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Bohm’s.approach to quantum mechanics. Alternative theory or practical picture?

Frontiers.of phys.cs 2019年第1期14卷 75-89页

作者： A. s. s.nz Department of Optics Faculty of Physical Sciences Universidad Complutense de Madrid Pza. Ciencias 1 Ciudad Universitaria E-28040 Madrid Spain

s.nce its.inception Bohmian mechanics.has.been generally regarded as.a hidden-variable theory aimed at providing an objective des.ription of quantum phenomena. To date, this.rather narrow conception of Bohm’s.propos.l has.caus.d it more rejection than acceptance. Now, after 65 years.of Bohmian mechanics. s.ould s.ill be s.ch an interpretational as.ect the prevailing apprais.l? Why not favoring a more pragmatic view, as.a legitimate picture of quantum mechanics. on equal footing in all res.ects.with any other more conventional quantum picture? Thes. ques.ions.are us.d here to introduce a dis.us.ion on an alternative way to deal with Bohmian mechanics.at pres.nt, enhancing its.as.ect as.an efficient and us.ful picture or formulation to tackle, explore, des.ribe and explain quantum phenomena where phas. and correlation (entanglement) are key elements. This.dis.us.ion is.pres.nted through two complementary blocks. The firs. block is.aimed at briefly revis.ting the his.orical context that gave ris. to the appearance of Bohmian mechanics. and how this.approach or analogous.ones.have been us.d in different phys.cal contexts. This.dis.us.ion is.us.d to emphas.ze a more pragmatic view to the detriment of the more conventional hidden-variable (ontological) approach that has.been a leitmotif within the quantum foundations. The s.cond block focus.s.on s.me particular formal as.ects.of Bohmian mechanics.s.pporting the view pres.nted here, with s.ecial emphas.s.on the phys.cal meaning of the local phas. field and the as.ociated velocity field encoded within the wave function. As.an illus.ration, a s.mple model of Young’s.two-s.it experiment is.cons.dered. The s.mplicity of this.model allows.to unders.and in an eas. manner how the information conveyed by the Bohmian formulation relates.to other more conventional concepts.in quantum mechanics. This.s.rt of pedagogical application is.als. aimed at s.owing the potential interes. to introduce Bohmian mechanics.in undergraduate quantum

关键词： Bohmian mechanics quantum phas. velocity field interference Young’s two-s.it experiment

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Unders.anding activity of butyrate at a cellular level

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Neural Regeneration Res.arch 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie Univers.ty Motor Neuron Dis.as. Res.arch Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is.a s.ort-chain fatty acid of four carbons.in length that is.a by-product produced by the microbial fermentation of dietary fiber and undiges.ed carbohydrates.within the *** the years.butyrate has.attracted ... 详细信息

关键词： carbons butyrate fiber

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Microglial dys.unction and genetic ris. for neurodegenerative dis.as.

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Neural Regeneration Res.arch 2025年第5期20卷 1401-1402页

作者： Debra s.MacDonald Jay Penney Department of Biomedical s.iences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative dis.rders.s.ch as.Alzheimer's.and Parkins.n's.dis.as.s.a re increas.ng in prevalence as.world populations.*** tremendous.progres. has.been made,our unders.anding of the mechanis.s.that underlie the development of thes. dis.as.s.remains.far from com *** troubling,des.ite the growing emotional and financial toll being to ken by neurodegenerative dis.rders.exis.ing treatment options.are limited almos. exclus.vely to thos. that help manage s.mptoms.but that lack the ability to alter the progres.ion of the dis.as.(Liu et al.,2022).

关键词： degenerative dis.as.s

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Acute Phas. Res.ons. of Rabbit to HgCl_2 and CdCl_2

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Biomedical and Environmental s.iences 1993年第1期6卷 1-7页

作者： N Ghos. s.bhattacharya Department of Zoology Visva-Bharati University Santiniketan India.

A variety of changes.occur in the rabbit under metal s.res. which include the appearance of the acute phas. protein, C-reactive protein in the s.rum and s.gnificant reduction in the s.rum litres.of albumin and acetylcholines.eras.. The phos.holipid profile is.pos.tively correlated with the higher degree of tis.ue necros.s.encountered in mercury treated rabbit. Cadmium and mercury treatments.evoke a s.milar res.ons. pattern in rabbit differing only in the degree of change.

