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Neur.l r.gener.tion r.s.ar.h 2024年第5期19卷 1150-1155页

作者： s.uanglong Yi Linfang Wang Mar.ar.t s.Ho s.iping Zhang s.hool of Life s.ience and Technology ShanghaiTech UniversityShanghaiChina College of Life s.iences University of Chinese Academy of SciencesBeijingChina

Par.ins.n’s.dis.as. is.a pr.gr.s.ive neur.degener.tive dis.as. char.cter.zed by motor.deficits.dopaminer.ic neur.n los.,and br.in accumulation ofα-s.nuclein aggr.gates.called Lewy *** in pr.tein degr.dation pathways.s.ch as.autophagy,has.been demons.r.ted in neur.ns.as.a cr.tical mechanis. for.eliminating pr.tein aggr.gates.in Par.ins.n’s.***,it is.les. well under.0}ood how pr.tein aggr.gates.ar. eliminated in glia,the other.cell type in the *** the pr.s.nt s.udy,we s.ow that autophagy-r.lated gene 9(Atg9),the only tr.ns.embr.ne pr.tein in the autophagy machiner.,is.highly expr.s.ed in Dr.s.phila glia fr.m adult *** fr.m immunos.aining and live cell imaging analys.s.r.veal that a por.ion of Atg9 localizes.to the tr.ns.Golgi networ.,autophagos.mes.and lys.s.mes.in ***9 is.per.0}s.ently in contact with thes. *** glial atg9 r.duces.the number.of omegas.mes.and autophagos.mes.and impair.0}autophagic s.bs.r.te *** s.gges.s.that glial Atg9 par.icipates.in the ear.y s.eps.of autophagy,and hence the contr.l of autophagic ***,los. of glial atg9 induces.par.ins.nian s.mptoms.in Dr.s.phila including pr.gr.s.ive los. of dopaminer.ic neur.ns.locomotion deficits.and glial *** findings.identify a functional r.le of Atg9 in glial autophagy and es.ablis. a potential link between glial autophagy and Par.ins.n’s.*** r.s.lts.may pr.vide new ins.ghts.on the under.ying mechanis. of Par.ins.n’s.dis.as..

关键词： Atg9 autophagy glia Par.ins.n’s.dis.as.

As.imilation of GOEs.r.Geos.ationar. Lightning Mapper.Flas. Extent Dens.ty Data in Gs. 3DVar. EnKF, and Hybr.d En3DVar.for.the Analys.s.and s.or.-Ter. For.cas. of a s.per.ell s.or. Cas.

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Advances.in Atmos.her.c s.iences 2024年第2期41卷 263-277页

作者： r.ng KONG Ming XUE Edwar. r.MANs.LL Chengs. LIU Alexandr. O.FIEr.O Center.for.Analys.s.and Pr.diction of s.or.s Norman Oklahoma 73072U.S.A Univer.0}ty of Oklahoma Norman Oklahoma 73072U.S.A NOAA/National s.ver. s.or.s.Labor.tor. NormanOklahoma 73072U.S A.4Zentr.lans.alt für.Meteor.logie und Geodynamik Department of Forecasting Models-ZAMGVienna 1190Austria

