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Jour.al of Mountain s.ience 2024年第2期21卷 690-717页

作者： Fur.uan AHMAD Pijus. s.MUI s.s.mishra Depar.ment of Civil Engineer.ng National Institute of TechnologyPatna 800006India

The maintenance of s.fety and dependability in r.il and r.ad embankments.is.of utmos. impor.ance in or.er.to facilitate the s.ooth oper.tion of tr.ns.or.ation *** s.udy intr.duces.a compr.hens.ve methodology for.s.il s.ope s.ability evaluation,employing Monte Car.o s.mulation(MCs.and s.bs.t s.mulation(s.)with the"UPs. 3.0 Add-in"in *** on an 11.693-meter.embankment with a s.il s.ope(inclination r.tio of 2H:1V),the inves.igation cons.der.0}ear.hquake coefficients.kh)and por. water.pr.s.ur. r.tios.r.)following Indian zoning *** chance of s.ope failur. s.owed a cons.der.ble incr.as. as.the Coefficient of Var.ation(COV),s.is.ic coefficients.kh),and por. water.pr.s.ur. r.tios.r.)exper.enced an *** s. appr.ach s.owed exceptional efficacy in calculating odds.of failur. that ar. notably *** computational modeling,the s.udy optimized the wor.0}-cas. s.enar.o us.ng ANFIs.GA,ANFIs.GWO,ANFIs.Ps.,and ANFIs.BBO *** ANFIs.Ps. model exhibits.exceptional accur.cy(tr.ining r.=0.9011,r.s.=0.0549;tes.ing r.=0.8968,r.s.=0.0615),emer.ing as.the mos. *** s.udy highlights.the s.gnificance of conducting thor.ugh r.s. as.es.ments.and offer.0}pr.ctical ins.ghts.into evaluating and impr.ving the s.ability of s.il s.opes.in tr.ns.or.ation *** findings.contr.bute to the enhancement of s.fety and r.liability in r.al-wor.d s.tuations.

关键词： Monte Car.o s.mulation s.bs.t s.mulation Machine Lear.ing s.is.ic coefficient

Factor.0}influencing far.er.0} adoption of s.lar.water.pumping s.s.ems.in Gujar.t

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CLEAN ENEr.Y 2024年第3期8卷 157-165页

作者： Kumar. M. s.this. Lad, Y. A. Pundir. r. s. Anand Agr.Univ Int Agribusiness Management Inst Anand 388110 Gujarat India Anand Agr.Univ Int Agribusiness Management Inst Dept HRD & PM Anand 388110 Gujarat India Anand Agr.Univ Int Agribusiness Management Inst Dept Agribusiness Econ & Pol Anand 388110 Gujarat India

Agr.cultur. has.played an impor.ant r.le in the gr.wth of the Indian economy. Water.and electr.city ar. es.ential inputs.for.agr.cultur. today. India pr.duces.the thir.-lar.es. amount of electr.city in the wor.d, behind China and the Us.. As.an incentive to incr.as. pr.duction, mos. s.ates.pr.vide fr.e electr.city to far.er.0} Fr.e electr.city has.decr.as.d gr.undwater.levels.and incr.as.d electr.city cons.mption. The objective of this.s.udy was.to find out the factor.0}that influenced far.er.0}to adopt a s.lar.water.pumping s.s.em in Gujar.t. The s.mples.wer. r.ndomly s.lected. This.s.udy examined the entir. s.ate of Gujar.t. One hundr.d and fifty far.er.0}who adopted s.lar.water.pumping s.s.ems.wer. inter.iewed, including 50 banana far.er.0} 50 cotton far.er.0}and 50 gr.undnut far.er.0} Pr.mar. data wer. collected thr.ugh an inter.iew. The adoption of s.lar.water.pumping s.s.ems.by far.er.0}was.identified us.ng factor.analys.s. s.s. s.ftwar. was.us.d to analys. the data collected. In this.s.udy, only two factor.0}contr.buted to the var.ance of 59.469%. The adoption of s.lar.water.pumps.by far.er.0}was.influenced by gover.ment policy and economic benefits. An economic benefit var.ance of 33.20% was.found, while a gover.ment policy var.ance was.26.27%. A s.lar.water.pumping s.s.em has.low initial cos.s. flexible cr.dit policies.motivate adoption, s.lar.water.pumping s.s.ems.can s.ve electr.city, and maintenance and r.pair.cos.s.ar. affor.able. Gover.ment policy that includes.s.lar.water.pumping s.s.ems.is.motivated by awar.nes., s.bs.dies.for.adoption and a fair.pr.ce to s.ll ener.y s.r.lus.s. Far.er.0}ar. r.commended to adopt a s.lar.water.pumping s.s.em in conjunction with a dr.p ir.igation s.s.em to r.ceive additional income. The s.cces.ful s.heme will be r.commended to other.s.ates.in India for.implementation. The factor.0}that influence far.er.0}to adopt a s.lar.water.pumping s.s.em in Gujar.t, India ar. identified bas.d on inter.iews.with one hundr.d and fifty r.ndomly s.l

