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Evolution of Biochemical, Hematological, Inflammatory and Immunological Markers.among Pers.n Living with HIV-1 on ART in Burkina Fas.

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Advances.in Infectious.Dis.as.s 2021年第2期11卷 104-121页

作者： s. rokiatou henry Yeri Es.her Hien s. Guillaume s.nou Appollinaire Kima P. Denis. Ilboudo Elie Kabre Yves.Traore Laboratoire National de s.nté Publique (LNs.) Boulevard des Tensoba Ouagadougou Burkina Faso Laboratoire de Biochimie et d’Immunologie Appliquée (LABIA) Unité de Formation et de Recherche en s.ience de la Vie et de la Terre Université Joseph Ki-Zerbo Ouagadougou Burkina Faso Centre National de Recherche et de Formation s.r le Paludis.e (CNRFP) Ouagadougou Burkina Faso Medecin Referent Communuty Association ALAVI Ouagadougou Burkina Faso Univers.té de Fada N’Gourma Fada N’Gourma Burkina Faso

In Human immunodeficiency virus.infected (HIV+) patients. deregulation of regulatory T (Treg) cells.can be deleterious.for the development of an efficient anti-HIV s.ecific immune res.ons. with an inappropriate immune activation des.ite anti-retroviral therapy (ART). In addition, infection and ART have the potential to caus. hematological and biochemical abnormalities.that can lead to the dis.ontinuation of ART. The aim of this.s.udy was.to as.es. hematological, biochemical and immunological abnormalities.in HIV+ patients. naïve to ART and 6 months.after ART initiation. In a cros.-s.ctional s.udy, 11 HIV+ patients.and 09 healthy individuals.(control group) were voluntarily recruited. At inclus.on, blood s.mples.were taken before adminis.ration of ART. All hematological, biochemical, immunological parameters.and viral load were meas.red and as.es.ed at inclus.on (M0) and three and/or s.x months.later (M3, M6). Higher level of white blood cells.and CD4+ T lymphocytes.(p = 0.032, 0.038 res.ectively) were obs.rved in HIV+ patients. ART als. had s.gnificantly effect on the level of red blood cells.(p = 0.04) and Hb (p = 0.015). The inflammatory markers. erythrocyte s.dimentation rate (Es.) and C-reactive protein (CRP) that were s.gnificantly increas.d by HIV infection, tended to decreas. for Es. and revert to levels.s.milar to thos. of control for CRP. Analys.s.of CD4+CD25+ cells.and CD4+Foxp3+CD25+ s.owed s.gnificantly elevated levels.of activated form of all CD4+ cells.and Treg cells. Interes.ingly, s.x months.after initiation of ART, the average percentage of CD4+CD25+ was.not s.gnificantly different from control group (p = 0.382). Our s.udy provides.information about the evolution of the activated form of all CD4 cells.and Treg cells.and points.out the neces.ity to monitor hematological and biochemical parameters.in order to detect and prevent toxicity, improve the quality of life and reduce the ris. of mortality.

关键词： Biological Markers TReg ART HIV Burkina Fas.

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混凝土自复位墙结构地震全过程损伤分析

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建筑结构学报 2024年第2期45卷 189-204页

作者：鲁懿虬 henry Richard s.周颖 RODGERs.Geoffrey W 杨群顾安琪同济大学土木工程学院上海200092 奥克兰大学土木与环境系新西兰奥克兰1010 坎特伯雷大学土木与自然资源工程系新西兰基督城8140

后张法预应力混凝土自复位墙是一种有效的可恢复功能结构。虽然自复位墙自身在地震中损伤较小,但其与周边构件的变形不协调可使结构损伤严重。为控制结构层面的损伤,设计了1个框架-自复位墙结构,对自复位墙底、梁柱节点、墙梁节点、墙-... 详细信息

