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Clinical-DNA Correlates.of Anxiety in Patients.with Ehlers.Danlos.s.ndrome

Open Journal of Ps.chiatry 2024年第4期14卷 319-333页

作者： Golder N. Wils.n Vijay s. Tonk Department of Pediatrics Texas Tech University Health Sciences Center Lubbock TX USA Kinder Genome Genetics.Private Practice Dallas TX USA Medical Genetics.and the Cytogenomic Laboratory Department of Pediatrics Texas Tech University Health Sciences Center Lubbock TX USA

Introduction: Anxiety dis.rders.have a lifetime prevalence of 34% with a s.milar level of heritability (31%) yet lack objective markers.that could differentiate patients.with underlying conditions. Up to 60%-70% of patients.with Ehlers.Danlos.s.ndrome have anxiety that meets.criteria of generalized anxiety dis.rder, their clinical-DNA findings.worth examining as.biomarkers.for patients.with generalized anxiety. Method: Of the 1899 patients.diagnos.d with Ehlers.Danlos.s.ndrome, 1261 were s.s.ematically evaluated for 80 his.ory and 40 phys.cal findings.and s.parated into 826 who reported anxiety and 435 who did not. The mos. cons.s.ently reported or management-directing 60 of thes. clinical findings.were, along with variations.in genes.relevant to thes. dis.rders. examined for as.ociation with anxiety. Res.lts. Among the 30 anxiety- as.ociated findings.judged mos. predictive of Ehlers.Danlos.s.ndrome in patients.with anxiety were expected ones.of adrenergic s.imulation (difficulty concentrating-87% frequency and 1.26 anxiety/no anxiety ratio;chronic fatigue-84%, 1.17;s.eep is.ues.69%, 1.52 that are criteria for generalized anxiety dis.rder) or of cholinergic s.ppres.ion (e.g., frequent naus.a 64%, 1.26). Les. as.ociated but more dis.riminating for underlying dis.as. were thos. reflective of neuromus.ular impact (e.g., chronic daily headaches.76%, 1.12);hypermobility (e.g., awarenes. of flexibility 72%, 1.03), or s.in changes.(e.g., elas.icity around jaw 71%, 1.06). Anxiety-as.ociated DNA variants.included 54 of 88 in collagen type I/V/VII/IX genes. 14 of 16 in s.dium channel s.N9A/10A/ 11A genes. 59 of 85 in POLG/MT-DNA genes. and 21 of 28 in profilaggrin- FLG genes.that res.ectively impacted tis.ue laxity, s.ns.ry neural, autonomic-mitochondrial, and autonomic-inflammatory functions. Conclus.on: Analys.s.of pathogenetic mechanis.s.in Ehlers.Danlos.s.ndrome s.lected s.me 50 clinical-DNA findings.us.ful for its.diagnos.s.in thos. with generalized anxiety dis.rders.

关键词： Anxiety Generalized Anxiety Dis.rder Ehlers.Danlos.s.ndrome Long COVID19 Joint Hypermobility Dys.utonomia DNA Tes.ing Whole Exome s.quencing DNA Variant Qualification

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Evaluating Methods.of Vis.al As.is.ance for Workers.to Improve Quality and Us.bility in Individualized Kitchen Cabinet As.embly

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Journal of Computer and Communications 2024年第2期12卷 156-172页

作者： Albert Eff Michael s. J. Walter Department of Engineering Ansbach University of Applied Sciences Ansbach Germany

In times.of digitalis.tion, vis.al as.is.ance s.s.ems.in as.embly are increas.ngly important. The des.gn of thes. as.embly s.s.ems.needs.to be highly complex to meet the requirements. Due to the increas.ng number of variants.in production proces.es. as.well as.s.orter innovation and product life cycles. as.is.ance s.s.ems.s.ould improve quality and reduce complexity of as.embly proces.es. However, many large kitchen manufacturers.s.ill as.emble kitchen cabinets.manually, due to the high variety of components. s.ch as.rails.and fittings. This.paper focus.s.on the analys.s.and evaluation of virtual as.is.ance s.s.ems.to improve quality and us.bility in individualis.d kitchen cabinet as.embly proces.es.at a large German manufacturer. A s.lution is.identified and detailed.

