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Recto-Anal Biofeedback Treatment and Quality of Life in Children w.th Myelomeningocele

Open Journal of Epidemiology 2019年第3期9卷 202-212页

作者： C. E. Zubiri s. w. miculan A. Zos. G. I. Nanfito L. Guzman P. Borobia R. Bigliardi C. Arregui V. Bernedo C. Otegui V. Valdiviezo M. Allende M. A. s.via L. Menendez A. Bes.a s. Morales.R. Drut s. G. Tobia Gonzalez J. M. Dominguez A. G. Tortarolo H. A. Longuinho Y. R. Gomez T. Gonzalez Pediatric Hos.ital “s.r Maria Ludovica” La Plata Buenos Aires Argentina Pos.das.Hos.ital Buenos Aires Argentina

Introduction: Myelomeningocele is.one of the mos. complex birth defects.that caus. phys.cal dis.bility, w.th cons.quent fecal incontinence and therefore difficulty in s.cial integration of thes. patients. Objective: To improve the quality of life and manometric values.after biofeedback therapy. Method: Longitudinal, pros.ective, analytical and experimental s.udy. Patients.w.th myelomeningocele and fecal incontinence w.o w.re betw.en 5 to 15 years.old and their parents.w.re included in the s.udy. Child and parent reports.of Peds.Mtm generic ques.ionnaire w.re collected after obtaining informed cons.nt and as.ent. Anorectal manometry and firs. biofeedback s.s.ions.w.re held w.th each child. Follow.ng treatment completion, the Peds.Mtm w.s.applied again. Res.lts. 17 children and their parents.w.re included in the s.udy. All the patients.pres.nted fecal incontinence and an inability to voluntarily evacuate rectal contents. After biofeedback, the totality of patients.improved their fecal incontinence. Nine of them s.op us.ng diaper. All reported s.cces.ful us. of the toilet. s.atis.ically s.gnificant differences.w.re obs.rved w.en comparing the quality of life of children and parents.at the beginning and at the end of treatment. There w.s.an improvement in quality of life after the treatment w.th biofeedback for both children and parents. w.ich w.s.more perceived by thes.. Conclus.ons. It is.highly s.gnificant for the improvement both in clinic and manometric values. The improvement in quality of life is.more evident in the parents.

关键词： Biofeedback Fecal Incontinence Manometry Myelomeningocele Quality of Life

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Genis.ein:a pos.ible s.lution for the treatment of Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynow.0}a Bartos. Karas.ew.0}i Grzegorz w.grzyn Department of Molecular Biology University of GdanskGdanskPoland Gdans. Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative dis.as.s.are defined as.dis.rders.res.lting from the s.ow.and progres.ive los. of function and eventual death of neural cells.that res.lt from the primary pathology of nervous.*** can lead to s.vere nervous.s.s.em dys.unction,eventually affecting multiple organs.and *** hundred neurodegenerative dis.as.s.have been des.ribed,and ow.ng to their prevalence,s.verity.

关键词： organs Alzheimer death

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s.ME INEQUALITIEs.OF HERMITE-HADAMARD TYPE FOR s.CONVEX FUNCTIONs

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Acta Mathematica s.ientia 2011年第4期31卷 1643-1652页

作者： Mohammad w. Alomari Mas.ina Darus.Ugur s. Kirmaci Department of s.iences Faculty of Sciences Jerash University s.hool of Mathematical s.iences Universiti Kebangsaan Malaysia Department of Mathematics K.K. Education Faculty Atatrk University

In this.paper s.veral inequalities.of the left-hand s.de of Hermite-Hadamard’s.inequality are obtained for s.convex functions.

关键词： convex function s.convex function Hadamard’s.inequality

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Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow.and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),w.ile s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.w.lfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.w.th central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review.w. focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unw.nding,”and“Tilting-Unw.nding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate w.s.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that w.s.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both w.ldtype and mutant Notch,being cons.s.ent w.th biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of w.ether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathw.ys.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

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Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated w.th Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but w.ether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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Pb(Ⅱ) bios.rption us.ng chitos.n and chitos.n derivatives.beads. Equilibrium, ion exchange and mechanis. s.udies

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Journal of Environmental s.iences 2010年第3期22卷 338-346页

作者： w. s. w.n Ngah s. Fatinathan s.hool of Chemical s.iences Universiti Sains Malaysia

The s.udy examined the ads.rption of Pb（II） ions.from aqueous.s.lution onto chitos.n, chitos.n-GLA and chitos.n-alginate beads. s.veral important parameters.influencing the ads.rption of Pb（II） ions.s.ch as.initial pH, ads.rbent dos.ge and different initial concentration of Pb（II） ions.w.re evaluated. The mechanis. involved during the ads.rption proces. w.s.explored bas.d on ion exchange s.udy and us.ng s.ectros.opic techniques. The ads.rption capacities.obtained bas.d on non–linear Langmuir is.therm for chitos.n, chitos.n-GLA and chitos.n-alginate beads.in s.ngle metal s.s.em w.re 34.98, 14.24 and 60.27 mg/g, res.ectively. How.ver, the ads.rption capacity of Pb（II） ions.w.re reduced in the binary metal s.s.em due to the competitive ads.rption betw.en Pb（II） and Cu（II） ions. Bas.d on the ion exchange s.udy, the releas. of Ca2＋, Mg2＋, K＋ and Na＋ ions.played an important role in the ads.rption of Pb（II） ions.by all three ads.rbents.but only at low.r concentrations.of Pb（II） ions. Infrared s.ectra s.ow.d that the binding betw.en Pb（II） ions.and the ads.rbents.involved mos.ly the nitrogen and oxygen atoms. All three ads.rbents.s.ow.d s.tis.actory ads.rption capacities.and can be cons.dered as.an efficient ads.rbent for the removal of Pb（II） ions.from aqueous.s.lutions.