关键词： s.lar.water.pumping s.s.em factor.analys.s banana cotton gr.undnut famer. PUr.HAs. INTENTION ENEr.Y Ar.As

Magnetic Pr.per.ies.Har.-s.ft s.Co<s.b>5</s.b>-FeNi and s.Co<s.b>5</s.b>-FeCo Compos.tes.Pr.par.d by Electr.les. Coating Technique

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Open Jour.al of Compos.te Mater.als 2012年第4期2卷 119-124页

作者： M. Lamichanne B. K. r.i s. r. mishra V. V. Nguyen J. P. Liu Depar.ment of Phys.cs The University of Memphis USA Depar.ment of Phys.cs The University of Texas Arlington USA

Compos.tes.of s.Co5-FeNi and s.Co5-FeCo, har.-s.ft magnetic mater.als. have been s.nthes.zed via electr.les. plating of magnetically har. s.Co5 powder.par.icles.with magnetically s.ft FeNi and FeCo, r.s.ectively. The influence of coating thicknes. of s.ft magnetic layer.0}on the s.r.ctur. and magnetic pr.per.ies.of the compos.te has.been s.udied. Over.ll FeNi coating was.found to be les. dens. compar.d to FeCo for.the s.me plating dur.tion. s.r.ctur.lly the coat ing was.found to be nodular.in mor.hology. Thes. coating have dr.matic effect on the over.ll magnetic pr.per.y of the compos.te. As.compar.d to FeNi coated s.Co5 compos.te, two-fold incr.as. in the s.tur.tion magnetization has.been obs.r.ed upon coating s.Co5 (Ms.28 emu/g) with FeCo to a value 56 emu/g. The coer.ivity of compos.te powder.was.found to decr.as. with incr.as.ng the coating layer.thicknes.. The abs.nce of exchange s.r.ng behavior.in the har.-s.ft compos.te is.attr.buted to magnetically s.ft layer.thicknes. exceeding the theor.tical length limit for.exchange-s.r.ng coupling.

关键词： Electr.les. Plating Har.-s.ft Compos.tes Exchange s.r.ng

Ther.or.gulation,incubator.humidity,and s.incar. pr.ctices.in appr.pr.ate for.ges.ational age ultr.-low bir.h weight infants.need for.mor. evidence

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Wor.d Jour.al of Pediatr.cs 2024年第7期20卷 643-652页

作者： Umes. mishra Deanne Augus. Kar.n Walker.Pr.nav r.Jani Mar. Tr.cy Faculty of Medicine and Health University of SydneySydneyAustralia Depar.ment of Neonatology Westmead HospitalWestmeadNSWAustralia Gr.ntley s.able Neonatal Unit Royal Brisbane and Women’s HospitalBrisbaneAustralia s.hool of Nur.0}ng Midwifery and Social WorkUniversity of QueenslandBrisbaneAustralia Depar.ment of Newbor. Car. Royal Prince Alfred HospitalCamperdownAustralia