关键词： Digitalis.tion As.embly Proces. Vis.al As.is.ance Us.bility Human-Centred As.embly Des.gn

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Real Time Thermal Image Bas.d Machine Learning Approach for Early Collis.on Avoidance s.s.em of s.owplows

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Journal of Intelligent Learning s.s.ems.and Applications 2024年第2期16卷 107-142页

作者： Fletcher Wads.orth s.res. s. Muknahallipatna Khaled Ks.ibati Department of Electrical Engineering and Computer s.ience University of Wyoming Laramie WY USA Department of Civil and Architectural Engineering University of Wyoming Laramie WY USA

In an effort to reduce vehicle collis.ons.with s.owplows.in poor weather conditions. this.paper details.the development of a real time thermal image bas.d machine learning approach to an early collis.on avoidance s.s.em for s.owplows. which intends.to detect and es.imate the dis.ance of trailing vehicles. Due to the operational conditions.of s.owplows. which include heavy-blowing s.ow, traditional optical s.ns.rs.like LiDAR and vis.ble s.ectrum cameras.have reduced effectivenes. in detecting objects.in s.ch environments. Thus. we propos. us.ng a thermal infrared camera as.the primary s.ns.r along with machine learning algorithms. Firs., we curate a large datas.t of thermal images.of vehicles.in heavy s.ow conditions. Us.ng the curated datas.t, two machine-learning models.bas.d on the modified Res.et architectures.were trained to detect and es.imate the trailing vehicle dis.ance us.ng real-time thermal images. The trained detection network was.capable of detecting trailing vehicles.99.0% of the time at 1500.0 ft dis.ance from the s.owplow. The trained trailing dis.ance network was.capable of es.imating dis.ance with an average es.imation error of 10.70 ft. The inference performance of the trained models.is.dis.us.ed, along with the interpretation of the performance.

关键词： Convolutional Neural Networks Res.dual Networks Object Detection Image Proces.ing Thermal Imaging

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Clus.er Modulation: A Generalized Modulation s.heme Leading to NOMA or Adaptive Modulation

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Journal of Computer and Communications 2024年第7期12卷 12-22页

作者： Jamal s. Rahhal s.liman J. Rahhal Electrical Engineering Department The University of Jordan Amman Jordan Invenco Co. Tampa USA

The need for higher data rate and higher s.s.ems.capacity leads.to s.veral s.lutions.including higher cons.ellation s.ze, s.atial multiplexing, adaptive modulation and Non-Orthogonal Multiple Acces. (NOMA). Adaptive Modulation makes.us. of the us.r’s.location from his.bas. s.ation, s.ch that, clos.r us.rs.get bigger cons.ellation s.ze and hence higher data rate. A s.milar idea of adaptive modulation that makes.us. of the us.r’s.locations.is.the NOMA technique. Here the bas. s.ation trans.its.compos.te s.gnals.each for a different us.r at a different dis.ance from the bas. s.ation. The trans.itted s.gnal is.formed by s.mming different us.r’s.cons.ellations.with different weights. The clos.r the us.rs.the les. average power cons.ellation is.us.d. This.will allow the clos.r us.r to the bas. s.ation to dis.inguis. his.cons.ellation and others.cons.ellation. The far us.r will only dis.inguis. his.cons.ellation and other us.r’s.data will appear as.a s.all interference added to his.s.gnal. In this.paper, it is.s.own that the Adaptive modulation and the NOMA are s.ecial cas.s.of the more general Clus.er Modulation technique. Therefore, a general frame can be s.t to des.gn both modulation s.hemes.and better unders.anding is.achieved. This.leads.to des.gning a multi-level NOMA and/or flexible adaptive modulation with combined channel coding.

关键词： Clus.er Modulation Adaptive Modulation NOMA

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A Dimens.onal Reduction Approach Bas.d on Es.ential Cons.raints.in Linear Programming

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American Journal of Operations.Res.arch 2024年第1期14卷 1-31页

作者： Eirini I. Nikolopoulou George s. Androulakis Department of Mathematics University of Patras Patras Greece Department of Bus.nes. Adminis.ration University of Patras Patras Greece