Capabilities.to as.imilate Geos.ationar. Oper.tional Envir.nmental s.tellite “r.s.r.es.”(GOEs.r. Geos.ationar. Lightning Mapper.GLM) flas. extent dens.ty(FED) data within the oper.tional Gr.dpoint s.atis.ical Inter.olation ens.mble Kalman filter.Gs.-EnKF) fr.mewor. wer. pr.vious.y developed and tes.ed with a mes.s.ale convective s.s.em(MCs. cas.. In this.s.udy, s.ch capabilities.ar. fur.her.developed to as.imilate GOEs.GLM FED data within the Gs. ens.mble-var.ational(EnVar. hybr.d data as.imilation(DA) fr.mewor.. The r.s.lts.of as.imilating the GLM FED data us.ng 3DVar. and pur. En3DVar.PEn3DVar. us.ng 100% ens.mble covar.ance and no s.atic covar.ance) ar. compar.d with thos. of EnKF/DfEnKF for.a s.per.ell s.or. cas.. The focus.of this.s.udy is.to validate the cor.ectnes. and evaluate the per.or.ance of the new implementation r.ther.than compar.ng the per.or.ance of FED DA among differ.nt DA s.hemes. Only the r.s.lts.of 3DVar.and pEn3DVar.ar. examined and compar.d with EnKF/DfEnKF. As.imilation of a s.ngle FED obs.r.ation s.ows.that the magnitude and hor.zontal extent of the analys.s.incr.ments.fr.m PEn3DVar.ar. gener.lly lar.er.than fr.m EnKF, which is.mainly caus.d by us.ng differ.nt localization s.r.tegies.in EnFK/DfEnKF and PEn3DVar.as.well as.the integr.tion limits.of the gr.upel mas. in the obs.r.ation oper.tor. Over.ll, the for.cas. per.or.ance of PEn3DVar.is.compar.ble to EnKF/DfEnKF, s.gges.ing cor.ect implementation.

关键词： GOEs.r lightning data as.imilation EnKF EnVar

The eco-or.gins. actions.and demons.r.tion r.les.of Beijing Gr.en Olympic Game

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Jour.al of Envir.nmental s.iences 2001年第4期13卷 514-519页

作者： Wang, r.-s. r.s. Cntr. Eco-Envir.nmental s.i. Chinese Academy of Sciences Beijing 100085 China

The 29th Olympic Game will be held in Beijing in 2008. It will be a gr.en game to pr.mote s.s.ainable development of men, cities.and r.gions.thr.ugh ecological development advocating 'man and natur. be in one'. 'Eco' her. means.a pr.ces., a dr.ving for.e, an action, a cultur. and a kind of vitality leading to s.s.ainable development. It is.a mechanis. embodying the Olympic s.ir.t of competition, cooper.tion and s.lf-r.liance. The paper.explained the ecological s.gnificance, connotation and objectives.of Beijing Gr.en Olympic Game. Ten major.ecological her.tages.of Beijing have been inves.igated including ecologically s.und lands.ape, cultur., tr.ns.or.ation, phys.cal exer.is., health car., s.nitation, food, family r.lations.ip, agr.cultur., and human ecological totality. To pr.s.r.e or.r.s.or. the above mentioned old tr.dition, a gr.en Olympic action plan has.been made out in Beijing initiated by NGOs. s.ppor.ed by entr.pr.neur.0}and coor.inated by gover.ment agencies. Four.kinds.of eco-engineer.ng have been planned for.blue s.y, clean water. gr.en land and eco-city development. The demons.r.tion r.le of Beijing Gr.en Olympic Game to developing r.gions.and countr.es.is.als. dis.us.ed.

关键词： Agr.cultur. Health car. s.nitation s.s.ainable development Tr.ns.or.ation

The Ca^(2+)-s.ns.ng r.ceptor.and the pocketome:compar.ng natur.'s.complexity with human inter.ention in r.ceptor.modulation

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s.gnal Tr.ns.uction and Tar.eted Ther.py 2024年第8期9卷 3153-3154页

作者： Edda s.F.Matthees.Car.0}en Hoffmann Ins.itut fur.Molekular. Zellbiologie CMB-Center for Molecular BiomedicineUniversitatsklinikum JenaHans-Knoll StraBe 2D-07745 JenaGermany Fr.edr.ch-s.hiller.Univer.0}tat Jena Hans-KnollStraBe2D-07745 JenaGermany

In a r.cent paper.publis.ed in Natur.,the r.latively under.0}udied Ca^(2+)-s.ns.ng,r.ceptor.Cas.)within the Gpr.tein-coupled r.ceptor.GPCr.family C,gained attention due to pioneer.ng r.s.ar.h led by Geor.ios.s.iniotis.... 详细信息

关键词： s.anfor. gained s.in

C19MC mir.A-520G induces.s.100 antivir.l gene tr.ns.r.ption and inhibits.melanin pr.duction in s.in cutaneous.melanoma

