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量子光学学报 2006年第B8期12卷 62-63页

作者： Weiping Zhang H. Y. Ling s. yi H. Pu D. Grochows.i Key Laboratory of Optical and Magnetic Res.nance s.ectros.opy （Minis.ry of Education） Department of Physics East China Normal University Shanghai 200062 P. R. China Department of Phys.cs.and As.ronomy and Rice Quantum Institute Rice University Houston TX 77251-1892 USA Department of Phys.cs.and As.ronomy Rowan University Glassboro New Jersey 08028-1700 USA

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NUMERICAL s.MULATION OF FLOW PATTERNs.IN PLANAR JETs

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Trans.ctions.of Nanjing Univers.ty of Aeronautics.and As.ronautics 2001年第Z1期18卷 77-81页

作者： K. s. Lau 1) yi Liu 1,2) yin Cheng Guo 2) C. K. Chan 3) Wen yi Lin 2) 1) Department of Applied Phys.cs. The Polytechnic Univers.ty, Hong Kong, China 2) Department of Engineering Mechanics. Ts.nghua Univers.ty, Be Department of Applied Phys.cs The Polytechnic University Hong Kong China Department of Applied Phys.cs The Polytechnic University Hong Kong China Department of Engineering Mechanics Tsinghua University Beijing 100084P. R. China Department of Engineering Mechanics Tsinghua University Beijing 100084P. R. China Department of Applied Mathematics The Polytechnic University Hong Kong China

Two dimens.onal s.atial developing turbulent planar jets.with different velocity ratios.of jet fluid to co flow fluid at the inlet s.ction are s.mulated with large eddy s.mulation give detailed information of trans.ent behaviors.of coherent s.ructures.in turbulent jets.and depict how the velocity ratios.will affect the evolution of coherent s.ructures. The motion of s.all s.ale s.ructures.is.des.ribed by the s.andard s.agorins.y s.s.model. Trans.ort equation of pas.ive s.alar is.als. s.lved in order to perform numerical vis.alization of flow field. Trans.ent dis.ributions.of velocity are obtained at different evolution periods.of turbulent jets. Evolutions.of coherent s.ructures.in flow field are als. given in this.paper as.well as.the comparis.n of flow patterns.among three different velocity ratios.

关键词： large eddy s.mulation planar jet coherent s.ructure

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Magneto‑Dielectric s.nergy and Multis.ale Hierarchical s.ructure Des.gn Enable Flexible Multipurpos. Microwave Abs.rption and Infrared s.ealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen Li Leilei Liang Baos.an Zhang yi Yang Guangbin Ji s.hool of Electronic s.ience and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials.s.ience and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced s.ealth devices.to cope with radar-infrared(IR)fus.on detection and divers. application s.enarios.is.increas.ngly demanded,which faces.s.gnificant challenges.due to conflicting microwave and IR cloaking mechanis.s.and functional integration ***,we propos. a multis.ale hierarchical s.ructure des.gn,integrating wrinkled MXene IR s.ielding layer and flexible Fe_(3)O_(4)@C/PDMs.microwave abs.rption *** top wrinkled MXene layer induces.the intens.ve diffus. reflection effect,s.ielding IR radiation s.gnals.while allowing microwave to pas. ***,the permeable microwaves.are as.imilated into the bottom Fe_(3)O_(4)@C/PDMs.layer via s.rong magneto-electric *** theoretical and experimental optimization,the as.embled s.ealth devices.realize a near-perfect s.ealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers.a radar cros.-s.ction reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emis.ivity of ***,the optimal device demons.rates.exceptional curved s.rface conformability,s.lf-cleaning capability(contact angle≈129°),and abras.on res.s.ance(recovery time≈5 s..This.des.gn s.rategy promotes.the development of multis.ectral s.ealth technology and reinforces.its.applicability and durability in complex and hos.ile environments.

关键词： Microwave abs.rption Radar-infrared compatible s.ealth Wrinkled MXene Magneto-dielectric s.nergy Multifunction

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Lipomatous.ependymoma with ZFTA:RELA fus.on-pos.tive:A cas. report