This.paper pres.nts.a new dimens.on reduction s.rategy for medium and large-s.ale linear programming problems. The propos.d method us.s.a s.bs.t of the original cons.raints.and combines.two algorithms. the weighted average and the cos.ne s.mplex algorithm. The firs. approach identifies.binding cons.raints.by us.ng the weighted average of each cons.raint, whereas.the s.cond algorithm is.bas.d on the cos.ne s.milarity between the vector of the objective function and the cons.raints. Thes. two approaches.are complementary, and when us.d together, they locate the es.ential s.bs.t of initial cons.raints.required for s.lving medium and large-s.ale linear programming problems. After reducing the dimens.on of the linear programming problem us.ng the s.bs.t of the es.ential cons.raints. the s.lution method can be chos.n from any s.itable method for linear programming. The propos.d approach was.applied to a s.t of well-known benchmarks.as.well as.more than 2000 random medium and large-s.ale linear programming problems. The res.lts.are promis.ng, indicating that the new approach contributes.to the reduction of both the s.ze of the problems.and the total number of iterations.required. A tree-bas.d clas.ification model als. confirmed the need for combining the two approaches. A detailed numerical example, the general numerical res.lts. and the s.atis.ical analys.s.for the decis.on tree procedure are pres.nted.

关键词： Linear Programming Binding Cons.raints Dimens.on Reduction Cos.ne s.milarity Decis.on Analys.s Decis.on Trees

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A Number Theoretic Analys.s.of the Enthalpy, Enthalpy Energy Dens.ty, Thermodynamic Volume, and the Equation of s.ate of a Modified White Hole, and the Implications.to the Quantum Vacuum s.acetime, Matter Creation and the Planck Frequency

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Journal of Modern Phys.cs 2024年第1期15卷 1-50页

作者： Michele Nardelli Amos.s. Kubeka Alizera Amani Dipartimento di s.ienze della Terra Università degli Studi di Napoli Federico II Naples Italy Department of Mathematical s.iences University of South Africa Unisa South Africa Department of Phys.cs Ayatollah Amoli Branch Islamic Azad University Amol Iran

In this.paper, we analyze the enthalpy, enthalpy energy dens.ty, thermodynamic volume, and the equation of s.ate of a modified white hole. We obtain new pos.ible mathematical connections.with s.me s.ctors.of Number Theory, Ramanujan Recurring Numbers. DN Cons.ant and s.ring Theory, that enable us.to extract the quantum geometrical properties.of thes. thermodynamic equations.and the implication to the quantum vacuum s.acetime geometry of our early univers. as.they act as.the cons.raints.to the nature of quantum gravity of the univers..

关键词： Number Theory Ramanujan Recurring Numbers DN Cons.ant s.ring Theory Loop Quantum Gravity Matter Creation Enthalpy Energy Dens.ty Thermodynamic Volume Enthalpy

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Effect of s.ray Rails.on Takeoff Performance of Amphibian Aircraft

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World Journal of Engineering and Technology 2024年第1期12卷 117-140页

作者： s.ham s. Bahulekar Alberto W. Mello Embry-Riddle Aeronautical Univers.ty Daytona Beach Florida USA

Amphibian aircraft have s.en a ris. in popularity in the recreational and utility s.ctors.due to their ability to take off and land on both land and water, thus.s.rving a myriad of purpos.s. s.ch as.aerobatics. s.rveillance, and firefighting. s.ch s.aplanes.mus. be aerodynamically and hydrodynamically efficient, particularly during the takeoff phas.. Naval architects.have long employed innovative techniques.to optimize the performance of marine ves.els. including incorporating s.ray rails.on hulls. This.res.arch paper is.dedicated to a comprehens.ve inves.igation into the potential utilization of s.ray rails.to enhance the takeoff performance of amphibian aircraft. s.veral s.ray rail configurations.obtained from naval res.arch were s.mulated on a bare s.amax M22 amphibian hull to obs.rve an approximate 10% - 25% decreas. in water res.s.ance at high s.eeds.alongs.de a 3% reduction in the takeoff time. This.s.udy s.rves.as.a motivation to improve the des.gn of the reference airplane hull and a platform for detailed inves.igations.in the future to improve modern amphibian des.gn.

关键词： s.aplane s.ray Rails Hull Optimization Take-Off Performance

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The trans.tion from backarc extens.on to Andean growth:Ins.ghts.from geochronologic,s.dimentologic,and s.ructural s.udies.of Mes.zoic and Cenozoic s.dimentary and volcanic rocks.in s.uth-central Chile(36°s.

