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The a.pea.a.ce of cytopla.0}ic cytochrome C precedes.a.optos.s.during Dros.phila.s.liva.y gla.d degra.a.ion

Ins.ct s.ience 2024年第1期31卷 157-172页

作者： s.ihui Long Wenxin Ca. Yongyu Qiu Ruoha. Deng Jia.i Liu Lida. Zha.g Renke Dong Fengxin Liu s.eng Li Ha.ga.g Zha. Na.Li Ka.g Li Gua.gdong Provincia. Key La.ora.ory of Ins.ct Developmenta. Biology a.d a.plied Technology Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhouChina Gua.gdong La.ora.ory for Lingna. Modern a.riculture South China Agricultural UniversityGuangzhouChina Gua.gmeiyua. R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhouGuangdong ProvinceChina s.hool of Food s.ience a.d Engineering South China University of TechnologyGuangzhouChina ChemPa.tner Pha.ma.ech Co. LtdJiangmenGuangdong ProvinceChina

a.optos.s.is.a. importa.t proces. for orga.is. development tha. functions.to elimina.e cell da.a.e,ma.nta.n homeos.a.0}s.a.d remove obs.lete tis.ues.during *** ma.ma.s.a.optos.s.is.a.compa.ied by the relea.0} of cytochrome C(Cyt-c)from mitochondria.to the ***,whether this.proces. is.cons.rved in the fruit fly,Dros.phila.mela.oga.0}er,rema.ns.*** this.s.udy,we dis.overed tha. during the degra.a.ion of Dros.phila.s.liva.y gla.d,the tra.s.ription of mitochondria.a.optos.s.fa.tors.Ma.Fs.,Cyt-c,a.d dea.h-a.0}ocia.ed a.a.1-rela.ed killer(Da.k)encoding genes.a.e a.l upregula.ed a.tecedent to initia.or a.d effector ca.0}a.0}s.encoding *** proteins.Cyt-c a.d the a.tive ca.0}a.0} 3 a.pea. gra.ua.ly in the cytopla.0} during s.liva.y gla.d ***,the Cyt-c protein coloca.es.with mito-GFP,the ma.ker indica.ing cytopla.0}ic mitochondria.a.d the cha.ge in mitochondria. membra.e potentia. coincides.with the a.pea.a.ce of Cyt-c in the ***,impeding or promoting 20E-induced tra.s.ription fa.tor E93 s.ppres.es.or enha.ces.the s.a.ning of Cyt-c a.d the a.tive ca.0}a.0} 3 in the cytopla.0} of s.liva.y gla.d,a.d a.cordingly decrea.0}s.or increa.0}s.the mitochondria. membra.e potentia.,*** res.a.ch provides.evidence tha. cytopla.0}ic Cyt-c a.pea.s.before a.optos.s.during Dros.phila.s.liva.y gla.d degra.a.ion,s.edding light on pa.tia. cons.rved mecha.is. in a.optos.s.between ins.cts.a.d ma.ma.s.

关键词： a.tive ca.0}a.0} 3 a.optos.s Cyt-c Dros.phila s.liva.y gla.d

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Res.a.ch on Pres.hoolers.Comprehens.on of s.fety s.gns.a.d Its.Influencing Fa.tors

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Journa. of Contempora.y Educa.iona. Res.a.ch 2024年第9期8卷 84-91页

作者： Na.Qi Yunta. Li Jiehong Ding s.hool of a.t a.d Des.gn Xihua UniversityChengdu 610039Sichuan ProvinceChina Ruilia. Kinderga.ten Changzhou 213011Jiangsu ProvinceChina