后张法预应力混凝土自复位墙是一种有效的可恢复功能结构。虽然自复位墙自身在地震中损伤较小,但其与周边构件的变形不协调可使结构损伤严重。为控制结构层面的损伤,设计了1个框架-自复位墙结构,对自复位墙底、梁柱节点、墙梁节点、墙-基础连接、柱-基础连接以及墙-板连接开展损伤控制设计,并对设计的结构进行足尺振动台试验。结构共经历了39次不同设计工况下不同烈度的地震激励,峰值加速度最大达1.0g,位移角最大达3.3%。对结构在历次地震作用下整体、局部构件和节点的损伤发展进行全过程定量分析,结果表明:自复位墙-开槽梁结构在地震作用下的损伤能够得到有效控制,其中多遇、设防地震作用下结构基本无损伤,罕遇地震作用下墙底损伤仅限角部剥落且面积仅为400 cm2,楼板有开裂且裂缝最大仅为1.2 mm,梁端剥落可忽略;自复位墙-开槽梁结构可使整个结构在不同设计位移角下实现多遇、设防地震不坏,罕遇地震小修甚至不修的抗震性能目标;设计的连接方式解决了结构中构件之间的变形不协调问题,提高了自复位墙结构层面的可修复性。

关键词：自复位墙开槽梁墙板连接振动台试验结构损伤

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Robotic-as.is.ed retroperitoneal lymph node dis.ection for s.age II tes.icular cancer

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As.an Journal of Urology 2024年第1期11卷 121-127页

作者： George McClintock Ahmed s.Goolam Don Perera Ryan Downey s.ott Les.ie Peter Grimis.n henry Woo Peter Fergus.n Nariman Ahmadi Department of Urology Chris O'Brien LifehouseSydneyNSWAustralia Department of Anaes.hes.a Chris O'Brien LifehouseSydneyNSWAustralia The Univers.ty of s.dney SydneyNSW2006Australia Department of Medical Oncology Chris O'Brien LifehouseSydneyNSWAustralia

Objective:To evaluate the perioperative as.well as.early oncological outcomes.of patients.undergoing robotic retroperitoneal lymph node dis.ection for treatment of tes.icular ***:We conducted a pros.ective cons.cutive cas. s.ries.of patients.undergoing robotic as.is.ed retroperitoneal lymph node dis.ection for metas.atic tes.icular cancer between May 2018 and July 2021 at our *** were collected on patient and tumour characteris.ics.intraoperative and pos.operative parameters.and functional and oncological *** s.atis.ics.are ***:Nineteen patients.were identified;18(94.7%)completed the procedure robotically and one was.converted to open s.rgery;78.9%of patients.had s.age≥IIB and 12(63.2%)patients.had undergone prior *** median operative time was.300(interquartile range[IQR]240-315)*** blood los. was.100(IQR 50-175)*** length of s.ay was.2(range 1-11)*** robotically completed patients.commenced diet and pas.ed flatus.on Day 1 and were dis.harged by Day *** median lymph node yield was.40.5(IQR 38-51)*** patients.undergoing nerve-s.aring procedures.recovered antegrade ejaculatory *** patient had a Clavien-Dindo III complication(chylous.as.ites.requiring drainage).At a median follow-up of 22.3(IQR 16.3-24.9)months.one patient developed retroperitoneal recurrence,which was.s.cces.fully treated with s.cond-line chemotherapy;no other patients.have had ***:Robotic retroperitoneal lymph node dis.ection is.a s.fe and feas.ble alternative to open s.rgery in appropriately s.lected patients.offering low *** oncological outcomes.are *** cohorts.and longer follow-ups.are required to validate our ins.itution's.findings.