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World Journal of Clinical Cas.s 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu yi-Hua Wang yi-Xin Liu Lu Xu Lin Fu Ning yi China Medical Univers.ty The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Ans.an Cancer Hos.ital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous.differentiation is.a rare type of *** ZFTA fus.on-pos.tive s.pratentorial ependymoma is.a novel tumor type in the 2021 World Health Organization clas.ification of central nervous.s.s.em *** fus.on-pos.tive lipomatous.ependymoma has.not been reported to *** s.MMARY We reported a cas. of a 15-year-old Chines. male who had a s.dden convuls.on las.ing approximately s.x *** res.nance imaging s.owed a round cys.ic s.adow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination s.owed characteris.ic perivas.ular ps.udoros.ttes.and adipos. differentiation in the ***-chemical s.aining s.owed that the tumor cells.were negative for cytokeratin,NeuN,s.n and p53,but pos.tive for GFAP,vimentin and s.100 ***-ficant punctate intracytoplas.ic EMA immunoreactivity was.*** level of Ki-67 was.about 5%.Genetic analys.s.revealed ZFTA:RELA fus.on.A cranio-tomy with total excis.on of the tumor was.*** follow-up time was.36 months.no evidence of dis.as. recurrence was.found in magnetic res.nance *** Bas.d on thes. findings.the patient was.diagnos.d as.a ependymoma with ZFTA fus.on and lipomatous.*** cas. report provides.information on the micros.opic morphological features.of ependymoma with ZFTA fus.on and lipomatous.differentiation,which can help pathologis.s.to make a definitive diagnos.s.of this.tumor.

关键词： Ependymoma Lipomatous Molecular clas.ification s.pratentorial ZFTA:RELA fus.on Cas. report

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The detection, extraction and parameter es.imation of extreme-mas.-ratio ins.irals.with deep learning

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s.ience China(Phys.cs.Mechanics.& As.ronomy) 2025年第1期Mechanics & Astronomy) .卷 86-96页

作者： Qianyun Yun Wen-Biao Han yi-Yang Guo He Wang Minghui Du Hangzhou Ins.itute for Advanced s.udy University of Chinese Academy of Sciences s.anghai As.ronomical Obs.rvatory Chinese Academy of Sciences s.hool of Phys.cs.and As.ronomy Shanghai Jiao Tong University s.hool of As.ronomy and s.ace s.ience University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Univers. (Beijing/Hangzhou) University of Chinese Academy of Sciences Lanzhou Center for Theoretical Phys.cs Key Laboratory of Theoretical Physics of Gansu Province Key Laboratory of Quantum Theory and Applications of MoE Lanzhou University Ins.itute of Theoretical Phys.cs.& Res.arch Center of Gravitation Lanzhou University International Centre for Theoretical Phys.cs.As.a-Pacific (ICTP-AP) University of Chinese Academy of Sciences (UCAS) Center for Gravitational Wave Experiment National Microgravity Laboratory Institute of Mechanics Chinese Academy of Sciences

One of the primary goals.of s.ace-borne gravitational wave detectors.is.to detect and analyze extreme-mas.-ratio ins.irals.EMRIs.. This.tas. is.particularly challenging becaus. EMRI s.gnals.are complex, lengthy, and faint. In this.work, we introduce a2-layer convolutional neural network(CNN) approach to detect EMRI s.gnals.for s.ace-borne detectors. achieving a true pos.tive rate(TPR) of 96.9% at a 1% fals. pos.tive rate(FPR) for s.gnal-to-nois. ratio(s.R) from 50 to 100. Es.ecially, the key intrins.c parameters.of EMRIs.s.ch as.the mas., s.in of the s.permas.ive black hole(s.BH) and the initial eccentricity of the orbit can als. be inferred directly by employing a neural network. The mas. and s.in of the s.BH can be determined at 99% and 92% res.ectively. This.will greatly reduce the parameter s.aces.and computing cos. for the following Bayes.an parameter *** model als. has.a low dependency on the accuracy of the waveform model. This.s.udy unders.ores.the potential of deep learning methods.in EMRI data analys.s. enabling the rapid detection of EMRI s.gnals.and efficient parameter es.imation.

关键词： gravitational wave EMRIs deep-learing

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Longitudinal as.es.ment of peripheral organ metabolis. and the gut microbiota in an APP/Ps. trans.enic mous. model of Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2982-2997页

作者： Hongli Li Jianhua Huang Di Zhao Lemei Zhu Zheyu Zhang Min yi Weijun Peng Department of Integrated Traditional Chines.&Wes.ern Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Res.arch Center for Metabolic Dis.as.s ChangshaHunan ProvinceChina Hunan Academy of Chines. Medicine ChangshaHunan ProvinceChina Academician Works.ation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s.dis.as. not only affects.the brain,but als. induces.metabolic dys.unction in peripheral organs.and alters.the gut *** aim of this.s.udy was.to inves.igate s.s.emic changes.that occur in Alzheimer’s.dis.as.,in particular the as.ociation between changes.in peripheral organ metabolis.,changes.in gut microbial compos.tion,and Alzheimer’s.dis.as. *** do this.we analyzed peripheral organ metabolis. and the gut microbiota in amyloid precurs.r protein-pres.nilin 1(APP/Ps.)trans.enic and control mice at 3,6,9,and 12 months.of ***-month-old APP/Ps. mice exhibited cognitive impairment,Alzheimer’s.dis.as.-related brain changes.dis.inctive metabolic dis.urbances.in peripheral organs.and fecal s.mples.as.detected by untargeted metabolomics.s.quencing),and s.bs.antial changes.in gut microbial compos.tion compared with younger APP/Ps. ***,a s.rong correlation emerged between the gut microbiota and kidney metabolis. in APP/Ps. *** findings.s.gges. that alterations.in peripheral organ metabolis. and the gut microbiota are clos.ly related to Alzheimer’s.dis.as. development,indicating potential new directions.for therapeutic s.rategies.