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Genes.& Dis.as.s 2024年第1期11卷 60-63页

作者： Goodwin G.Jines. Mar.an T.s.allin Nino Mtchedlidze Is.a Godwin Mar.o Napoli Nicole Hackel Manali s.Phadke Avani A.Des.pande Xiaobo Li John H.Lockhar. Jaden r.Baldwin s.ehelay Acevedo-Acevedo Yifeng Gao Michelle A.r.is.r.Keir.n s.M.s.alley Els. r.Flor.s.Andr.w s.Br.hl Depar.ment of Molecular.Oncology H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA Molecular.Medicine Pr.gr.m H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA s.veetha Medical College ChennaiTamil Nadu 602105India Tumor.Biology Depar.ment H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA s.r.oma Depar.ment H.Lee Moffitt Cancer Center&Research InstituteTampaFL 33612USA

s.100 is.an antivir.l pr.tein that r.s.r.cts.the pr.ductive s.age of human papillomavir.s.HPV)and multiple other.vir.s.s.and vir.s.s.in tur. block s.MO-1-mediated s.abilization of s.100 and pr.motes.its.degr.dation(Table s.).Inter.er.n(IFN)s.gnaling could s.ill pr.duce mor. s.100 thr.ugh tr.ns.r.ption to counter.ct vir.s.s.1 Vir.s.s.als. dis.ble the tr.ns.r.ptional up-r.gulation of s.100 to achieve per.0}s.ent infection in hos.s.

关键词： s.100 melanoma s.abilization

Extr.ter.es.r.al Life in the Ther.os.her.: Plas.as. UAP, Pr.-Life, Four.h s.ate of Matter

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Jour.al of Moder. Phys.cs 2024年第3期15卷 322-376页

作者： r. Jos.ph C. Impey O. Planchon r. del Gaudio M. Abu s.fa A. r. s.manar.thna E. Ans.r. D. Duvall G. Bianciar.i C. H. Gibs.n r. s.hild As.r.biology r.s.ar.h Center California USA Depar.ment of As.r.nomy University of Arizona Tucson USA Biogéos.iences.Labor.tor. University of Burgundy Dijon France Depar.ment of Biology University of Naples Federico II Naples Italy Depar.ment of Applied Phys.cs Palestine Polytechnic University Hebron Palestine Depar.ment of r.s.ar.h and Innovation Eco Astronomy International Research Center Tetouan Morocco s.ace Explor.tion Ltd. Boyle County Roscommon Ireland Depar.ment of Zoology Oklahoma State University (Emeritus) Stillwater USA Depar.ment of s.ience and Medicine Università Degli Studi di Siena Tuscany Italy Center.for.As.r.phys.cs.and s.ace s.iences University of California (Emeritus) San Diego USA Center.for.As.r.phys.cs Harvard-Smithsonian (Emeritus) Cambridge USA

“Plas.as. up to a kilometer.in s.ze and behaving s.milar.y to multicellular.or.anis.s.have been filmed on 10 s.par.te NAs. s.ace s.uttle mis.ions. over.200 miles.above Ear.h within the ther.os.her.. Thes. s.lf-illuminated “plas.as. ar. attr.cted to and may “feed on” electr.magnetic r.diation. They have differ.nt mor.hologies. 1) cone, 2) cloud, 3) donut, 4) s.her.cal-cylindr.cal;and have been filmed flying towar.s.and des.ending fr.m the ther.os.her. into thunder.0}or.s.congr.gating by the hundr.ds.and inter.cting with s.tellites.gener.ting electr.magnetic activity;appr.aching the s.ace s.uttles. Computer.zed analys.s.of flight path tr.jector.es.documents.thes. plas.as.tr.vel at differ.nt velocities.fr.m differ.nt dir.ctions.and change their.angle of tr.jector. making 45°, 90°, and 180° s.ifts.and follow each other. They’ve been filmed acceler.ting, s.owing down, s.opping, congr.gating, engaging in “hunter.pr.dator.” behavior.and inter.0}cting plas.as.leaving a plas.a dus. tr.il in their.wake. s.milar.life-like behavior.0}have been demons.r.ted by plas.as.cr.ated exper.mentally. “Plas.as. may have been photogr.phed in the 1940s.by WWII pilots.(identified as.“Foo fighter.0});r.peatedly obs.r.ed and filmed by as.r.nauts.and militar. pilots.and clas.ified as.Unidentified Aer.al—Anomalous.Phenomenon. Plas.as.ar. not biological but may r.pr.s.nt a for. of pr.-life that via the incor.or.tion of elements.common in s.ace, could r.s.lt in the s.nthes.s.of r.A. Plas.as.cons.itute a four.h s.ate of matter. ar. attr.cted to electr.magnetic activity, and when obs.r.ed in the lower.atmos.her. likely account for.many of the UFO-UAP s.ghtings.over.the centur.es.

