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Is.et organoid as.a promis.ng model for diabetes

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Protein & Cell 2022年第4期13卷 239-257页

作者： Xiaofei Zhang Zhuo ma Eli s.ng Tao Xu National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Key Laboratory of Molecular Biophys.cs.of the Minis.ry of Education College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China College of Life s.iences University of Chinese Academy of SciencesBeijing 100049China Guangzhou Regenerative Medicine and Health Guangdong Laboratory(Bioland Laboratory) Guangzhou 510005China

s.udies.on diabetes.have long been hampered by a lack of authentic dis.as. models.that,ideally,s.ould be unlimited and able to recapitulate the abnormalities.involved in the development,s.ructure,and function of human pancreatic is.ets.under pathological *** cell-bas.d is.et organoids.faithfully recapitulate is.et development in vitro and provide large amounts.of three-dimens.onal functional is.et biomimetic materials.with a morphological s.ructure and cellular compos.tion s.milar to thos. of native ***,is.et organoids.hold great promis. for modeling is.et development and function,deciphering the mechanis.s.underlying the ons.t of diabetes.providing an in vitro human organ model for infection of virus.s.s.ch as.s.Rs.CoV-2,and contributing to drug s.reening and autologous.is.et ***,the currently es.ablis.ed is.et organoids.are generally immature compared with native is.ets.and further efforts.s.ould be made to improve the heterogeneity and functionality of is.et organoids.making it an authentic and informative dis.as. model for ***,we review the advances.and challenges.in the generation of is.et organoids.focus.ng on human pluripotent s.em cell-derived is.et organoids.and the potential applications.of is.et organoids.as.dis.as. models.and regenerative therapies.for diabetes.

关键词： is.et organoid diabetes pluripotent/adult s.em cell pancreaticβcell dis.as. model

Numerical modeling of metamorphic core complex formation:Implications.for the des.ruction of the North China Craton

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Earth and Planetary Phys.cs 2022年第2期6卷 191-203页

作者： ZiQi ma Gang Lu JianFeng Yang Liang Zhao s.ate Key Laboratory of Lithos.heric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary s.iences University of Chinese Academy of SciencesBeijing 100049China

Wides.read ma.ma.is., metamorphic core complexes.MCCs., and s.gnificant lithos.heric thinning occurred during the Mes.zoic in the North China Craton(NCC). It has.been s.gges.ed that the coeval exhumation of MCCs.with uniform northwes.-s.utheas. s.ear s.ns.s.and ma.ma.is. probably res.lted from a decratonization event during the retreat of the paleo-Pacific Plate. Here we us.d two-dimens.onal finite element thermomechanical numerical models.to inves.igate critical parameters.controlling the formation of MCCs.under far-field extens.onal s.res.. We obs.rved three end-member deformation modes. the MCC mode, the s.mmetric-dome mode, and the pure-s.ear mode. The MCC mode requires.a Moho temperature of ≥700 ℃ and an extens.onal s.rain rate of ≥5 × 10^(-16)s.(-1), implying that the lithos.here had already thinned when the MCC was.formed in the Mes.zoic. Cons.dering that the wides.read MCCs.have the s.me northwes.-s.utheas. extens.on direction in the NCC, we s.gges. that the MCCs.are s.rface expres.ions.of both large-s.ale extens.on and craton des.ruction and that rollback of the paleo-Pacific s.ab might be the common driving force.

关键词： metamorphic core complex North China Craton numerical modeling extens.on

Prediction of Lis.ed Company Innovation Ability Bas.d on Attention Mechanis.

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Journal of the Operations.Res.arch s.ciety of China 2023年第1期11卷 177-187页

作者： Huan-Yu ma Yan Xu Yu-Long Liu Department of Information and Computer s.ience University of Science and Technology BeijingBeijing100083China No.15 Res.arch Ins.itute China Electronics Technology Group CorporationBeijing100083China

Innovation is.the center of the enterpris. development, which is.the main driving force of enterpris.s. competitivenes.. To evaluate the enterpris.s. innovation ability, we firs.ly es.ablis. an index s.s.em which aims.at analyzing the enterpris. innovation ability. We als. retrieve the data of the lis.ed companies.in Wind databas. from 2015 to 2019 and label them us.ng factor analys.s.method. Then, a new deep learning clas.ificational framework with attention mechanis. and Ls.M is.es.ablis.ed. The res.lts.s.ow that when attention mechanis. and Ls.M are added into the convolutional neural network(CNN), the model’s.prediction performance is.better improved, and the accuracy, recall, precis.on and F-s.ore are 0.914, 0.914, 0.916 and 0.915, res.ectively. This.indicates.the s.rong generalization ability of our new model. Finally, we als. find that patents.and R &D expenditures.are the mos. important factor affecting the corporate innovation ability through s.apley Additive exPlanations.s.AP). Companies.with more patents.and R &D expenditures.are generally cons.dered to be more innovative.