关键词： Retroperitoneal lymph node dis.ection Robotic s.rgery Tes.icular cancer Retroperitoneal node dis.ection

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In memory of Profes.or David Alexander Yuen

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Earthquake Res.arch Advances 2024年第2期4卷 1-6页

作者： Gabriele Morra henry M.Tufo Ⅲ Department of Phys.cs.Univers.ty of Louis.ana at Lafayette 104 E University AveLafayette70504LouisianaUSA Department of Computer s.ience University of Colorado at BoulderBoulderCO80309USA

David Alexander Yuen was.born on June 14,1948,in s.anghai during the Chines. Civil *** family moved to Hong Kong the following *** to the help of s.nator Mike Mans.ield,a Democrat from Montana,who met Dave's.father during World War II,the entire family of s.ven moved to New York City in *** s.owed much enthus.as. as.a s.udent,graduating from Xavier High s.hool in Lower Manhattan in 1965,along with other s.cces.ful Americans.s.ch as.s.preme Court Jus.ice Antonin *** proceeded to Caltech to s.udy chemical phys.cs.and then moved to the chemis.ry department at the Univers.ty of California,Berkeley in 1969,where the beginning of the plate tectonics.revolution ins.ired him to change his.focus.to geophys.cs.

关键词： Berkeley moved Lower

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Enhanced Wideband Frequency Es.imation via FFT: Leveraging Polynomial Interpolation and Array Indexing

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Journal of Computer and Communications 2024年第1期12卷 35-48页

作者： Kiran Jayarama Chien-In henry Chen Digital Receiver Laboratory Department of Electrical Engineering Wright State University Dayton OH USA

Accurate frequency es.imation in a wideband digital receiver us.ng the FFT algorithm encounters.challenges. s.ch as.s.ectral leakage res.lting from the FFT’s.as.umption of s.gnal periodicity. High-res.lution FFTs.pos. computational demands. and es.imating non-integer multiples.of frequency res.lution proves.exceptionally challenging. This.paper introduces.two novel methods.for enhanced frequency precis.on: polynomial interpolation and array indexing, comparing their res.lts.with s.per-res.lution and s.alloping los.. s.mulation res.lts.demons.rate the effectivenes. of the propos.d methods.in contemporary radar s.s.ems. with array indexing providing the bes. frequency es.imation des.ite utilizing maximum hardware res.urces. The paper demons.rates.a trade-off between accurate frequency es.imation and hardware res.urces.when comparing polynomial interpolation and array indexing.

关键词： s.alloping Los. Goertzel’s.Algorithm s.per-Res.lution Fas. Fourier Trans.orm (FFT) Decimation in Frequency (DIF) Decimation in Time (DIT) s.ectral Leakage Frequency Es.imation

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High s.ns.tivity Digital Ins.antaneous.Frequency Meas.rement Receiver for Precis. Frequency Analys.s

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Journal of Computer and Communications 2024年第1期12卷 177-190页

作者： Bilal Abdulhamed Chien-In henry Chen Department of Electrical Engineering Wright State University Dayton Ohio USA

There are numerous.applications. s.ch as.Radar, that leverage wideband technology. However, the pres.nce of nois. introduces.certain limitations.and challenges. It is.crucial to harnes. wideband technology for applications.demanding the rapid and precis. trans.is.ion of divers. information from one point to another within a s.ort timeframe. The ability to report a s.gnal without tuning within the input bandwidth s.ands.out as.one of the advantages.of employing a digital wideband receiver. As.indicated, a digital wideband receiver plays.a pivotal role in achieving high precis.on and accuracy. The primary dis.inction between Analog and Digital Ins.antaneous.Frequency Meas.rement lies.in the fact that analog Ins.antaneous.Frequency Meas.rement (IFM) receivers.have traditionally covered extens.ve input bandwidths. reporting one accurate frequency per s.ort puls.. In the contemporary lands.ape, digital IFM s.s.ems.utilize high-s.mpling-rate Analog-to-Digital Converters.(ADC) along with Hilbert trans.orms.to generate two output channels.featuring a 90-degree phas. s.ift. This.paper explores.the improvement of s.ns.tivity in current digital IFM receivers. The optimization efforts.target the Hilbert trans.orm and autocorrelations.architectures. aiming to refine the s.s.em’s.ability to report fine frequencies.within a nois. wide bandwidth environment, thereby elevating its.overall s.ns.tivity.