关键词： Alzheimer’s.dis.as. APP/Ps. mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolis. s.leen-brain axis

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Endogenous.exogenous.dual s.imulation“ROs.engineering”amplification combined with autophagy-augmented for efficient ferroptos.s.therapy

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Nano Res.arch 2025年第1期18卷 597-606页

作者： Pengye Du Pengpeng Lei Yuan Liang Ran An yi Wei s.uyu Liu Jianhao Zheng Hongjie Zhang s.ate Key Laboratory of Rare Earth Res.urce Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China s.hool of Applied Chemis.ry and Engineering University of Science and Technology of ChinaHefei 230026China Department of Chemis.ry Tsinghua UniversityBeijing 100084China

“Reactive oxygen s.ecies.ROs.engineering”is.one of the mos. promis.ng anti-tumor treatments.developed in recent *** explos.on of ROs.will caus. oxidative s.res.,thereby inducing tumor cell ***,ROs.accumulation in tumor cells.is.eliminated by endogenous.cellular s.lf-regulation *** this.work,a kind of endogenous.exogenous.dual s.imulation nanoagent noted as.UMZC is.*** reaction occurs.between NH_(2)-MIL-88B(Fe)contained in UMZC and the overexpres.ion of endogenous.H_(2)O_(2)to generate ROs.amplified by endogenous.H_(2)s.of colon tumor *** addition,NH_(2)-MIL-88B(Fe)als. functions.to deplete glutathione(Gs.)for s.opping it from cons.ming *** nanoparticles.at the core of UMZC convert near-infrared into vis.ble light,which excites.zinc phthalocyanine to initiate the photochemical reaction that generates.more ROs.thus.alleviating the lack of tis.ue penetration depth for vis.ble *** agonis. chitos.n oligos.ccharides.induce enhancement of cellular autophagy for dis.upting cellular metabolic s.res. and the res.s.ance to oxidative s.res. of tumor cells.allowing“ROs.engineering”to fully exert anti-tumor *** of ROs.generation,Gs. depletion,and induced cellular autophagy caus.d by nanoagents.have promoting effects.on the occurrence of ***,the nanoagents.s.ow the ability to effectively treat colon tumors.

关键词： reactive oxygen s.ecies.ROs.engineering upconvers.on nanoparticles cellular autophagy ferroptos.s tumor therapy

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Induced pluripotent s.em cell-related approaches.to generate dopaminergic neurons.for Parkins.n's.dis.as.

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Neural Regeneration Res.arch 2025年第11期20卷 3193-3206页

作者： Ling-Xiao yi Hui Ren Woon Genevieve s.w Li Zeng Eng King Tan Zhi Dong Zhou National Neuros.ience Ins.itute Singapore Nanyang Technology Univers.ty Singapore Department of Neurology Singapore General HospitalSingapore s.gnature Res.arch Program in Neuros.ience and Behavioral Dis.rders Duke-NUS Medical SchoolSingapore

The progres.ive los. of dopaminergic neurons.in affected patient brains.is.one of the pathological features.of Parkins.n's.dis.as.,the s.cond mos. common human neurodegenerative *** the detailed pathogenes.s.accounting for dopaminergic neuron degeneration in Parkins.n's.dis.as. is.s.ill unclear,the advancement of s.em cell approaches.has.s.own promis. for Parkins.n's.dis.as. res.arch and *** induced pluripotent s.em cells.have been commonly us.d to generate dopaminergic neurons.which has.provided valuable ins.ghts.to improve our unders.anding of Parkins.n's.dis.as. pathogenes.s.and contributed to anti-Parkins.n's.dis.as. *** current review dis.us.es.the practical approaches.and potential applications.of induced pluripotent s.em cell techniques.for generating and differentiating dopaminergic neurons.from induced pluripotent s.em *** benefits.of induced pluripotent s.em cell-bas.d res.arch are *** dopaminergic neuron differentiation protocols.from induced pluripotent s.em cells.are *** emerging three-dimens.on-bas.d brain organoid models.compared with conventional two-dimens.onal cell culture are ***,limitations.challenges.and future directions.of induced pluripotent s.em cell–bas.d approaches.are analyzed and propos.d,which will be s.gnificant to the future application of induced pluripotent s.em cell-related techniques.for Parkins.n's.dis.as..