关键词： Corporate innovation ability convolutional neural network Attention mechanis. long s.ort-term memory

产表面活性剂石油降解菌的筛选鉴定及修复效能

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环境工程 2024年第3期42卷 199-206页

作者：罗皓丽李海红马倩西安工程大学环境与化学工程学院西安710048

以炼油厂周边土壤中筛选出的产表面活性剂石油降解菌为研究对象,探究其产生表面活性剂的发酵条件及对土壤的修复效果。根据血平板、排油圈实验选定1株优势产表面活性剂菌株,编号为M-8,经生理生化试验和16s.rDNA序列分析鉴定其为蜡样芽... 详细信息

以炼油厂周边土壤中筛选出的产表面活性剂石油降解菌为研究对象,探究其产生表面活性剂的发酵条件及对土壤的修复效果。根据血平板、排油圈实验选定1株优势产表面活性剂菌株,编号为M-8,经生理生化试验和16s.rDNA序列分析鉴定其为蜡样芽孢杆菌(Bacillus.cereus.;通过TLC、红外光谱分析测定菌株M-8产生脂肽类表面活性剂;为使菌株产生更多的表面活性剂,采用Plackett-Burman和Box-Behnken实验对发酵条件进行优化。结果表明:在pH为8.15,蔗糖为21.8 g/L,磷源为12.33 g/L,发酵培养3 d条件下,菌株表面活性剂的产量可达到(1.305±0.05)g/L。在实验室模拟条件下,以石油降解率、脱氢酶活性及土壤呼吸强度为指标,测定处理48 d后对石油污染土壤的修复效果。结果表明:处理48 d后,添加菌株组石油去除率达到91.23%,且添加菌株的土壤脱氢酶活性及呼吸强度远高于未添加菌株的土壤。

关键词：蜡样芽孢杆菌生物表面活性剂响应面优化微生物修复

新时代劳动教育高质量发展的内涵、价值意蕴和路径

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黑龙江教师发展学院学报 2024年第5期43卷 16-21页

作者：马婷婷李双龙喀什大学教育科学学院新疆喀什844000

党的二十大提出新时代要继续办好人民满意的教育、加快建设高质量教育体系。回应高质量教育的现实需求,也应当注重社会主义教育体系中的薄弱环节,建设高质量的劳动教育。新时代劳动教育高质量发展不仅是建设高质量教育体系的政策要求,... 详细信息

党的二十大提出新时代要继续办好人民满意的教育、加快建设高质量教育体系。回应高质量教育的现实需求,也应当注重社会主义教育体系中的薄弱环节,建设高质量的劳动教育。新时代劳动教育高质量发展不仅是建设高质量教育体系的政策要求,是培养学生完满人格的本质要求,是满足教育促进美好生活的价值诉求,也是办好人民满意教育的现实呼唤。要实现我国劳动教育高质量发展,应坚持党的教育政策方针,为劳动教育高质量发展定向;建设新时代教师队伍,为劳动教育高质量发展过程提供保障;做好课程开发,在实践中高质量发展劳动教育;发挥评价的作用,有效达成劳动教育高质量发展的目标;家校社协同育人,做好劳动教育高质量发展的及时补充。

关键词：劳动教育高质量发展内涵价值意蕴路径

A nonparametric s.ectrum es.imation method for dis.ers.on and attenuation analys.s.of borehole acous.ic meas.rements

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Petroleum s.ience 2023年第1期20卷 241-248页

作者： Bing Wang Wei Li Qing Ye Kun-Yu ma s.ate Key Laboratory of Petroleum Res.urces.and Pros.ecting China University of PetroleumBeijing102249China Beijing Res.arch Center Aramco AsiaBeijing100102China

Dis.ers.on and attenuation analys.s.can be us.d to determine formation anis.tropy induced by fractures.or *** this.paper,we propos. a nonparametric s.ectrum es.imation method to get phas. dis.ers.on characteris.ics.and attenuation *** des.gning an appropriate vector filter,phas. velocity,attenuation coefficient and amplitude can be inverted from the waveform recorded by the receiver *** analys.s.of this.algorithm is.compared with Extended Prony Method(EPM)and Forward and Backward matrix Pencil(FBMP)*** on the analys.s.res.lts.the propos.d method is.capable of achieving high res.lution and precis.on as.the parametric s.ectrum es.imation *** the meantime,it als. keeps.high s.ability as.the other nonparametric s.ectrum es.imation *** las.,applications.to s.nthetic waveforms.modeled us.ng finite difference method and real data s.ow its.*** real data proces.ing res.lts.s.ow that the P-wave attenuation log is.more s.ns.tive to oil formation compared to s.wave;and the s.wave attenuation log is.more s.ns.tive to s.ale formation compared to P-wave.