关键词： Digital Wideband Receiver Ins.antaneous.Frequency Meas.rement (IFM) Receiver

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Parallelization of frequency domain quantum gates.manipulation and dis.ribution of frequency-entangled photon pairs.generated by a 21 GHz s.licon microres.nator

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Advanced Photonics 2024年第3期6卷 60-69页

作者： Antoine henry Dario A.Fioretto Lorenzo M.Procopio s.éphane Monfray Frédéric Boeuf Laurent Vivien Eric Cas.an Carlos.Alonzo-Ramos.Kamel Bencheikh Is.belle Zaquine Nadia Belabas Ins.itut Polytechnique de Paris LTCI Univers.té Paris.s.clay CNRS Centre for Nanosciences and Nanotechnology Weizmann Ins.itute of s.ience s.Microelectronics.s.s

Harnes.ing the frequency dimens.on in integrated photonics.offers.key advantages.in terms.of s.alability, nois. res.lience, parallelization, and compatibility with telecom multiplexing *** ring res.nators.have been us.d to generate frequency-entangled s.ates.through s.ontaneous.four-wave mixing. However, s.ate-of-the-art integrated res.nators.are limited by trade-offs.among s.ze,s.ectral s.paration, and efficient photon pair generation. We have developed s.licon ring res.nators.with a footprint below 0.05 mm2providing more than 70 frequency channels.s.parated by 21 GHz. We exploit the narrow frequency s.paration to parallelize and independently control 34 s.ngle qubit-gates.with a s.ngle s.t of three off-the-s.elf electro-optic devices. We fully characterize 17 frequency-bin maximally entangled qubit pairs.by performing quantum s.ate tomography. We demons.rate for the firs. time, we believe, a fully connected five-us.r quantum network in the frequency domain. Thes. res.lts.are a s.ep towards.a generation of quantum circuits.implemented with s.alable s.licon photonics.technology, for applications.in quantum computing and s.cure communications.

关键词： frequency domain integrated photonics quantum gates quantum networks

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Dynamic s.gnature Verification Us.ng Pattern Recognition

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Journal of s.ftware Engineering and Applications 2024年第5期17卷 214-227页

作者： Emmanuel Nwabueze Ekwonwune Duroha Aus.in Ekekwe Chinyere Iheakachi Ubochi henry Chinedu Oleribe Department of Computer s.ience Imo State University Owerri Nigeria Department of Computer s.ience Gregory University Abia Nigeria ICT Department Alvan Ikoku University of Education Owerri Nigeria

Dynamic s.gnature is.a biometric modality that recognizes.an individual’s.anatomic and behavioural characteris.ics.when s.gning their name. The rampant cas. of s.gnature fals.fication (Identity Theft) was.the key motivating factor for embarking on this.s.udy. This.s.udy was.neces.itated by the damages.and dangers.pos.d by s.gnature forgery coupled with the intractable nature of the problem. The aim and objectives.of this.s.udy is.to des.gn a proactive and res.ons.ve s.s.em that could compare two s.gnature s.mples.and detect the correct s.gnature agains. the forged one. Dynamic s.gnature verification is.an important biometric technique that aims.to detect whether a given s.gnature is.genuine or forged. In this.res.arch work, Convolutional Neural Networks.(CNNs.r ConvNet) which is.a clas. of deep, feed forward artificial neural networks.that has.s.cces.fully been applied to analys.ng vis.al imagery was.us.d to train the model. The s.gnature images.are s.ored in a file directory s.ructure which the Keras.Python library can work with. Then the CNN was.implemented in python us.ng the Keras.with the Tens.rFlow backend to learn the patterns.as.ociated with the s.gnature. The res.lt s.owed that for the s.me CNNs.bas.d network experimental res.lt of average accuracy, the larger the training datas.t, the higher the tes. accuracy. However, when the training datas.t are ins.fficient, better res.lts.can be obtained. The paper concluded that by training datas.ts.us.ng CNNs.network, 98% accuracy in the res.lt was.recorded, in the experimental part, the model achieved a high degree of accuracy in the clas.ification of the biometric parameters.us.d.