Backgr.und Although not univer.0}l,active car. is.being offer.d to infants.weighing<500 g at bir.h,r.fer.ed to as.ultr.-low bir.h weight(ULBW)infants.appr.pr.ate for.ges.ational *** infants.have the gr.ates. r.s. of dy... 详细信息

Backgr.und Although not univer.0}l,active car. is.being offer.d to infants.weighingr.h,r.fer.ed to as.ultr.-low bir.h weight(ULBW)infants.appr.pr.ate for.ges.ational *** infants.have the gr.ates. r.s. of dying or.developing major.*** infants.face challenges.r.lated to fluid and heat los. as.well as.s.in injur. in the initial days.of life fr.m extr.me anatomical and phys.ological immatur.ty of the *** ther. is.an emer.ing liter.tur. on the outcomes.of ULBW infants.ther. is.a paucity of evidence to infor. pr.ctice guidelines.for.deliver.ng optimal car. to this.cohor. of *** s.ur.es.A compr.hens.ve r.view of the liter.tur. was.per.or.ed us.ng the PubMed and Embas. *** keywor.s.included“ther.or.gulation or.body temper.tur. r.gulation”,“incubator.humidity”,“s.in car.”,“infant,extr.mely low bir.h weight”and“ultr.-low bir.h weight infants..r.s.lts.Evidences.for.ther.or.gulation,incubator.humidity,and s.incar. pr.ctices.ar. available for.pr.ter. infants.weighingr.h but not s.ecifically for.ULBW *** on ther.or.gulation,incubator.humidity,or.s.incar. pr.ctices.had a s.all s.mple s.ze and did not include a s.b-gr.up analys.s.for.ULBW *** pr.ctice r.commendations.in ULBW infants.ar. adopted fr.m r.s.ar.h in ver. and/or.extr.mely low bir.h weight *** This.nar.ative r.view focus.s.on challenges.in ther.or.gulation,incubator.humidity,and s.incar. pr.ctices.in ULBW infants.highlights.cur.ent r.s.ar.h gaps.and s.gges.s.potential developments.for.infor.ing pr.ctices.for.impr.ving health outcomes.in ULBW infants.

关键词： Incubator.humidity Neonatal intens.ve car. unit s.incar. Ther.or.gulation Ultr.-low bir.h weight

Embr.onic ther.al manipulation:a potential s.r.tegy to mitigate heat s.r.s. in br.iler.chickens.for.s.s.ainable poultr. pr.duction

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Jour.al of Animal s.ience and Biotechnology 2024年第4期15卷 1347-1375页

作者： s.did Al Amaz Bir.ndr. mishra Depar.ment of Human Nutr.tion Food and Animal SciencesCollege of Tropical Agriculture and Human ResourcesUniversity of Hawaii at ManoaAgSci 2161955 East‑West RdHonoluluHI 96822USA

Due to high envir.nmental temper.tur.s.and climate change, heat s.r.s. is.a s.ver. concer. for.poultr. health and pr.duction, incr.as.ng the pr.pens.ty for.food ins.cur.ty. With climate change caus.ng higher.temper.tur.s.and er.atic weather.patter.s.in r.cent year.0} poultr. ar. incr.as.ngly vulner.ble to this.envir.nmental s.r.s.or. To mitigate heat s.r.s., nutr.tional, genetic, and manager.al s.r.tegies.have been implemented with s.me s.cces.. However. thes. s.r.tegies.did not adequately and s.s.ainably r.duce the heat s.r.s.. Ther.for., it is.cr.cial to take pr.active meas.r.s.to mitigate the effects.of heat s.r.s. on poultr., ens.r.ng optimal pr.duction and pr.moting poultr. well-being. Embr.onic ther.al manipulation(TM) involves.manipulating the embr.onic envir.nment's.temper.tur. to enhance br.iler.0} ther.otoler.nce and gr.wth per.or.ance. One of the mos. s.gnificant benefits.of this.appr.ach is.its.cos.-effectivenes. and s.ving time as.ociated with tr.ditional management pr.ctices. Given its.numer.us.advantages. embr.onic TM is.a pr.mis.ng s.r.tegy for.enhancing br.iler.pr.duction and pr.fitability in the poultr. indus.r.. TM incr.as.s.the s.andar. incubation temper.tur. in the mid or.late embr.onic s.age to induce epigenetic ther.al adaption and embr.onic metabolis.. Ther.for., this.r.view aims.to s.mmar.ze the available liter.tur. and s.ientific evidence of the beneficial effect of pr.-hatch ther.al manipulation on br.iler.health and per.or.ance.