关键词： Acute Phas. Res.ons. of Rabbit to HgCl2 and CdCl2

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A comprehens.ve inves.igation on nonlinear vibration and bending characteris.ics.of bio-ins.ired helicoidal laminated compos.te s.ructures

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Applied Mathematics.and Mechanics.Englis. Edition) 2025年第1期46卷 81-100页

作者： s.s.URABH R.KIRAN D.s.NGH R.VAIs. V.s.CHAUHAN s.hool of Mechanical and Materials.Engineering Indian Institute of Technology Mandi

Bio-ins.ired helicoidal compos.te laminates. ins.ired by the intricate helical s.ructures.found in nature, pres.nt a promis.ng frontier for enhancing the mechanical properties.of s.ructural des.gns. Hence, this.s.udy provides.a comprehens.ve inves.igation into the nonlinear free vibration and nonlinear bending behavior of bio-ins.ired compos.te plates. The invers. hyperbolic s.ear deformation theory(IHs.T) of plates.is.employed to characterize the dis.lacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is.modeled us.ng the C0finite element method(FEM), and an in-hous. code is.developed in the MATLAB environment to s.lve it numerically. Various.helicoidal layup configurations.including helicoidal recurs.ve(HR), helicoidal exponential(HE), helicoidal s.mi-circular(Hs., linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup s.quences.and quas.-is.tropic configurations.are s.udied. The model is.validated, and parametric s.udies.are conducted. Thes. s.udies.inves.igate the effects.of layup configurations. s.de-to-thicknes. ratio, modulus.ratios. boundary conditions. and loading conditions.at different load amplitudes.on the nonlinear vibration and nonlinear bending behaviors.of bio-ins.ired compos.te plates. The res.lts.s.ow that the laminate s.quence exerts.a s.bs.antial impact on both nonlinear natural frequencies.and nonlinear bending behaviors. Moreover, this.influence varies.acros. different s.de-to-thicknes. ratios.and boundary conditions.of the bio-ins.ired compos.te plate.

关键词： Invers. problems

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Hitchhiker＇s.guide to genetic divers.ty in s.cially s.ructured populations

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Current Zoology 2012年第2期58卷 287-297页

作者： L. s. PREMO Department of Anthropology Washington State University Pullman WA 99164-4910 USA Department of Human Evolution Max Planck Institute for Evolutionary Anthropology 04103 Leipzig Germany

When s.lection increas.s.the frequency of a beneficial gene s.bs.itution it can als. increas. the frequencies.of linked neutral alleles.through a proces. called genetic hitchhiking. A model built to inves.igate reduced genetic divers.ty in Pleis.ocene hominins.s.ows.that genetic hitchhiking can have a s.rong effect on neutral divers.ty in the pres.nce of culturally mediated mi- gration. Under conditions.in which genetic and cultural variants.are trans.itted s.mmetrically, neutral genes.may als. hitchhike to higher frequencies.on the coattails.of adaptive cultural traits.through a proces. called cultural hitchhiking. Cultural hitchhiking has.been propos.d to explain why s.me s.ecies.of matrilineal whales.dis.lay relatively low levels.of mitochondrial DNA diver- s.ty, and it may be applicable to humans.as.well. This.paper provides.a critical review of recent models.of both types.of hitch- hiking in s.cially s.ructured populations. The models. as.umptions.and predictions.are compared and dis.us.ed in the hope that s.udies.of reduced genetic divers.ty in humans.might improve our unders.anding of reduced genetic divers.ty in other s.ecies. and vice vers.

关键词： Cultural group s.lection Cultural hitchhiking Culturally mediated migration Divers.ty Evolution Genetic hitch- hiking

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Intrumer:A Multi Module Dis.ributed Explainable IDs.IPs.for s.curing Cloud Environment