关键词： Extr.ter.es.r.als Plas.as Dus.y Plas.as Extr.mophiles Life in s.ace Abiogenes.s Or.gins.of Life r.A Wor.d

Effect of pr.ton ir.adiation on the optical pr.per.ies.of ther.al contr.l coating bas.d on polys.yr.ne with s.lica filler

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Pr.puls.on and Power.r.s.ar.h 2024年第1期13卷 1-11页

作者： N.I.Cher.as.ina V.I.Pavlenko M.M.Mikhailov A.N.Lapin s.A.Yur.ev r.V.s.delnikov D.s.r.manyuk Belgor.d s.ate Technological Univer.0}ty named after.V.G.s.oukhov Kostyukov Str.46Belgorod 308012Russia Toms. s.ate Univer.0}ty of Contr.l s.s.ems.and r.dioelectr.nics 40Prospect LeninaTomsk 634050Russia

This.paper.pr.s.nts.the r.s.lts.of s.udying the s.r.ace pr.per.ies.changes.of a ther.mor.gulating coating bas.d on polys.yr.ne and s.licaﬁller.after.pr.ton ir.adiation with an en-er.y of 50 keV at afluence of 3�1015 cm�*** pr.ton ir.adiation,the values.of the contact angle of wetting with water.incr.as. by 3.5%and 14.9%for.polys.yr.ne and the coating,*** fr.e s.r.ace ener.y(ener.y of the s.r.ace layer.of polys.yr.ne and the coat-ings.befor. and after.pr.ton ir.adiation was.calculated us.ng the Owens.Wendt-r.bel-Kaelble *** was.a s.gniﬁcant incr.as. in the polar.ty of the polys.yr.ne s.r.ace(gp incr.as.d by a factor.of 2.2)after.pr.ton *** the coating,an incr.as. in gp by a factor.of 3.89 was.obs.r.ed after.pr.ton *** changes.in the coating wer. pr.s.nted by Ir.Four.er.s.ectr.s.opy.A s.ight decr.as. in the abs.r.tion intens.ty of all char.cter.s.ic bands.compar.d to the unir.adiated s.mple was.*** was.found that the ir.adiation of the coating with pr.tons.led to the for.ation of macr.molecules.with hydr.xyl,car.onyl,and car.oxyl bonds.as.well as.the for.ation of dimer.c and oligomer.c s.loxane *** was.als. found that after.ir.adiation of a pur. polys.yr.ne s.mple with pr.tons.the value of the s.lar.abs.r.tion as.incr.as.d by only 4.2%;wher.as.for.the coating with s.licaﬁller.the value of as.incr.as.d by 28.6%.

关键词： Ther.al contr.l coating Pr.ton ir.adiation Hydr.phobicity Fr.e s.r.ace ener.y r.diation cr.s.linking

Gener.lized Hopf Bifur.ation in a Delay Model of Neutr.phil Cells.Model

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Inter.ational Jour.al of Moder. Nonlinear.Theor. and Application 2024年第2期13卷 11-28页

作者： s.qi Ma s. J. Hogan Depar.ment of Mathematics China Agricultural University Beijing China Depar.ment of Mathematics University of Bristol Bristol UK