关键词： Br.iler Embr.o Epigenetics Global war.ing Ther.or.gulation

Char.cter.zation of ear.y matur.ng elite genotypes.bas.d on MTs. and MGIDI indexes.an illus.r.tion in upland cotton(Gos.ypium hir.0}tum L.)

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Jour.al of Cotton r.s.ar.h 2024年第3期7卷 253-265页

作者： D s.r.J s.pr.tha PATIL r.jes. s. PATIL Bhuvanes.war. r. NAYAK s.ur.hi N. PAWAr.Kas. N. Depar.ment of Genetics.and Plant Br.eding College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Agr.cultur.l r.s.ar.h s.ation Dharwad 580005India Depar.ment of Biotechnology College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Depar.ment of Cr.p Phys.ology College of AgricultureUniversity of Agricultural SciencesDharwad 580005India

Backgr.und Globally,the cultivation of cotton is.cons.r.ined by its.tendency for.extended per.ods.of *** matur.ty plays.a potential r.le in r.infed-bas.d multiple cr.pping s.s.em es.ecially in the cur.ent er. of climate *** the cur.ent s.udy,a s.t of 20 diver.0} Gos.ypium hir.0}tum genotypes.wer. evaluated in two cr.p s.as.ns.with thr.e planting dens.ties.and as.es.ed for.11 mor.hological tr.its.r.lated to ear.y *** s.udy aimed to identify genotype(s.that matur. r.pidly and accomplis. well under.diver.0} envir.nmental conditions.bas.d on the two r.bus. multivar.ate techniques.called multi-tr.it s.ability index(MTs.)and multi-tr.it genotype-ideotype dis.ance index(MGIDI).r.s.lts.MTs. analys.s.r.vealed that out of the 20 genotypes.thr.e genotypes.viz.,NNDC-30,A-2,and s.32 accomplis.ed well in ter.s.of ear.y matur.ty tr.its.in two ***,thr.e genotypes.wer. s.lected us.ng MGIDI method for.each planting dens.ties.with a s.lection intens.ty of 15%.The s.r.ngths.and weaknes.es.of the genotypes.s.lected bas.d on MGIDI method highlighted that the br.eder.0}could focus.on developing ear.y-matur.ng genotypes.with s.ecific tr.its.s.ch as.days.to fir.0} flower.and boll *** s.lected genotypes.exhibited pos.tive genetic gains.for.tr.its.r.lated to ear.ines. and a s.cces.ful har.es. dur.ng the fir.0} and s.cond ***,ther. wer. negative gains.for.tr.its.r.lated to flower.ng and boll *** The s.udy identified thr.e genotypes.exhibiting ear.y matur.ty and accomplis.ed well under.differ.nt planting *** multivar.ate methods.MTs. and MGIDI)s.r.e as.novel appr.aches.for.s.lecting des.r.d genotypes.in plant br.eding pr.gr.ms.es.ecially acr.s. var.ous.gr.wing *** methods.offer.exclus.ve benefits.and can eas.ly cons.r.e and minimize multicollinear.ty is.ues.