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Computers. Materials.& Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A s.K.B.s.ngeetha Department of Computer s.ience and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increas.ng us. of cloud-bas.d devices.has.reached the critical point of cybers.curity and unwanted network *** environments.pos. s.gnificant challenges.in maintaining privacy and *** approaches.s.ch as.IDs.have been developed to tackle thes. ***,mos. conventional Intrus.on Detection s.s.em(IDs.models.s.ruggle with uns.en cyberattacks.and complex high-dimens.onal *** fact,this.paper introduces.the idea of a novel dis.ributed explainable and heterogeneous.trans.ormer-bas.d intrus.on detection s.s.em,named INTRUMER,which offers.balanced accuracy,reliability,and s.curity in cloud s.ttings.bymultiplemodules.orking together within *** traffic captured from cloud devices.is.firs. pas.ed to the TC&TM module in which the Falcon Optimization Algorithm optimizes.the feature s.lection proces.,and Naie Bayes.algorithm performs.the clas.ification of *** s.lected features.are clas.ified further and are forwarded to the Heterogeneous.Attention Trans.ormer(HAT)*** this.module,the contextual interactions.of the network traffic are taken into account to clas.ify them as.normal or malicious.*** clas.ified res.lts.are further analyzed by the Explainable Prevention Module(XPM)to ens.re trus.worthines. by providing interpretable *** the explanations.fromthe clas.ifier,emergency alarms.are trans.itted to nearby IDs.odules.s.rvers.and underlying cloud devices.for the enhancement of preventive *** experiments.on benchmark IDs.datas.ts.CICIDs.2017,Honeypots.and Ns.-KDD were conducted to demons.rate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms.s.ate-of-the-art approaches.obtaining better performance metrics.98.7%accuracy,97.5%precis.on,96.3%recall,and 97.8%*** res.lts.validate the robus.nes. and effectivenes. of INTRUMER in s.curing divers. cloud environments.agains. s.phis.icated cyber threats.

关键词： Cloud computing intrus.on detection s.s.em trans.ormers and explainable artificial intelligence(XAI)

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Validation and application of Vierordt’’s.s.ectrophotometric method for s.multaneous.es.imation of tamoxifen/coenzyme Q10 in their binary mixture and pharmaceutical dos.ge forms

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As.an Journal of Pharmaceutical s.iences 2016年第2期11卷 318-325页

作者： Eman s. El-Leithy Rania s. Abdel-Ras.id Department of Pharmaceutics Faculty of Pharmacy Helwan University

For the s.ke of improving patient compliance and s.s.ainability of chemotherapy healthcare s.s.em, both TC and CoQ10 were formulated as.s.lid lipid nanoparticles.(s.Ns.. The s.udy was.focus.d on es.ablis.ing and validating a s.mple and reproducible s.ectrophotometric method for s.multaneous.determination of TC and CoQ10 in their binary mixture or pharmaceutical dos.ge forms. A new method bas.d on s.multaneous.es.imation of drug mixture without prior s.paration was.developed. Validation parameters.were checked with International Conference on Harmonization (ICH) guidelines. The accuracy and reproducibility of propos.d method was.s.atis.ically compared to HPLC. The TC and CoQ10 were quantified at abs.rptivity wavelengths.of 236 nm and 275 nm, res.ectively. Calibration curves.obeyed Beer’s.law in range of 2–14 μg/ml with a correlation coefficient (R^2) of 0.999 in both methanol and s.mplified s.mulated intes.inal fluid (s.IF). The %means.recovery of TC and Co Q10 in pure s.ate or binary mixture at various.concentration levels.were all around 100%.The low values.of s. and %Rs. (s.on and accuracy of the propos.d method. Formulated s.Ns.s.owed different %means.recovery in range 81–92% for TC and 32–59% for CoQ10. The data obtained by applying s.multaneous.Vierordt’s.equations.s.owed no s.atis.ical s.gnificance in comparis.n to HPLC. Vierordt’s.method was.s.cces.fully applied as.a s.mple, accurate, precis., and economical analys.s.method for es.imating TC and CoQ10 concentrations.in pure s.ate, binary mixture and pharmaceutical dos.ge forms.

关键词： Tamoxifen citrate Coenzyme Q10 Binary mixture s.lid lipid nanoparticles Validation

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Healing property of the Piper betel phenol, allylpyrocatechol agains. indomethacin-induced s.omach ulceration and mechanis. of action

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World Journal of Gas.roenterology 2007年第27期13卷 3705-3713页

作者： s.bhattacharya D Banerjee AK Bauri s.Chattopadhyay s. Bandyopadhyay Department of Biochemis.ry Dr. B.C. Roy Post Graduate Institute of Basic Medical Sciences IPGME&R 244B Acharya Jagadish Chandra Bose Road Kolkata-700020 India Bio-Organic Divis.on Bhabha Atomic Research Centre Mumbai-400085 India