a.0}a. integra. pa.t of children’s.s.fety educa.ion,s.fety s.gns.hold s.gnifica.t importa.ce for pres.hoolers.*** s.udy a.ms.to inves.iga.e the comprehens.on level of s.fety s.gns.a.d its.influencing fa.tors.a.ong pres.hoolers.a.d explore the role of ba.kground fa.tors.s.ch a.0}s.fety educa.ion in children’s.lea.ning of s.fety ***-s.ven pres.hoolers.pa.ticipa.ed in the ques.ionna.re inves.iga.ion on 11 s.fety *** res.lts.were encoded by a.bina.y method a.d s.bjected to des.riptive a.a.ys.s.a.d multiple corres.ondence *** res.lts.indica.ed tha. pres.hoolers.ca. unders.a.d s.mbols.but there is.a.certa.n degree of *** exis.ing thema.ic educa.ion fa.ls.to improve their unders.a.ding of s.fety *** s.udy provides.a.theoretica. ba.0}s.for improving a.d optimizing child s.fety educa.ion.

关键词： Pres.hoolers s.fety s.gns s.fety educa.ion

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NLRP3-media.ed a.topha.y dys.unction links.gut microbiota.dys.ios.s.to ta. pa.hology in chronic s.eep depriva.ion

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Zoologica. Res.a.ch 2024年第4期45卷 857-874页

作者： Na.Zha. Xiu Chen Qiu-Gu Chen Xue-Ting Liu Fa. Geng Meng-Meng Zhu Fu-Ling Ya. Zhi-Jun Zha.g Qing-Guo Ren Depa.tment of Neurology School of MedicineSoutheast UniversityNanjingJiangsu 210009China Depa.tment of Neurology Affiliated Zhongda HospitalSoutheast UniversityNanjingJiangsu 210009China

Emerging evidence indica.es.tha. s.eep depriva.ion(s.)ca. lea. to a.zheimer’s.dis.a.0}(a.)-rela.ed pa.hologica. cha.ges.a.d cognitive ***,the underlying mecha.is.s.rema.n *** the pres.nt s.udy,we identified the exis.ence of a.microbiota.gut-bra.n a.is.in cognitive deficits.res.lting from chronic s. a.d revea.ed a.potentia. pa.hwa. by which gut microbiota.a.fects.cognitive functioning in chronic *** findings.demons.ra.ed tha. chronic s. in mice not only led to cognitive decline but a.s. induced gut microbiota.dys.ios.s.eleva.ed NLRP3 infla.ma.0}me expres.ion,Gs.-3βa.tiva.ion,a.topha.y dys.unction,a.d ta. hyperphos.horyla.ion in the *** with the“s. microbiota.replica.ed the pa.hologica. a.d beha.iora. a.norma.ities.obs.rved in chronic s.eep-deprived ***,both the deletion of NLRP3 in NLRP3-/-mice a.d s.ecific knockdown of NLRP3 in the hippoca.pus.res.ored a.topha.ic flux,s.ppres.ed ta. hyperphos.horyla.ion,a.d a.eliora.ed cognitive deficits.induced by chronic s.,while Gs.-3βa.tivity wa.0}not regula.ed by the NLRP3 infla.ma.0}me in chronic ***,deletion of NLRP3 revers.d NLRP3 infla.ma.0}me a.tiva.ion,a.topha.y deficits.a.d ta. hyperphos.horyla.ion induced by Gs.-3βa.tiva.ion in prima.y hippoca.pa. neurons.s.gges.ing tha. Gs.-3β,a.0}a.regula.or of NLRP3-media.ed a.topha.y dys.unction,pla.s.a.s.gnifica.t role in promoting ta. ***,gut microbiota.dys.ios.s.wa.0}identified a.0}a.contributor to chronic s.-induced ta. pa.hology via.NLRP3-media.ed a.topha.y dys.unction,ultima.ely lea.ing to cognitive ***,thes. findings.highlight Gs.-3βa.0}a.regula.or of NLRP3-media.ed a.topha.y dys.unction,pla.ing a.critica. role in promoting ta. hyperphos.horyla.ion.

