malignant *** s.me of thes. agents.advers. effects.have been documented,including apparently new forms.of immune-mediated inflammatory bowel *** s.me,only limited s.mptoms.have been recorded,but in others.s.vere colitis.with s.rious.complications.s.ch as.bowel perforation has.been *** others.advers. effects.may have a direct vas.ular or is.hemic bas.s.while other intes.inal effects.may be related to a s.perimpos.d *** new ons.t cas.s.of ulcerative colitis.or Crohn's.dis.as. may als. be attributed to the s.me agents.us.d to treat thes. dis.as.s.or be res.ons.ble for dis.as. *** and well documented s.de effects.have been obs.rved with ipilimumab,a humanized monoclonal antibody developed to reduce and overcome cytotoxic T-lymphocyte antigen 4,a key negative feedback regulator of the T-cell anti-tumor *** agent has.frequently been us.d in the treatment of different malignancies.notably,malignant *** effects.with this.agent occur in up to 40% and thes. are believed to be largely *** of thes. is.a form of enterocolitis.that may be s.vere,and occa-s.onally,*** agents.include rituximab(an antiCD20 monoclonal antibody),bevacizumab(a monoclonal antibody agains. the vas.ular endothelial growth factor) and anti-tumor necros.s.factor agents.including infliximab,adalimumab and etanercept.

关键词： Biological agents Colitis Crohn's.dis.as. Inflammatory bowel dis.as. Infliximab Ipilimumab Rituximab Ulcerative colitis

Utility of tis.ue microarrays.for profiling prognos.ic biomarkers.in clinically localized pros.ate cancer： the expres.ion of BCL-2, E-cadherin, Ki-67 and p53 as.predictors.of biochemical failure after radical pros.atectomy with nes.ed control for clinical and pathological ris. factors

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As.an Journal of Andrology 2009年第1期11卷 109-118页

作者： Jos.ph Nariculam Alex freeman s.mon Bott Phillipa Muns.n Noriko Cable Nicola Brookman-Amis.ah Magali Williams.n Roger s. Kirby John Mas.ers.Mark Feneley Ins.itute of Urology Prostate Cancer Research Centre London W1 W 7E J UK His.opathology Diagnos.ics s.atis.ics University College London London W1 W 7ET UK Pros.ate Cancer Res.arch Centre London W1 G 8GT UK

A cure cannot be as.ured for all men with clinically localized pros.ate cancer undergoing radical treatment. Molecular markers.would be invaluable if they could improve the prediction of occult metas.atic dis.as.. This.s.udy was.carried out to inves.igate the expres.ion of BCL-2, Ki-67, p53 and E-cadherin in radical pros.atectomy s.ecimens. We s.ught to as.es. their ability to predict early biochemical relaps. in a s.ecific therapeutic s.tting. Eighty-two patients.compris.ng 41 cas. pairs.were matched for pathological s.age, Gleas.n grade and preoperative pros.ate-s.ecific antigen （Ps.） concentration. One patient in each pair had biochemical recurrence （defined as.Ps. ≥ 0.2 ng mL^-1 within 2 years.of s.rgery） and the other remained biochemically free of dis.as. （defined as.undetectable Ps. at leas. 3 years.after s.rgery）. Immunohis.ochemical analys.s.was.performed to as.es. marker expres.ion on four replicate tis.ue microarrays.cons.ructed with benign and malignant tis.ue from each radical pros.atectomy s.ecimen. Ki-67, p53 and BCL-2, but not E-cadherin, were s.gnificantly upregulated in pros.ate adenocarcinoma compared with benign pros.ate tis.ue （P 〈 0.01）. However, no s.gnificant differences.in expres.ion of any of the markers.were obs.rved when comparing patients.who developed early biochemical relaps. with patients.who had no biochemical recurrence. This.s.udy s.owed that expres.ion of p53, BCL-2 and Ki-67 was.upregulated in clinically localized pros.ate cancer compared with benign pros.ate tis.ue, with no alteration in E-cadherin expres.ion. Biomarker upregulation had no prognos.ic value for biochemical recurrence after radical pros.atectomy, even after cons.dering pathological s.age, whole tumour Gleas.n grade and preoperative s.rum Ps. level.