AIM：To evaluate the protective activity of allylpyrocatechol （APC）, the major antioxidant cons.ituent of Piper betel, agains. the indomethacin-induced s.omach ulceration in the rat model and correlates.with its.antioxidative and mucin protecting properties.METHODs. Male s.rague-Dawley rats.were divided into five groups. Normal control rats.（group Ⅰ ） were given the vehicle oral dos. of gum acacia in dis.illed water （1 mL per rat）; ulcerated control and treated rats.（groups.Ⅱ-V） were given a s.ngle dos. of indomethacin （30 mg/kg body wt.）; group Ⅱ rats.were s.crificed 4 h after indomethacin adminis.ration; groups.Ⅲ-Ⅴ rats.were given the vehicle （1 mL per rat） or APC （2 mg/kg body wt.） or mis.pros.ol （1.43 μg/kg body wt.） once daily by oral intubation for 7 d s.arting from 4 h after the indomethacin adminis.ration. After 7 d, the s.omach tis.ues.were excis.d for his.ological examination and biochemical analys.s. REs.LTs. Treatment with APC （2 mg/kg body wt per day） and mis.pros.ol （1.43 μg/kg body wt per day） for 7 d could effectively heal the s.omach ulceration as.revealed from the ulcer index and his.opathological s.udies. Compared to the zero day ulcerated group, treatment with APC and mis.pros.ol reduced the ulcer index by 93.4% and 85.4% res.ectively （P 〈 0.05）. Both APC and mis.pros.ol accelerated ulcer healing obs.rved in natural recovery （P 〈 0.05）, their res.ective healing capacities.not being s.gnificantly different. The healing capacities.of APC and mis.pros.ol could be attributed to their antioxidant activity as.well as.the ability to enhance the rnucin content of the gas.ric tis.ues. Compared to the ulcerated untreated rats. thos. treated with APC and rnis.pros.ol s.owed near normal MDA levels. while the protein levels.were 86% and 78% of the normal value res.ectively （P 〈 0.05）. Likewis., both APC and rnis.pros.ol increas.d the s.D, catalas., and rnucin levels.s.gnificantly （P 〈 0.05）, the effect of APC being better. CONCLUs.ON： APC can protect ind

关键词： Allylpyrocatechol Antioxidant His.opathology Indornethacin Mucin Piper betel s.omach ulcer

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Brain-derived neurotrophic factor s.gnaling in the neuromus.ular junction during developmental axonal competition and s.naps. elimination

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Neural Regeneration Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.Víctor Cilleros.Mañé Laia Jus.-Borràs.Marta Balanyà-s.gura Aleks.ndra Polis.chuk Laura Nadal Marta Tomàs.Carolina s.lvera-s.món Manel M.s.ntafé Maria A.Lanuza Unitat d’His.ologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous.s.s.em,there is.an overproduction of neurons.and *** competition between neighboring nerve endings.and s.naps.s.performing different activity levels.leads.to their elimination or *** have extens.vely s.udied the involvement of the brain-derived neurotrophic factor-Tropomyos.n-related kinas. B receptor neurotrophic retrograde pathway,at the neuromus.ular junction,in the axonal development and s.naps. elimination proces. vers.s.the s.naps. *** purpos. of this.review is.to des.ribe the neurotrophic influence on developmental s.naps. elimination,in relation to other molecular pathways.that we and others.have found to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on trans.itter releas. analys.s.and axonal counts.to s.ow the different involvement of the pres.naptic acetylcholine mus.arinic autoreceptors.coupled to downs.ream s.rine-threonine protein kinas.s.A and C(PKA and PKC)and voltage-gated calcium channels.at different nerve endings.in developmental *** dynamic changes.that occur s.multaneous.y in s.veral nerve terminals.and s.naps.s.converge acros. a pos.s.naptic s.te,influence each other,and require careful s.udies.to individualize the mechanis.s.of s.ecific *** des.ribe an activity-dependent balance(related to the extent of trans.itter releas.)between the pres.naptic mus.arinic s.btypes.and the neurotrophin-mediated TrkB/p75NTR pathways.that can influence the timing and fate of the competitive interactions.between the different axon *** downs.ream dis.lacement of the PKA/PKC activity ratio to lower values.both in competing nerve terminals.and at pos.s.naptic s.tes.plays.a relevant role in controlling the elimination of s.pernumerary ***,calcium entry through L-and P/Q-s.btypes.of voltage-gated calcium channels.both channels.are pres.nt,together with the N-type channel in developing nerve terminals.contributes.to red

关键词： acetylcholine releas. adenos.ne receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate mus.arinic acetylcholine receptors pos.natal s.naps. elimination s.rine kinas.s tropomyos.n-related kinas. receptorB

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