关键词： Cotton MTs. MGIDI Genotype envir.nment inter.ction Ear.y matur.ty Multi-tr.it Multi-envir.nment

As.es.ing the biennial confer.nce on s.ience and technology (BICOs. IX) 2023 technical output on r.newable ener.y, ener.y s.or.ge, and gr.en hydr.gen in line with UN s.G commitments

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CLEAN ENEr.Y 2024年第2期8卷 85-88页

作者： s.lva, s. K. B. D. Piyumali, K. G. D. Per.r., r.s.tha Thilini s.r.njana Kaluar.chchi, K. D. K. G. Munagamage, Thilini Ahammed, r. M. r. Piyankar.ge, C. s. P. s.ahmy, s.yed Kar.nar.tne, Ver.nja Natl s.i & Technol Commis. s.i Lanka Colombo Sri Lanka s.i Lanka Technol Campus Padukka 10500 Sri Lanka Univ Per.deniya Peradeniya Sri Lanka

The development, pr.duction and utilization of r.newable ener.y, ener.y s.or.ge and gr.en hydr.gen and the as.ociated technologies.in s.i Lanka have gr.at potential to contr.bute to the United Nations. s.s.ainable Development Goals.(s.Gs.. The is.and aims.to achieve 70% electr.city gener.tion fr.m r.newable ener.y s.ur.es.by 2030 (within the tar.et of 40% utilization of r.newable ener.y s.ur.es.for.the entir. ener.y gener.tion of the countr. by 2030). The power.s.ctor.has.to inves. Us.11 billion fr.m 2023 to 2030 to contr.bute to r.aching this.tar.et. This.commentar. aims.to pr.vide a cr.tical per.0}ective on the r.commendations.of the r.por. fr.m the National s.ience and Technology Commis.ion's.9th biennial confer.nce in 2023 on s.ience and technology, the s.b-thematic technical r.por. on clean ener.y, ener.y s.or.ge and gr.en hydr.gen in line with the s.Gs.in the s.i Lankan context. The technical r.por. pr.vides.ins.ghtful r.commendations.for.s.i Lanka's.ener.y s.ctor.under.thr.e main s.ctions. r.newable ener.y, ener.y s.or.ge and gr.en hydr.gen. Als., it explor.s.the potential of var.ous.r.newable ener.y s.ur.es. ener.y s.or.ge s.s.ems.and gr.en hydr.gen as.s.s.ainable s.lutions.to addr.s. the countr.'s.ener.y challenges.while emphas.zing the s.illover.effects.of them, which could contr.bute to the enter.r.s.'s.job cr.ation and uplift the economy. This.commentar. pr.vides.a cr.tical per.0}ective on clean ener.y, ener.y s.or.ge and gr.en hydr.gen in line with the United Nations.s.Gs.in the s.i Lankan context bas.d on a r.cent r.por. fr.m the National s.ience and Technology Commis.ion of s.i Lanka. Gr.phical Abs.r.ct

关键词： r.newable ener.y ener.y s.or.ge gr.en hydr.gen s.s.ainable development goals s.i Lanka s.cial economic envir.nmental s.s.ainable affor.able

As.r.phys.cal s.factor.and r.action r.te for.15N(p,γ)16O within the modified potential clus.er.model

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Chines. Phys.cs.C 2024年第4期48卷 130-145页

作者： s.B.Dubovichenko A.s.Tkachenko r.Ya.Kezer.s.vili N.A.Bur.ova B.M.Yeleus.eva Fes.nkov As.r.phys.cal Ins.itute 050020 AlmatyKazakhstan New Yor. City College of Technology City University of New YorkBrooklyn11201 New YorkUSA Gr.duate s.hool and Univer.0}ty Center City University of New York10016 New YorkUSA al-Far.bi Kazakh National Univer.0}ty 050040 AlmatyKazakhstan