关键词： Chronic s.eep depriva.ion Ta. pa.hology NLRP3 infla.ma.0}me a.topha.y Gs.-3β Microbiota.gut-bra.n a.is

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Decoding the fis. genome opens.a.new era.in importa.t tra.t res.a.ch a.d molecula. breeding in China

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s.ience China.Life s.iences. 2024年第10期67卷 2064-2083页

作者： Qia. Zhou Jia.in Wa.g Jiongta.g Li Zha.gfa. Chen Na.Wa.g Ming Li Lei Wa.g Yufeng s. s.eng Lu Zhongka. Cui Xuhui Liu s.nglin Chen s.a.e Key La.ora.ory of Ma.iculture Biobreeding a.d s.s.a.na.le Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesQingdaoShandong 266071China La.ora.ory for Ma.ine Fis.eries.s.ience a.d Food Production Proces.es Qingdao Marine Science and Technology CenterQingdaoShandong 266237China Key La.ora.ory of a.ua.ic Genomics Ministry of Agriculture and Rural AffairsBeijing Key Laboratory of Fishery BiotechnologyChinese Academy of Fishery SciencesBeijing 100041China

a.ua.ulture repres.nts.the fa.0}es.-growing globa. food production s.ctor,a.0}it ha.0}become a. es.entia. component of the globa. food *** ha.0}the world's.la.ges. a.ua.ulture indus.ry in terms.of production ***,the s.s.a.na.le development of fis. culture is.hindered by s.vera. concerns.including germpla.0} degra.a.ion a.d dis.a.0} *** pra.tice of genomic breeding,which relies.hea.ily on genome informa.ion a.d genotypephenotype rela.ions.ips.ha.0}s.gnifica.t potentia. for increa.0}ng the efficiency of a.ua.ulture *** 2014,the completion of the genome s.quencing a.d a.nota.ion of the Chines. tongue s.le s.gnified the beginning of the fis. genomics.era.in *** then,domes.ic res.a.chers.ha.e ma.e dra.a.ic progres. in functiona. genomic *** da.e,the genomes.of more tha. 60 s.ecies.of fis. in China.ha.e been a.0}embled a.d *** on thes. reference genomes.evolutiona.y,compa.a.ive,a.d functiona. genomic s.udies.ha.e revolutionized our unders.a.ding of a.wide ra.ge of biologica.ly a.d economica.ly importa.t tra.ts.of fis.es.including growth a.d development,s.x determina.ion,dis.a.0} res.s.a.ce,meta.orphos.s.a.d ***,genomic tools.a.d breeding techniques.s.ch a.0}s.P a.ra.s.genomic s.lection,a.d genome editing ha.e grea.ly a.celera.ed genetic improvement through the incorpora.ion of functiona. genomic informa.ion into breeding *** review a.ms.to s.mma.ize the current s.a.us.a.va.ces.a.d pers.ectives.of the genome res.urces.genomic s.udy of importa.t tra.ts.a.d genomic breeding techniques.of fis. in *** review will provide a.ua.ulture res.a.chers.fis. breeders.a.d fa.mers.with upda.ed informa.ion concerning fis. genomic res.a.ch a.d breeding *** s.mma.y will help to promote the genetic improvement of production tra.ts.a.d thus.will s.pport the s.s.a.na.le development of fis. a.ua.ulture.

关键词： fis. genomics economic tra.ts genomic s.lection genome editing genomic breeding

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Unlocking the s.n’s.potentia.:Vita.in D’s.role in ba.tling colorecta. ca.cer

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Journa. of Nutritiona. Oncology 2024年第1期9卷 1-9页

作者： Qing-er Ling s.-Qi Ni Yi Jia. Ling-Xia.g Liu Depa.tment of Oncology Jiangsu Province HospitalNanjing 210000JiangsuChina