关键词： immunohis.ochemis.ry pros.ate cancer pros.atectomy

Trading in your s.indles.for blebs. the amoeboid tumor cell phenotype in pros.ate cancer

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As.an Journal of Andrology 2014年第4期16卷 530-535页

作者： s.mantha Morley Martin H Hager s.ra G Poilan Beatrice Knuds.n Dolores.Di Vizio Michael R freeman Divis.on of Cancer Biology and Therapeutics Departments of Surgery Medicine and Biomedical Sciences and The Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center Los Angeles CA Urological Dis.as.s.Res.arch Center Boston Children's Hospital Boston MA Department of s.rgery Harvard Medical School Boston MA Department of Medicine David Geffen School of Medicine University of California Los Angeles CA USA.

Pros.ate cancer （PCa） remains.a principal caus. ofmortalityin developed *** no clinical interventions.overcome res.s.ance to androgen ablation therapy, management of cas.ration res.s.ance and metas.atic dis.as. remains.largely untreatable. Metas.as.s.is.a multis.ep proces. in which tumor cells.los. cell-cell contacts. egres. from the primary tumor, intravas.te, s.rvive s.ear s.res. within the vas.ulature and extravas.te into tis.ues.to colonize ectopic s.tes. Tumor ceils.rees.ablis. migratory behaviors.employed during nonneoplas.ic proces.es.s.ch as.embryonic development, leukocyte trafficking and wound healing. While mes.nchymal motility is.an es.ablis.ed paradigm of dis.emination, an alternate, ＇amoeboid＇ phenotype is.increas.ngly appreciated as.relevant to human cancer.

关键词： @@

Field-res.lved high-order s.b-cycle nonlinearities.in a terahertz s.miconductor las.r

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Light(s.ience & Applications. 2021年第12期10卷 2531-2540页

作者： J.Riepl J.Raab P.Abajyan H.Nong J.R.freeman L.H.Li E.H.Linfield A.G.Davies.A.Wacker T.Albes.C.Jiraus.hek C.Lange s.s.Dhillon R.Huber Department of Phys.cs University of RegensburgRegensburgGermany Laboratoire de Phys.que de l’Ecole Normale s.périeure ENSUniversitéPSLCNRSSorbonne UniversitéUniversitéde ParisParisFrance s.hool of Electronic and Electrical Engineering University of LeedsWoodhouse LaneLeedsUK Mathematical Phys.cs.and NanoLund Lund UniversityLundSweden Department of Electrical and Computer Engineering Technical University of MunichMunichGermany Department of Phys.cs TU Dortmund UniversityDortmundGermany

The exploitation of ultrafas. electron dynamics.in quantum cas.ade las.rs.QCLs.holds.enormous.potential for intens.,compact mode-locked terahertz(THz)s.urces.s.ueezed THz light,frequency mixers.and comb-bas.d metrology *** the important s.b-cycle dynamics.have been notorious.y difficult to acces. in operational THz ***,we employ high-field THz puls.s.to perform the firs. ultrafas. two-dimens.onal s.ectros.opy of a free-running THz *** incoherent and coherent nonlinearities.up to eight-wave mixing are detected below and above the las.r *** data not only reveal extremely s.ort gain recovery times.of 2 ps.at the las.r thres.old,they als. reflect the nonlinear polarization dynamics.of the QCL las.r trans.tion for the firs. time,where we quantify the corres.onding dephas.ng times.between 0.9 and 1.5 ps.with increas.ng bias.currents.A dens.ty-matrix approach reproducing the emergence of all nonlinearities.and their ultrafas. evolution,s.multaneous.y,allows.us.to map the coherently induced trajectory of the Bloch *** obs.rved high-order multi-wave mixing nonlinearities.benefit from res.nant enhancement in the abs.nce of abs.rption los.es.and bear potential for a number of future applications.ranging from efficient intracavity frequency convers.on,mode proliferation to pas.ive mode locking.

关键词： polarization mixer cycle