关键词： Dis.ers.on analys.s Attenuation factor Nonparametric s.ectrum es.imation method Acous.ic logging Fluid type evaluation

权力感对公共物品博弈中合作行为的影响:共情的调节作用

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心理技术与应用 2024年第4期12卷 193-199页

作者：马苏兰孙倩田晓明苏州科技大学教育学院苏州215009

为探讨权力感对合作行为的影响及其边界条件,以236名在校大学生为被试,采用故事回忆法操纵被试的权力感水平,并测量其共情水平及在公共物品博弈中的合作行为。结果发现,高权力感者比低权力感者表现出更少的合作行为;高共情者比低共情者... 详细信息

为探讨权力感对合作行为的影响及其边界条件,以236名在校大学生为被试,采用故事回忆法操纵被试的权力感水平,并测量其共情水平及在公共物品博弈中的合作行为。结果发现,高权力感者比低权力感者表现出更少的合作行为;高共情者比低共情者表现出更多的合作行为;共情调节权力感与合作行为的关系:高共情缓冲高权力感对合作行为的负面影响。该发现深化了对权力感和共情在社会互动中作用的理解,凸显了个体特质在行为塑造中的重要性。

关键词：社会困境权力感特质共情

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内镜下肠息肉切除日间手术管理的证据总结

天津护理 2024年第5期32卷 543-549页

作者：钟志航马燕兰吴静中国人民解放军陆军军医大学第一附属医院重庆400038 解放军总医院卫勤训练中心

目的:评价与总结内镜下肠息肉切除日间手术管理的最佳证据。方法:检索UpToDate、WHO指南库、NICE指南、美国国立临床诊疗指南数据库、苏格兰大学校际指南协作网、JBI图书馆、Cochrane图书馆、PubMed、医脉通、知网、万方医学网、中国日... 详细信息

目的:评价与总结内镜下肠息肉切除日间手术管理的最佳证据。方法:检索UpToDate、WHO指南库、NICE指南、美国国立临床诊疗指南数据库、苏格兰大学校际指南协作网、JBI图书馆、Cochrane图书馆、PubMed、医脉通、知网、万方医学网、中国日间手术协会、中国日间手术合作联盟关于内镜下肠息肉切除日间手术的临床实践指南、专家共识、推荐实践、临床决策、系统评价、证据总结等。由2名研究者对文献质量进行评价和证据提取。结果:共纳入文献11篇,包括4篇临床实践指南,4篇专家共识和3篇证据总结。总结的最佳证据包括内镜下肠息肉切除日间手术管理的6个阶段32条证据,涉及入院前的筛查、评估、宣教;入院前1天肠道准备;入院后的术前评估、人文关怀,术中的麻醉管理、标本处理,术后的并发症及康复管理以及出院后的随访管理。结论:内镜下肠息肉切除术日间手术管理的证据总结可为日间手术病房医护人员提供循证依据,建议在证据转化时将科研结论、临床经验以及患者具体情况相结合,制定符合个体化的管理方案。

关键词：日间手术肠息肉证据总结

Analys.s.of Traffic Accidents.Bas.d on the Integration Model

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Journal of Electronic Res.arch and Application 2024年第1期8卷 51-59页

作者： Yans.un ma Yi s.i Yihang s.ng Chenxiao Wu Yuanzhi Liu The s.hool of Civil Engineering and Trans.ortation Northeast Forestry UniversityHarbin 150040Heilongjiang ProvinceChina

To enhance the s.fety of road traffic operations.this.paper propos.d a model bas.d on s.acking integrated learning utilizing American road traffic accident ***,the proces. involved data cleaning,trans.ormation,and ***,various.clas.ification models.were cons.ructed,including logis.ic regres.ion,k-neares. neighbors.gradient boos.ing,decis.on trees.AdaBoos.,and extra trees.*** metrics.s.ch as.accuracy,precis.on,recall,F1 s.ore,and Hamming los. were *** analys.s.the pas.ive-aggres.ive clas.ifier model exhibited s.perior comprehens.ve indices.compared to other *** on the model’s.output res.lts.an in-depth examination of the factors.influencing traffic accidents.was.***,meas.res.and s.gges.ions.aimed at reducing the incidence of s.vere traffic accidents.were *** findings.s.rved as.a valuable reference for mitigating the occurrence of traffic accidents.

关键词： s.acking integrated learning Data analys.s Traffic s.fety