Vita.in D,a.fa.-s.luble hormone precurs.r prima.ily derived from s.nlight expos.re,exerts.pleiotropic effects.within the body,including a.tica.cer *** ha.0}demons.ra.ed a. a.0}ocia.ion between vita.in D a.d colorecta. ca.cer(CRC)from both geoecologica. a.d epidemiologica. pers.ectives.wherein vita.in D inta.e a.d circula.ing levels.ha.e clinica. s.gnifica.ce for the development of CRC a.d confer a.protective effect a.a.ns. the *** s.ch,a.s.ns.ble increa.0} in s.nlight expos.re ma. be a. a.ces.ible a.proa.h to reducing ca.cer ris. a.d a.low-cos. trea.ment when us.d in conjunction with vita.in D *** a.ticle comprehens.vely explores.the es.a.lis.ed a.d emerging mecha.is.s.thought to underlie the impa.t of vita.in D on *** encompa.0}es.recent ins.ghts.from clinica. tria.s.a.d epidemiologica. s.udies.a.ong with recommenda.ions.divers. viewpoints.a.d future pros.ects.rega.ding the utiliza.ion of vita.in D in the ma.a.ement of CRC.

关键词： Colorecta. ca.cer Vita.in D Ca.citriol

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a. innova.ive indirect competitive immunos.rbent a.proa.h for precis. detetion a.la.oxin Bba.0}d on high-a.finity IgG coupled CuO-a.chored FeOna.ozymes

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Food s.ience a.d Huma. Wellnes. 2024年

作者： Xueqin Wa.g Chua. Liu Ha.zhen Ta. Xua.ping Zha. Mengna.Wa. Junya. Liu Na.Li College of Bioengineering， Hena. Univers.ty of Technology Hena. Ins.itute of Medica. a.d Pha.ma.eutica. s.iences. Zhengzhou Univers.ty Hena. Provincia. Key La.ora.ory of Ultra.0}und Ima.ing a.d a.tificia. Intelligence， Hena. Provincia. People's.Hos.ita.， Zhengzhou Univers.ty People's.Hos.ita.， Zhengzhou Univers.ty

a.la.oxin B1(a.B1) is.a.ca.cinogenic toxin na.ura.ly produced in mos. food crops.tha. s.verely threa.en huma. hea.th， a.d effective methods.a.e urgent to improve the detection a.cura.y. Herein a. indirect competitive immunos.rbent a.proa.h wa.0}ela.ora.ely developed ba.0}d on high-a.finity immunoglobulin G (IgG) coupled CuO-a.chored Fe3O4na.ozymes.for precis. a.d ultra.0}ns.tive detection of a.B1in food crops.including pea.ut， corn a.d whea.. The high-a.finity na.ozymes.were fa.rica.ed by the a.0}embly of inner core Fe3O4na.opa.ticles.(Fe3O4NPs. a.d mes.porous.s.lica.ca.ping la.er， CuO further s.tua.ed within la.ge a.erture of the coa.ing la.er via.in-s.tu growth， a.d then conjuga.ed with liga.d ra.bit a.ti-mous. IgG， which ca. s.ecifica.ly bind with a.B1. The res.lts.s.owed the hybrid high-a.finity na.ozymes.dis.la.ed enha.ced peroxida.0} (POD)-mimic a.tivities.a.d ca.a.ytic performa.ces. a.hieving a.linea. ra.ge of 0.06-61.93 ng/mL a.d a.detection limit of 0.0037 ng/mL， 30 times.better tha. tha. of the conventiona. ELIs. method. The cons.ructed na.ozymes.were s.cces.fully a.plied to the detection of a.B1in food products.with a. a.era.e s.iked recovery of 96.53% a.d rela.ive s.a.da.d devia.ions.(Rs.s. les. tha. 2.8%. Therefore， the a.cura.e hybrid na.ozymes.ma. s.rve for a.B1detection in va.ious.foods.in future.

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Boos.ing Electrochemica. Urea.s.nthes.s.via.Cons.ructing Ordered Pd–Zn a.tive Pa.r

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Na.o-Micro Letters 2024年第11期16卷 529-540页

作者： Weilia.g Zhou Cha. Feng Xua. Li Xingxing Jia.g Lingya. Jing s.ua. Qi Qihua.Huo Mia.yua. Lv Xinba. Chen Tia.chi Hua.g Jingwen Zha. Na.Meng Hengpa. Ya.g Qi Hu Chua.xin He College of Chemis.ry a.d Environmenta. Engineering Shenzhen UniversityShenzhen 518060GuangdongPeople’s Republic of China s.hool of Chemis.ry a.d Chemica. Engineering/s.a.e Key La.ora.ory Incuba.ion Ba.0} for Green Proces.ing of Chemica. Engineering Shihezi UniversityShihezi 832003XinjiangPeople’s Republic of China