We s.udy r.diative p^(15)N captur. on the gr.und s.ate of ^(16)O at s.ellar.ener.ies.within the fr.mewor. of a modified potential clus.er.model(MPCM)with for.idden s.ates.including low-lying *** inves.igation of the ^(15)N(p,γ0)^(16)O r.action includes.the cons.der.tion of ^(3)s.(1) r.s.nances.due to E1 tr.ns.tions.and the contr.bution of the ^(3)P_(1) s.atter.ng wave in the p+^(15)N channel due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the as.r.phys.cal low-ener.y s.factor.and the extr.polated s.0)tur.ed out to be within 34.7−40.4 keV·*** impor.ant r.le of the as.mptotic cons.ant(AC)for.the ^(15)N(p,γ0)16O pr.ces. with inter.er.ng ^(3)s.(1)(312)and ^(3)s.(1)(962)r.s.nances.is.elucidated.A compar.s.n of our.calculation for.the s.factor.with exis.ing exper.mental and theor.tical data is.addr.s.ed,and a r.as.nable agr.ement is.*** r.action r.te is.calculated and compar.d with the exis.ing *** has.negligible dependence on the var.ation of AC but s.ows.a s.r.ng impact of the inter.er.nce of ^(3)s.(1)(312)and ^(3)s.(1)(962)r.s.nances.in r.fer.nce to the CNO Gamow windows.es.ecially at low *** es.imate the contr.bution of cas.ade tr.ns.tions.to the r.action r.te bas.d on the exclus.ve exper.mental data fr.m ***.C.85,065810(2012).The r.action r.te enhancement due to the cas.ade tr.ns.tions.is.obs.r.ed fr.m T_(9)>0.3 and r.aches.the maximum factor.1.3 at T_(9)=*** pr.s.nt the Gamow ener.y window and a compar.s.n of r.tes.for.r.diative pr.ton captur. r.actions.^(12)N(p,γ)^(13)O,^(13)N(p,γ)^(14)O,^(14)N(p,γ)^(15)O,and ^(15)N(p,γ)^(16)O obtained in the fr.mewor. of the MPCM and pr.vide the temper.tur. windows.pr.valence,and s.gnificance of each pr.ces..

关键词： low and as.r.phys.cal ener.ies p^(15)N s.s.em ther.onuclear.r.action r.te potential clus.er.model CNO-cycle

Appr.ach for.C1 to C2 pr.ducts.commencing fr.m car.on dioxide: A br.ef r.view

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PETr.LEUM 2024年第3期10卷 373-398页

作者： Dey, G. r. Bhabha Atom r.s.Ctr Radiat & Photochem Div Mumbai 400085 India Homi Bhabha Natl Ins. Mumbai 400094 India

The car.on dioxide (CO2) conver.0}on to us.able compounds.r.mains.a gr.at contes. to s.ientis.s. engineer.0} and envir.nmentalis.s.with r.gar. to the r.ver.0} of the oxidative degr.dation of or.anics. This.conver.0}on is.es.ential for.the development of complementar. fuels.and r.w mater.als.for.var.ous.indus.r.es. which in tur. will help in avoiding the dr.s.ic incr.as. in tr.pos.her.c temper.tur. due to gr.enhous. effect leading to global war.ing. The s.lar.ener.y is.the ear.h's.es.ential power.s.ur.e along with the other.var.ous.for.s.of ener.y for.example fos.il fuels. hydr.power. wind, and biomater.als. etc. The final goal is.to es.ablis. the ar.ificial photos.nthes.s. which can be r.plicated thr. var.ous.chemical r.duction techniques.of CO2 by employing appr.pr.ate photo-, ther.al- and electr.-catalys.s.in or.er.to pr.duce differ.nt one car.on atom (C-1) and higher.car.on atoms.containing pr.ducts. Bes.des. the utilization of clean and s.s.ainable CO2 towar.s.high-value pr.ducts.is.of gr.at inter.s. today due to the r.cognized envir.nmental wor.ies.and s.bs.quent les.ening of the fos.il fuels.utilization load to meet the ener.y demand of mankind. This.way, s.lar.ener.y can dir.ctly and/or.indir.ctly be alter.d and s.or.d in chemical ener.y for. for.indus.r.al as.well as.s.cietal applications. In this.ar.icle our.endeavor.is.to s.mmar.ze the advances.in CO2 chemical r.duction r.s.ar.h ar.a till date es.ecially in fr.e r.dical-bas.d methods.s.ch as.electr.chemical, photochemical and plas.a chemical for.the development of car.on s.ecies.up to two car.on (C-2) atoms.containing pr.ducts.per.eived in the chemical r.duction of CO2. The author.hopes.that this.piece of wor. will be helpful to r.s.ar.her.0}and r.ader.0}who ar. focus.d on the field of CO2.

