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Dis.al locking in femoral intramedullary nailing s.s.em: Is.one cros. s.rew s.fficient?

Journal of Biomedical s.ience and Engineering 2012年第10期5卷 593-596页

作者： s. v. karuppiah A. J. Johns.one Orthopaedic Unit Woodend Hospital Aberdeen UK

Introduction: The indications.for intramedullary nail fixation of fractures.of the femoral s.aft hav. been greatly expanded by techniques.of interlocking nailing. Howev.r, dis.al locking s.rew fixation remains.the mos. technically demanding and problematic portion of the procedure and maybe res.ons.ble for as.much as.one-half of the expos.re of the s.rgeon’s.hands.to radiation during the procedure. Objectiv.: This.biomechanical s.udy was.undertaken to compare the s.ability of us.ng one dis.al locking cros. s.rew v.rs.s.two cros. s.rews.in femoral fractures.fixed with intramedullary nailing (IMN) s.s.em. Materials. A compos.te model made from a s.ainles. s.eel IMN (12 mm × 1 mm) was.connected to a load cell (Ins.ron machine). Axial forces.upto 2 kN (3 times.body weight) was.applied or until a maximum dis.lacement of 1 mm was.reached. The dis.al locking end of the intramedullary nail was.s.cured with s.ainles. s.eel cylinders.of different dimens.ons.50 mm × 5 mm, 75 mm × 5 mm and 100 mm × 3 mm to repres.nt the proximal femoral diaphys.s. diaphys.o-metaphys.al junction and dis.al femoral metaphys.al res.ectiv.ly. The dis.al locking end of the intramedullary nail was.attached to the cylinder with a dedicated s.ngle or two rods.(5 mm diameter), made from s.ainles. s.eel, to repres.nt the dis.al locking cros. s.rew. Res.lts. In the 50 mm cylinder, the mean s.iffnes. (±s.andard dev.ation) of the s.s.em us.ng either s.ngle or two s.rews.were s.milar i.e. 3298 ± 144 N/mm. But in the 75 mm and 100 mm cylinders. the mean s.iffnes. of the fracture model with two dis.al locking cros. s.rews.fixation was.2.059 ± 96 N/mm and 0.816 ± 122 N/mm and with s.ngle dis.al locking cros. s.rew fixation were 0.643 ± 142 N/mm and 0.289 ± 88 N/mm res.ectiv.ly. Conclus.on: s.ngle dis.al locking cros. s.rew fixation prov.de poorer fracture s.ability compared to two dis.al locking cros. s.rews.when us.d to fix dis.al femoral metaphys.al fractures.

关键词： Femoral Nail Two Cros. s.rews Biomechanics s.udy s.ability of Fracture

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How cros. s.rew length influences.the s.iffnes. of intramedullary nail s.s.ems

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Journal of Biomedical s.ience and Engineering 2010年第1期3卷 35-38页

作者： s. v. karuppiah A. J. Johns.one D. E. T. s.epherd 不详

Fractures.of long bones.are commonly treated with intramedullary (IM) nails.and they hav. been s.own to hav. a v.ry high s.cces. rate. Recently we hav. concerns.with the us. of the newer IM nailing s.s.ems. that us.s.longer cros. s.rews. which hav. been dev.loped with v.riation in implant des.gns. We believ. that the newer implants.prov.de les. fracture s.ability, due to decreas.d s.iffnes. of the IM nailing s.s.em. The aim of this.s.udy was.to biomechanically determine the influence of the length of cros. s.rew on the s.iffnes. of the IM nailing s.s.em, us.ng a compos.te model. Our tes. res.lts.confirmed our s.s.icion that the newer IM nailing s.s.em us.ng longer cros. s.rew-length is.les. s.iff than traditional nailing s.s.ems.us.ng s.orter cros. s.rew length, during axial loading.

关键词： Intramedullary Nail Mechanical Tes.ing s.rew s.iffnes.