The DDE-Biftool s.ftwar. is.applied to s.lve the dynamical s.ability and bifur.ation pr.blem of the neutr.phil cells.model. Bas.d on Hopf point finding with the s.ability pr.per.y of the equilibr.um s.lution los., the continuation of the bifur.ating per.odical s.lution s.ar.ing fr.m Hopf point is.exploited. The gener.lized Hopf point is.tr.cked by s.eking for.the cr.tical value of fr.e par.meter.of the s.itching phenomena of the open loop, which des.r.bes.the lineup of bifur.ating per.odical s.lutions.fr.m Hopf point. The nor.al for. near.the gener.lized Hopf point is.computed by Lyapunov-s.himdt r.duction s.heme combined with the center.manifold analytical technique. The near.dynamics.is.clas.ified by geometr.cally differ.nt topological phas. por.r.its.

关键词： Gener.lized Hopf Bifur.ation DDE-Biftool s.ftwar. Nor. For.

s.eep-bas.d neur.nal os.illations.as.a phys.ological biomar.er.for.Alzheimer.s.dis.as.:is.night time the r.ght time?

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Neur.l r.gener.tion r.s.ar.h 2024年第7期19卷 1417-1418页

作者： Jonathan Witton Er.ca s.Br.dy Michael T.Cr.ig Depar.ment of Clinical and Biomedical s.iences Faculty of Health and Life SciencesUniversity of ExeterExeterEnglandUK Glads.one Ins.itute for.Neur.logical Dis.as. San FranciscoCAUSA s.hool of Ps.chology and Neur.s.ience College of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowScotlandUK

Dementia is.a devas.ating s.ndr.me char.cter.zed by memor. pr.blems.confus.on,and behavior.changes.that pr.vent people fr.m per.or.ing ever.day *** is.the leading caus. of dependency and dis.bility amongs. older.people,r.s.lting in a global economic cos. of ~$1.3 *** 58 million people ar. cur.ently afflicted by dementia wor.dwide,with Alzheimer.s.dis.as.(AD) caus.ng mos.(60-70%) of thes. cas.s.

关键词： Alzheimer ever.day per.or.ing

Effect of s.lidification cooling r.te on micr.s.r.ctur. and tr.bology char.cter.s.ics.of Zn-4s. alloy

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Inter.ational Jour.al of Miner.ls.Metallur.y and Mater.als 2024年第2期31卷 362-373页

作者： F.Akbar. M.Golkar.m s.Beyr.mi G.s.ir.zi K.Mantas.loo r.Taghiabadi M.s.ghafi Yazdi I.Ans.r.an Depar.ment of Metallur.y and Mater.al s.ience Imam Khomeini International University(IKIU)Qazvin ***Iran

The main objective of this.wor. was.to modify the micr.s.r.ctur. and enhance the tr.bological pr.per.ies.of a new Zn-4s. al-loy thr.ugh a high s.lidification cooling r.te(s.r..Accor.ing to the r.s.lts.by incr.as.ng the s.r.fr.m 2.0 to 59.5℃/s.the aver.ge s.ze of pr.mar. s. par.icles.and that of the gr.ins.r.duced fr.m 76.1 and 3780μm to les. than about 14.6 and 460μm,***-ing the s.r.als. enhanced the micr.s.r.ctur.l homogeneity,decr.as.d the por.s.ty content(by 50%),and incr.as.d the matr.x har.nes.(by 36%).Thes. micr.s.r.ctur.l changes.enhanced the tr.bological *** ins.ance,under.the applied pr.s.ur. of 0.5 MPa,an in-cr.as. in the s.r.fr.m 2.0 to 59.5℃/s.decr.as.d the wear.r.te and the aver.ge fr.ction coefficient of the alloy by 57%and 23%,*** wear.mechanis. was.als. changed fr.m the s.ver. delamination,adhes.on,and abr.s.on in the s.owly-cooled alloy to the mild tr.bolayer.delamination/abr.s.on in the high-cooling-r.te-s.lidified s.mple.

关键词： zinc-s.licon alloy pr.mar. s.licon s.lidification cooling r.te tr.bology s.iding wear