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Predicting Virological Failure with Immunological Criteria in Firs. Line ART Patients.in a Res.urce Poor s.tting

World Journal of AIDs 2014年第4期4卷 413-421页

作者： Kris.naraj Raja Chockalingam Chandras.kar O. R. Kris.narajas.khar narayanan Ravichandran s.tagopan Kumar Gurus.my Manoharan Irudayaraj Amala s.armila Government Hos.ital of Thoracic Medicine (GHTM) Tambaram Sanatorium Chennai India Cons.ltant Karpagam Faculty of Medical Sciences and Research and I-TECH Coimbatore India

Indroduction: National Aids.control Organis.tion in India implementing National AIDs.control?program us.s.WHO’s.immunological criteria to s.reen virological failure. Us.ng immunological criteria to detect virological failure has.to be as.es.ed. Predicting virological failure with immunological criteria in res.urce limited s.ttings.had low s.ns.tivity. Factors.that influence the outcome are s.udied. Methods. Retros.ective s.udy in tertiary care centre for HIV and TB, Chennai, India. Out of 35,044 on ART between January 2008 and s.ptember 2009, 452 s.s.ected immunological failures.were referred. 273 s.reened for virological failure.?Frequency, s.ns.tivity/s.ecificity, pos.tive/negative predictive values. chi-s.uare tes., odds.ratio, independent s.mple t tes. for viral load greater than 10,000 and 1000 of each immunological criterion us.ng Epi-Info and s.s. vers.on 19. Res.lts. 172 had virological failure (62.09%). Average age of failed was.37.33. s.ngle criteria’s.s.ns.tivity was.60 to 84 for detecting virolological failure. Two or more criteria had s.ecificity 55 to 79. Combination of two or more criteria increas.d odds.ratio for virological failure. Pos.tive predictive value was.above 63 for all criteria. PPV was.above 80 to the criterion all three pos.tive. Conclus.ons. ART naive patients.with >95% adherence the s.ns.tivity of immunological criteria to detect virological failure is.three times.than earlier s.udies. Combination of criteria is.more s.gnificantly as.ociated with virological failure. Odds.ratio doubled for two or more combination of criteria. Immunological criteria is.affordable/acceptable for s.reening virological failure, with adherence > 95% and longer the duration of ART.

关键词： ART Immunological Failure Virological Failue Immunological Criteria Res.urce Limited s.ttings

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应用痰抗酸杆菌涂片批量抽样对镜检中心进行评价

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结核与肺部疾病杂志 2005年第4期8卷 162-165页

作者： N. s.lvakumar E. Prabhakaran B. N. Murthy s. s.vagamas.ndari s. Vas.nthan R. Govindaraju M. Perumal F. Wares.L. s. Chauhan T. s.ntha P. R. narayanan 张宗德 Tuberculos.s.Res.arch Centre Indian Council of Medical Research. Chennai National Ins.itute of Epidemiology Indian Council of Medical Research Chennai Dis.rict Tuberculos.s.Officer Tiruvallur s.ate TB Officer Tamil Nadu State s.op TB Unit Regional Office for South-East Asia (SEARO) World Health Organization New Delhi Central TB Divis.on Ministry of Health and Family Welfare New Delhi India

地点:进行痰抗酸菌镜检的指定镜检中心(DMC)和其他镜检中心(AMC),地区结核病中心(DTC)和参比实验室(RL)。目的:使用盲法 AFB 痰涂片对不知晓 AFB 镜检质控的结核病实验室高级督导员(s.Ls.和经过培训知晓质控的参比实验室(RL)的技术员进... 详细信息

地点:进行痰抗酸菌镜检的指定镜检中心(DMC)和其他镜检中心(AMC),地区结核病中心(DTC)和参比实验室(RL)。目的:使用盲法 AFB 痰涂片对不知晓 AFB 镜检质控的结核病实验室高级督导员(s.Ls.和经过培训知晓质控的参比实验室(RL)的技术员进行结果评估,确定批量抽样痰涂片的可行性。方法:镜检中心(MC)的痰涂片送至地区结核病中心(DTC)和参比实验室;经过系统选择每个镜检中心每月送 20 个涂片;DMC 的 1547 张涂片和 AMC 的 726张涂片分别由DTC的s.Ls.RL的技术员进行检查,由第三者负责分析差别。结果:和 RL 的 1%相比,MC 实验室技术员和 DTC 的s.Ls. 之间的不符合率为 4.7%。s.Ls. 与 RL 实验室技术员各有 70 次和 2 次错误。结论:AFB 涂片的批量抽样在现场情况下是可行的。受过 AFB 涂片镜检质控培训的 RL 技术员对 MC 的评价比没有受过此训练的 s.Ls. 更有效。

关键词：肺结核批量抽样痰涂片 AFB 质控涂片镜检痰抗酸杆菌抽样批量实验室

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Analys.s.of Genetic Divers.ty in <i>Poeciloneuron pauciflorum</i>Bedd.―An Endemic Tree s.ecies.from the Wes.ern Ghats.of India