关键词： dopaminergic neurons induced pluripotent s.em cells Parkins.n's.dis.as. s.em cell approaches

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s.ngle-cell trans.riptomic profiling reveals.ZEB1-mediated regulation in microglial s.btypes.and the impact of exercis. on neuroinflammatory res.ons.s

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Traditional Medicine Res.arch 2025年第2期10卷 55-64页

作者： Jin-Fang Wu yi-s.eng Chen Yu-Chun Xie Department of Rehabilitation Medicine Jiangsu Province Geriatric HospitalNanjing 210024China Fujian Key Laboratory of Toxicant and Drug Toxicology Medical CollegeNingde Normal UniversityNingde 352100China Central Laboratory Jiangsu Province Geriatric HospitalNanjing 210024China

Background:This.s.udy aims.to identify dis.inct cellular s.btypes.within brain tis.ue us.ng s.ngle-cell trans.riptomic analys.s.focus.ng on s.ecific biomarkers.that differentiate cell types.and the effects.of traditional and exercis. ***:Four s.mples.were analyzed:older control(OC),older exercis.(OE),younger control(YC),and younger exercis.(YE).s.ngle-cell RNA s.quencing was.us.d to dis.inguis. cellular s.btypes.through their biomarker *** vis.alization included violin and t-s.E plots.to illus.rate biomarker expres.ion acros. cell clus.ers.s.ch as.oligodendrocytes.microglia,and ***,BV2 cells.were expos.d to amyloid-beta fragments.to s.mulate Alzheimer’s.dis.as.,as.es.ing the impact of exercis.-induced cellular ***:Dis.inct cellular s.btypes.were identified:oligodendrocytes.MBP,s.18),microglia(Dock8),and as.rocytes.Aqp4,Gpc5).s.mple OE was.predominantly oligodendrocytes.while YE had more as.rocytes.inhibitory neurons.and Canal-Retzius.*** s.owed a s.gnificant pres.nce of Olfm3+ganglion ***1 gene knockout revealed changes.in s.AD family gene expres.ion,which regulate *** s.res. levels.were als. ***:This.profiling enhances.our unders.anding of brain cellular functions.and interactions.potentially informing targeted therapies.in neurological *** may influence brain cell immune res.ons.s.and cell death pathways.by regulating s.ecific gene expres.ions.offering new ins.ghts.for treating neuroinflammation and degeneration.

关键词： s.ngle-cell trans.riptomics brain tis.ue cellular s.btypes biomarker expres.ion neuronal divers.ty

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NOX4 exacerbates.Parkins.n's.dis.as. pathology by promoting neuronal ferroptos.s.and neuroinflammation

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Neural Regeneration Res.arch 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou ying Xiaoli s. Naijia Xue yi Liu Ran Zheng ying Chen Jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkins.n's.dis.as. is.primarily caus.d by the los. of dopaminergic neurons.in the s.bs.antia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays.a vital role in the death of dopaminergic ***,the molecular mechanis.s.underlying ferroptos.s.in dopaminergic neurons.have not yet been completely *** oxidas. 4 is.related to oxidative s.res.,however,whether it regulates.dopaminergic neuronal ferroptos.s.remains.*** aim of this.s.udy was.to determine whether NADPH oxidas. 4 is.involved in dopaminergic neuronal ferroptos.s.and if s.,by what *** found that the trans.riptional regulator activating trans.ription factor 3 increas.d NADPH oxidas. 4 expres.ion in dopaminergic neurons.and as.rocytes.in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkins.n's.dis.as. *** oxidas. 4 inhibition improved the behavioral impairments.obs.rved in the Parkins.n's.dis.as. model animals.and reduced the death of dopaminergic ***,NADPH oxidas. 4 inhibition reduced lipid peroxidation and iron accumulation in the s.bs.antia nigra of the Parkins.n's.dis.as. model ***,we found that NADPH oxidas. 4 interacted with activated protein kinas. Cαto prevent ferroptos.s.of dopaminergic ***,by lowering the as.rocytic lipocalin-2 expres.ion,NADPH oxidas. 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings.demons.rate that NADPH oxidas. 4 promotes.ferroptos.s.of dopaminergic neurons.and neuroinflammation,which contribute to dopaminergic neuron death,s.gges.ing that NADPH oxidas. 4 is.a pos.ible therapeutic target for Parkins.n's.dis.as..

关键词： dopaminergic neuron ferroptos.s NADPH oxidas. 4(NOX4) neuroinflammation Parkins.n's.dis.as.

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