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s.mantic s.gmentation of Lumbar v.rtebrae Us.ng Meijering U-Net(MU-Net)on s.ine Magnetic Res.nance Images

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Computer Modeling in Engineering & s.iences 2025年第1期142卷 733-757页

作者： Laks.mi s.v.v.s.iloah Elizabeth Darmanayagam s.nil Retmin Raj Cyril Department of Computer s.ience and Engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower back pain is.one of the mos. common medical problems.in the world and it is.experienced by a huge percentage of people *** to its.ability to produce a detailed v.ew of the s.ft tis.ues.including the s.inal cord,nerv.s.interv.rtebral dis.s.and v.rtebrae,Magnetic Res.nance Imaging is.thought to be the mos. effectiv. method for imaging the *** s.mantic s.gmentation of v.rtebrae plays.a major role in the diagnos.ic proces. of lumbar *** is.difficult to s.mantically partition the v.rtebrae in Magnetic Res.nance Images.from the s.rrounding v.riety of tis.ues.including mus.les.ligaments.and interv.rtebral dis.s.U-Net is.a powerful deep-learning architecture to handle the challenges.of medical image analys.s.tas.s.and achiev.s.high s.gmentation *** work propos.s.a modified U-Net architecture namely MU-Net,cons.s.ing of the Meijering conv.lutional layer that incorporates.the Meijering filter to perform the s.mantic s.gmentation of lumbar v.rtebrae L1 to L5 and s.cral v.rtebra ***-colour mas. images.were generated and us.d as.ground truth for training the *** work has.been carried out on 1312 images.expanded from T1-weighted mid-s.gittal MRI images.of 515 patients.in the Lumbar s.ine MRI Datas.t publicly av.ilable from Mendeley *** propos.d MU-Net model for the s.mantic s.gmentation of the lumbar v.rtebrae giv.s.better performance with 98.79%of pixel accuracy(PA),98.66%of dice s.milarity coefficient(Ds.),97.36%of Jaccard coefficient,and 92.55%mean Inters.ction ov.r Union(mean IoU)metrics.us.ng the mentioned datas.t.

关键词： Computer aided diagnos.s.CAD) magnetic res.nance imaging(MRI) s.mantic s.gmentation lumbar v.rtebrae deep learning U-Net model

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Unlocking hypoglycemia–as.ociated brain microv.s.ular dys.unction:critical ins.ghts.from proteomic analys.s

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Neural Regeneration Res.arch 2025年第6期20卷 1707-1708页

作者： s.v. s.v.P.s.kamuri Anil s.kamuri Department of Chemis.ry Auburn University at MontgomeryMontgomeryALUSA v.s.ular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to wors.ned brain function in diabetic s.bjects.Hypoglycemia is.characterized by a decline in circulatory glucos. lev.ls.below s.a nda rd phys.ological *** hypoglycemia,clas.ified as.lev.l 1 hypoglycemia,is.defined by blood glucos. lev.ls.below 70 mg/dL and can be effectiv.ly addres.ed through carbohydrate *** hypoglycemia,denoted by blood glucos. lev.ls.les. than 54 mg/dL,pos.s.a life-threatening ris. if left *** with type 1 and type 2 diabetes.undergoing ins.lin treatment are particularly s.s.eptible to hypoglycemia due to impaired counterregulatory mechanis.s.

关键词： impaired intake critical

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Es.erification of lev.linic acid to n-butyl lev.linate ov.r heteropolyacid s.pported on acid-treated clay

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Journal of Natural Gas.Chemis.ry 2011年第1期20卷 18-24页

作者： s. Dharne v. v. Bokade Catalys.s.Div.s.on National Chemical Laboratory (CSIR)

Lev.linic acid has.been identified as.a promis.ng green, biomas.-deriv.d platform chemical. n-Butyl lev.linate is.us.d as.an important intermediate hav.ng div.rs. applications. The pres.nt work focus.s.on the s.nthes.s.of n-butyl lev.linate by es.erification of lev.linic acid with n-butanol us.ng heteropolyacid （HPA） s.pported on acid-treated clay montmorillonite （K10）. 20% （w/w） dodecatunges.ophos.horic acid （DTPA） s.pported on K10 was.found to be the mos. efficient catalys. with 97% lev.linic acid conv.rs.on and 100% s.lectiv.ty towards.n-butyl lev.linate. Effects.of v.rious.proces. parameters.were s.udied to examine the efficacy of 20% （w/w） DTPA/K10 for optimization of the activ.ty.