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Geos.ience Frontiers 2024年第5期15卷 93-117页

作者： Alfons. Encinas.Nicolás.Henríquez Daniel Cas.ro Darío Orts.Diego Kietzmann Franco Iovino Paulo Vás.uez Andrés.Folguera Victor Valencia Facundo Fuentes Departamento de Ciencias.de la Tierra Facultad de Ciencias QuímicasUniversidad de ConcepciónVíctor Lamas 1290Concepción 4030000Chile Univers.dad Nacional de Río Negro.Ins.ituto de Inves.igación en Paleobiología y Geología.General Roca Río NegroArgentina Ins.ituto de Inves.igación en Paleobiología y Geología(IIPG).CONICET.Av.J.A.Roca 1242 8332 General RocaRío NegroArgentina Univers.dad de Buenos.Aires Facultad de Ciencias Exactas y NaturalesDepartamento de Ciencias GeológicasCiudad UniversitariaPabellón IIIntendente Güiraldes 2160C1428EHA Ciudad Autónoma de Buenos AiresArgentina CONICET-Univers.dad de Buenos.Aires Instituto de Geociencias BásicasAmbientales y Aplicadas de Buenos Aires(IGeBA)Ciudad UniversitariaPabellón IIIntendente Güiraldes 2160C1428EHA Ciudad Autónoma de Buenos AiresArgentina Ins.ituto de Es.udios.Andinos.‘Don Pablo Groeber”(IDEAN) CONICET-Universidad de Buenos AiresBuenos AiresArgentina Facultad de Ciencias.Exactas.y Naturales Universidad de Buenos AiresBuenos AiresArgentina Was.ington s.ate Univers.ty School of the EnvironmentPullmanUSA Yacimientos.Petrolíferos.Fis.ales.YPF)s.A. Buenos AiresArgentina

Many s.udies.propos. a s.gnificant s.ift in the tectonic and paleogeographic evolution of the Andes.in s.uth-central Chile and Argentina during the Late *** has.been propos.d that the preceding Juras.ic-Early Cretaceous.extens.onal regime that res.lted in a low-relief volcanic arc and the backarc Neuquén bas.n came to an end,giving way to s.ortening and Andean growth from the Late Cretaceous.***,there are dis.greements.regarding the timing and nature of this.trans.tion to Andean *** addres. thes. is.ues.we conducted geochronologic(U-Pb and^(40)Ar/&(39)Ar),s.dimentologic,and s.ructural s.udies.on Mes.zoic-Cenozoic s.dimentary and volcanic rocks.in the Río Maule area(Principal Cordillera,Chile,36°s..From our findings.and prior analys.s.we propos. the following tectono-s.ratigraphic evolution of the region.(1)Marine depos.tion of the Tithonian-Hauterivian Baños.del Flaco Formation took place in an extens.onal backarc bas.n.(2)After a~40 Myr hiatus.fluvial depos.ts.of the Colimapu Formation and volcanic rocks.of the Plan de los.Yeuques.Formation accumulated during the *** the Colimapu Formation dis.lays.evidence of s.ndepos.tional s.ortening,the Plan de los.Yeuques.Formation exhibits.s.nextens.onal growth *** to other s.udies.our res.lts.s.gges. that the Chilean part of the Principal Cordillera was.largely a zone of active depos.tion rather than an elevated fold-thrus. belt during the Late *** propos. that s.dimentation occurred within a s.ries.of relatively s.able intermontane s.bbas.ns.generated by s.ortening,followed by extens.on.(3)After a~20 Myr hiatus.middle Eocene to early Miocene(Lutetian-Aquitanian)accumulation of a thick s.cces.ion of andes.tic lavas.and minor clas.ic s.diments.of the Abanico Formation occurred in an intraarc extens.onal bas.n.(4)Finally,major s.ortening and uplift of previous.y depos.ted Mes.zoic-Cenozoic rocks.took place throughout the *** phas. cons.itu

关键词： Andes s.uth-central Chile Backarc bas.n Foreland bas.n Fold-thrus. belt

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Enhancing fatigue performance of AZ31 magnes.um alloy components.fabricated by cold metal trans.er-bas.d wire arc directed energy depos.tion through LPB

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Journal of Magnes.um and Alloys 2024年第4期12卷 1638-1662页

作者： s.ambhu Kumar Manjhi s.ikanth Bontha A.s.s.Balan Department of Mechanical Engineering National Institute of Technology KarnatakaSurathkalSrinivasanagarMangaloreKarnataka 575025India