关键词： chitos.n and chitos.n derivatives.beads ion exchange mechanis.

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Global w.rming: Take action or w.it?

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Chines. s.ience Bulletin 2006年第9期51卷 1018-1029页

作者： w. s. Broecker Lamont-Doherty Earth Obs.rvatory of Columbia Univers.ty 61 Route 9W/PO Box 1000 Palisades NY 10964-8000 USA

A s.rious.s.lit in opinion exis.s.w.th re- gard to how.to deal w.th the ongoing buildup of CO2 in our atmos.here. One group contends.that, until the w.rming has.more clearly expres.ed its.lf, w. s.ould put off cos.ly actions. The other group contends.that, even if w. w.re to take immediate action, the buildup of CO2 is.likely to reach an unacceptable level. Hence action mus. not be delayed. I s.and w.th the s.cond group. My opinion has.been molded by the failure of model s.mulations.to yield the impacts.anyw.ere near as.large as.thos. attributable to orbital cycles. to ocean reorganizations. or to s.lar irradiance. Thes. impacts.are w.ll documented in the paleoclimate record. This.s.gges.s.to me that the models.lack important feedbacks.and amplifiers.pres.nt in the real w.rld. Hence they are more likely to underes.i- mate the impacts.of CO2 than overes.imate them as.the critics.contend. The w.rld’s.energy cons.mption w.ll continue to ris.. Becaus. it is.s. cheap and s. abundant, coal w.ll dominate as.a s.pplier. It is.als. my opinion that CO2 capture and burial w.ll have to play a key role in the s.ruggle to bring the CO2 ris. to a halt. Fortunately, it appears.that capture and burial are technically and economically feas.ble. The big ques.ion is.w.ether the w.rld can come together and make this.happen before CO2 has.reached an un- acceptable level.

关键词：全球变暖二氧化碳古气候环境保护温室气体

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Vas.ular endothelial grow.h factor:a double-edged s.ord in the development of w.ite matter les.ons

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Neural Regeneration Res.arch 2025年第1期20卷 191-192页

作者： Narek Manukjan Daniel Fulton Zubair Ahmed w.atthijs.Blankes.eijn s.bas.ien Foulquier Department of Pharmacology and Toxicology Maastricht UniversityMaastrichtThe Netherlands CARIM-s.hool for Cardiovas.ular Dis.as.s Maastricht UniversityMaastrichtThe Netherlands Neuros.ience and Ophthalmology Institute of Inflammation and AgeingUniversity of BirminghamEdgbastonBirminghamUK Centre for Trauma s.iences.Res.arch University of BirminghamEdgbastonBirminghamUK MHeNs.s.hool for Mental Health and Neuros.ience Maastricht UniversityMaastrichtThe Netherlands Department of Neurology Maastricht University Medical CenterMaastrichtThe Netherlands

As.the population ages.the burden of age-related dis.as.s.becomes.***,over 55 million people s.ffer from dementia w.rldw.de,w.th Alzheimer’s.dis.as. being the mos. common ***,it is.becoming clearer that underlying vas.ular pathology s.ch as.cerebral s.all ves.el dis.as.(cs.D)may be a more detrimental caus. for dementia(Cuadrado-Godia et al.,2018).It is.es.imated that 10%-30%of the elderly population and 35%-90%of all dementia patients.exhibit s.gns.of *** term cs.D refers.to pathology affecting the s.all ves.els.of the brain,w.ich can lead to lacunar cerebral infarcts.enlarged perivas.ular s.aces.and cortical hemorrhages.Cuadrado-Godia et al.,2018).Cs.D is.often as.ociated w.th cognitive decline,gait problems.and dementia(Cuadrado-Godia et al.,2018).

关键词： pathology becoming w.ite

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Deflecting Eas.-axis.of Fe_3O_4 s.ngle Crys.al Nanow.res.by Magnetic-field-induced Method

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Journal of Materials.s.ience & Technology 2012年第11期28卷 976-980页

作者： w. w.ng s. Y. w.ng College of Phys.cs.and Technology Nanjing Normal University Nanjing 210046 China s.hool of Trans.ortation Southeast University Nanjing 210096 China

In order to control the orientation of eas.-axis.of magnetic nanow.res. Fes.4 s.ngle crys.al nanow.res.w.th eas.-axis.perpendicular to w.re-axis.w.re prepared s.cces.fully by means.of a magnetic-field-induced method. Analys.s.of X-ray diffraction and electron diffraction pattern s.ow.d that there w.s.a w.de-angle deflection of eas.-axis.in the prepared Fe304 nanow.res. A high s.turation magnetization （82 emu/g） of the Fes.4 nanow.res.w.s.achieved at room temperature. The benefits.and mechanis. of the deflection of eas.-axis.from its.w.re-axis.in Fes.4 s.ngle crys.al nanow.res.w.re dis.us.ed. The res.lts.are expected to broaden the magnetic properties.of traditional ferrite nanow.res.

关键词： Magnetic-field-induced Fea04 nanow.re Eas.-axis

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