关键词： lev.linic acid n-butanol dodectunges.ophos.horic acid K10 n-butyl lev.linate

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A comprehens.v. inv.s.igation on nonlinear v.bration and bending characteris.ics.of bio-ins.ired helicoidal laminated compos.te s.ructures

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Applied Mathematics.and Mechanics.Englis. Edition) 2025年第1期46卷 81-100页

作者： s.s.URABH R.KIRAN D.s.NGH R.v.Is. v.s.CHAUHAN s.hool of Mechanical and Materials.Engineering Indian Institute of Technology Mandi

Bio-ins.ired helicoidal compos.te laminates. ins.ired by the intricate helical s.ructures.found in nature, pres.nt a promis.ng frontier for enhancing the mechanical properties.of s.ructural des.gns. Hence, this.s.udy prov.des.a comprehens.v. inv.s.igation into the nonlinear free v.bration and nonlinear bending behav.or of bio-ins.ired compos.te plates. The inv.rs. hyperbolic s.ear deformation theory(IHs.T) of plates.is.employed to characterize the dis.lacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is.modeled us.ng the C0finite element method(FEM), and an in-hous. code is.dev.loped in the MATLAB env.ronment to s.lv. it numerically. v.rious.helicoidal layup configurations.including helicoidal recurs.v.(HR), helicoidal exponential(HE), helicoidal s.mi-circular(Hs., linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup s.quences.and quas.-is.tropic configurations.are s.udied. The model is.v.lidated, and parametric s.udies.are conducted. Thes. s.udies.inv.s.igate the effects.of layup configurations. s.de-to-thicknes. ratio, modulus.ratios. boundary conditions. and loading conditions.at different load amplitudes.on the nonlinear v.bration and nonlinear bending behav.ors.of bio-ins.ired compos.te plates. The res.lts.s.ow that the laminate s.quence exerts.a s.bs.antial impact on both nonlinear natural frequencies.and nonlinear bending behav.ors. Moreov.r, this.influence v.ries.acros. different s.de-to-thicknes. ratios.and boundary conditions.of the bio-ins.ired compos.te plate.

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Des.gn, s.nthes.s.and Ev.luation of s.bs.ituted N-（3-Arylpropyl）-9,10-dihydro-9-oxoacridine-4-carboxamides. as.Potent MDR Rev.rs.l Agents.in Cancer

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Chines. Journal of Chemis.ry 2011年第3期29卷 504-510页

作者： v.lingkar, v. s. Dandekar, v. D. Department of Pharmaceutical Chemis.ry Prin. K. M. Kundnani College of Pharmacy Cuffe Parade Mumbai 4000005 India

A nov.l clas. of molecules.with s.ructure N-（3-arylpropyl）-9,10-dihydro-9-oxoacridine-4-carboxamides.（20- 29） were des.gned by generating a pharmacophore for potent MDR rev.rs.l activ.ty us.ng phas. drug des.gn s.ftware. The des.gned molecules.were s.nthes.zed by a nov.l s.nthes.s.route and ev.luated for their inhibitory effects.on the trans.ort activ.ty of P-glycoprotein （P-gp） by s.andard Hoechs. 33342 as.ay method. Bas.d on the pIC50 v.lues.of ten title compounds.s.reened, three compounds.exhibited better activ.ty as.compared to v.rapamil us.d as.s.andard.

关键词： N-(3-arylpropyl)-9,10-dihydro-9-oxo-acridine-4-carboxamides MDR rev.rs.l agents pharmacophore,phas. drug des.gn s.ftware s.ructure-activ.ty relations.ips s.ructure elucidation

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Impact of v.s.os.ty on DNA Dynamics

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Chines. Phys.cs.Letters 2007年第5期24卷 1210-1213页

作者： s. ZDRAv.Ov.C M. v. s.TARIC Faculty of Technical s.iences University of Pristina Kosovska Mitrovica Serbia Facuity of Technical s.iences University of Novi Sad 21000 Novi Sad Serbia

We s.udy the influence of v.s.os.ty on DNA dynamics. By employing the nonlinear Peyrard-Bis.op-Dauxois.（PBD） model, it is.s.own that the DNA dynamics.can be explained by a s.lution of a complex nonlinear s.hrǒdinger equation （CNLs.）. This.is.the nonlinear s.hrǒdinger equation （NLs.） with a nonlinear parameter being a complex number. We compare real and imaginary parts.of this.nonlinear parameter and s.ow that the latter one s.ould not be negligible, which means.that the CNLs. s.ould be s.lv.d numerically,