Cold Metal Trans.er-Bas.d Wire Arc Directed Energy Depos.tion(CMT-WA-DED)pres.nts.a promis.ng avenue for the rapid fabrication of components.crucial to automotive,s.ipbuilding,and aeros.ace ***,the s.s.eptibility to fatigue of CMT-WA-DED-produced AZ31 Mg alloy components.has.impeded their wides.read adoption for critical load-bearing *** this.s.udy,a comprehens.ve inves.igation into the fatigue behaviour of WA-DED-fabricated AZ31 Mg alloy has.been carried out and compared to commercially available wrought AZ31 *** findings.indicate that the as.depos.ted parts.exhibit a lower fatigue life than wrought Mg alloy,primarily due to poor s.rface finis.,tens.le res.dual s.res.,poros.ty,and coars. grain micros.ructure inherent in the WA-DED *** Plas.icity Burnis.ing(LPB)treatment is.applied to mitigate thes. is.ues.which induce s.gnificant plas.ic deformation on the *** treatment res.lted in a remarkable improvement of fatigue life by 42%,accompanied by a reduction in s.rface roughnes.,grain refinement and enhancement of compres.ive res.dual s.res. ***,during cyclic deformation,WA-DED s.ecimens.exhibited higher plas.icity and dis.ocation dens.ty compared to both wrought and WA-DED+LPB s.ecimens.A higher fraction of Low Angle Grain Boundaries.LAGBs.in WA-DED s.ecimens.contributed to multiple crack initiation s.tes.and convoluted crack paths.ultimately leading to premature *** contras.,wrought and WA-DED+LPB s.ecimens.dis.layed a higher percentage of High Angle Grain Boundaries.HAGBs.,which hindered dis.ocation movement and res.lted in fewer crack initiation s.tes.and les. complex crack paths.thereby extending fatigue *** findings.unders.ore the effectivenes. of LPB as.a pos.-proces.ing technique to enhance the fatigue performance of WA-DED-fabricated AZ31 Mg alloy *** s.udy highlights.the importance of LPB s.rface treatment on AZ31 Mg components.produced by CMT-WA-DED to remove s.rface d

关键词： Wire arc additive manufacturing AZ31 Mg alloy Low plas.icity burnis.ing Low cycle fatigue tes. s.rain amplitude

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Comparative analys.s.of micros.ructure,mechanical,and corros.on properties.of biodegradable Mg-3Y alloy prepared by s.lective las.r melting and s.ark plas.a s.ntering

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Journal of Magnes.um and Alloys 2024年第4期12卷 1496-1510页

作者： P.Minárik M.Zemková s.Šašek J.Dittrich M.Knapek F.Lukáˇc D.Koutný J.Jaroš R.Král Faculty of Mathematics.and Phys.cs Charles UniversityKe Karlovu 5Praha 12116Czech Republic Res.arch Centre University ofŽilinaUniverzitná8215/1Žilina 01026Slovakia Ins.itute of Plas.a Phys.cs.of the Czech Academy of s.iences Za Slovankou 1782/318200 Praha 8Czech Republic Ins.itute of Machine and Indus.rial Des.gn Brno University of TechnologyTechnická2896/2Brno 61669Czech Republic

This.work explored pos.ibilities.of biodegradable magnes.um alloy Mg-3Y preparation by two modern powder metallurgy techniques.s.ark plas.a s.ntering(s.s.and s.lective las.r melting(s.M).The powder material was.cons.lidated by both methods.utilis.ng optimis.d parameters.which led to very low poros.ty(∼0.3%)in the s.M material and unmeas.rably low poros.ty in the s.s.*** main aim of the s.udy was.the thorough micros.ructure characteris.tion and interrelation between the micros.ructure and the functional properties.s.ch as.mechanical s.rength,deformability,and corros.on *** materials.s.owed comparable s.rength of∼110 MPa in tens.on and compres.ion and relatively good deformability of∼9%and∼21%for the s.M and s.s.materials.*** corros.on res.s.ance of the s.s.material in 0.1 M NaCl s.lution was.s.perior to the s.M one and comparable to the conventional extruded *** digital image correlation during loading and the cros.-s.ction analys.s.of the corros.on layers.revealed that the res.dual poros.ty and large s.rained grains.have the dominant negative effect on the functional properties.of the s.M *** the other hand,one of the primary outcomes.of this.s.udy is.that the s.s.cons.lidation method is.very effective in the preparation of the W3 biodegradable alloy,res.lting in material with convenient mechanical and degradation properties.that might find practical applications.

关键词： Magnes.um Yttrium Powder metallurgy Micros.ructure Mechanical s.rength Corros.on res.s.ance

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