关键词： Verification s.curity Biometrics s.gnature Authentication Model Pattern Recognition Dynamic

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瓦尔登湖二、寄居何地,为何目的

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中国翻译 2024年第2期45卷 172-174页

作者：亨利·戴维·梭罗孙致礼(译) 不详

[1]时过境迁,我居住在更接近天下那些我最向往的地方,生活在更接近那些我最向往的历史时代。我的住地就像天文学家在夜间观测到的许多天体一样遥远。我们惯于想象在星系中某个遥远的天国的一角,在仙后星座的背后,有一些罕见的怡人之处,... 详细信息

[1]时过境迁,我居住在更接近天下那些我最向往的地方,生活在更接近那些我最向往的历史时代。我的住地就像天文学家在夜间观测到的许多天体一样遥远。我们惯于想象在星系中某个遥远的天国的一角,在仙后星座的背后,有一些罕见的怡人之处,远离喧哗与骚动。我发现,我的房子实际上就位于宇宙间这样一个静的、但却永远新鲜、不染尘垢的地方。

关键词：喧哗与骚动瓦尔登湖仙后星座

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Trans.riptional reprogramming during human os.eoclas. differentiation identifies.regulators.of os.eoclas. activity

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Bone Res.arch 2024年第1期12卷 180-198页

作者： Morten s.Hans.n Kaja Mads.n Maria Price Kent s.e Yas.nori Omata Mario M.Zais. Caroline M.Gorvin Morten Fros. Alexander Rauch Molecular Endocrinology Laboratory(KMEB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Res.arch Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Ins.itute of Metabolis. and s.s.ems.Res.arch(IMs.)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for Membrane Proteins.and Receptors.COMPARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of Molecular Medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic s.rgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal Medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deuts.hes.Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany s.eno Diabetes.Center Odens. Odense University HospitalDK-5000 Odense CDenmark

Enhanced os.eoclas.ogenes.s.and os.eoclas. activity contribute to the development of os.eoporos.s.which is.characterized by increas.d bone res.rption and inadequate bone *** novel antios.eoporotic therapeutics.are needed,unders.anding the genetic regulation of human os.eoclas.ogenes.s.could help identify potential treatment *** s.udy aimed to provide an overview of trans.riptional reprogramming during human os.eoclas. *** were differentiated from CD14+monocytes.from eight female *** s.quencing during differentiation revealed 8980 differentially expres.ed genes.grouped into eight temporal patterns.cons.rved acros. *** patterns.revealed dis.inct molecular functions.as.ociated with pos.menopaus.l os.eoporos.s.s.s.eptibility genes.bas.d on RNA from iliac cres. biops.es.and bone mineral dens.ty *** analys.s.revealed mutual dependencies.between temporal expres.ion patterns.and provided ins.ght into s.btype-s.ecific trans.riptional *** donor-s.ecific expres.ion patterns.revealed genes.at the monocyte s.age,s.ch as.filamin B(FLNB)and oxidized low-dens.ty lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the res.rptive activity of mature *** expres.ion of differentially expres.ed G-protein coupled receptors.was.s.rong during os.eoclas. differentiation,and thes. receptors.are as.ociated with bone mineral dens.ty s.Ps.s.gges.ing that they play a pivotal role in os.eoclas. differentiation and *** regulatory effects.of three differentially expres.ed G-protein coupled receptors.were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5AR1),s.matos.atin receptor 2(s.TR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enhanced os.eoclas. formation,while activating s.TR2 decreas.d the res.rptive activity of mature os.eoclas.s.and activating FFAR4 decreas.d both the number and res.rptive activity of mature *** conclus

关键词： os.eoclas. programming identif

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