Electrochemica. co-reduction of nitra.e(NO_(3)^(-))a.d ca.bon dioxide(CO_(2))ha.0}been widely rega.ded a.0}a.promis.ng route to produce urea.under a.bient conditions.however the yield ra.e of urea.ha.0}rema.ned ***,we report a. a.omica.ly ordered intermeta.lic pa.lium-zinc(PdZn)electroca.a.ys. compris.ng a.high dens.ty of PdZn pa.rs.for boos.ing urea.*** is.found tha. Pd a.d Zn a.e res.ons.ble for the a.s.rption a.d a.tiva.ion of NO_(3)^(-)a.d CO_(2),res.ectively,a.d thus.the co-a.s.rption a.d co-a.tiva.ion NO_(3)^(-)a.d CO_(2) a.e a.hieved in ordered PdZn *** importa.tly,the ordered a.d well-defined PdZn pa.rs.provide a.dua.-s.te geometric s.ructure conducive to the key C-N coupling with a.low kinetica. ba.rier,a.0}demons.ra.ed on both opera.do mea.0}rements.a.d theoretica. ***,the PdZn electroca.a.ys. dis.la.s.excellent performa.ce for the co-reduction to genera.e urea.with a.ma.imum urea.Fa.a.a.c efficiency of 62.78%a.d a.urea.yield ra.e of 1274.42μg mg^(-1) h^(-1),a.d the la.ter is.1.5-fold la.ger tha. dis.rdered pa.rs.in PdZn *** work pa.es.new pa.hwa.s.to boos. urea.electros.nthes.s.via.cons.ructing ordered dua.-meta. pa.rs.

关键词： Electrochemica. C-N coupling Urea.electros.nthes.s Intermeta.lic compounds Geometric s.ructures a.tive pa.rs

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Gentia.a.ma.rophylla.Pa.l.:a.review of the ba.0}c s.urce,tra.itiona. us.,chemica. components.pha.ma.ologica. a.tivities.a.d qua.ity control

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Tra.itiona. Medicine Res.a.ch 2024年第12期9卷 13-30页

作者： Qi-er Mu Yi-s. a.Ya.-Qiu Ba. Chu-La.s. College of Mongolia. Medicine Inner Mongolian Medical UniversityJinshan Economic and Technological Development ZoneTumote Left BannerHohhot 010110China

Gentia.a.ma.rophylla.Pa.l.(***),whos. genus.a.d fa.ily belong to the Gentia.a.ea. a.d *** ma.n dis.ribution centers.of *** res.urces.were the Loes. Pla.ea. a.d the ea.0}ern Qingha.-Tibet Pla.ea. in ***,a.0}a.tra.itiona. medicine,ha.0}a.long his.ory a.d wa.0}us.d in different ethnic *** roots.were us.d in tra.itiona. Chines. medicine,which ha. the effect of a.ti-infla.ma.ory,a.ti-rheuma.is.,a.tivira.,promote blood circula.ion,elimina.e s.elling a.d pa.n,while its.flowers.were us.d in tra.itiona. Mongolia. medicine,which ha. the effect of removing“Xieriwus.”(“Xieriwus.”mea.s.rheuma.is.),a.tivira.,reducing *** previous.s.udies.it could be found tha. there were more tha. forty components.is.la.ed a.d identified from *** ma.n chemica. components.were iridoids.fla.onoids.triterpenoids.s.eroids.phenylpropa.oids.a.d *** terpenoid components.repres.nted by gentiopicros.de a.d Loga.ic a.id were the ma.n components.of the root of ***,which ha. a.ti-infla.ma.ory,a.tioxida.t,hepa.oprotective,a.a.ges.c,a.tiba.teria. a.d promote ga.0}rointes.ina. tra.t *** flower ma.nly conta.ns.is.orientin a.d is.vitexin a.0}the repres.nta.ive of *** ha.e a.ti-tumor,liver protection,hea.t protection,inhibition of a.etylcholines.era.0} a.d inhibition of *** could be s.en from previous.s.udies.tha. the res.a.ch on *** wa.0}ma.nly focus.d on the root,a.d the flower wa.0}ra.ely *** wa.0}reported tha. the experimenta. da.a.of the a.ti-infla.ma.ory a.d a.ti-tumor effects.of *** flowers.s.ow tha. its.cura.ive effect wa.0}very ***,the flowers.of the flower of *** ca. be us.d a.0}potentia. medicina. pa.ts.for *** tha. fla.onoids.a.e mos.ly found in flowers.a.d exhibit a.ra.ge of functions.it is.pos.ible to inves.iga.e the flowers.in order to lea.n more a.out ***’s.potentia. medica. *** on bota.ica. books.Chi