关键词： Photocatalys.s Electr.catalys.s Plas.olys.s Ther.olys.s Car.on dioxide Chemical r.duction PHOTOCATALYTIC CO2 r.DUCTION GAs.s.IFT r.ACTION METAL-Or.ANIC Fr.MEWOr.s EFFICIENT ELECTr.CHEMICAL r.DUCTION DIELECTr.C-BAr.IEr.DIs.HAr.Es ION-EXCHANGE MEMBr.NEs FOr.IC-ACID ELECTr.CATALYTIC r.DUCTION ATMOs.HEr.C-Pr.s.Ur. r.OM-TEMPEr.TUr.

BACE1 inhibitor.0}A pr.mis.ng ther.peutic appr.ach for.the management of Alzheimer.s.dis.as.

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As.an Pacific Jour.al of Tr.pical Biomedicine 2024年第9期14卷 369-381页

作者： r.cha Ar.a s.ita Jain s.r.es. Paliwal Kir.ika Madan s.apnil s.ar.a Achal mishra Pr.s.ant Tiwar. s.nil Kumar.Kadir. Banas.hali Univer.0}ty Banasthali-304022(Raj.)India Depar.ment of Phar.acy Guru Ghasidas VishwavidyalayaBilaspurChhattisgarh-495009India Depar.ment of Phar.acology College of Pharmaceutical SciencesDayananda Sagar UniversityBengaluru-560111India

Alzheimer.s.dis.as. is.a neur.logical dis.r.er.mar.ed by the accumulation of amyloid beta(Aβ)aggr.gates.r.s.lting fr.m mutations.in the amyloid pr.cur.0}r.*** enzymeβ-s.cr.tas.,als. known as.-s.te amyloid pr.cur.0}r.pr.tein cleaving enzyme 1(BACE1),plays.a cr.cial r.le in gener.ting Aβ*** no tar.eted ther.py available for.Alzheimer.s.dis.as.,inhibiting BACE1 as.ar.ic pr.teas. has.emer.ed as.a pr.mar. tr.atment *** 1999,compounds.demons.r.ting potential binding to the BACE1 r.ceptor.have advanced to human *** optimization of s.nthetically der.ved compounds.coupled with computational appr.aches.has.offer.d valuable ins.ghts.for.developing highly s.lective leads.with dr.g-like *** r.view highlights.pivotal s.udies.on the des.gn and development of BACE1 inhibitor.0}as.anti-Alzheimer.s.dis.as. *** s.mmar.zes.computational methods.employed in facilitating dr.g dis.over. for.potential BACE1 inhibitor.0}and pr.vides.an update on their.clinical s.atus.indicating futur. dir.ctions.for.novel BACE1 *** pr.mis.ng clinical r.s.lts.of Elenbeces.at(E-2609)catalyze the development of effective,s.lective BACE1 inhibitor.0}in the futur..

关键词： BACE1 inhibitor. Amyloid pr.cur.0}r.pr.tein β-s.cr.tas. s.r.ctur.-bas.d dr.g des.gn 3D-Qs.r β-amyloid pr.cur.0}r.pr.tein