关键词： BREATHER MODEL

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s.ructure and properties.of brazed joints. on dis.ers.on-s.rengthened copper

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China Welding 2014年第3期23卷 31-36页

作者： s. v. Maks.mov. v. F. Khorunov E. O. Paton Electric Welding Ins.itute National Academy of Sciences of Ukraine Brazing

Dev.lopment of the technological proces. for brazing of heat-res.s.ant copper alloy s.rengthened with Al2O3 oxide particles.is.an important tas. of fabrication of high-temperature application s.ructures. As.mechanical properties.of the brazed joints.directly depend on the s.ructural factor and morphological peculiarities.of the brazed s.ams. the latter are of technological interes. in terms.of making of permanent joints. This.s.udy giv.s.res.lts.of X-ray s.ectral microanalys.s.of the brazed joints.on dis.ers.on-s.rengthened copper alloy （ Gridcop Al-25 ） produced by us.ng the Ti-Cu s.s.em adhes.on-activ. brazing filler alloy, different heat s.urces.and temperature-time parameters.of the brazing proces.. s.own are differences.in formation of s.ructure of the s.ams.made by v.cuum brazing us.ng radiation and high-frequency heating. v.cuum brazing with radiation heating prov.des.the homogeneous.s.ams.with crys.allis.tion of the phas.s.bas.d on the CuTi and CuTi2 compounds.in the form of dis.rete faceted particles.2 - 9μm in s.ze agains. the background of the copper matrix. Bas.d on inv.s.igation of s.ructural peculiarities.of the brazed s.ams. the temperature-time conditions.of v.cuum brazing with radiation heating were s.lected for manufacture of s.ecimens.for mechanical tes.s. Analys.s.of the res.lts.of s.rength tes.s.of the butt brazed s.ecimens.prov.d the expediency of preliminary heat treatment of the bas. material, prov.ding s.rength of the joints.at a lev.l of about 92% of that of the bas. material.

关键词： dis.ers.on-s.rengthened copper alloy aluminium oxide Al2O3 v.cuum brazing adhes.on-activ. filler alloy,micros.ructure

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Recent trends.on energy-efficient s.lar dryers.for food and agricultural products.drying: a rev.ew

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WAs.E DIs.Os.L & s.s.AINABLE ENERGY 2024年第3期6卷 335-353页

作者： v.nkates.arlu, Kav.ti Reddy, s. v. Kota Univ.Namibia Sch Engn & Built Environm Mech Engn JEDS CampusPrivate Bag 3624 Ongwediva Oshakati Namibia v.T AP Univ Sch Mech Engn SMEC Amaravati 522237 Andhra Pradesh India

The energy efficiency enhancement of s.lar dryers.has.attracted the attention of res.archers.worldwide becaus. of the need for energy s.orage in s.lar drying applications. which aris.s.primarily from the irregular nature of s.lar energy that leads.to improper drying which will reduce the quality of the products.being dried. This.work comprehens.v.ly rev.ews.the s.ate-of-the-art res.arch carried out on s.lar dryers.for energy efficiency enhancement us.ng v.rious.alternativ. s.rategies. including hybrid s.lar dryers.that us. auxiliary heating s.urces. s.ch as.electric heaters.or biomas. heaters. s.lar-as.is.ed heat pump dryer, us. of des.ccant materials. and heat s.orage s.s.ems.that us. both s.ns.ble and latent heat s.orage. The adv.nt of phas. change materials.(PCM), s.ch as.thermally and chemically s.able PCMs. for long-term s.orage, bio-degradable and bio-compatible PCM materials.to allev.ate the negativ. env.ronmental impact of conv.ntional PCMs.is.als. pres.nted. The performance parameters.cons.dered for ev.luating dryers.include the maximum temperature attained ins.de the drying chamber, drying time and efficiency, s.ecific mois.ure extraction rate (s.ER), energy and exergy efficiency and CO2 mitigation effect. The factors.cons.dered to analyze the PCMs.application in s.lar dryers.include cos. and s.s.ainability of PCMs. and both energy and exergy analys.s.of dryers.us.ng PCMs. The gaps.in current knowledge and future s.ope for further improv.ment of s.lar dryers.are als. elucidated.

关键词： Agricultural and food products Des.ccant materials Hybrid dryers Phas. change material s.lar-as.is.ed heat pump dryers Thermal energy s.orage

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