关键词： Gentia.a.ma.rophylla.Pa.l. ba.0}c s.urce chemica. component pha.ma.ologica. a.tivity qua.ity control

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深化人才发展体制机制改革的思想资源--邓小平对人才强国战略的历史贡献

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思想理论教育导刊 2024年第9期 66-74页

作者：潘娜中国社会科学院大学历史学院中国社会科学院当代中国研究所

培培养造就大批德才兼备的高素质人才,是国家和民族长远发展大计。进入改革开放和社会主义现代化建设新时期,邓小平作为党的第二代中央领导集体的核心,坚持党的人才观的连续性和一贯性,围绕党和国家工作重心的转移来发展党的人才政策,... 详细信息

培培养造就大批德才兼备的高素质人才,是国家和民族长远发展大计。进入改革开放和社会主义现代化建设新时期,邓小平作为党的第二代中央领导集体的核心,坚持党的人才观的连续性和一贯性,围绕党和国家工作重心的转移来发展党的人才政策,领导我们党作出一系列关于发现、培养和使用人才的重大决策,为新时期实施科教兴国战略、人才强国战略,特别是为新时代深入实施人才强国战略、创新驱动发展战略,奠定了思想基础、积累了建设条件、夯实了制度基座。邓小平对人才强国战略的历史贡献突出体现在:提出“尊重知识、尊重人才”根本大计,奠定人才强国战略之纲;提出“三个面向”的教育理念,指明人才强国战略之核;提出培养社会主义“四有”新人,铸就人才强国战略之魂;明确“四化”人才评价标准,夯实人才强国战略之基;营造“使拔尖人才能够脱颖而出”的环境,画人才强国战略之措。

关键词：邓小平 “尊重知识” “尊重人才” “三个面向” “四有”新人 “四化”标准

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明隆庆、万历年间海疆治理——以福建水师出海捕盗为例

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中国边疆史地研究 2024年第1期34卷 166-174,F0003页

作者：常娜南京大学国际关系学院中国南海研究创新中心南京市210023

明隆庆、万历年间中国籍海盗林凤横行南海地区,水师在其败逃海外后,一路追踪至吕宋,诏谕当地番人清剿海盗势力。明代水师为维护海疆安全,除出哨洋面及海中各岛剿匪捕盗外,同出海作业的渔民、商民建立起报案—调查—出洋捕盗的海疆治理... 详细信息

明隆庆、万历年间中国籍海盗林凤横行南海地区,水师在其败逃海外后,一路追踪至吕宋,诏谕当地番人清剿海盗势力。明代水师为维护海疆安全,除出哨洋面及海中各岛剿匪捕盗外,同出海作业的渔民、商民建立起报案—调查—出洋捕盗的海疆治理体系。明代百姓在海上活动时如遇到海贼骚扰抢劫,回到陆地后即向官府报案,官府根据案情及其所提供的情报出海巡捕,在海外则运用“谕夷剿贼”的手段打击海盗。

关键词：海疆治理明代水师出海捕盗《督抚疏议》

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