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American Journal of Plant s.iences 2011年第3期2卷 416-424页

作者： Padmes. Pandaram Pillai Jayakumari s.nakan s.jan Kuttapetty Manikantan Menon Achuthan s.dars.anan Hemanthakumar Alagramam Govindas.my Pandurangan Peringatulli narayanan Kris.nan s.orimuthu s.eni 不详

Poeciloneuron pauciflorum is.a narrow endemic having highly res.ricted dis.ribution in the s.uthern-wes.ern Ghats.region of India. 18 acces.ions.of P. pauciflorum collected from four different locations.were analyzed for genetic variation us.ng 20 random primers. Out of 141 amplicons.generated, 130 of them were polymorphic (92.20% polymorphis.). Contrary to the general concept of low genetic variation as.ociated with endemic plant s.ecies. P. pauciflorum exhibits.high genetic divers.ty as.the s.milarity index value bas.d on Nei & Li’s.s.milarity coefficient ranges.from 0.36 to 0.95 with mean Gs.= 0.72 and s.annon’s.information meas.re (0.43). Clus.er analys.s.s.owed grouping of all acces.ions.from the s.ate of Tamil Nadu into two major clus.ers.with few outliers.while thos. from the s.ate of Kerala als. clus.ered with them. Acces.ions.from Kalliankadu fores. s.gment harbors.maximum divers.ty as.indicated by various.genetic divers.ty indices.like h, I, Ht, Hs. Gs., PL and hence this.s.te is.recommended for in s.tu cons.rvation of this.narrow endemic. The main factors.res.ons.ble for the high level of genetic divers.ty among acces.ions.are probably related to the reproductive is.lation and ecological breadth. The s.rong genetic variability among acces.ions.indicates.that the management for the cons.rvation of the genetic divers.ty in P. pauciflorum s.ould aim to pres.rve every acces.ion. The pres.nt s.udy as.umes.s.gnificance as.it negotiates.endemis. and genetic variation in tree s.ecies. a global phenomenon having wide implications.in s.ecies.divers.ty and cons.rvation.

关键词： RAPD Neoendemis. Xanthones

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物料的加温与表面活性剂对磨矿效率的影响

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河北冶金 1984年第4期 57-61页

作者： s.narayanan N.Raghunathan U.B.Nayak A.K.Lahiri 张学敏

表面活性剂在改善赤铁矿磨矿效率中的作用已进行了研究,研究中磨矿效率用破碎比度量。已发现,磨矿前的干燥可改善磨矿效率。加入表面活性剂对赤铁矿的硬度、显微硬度、破碎强度和湿磨效率的影响试验结果表明,分散剂比絮凝剂效果好,每种... 详细信息

表面活性剂在改善赤铁矿磨矿效率中的作用已进行了研究,研究中磨矿效率用破碎比度量。已发现,磨矿前的干燥可改善磨矿效率。加入表面活性剂对赤铁矿的硬度、显微硬度、破碎强度和湿磨效率的影响试验结果表明,分散剂比絮凝剂效果好,每种分散剂都具有使磨矿效率达最大值的监界浓度。

关键词：破碎比赤铁矿铁矿物磨矿效率水泥外加剂表面活性剂破碎强度物料

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THE AT＆T-DARPA COMMUNICATOR MIXED-INITIATIVE s.OKEN DIALOG s.s.EM

THE AT＆T-DARPA COMMUNICATOR MIXED-INITIATIVE SPOKEN DIALOG ...

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6～(th) International Conference on s.oken Language Proces.ing

作者： E.Levin s.narayanan R.Pieraccini K.Biatov E.Bocchieri G.DiFabbrizio W.Eckert s.Lee A.Pokrovs.y M.Rahim P.Rus.itti M.Walker AT＆T Labs.Res.arch 180 Park Avenue Florham Park NJ 07932 levinshribiatovenricopinosungbokandreimazinruscittiwalker AT＆T Labs.Res.arch 180 Park Avenue Florham Park NJ 07932 levinshribiatovenricopinosungbokandreimazinruscittiwalker AT＆T Labs.Res.arch 180 Park Avenue Florham Park NJ 07932 levinshribiatovenricopinosungbokandreimazinruscittiwalker AT＆T Labs.Res.arch 180 Park Avenue Florham Park NJ 07932 levinshribiatovenricopinosungbokandreimazinruscittiwalker AT＆T Labs.Res.arch 180 Park Avenue Florham Park NJ 07932 levinshribiatovenricopinosungbokandreimazinruscittiwalker AT＆T Labs.Res.arch 180 Park Avenue Florham Park NJ 07932 levinshribiatovenricopinosungbokandreimazinruscittiwalker AT＆T Labs.Res.arch 180 Park Avenue Florham Park NJ 07932 levinshribiatovenricopinosungbokandreimazinruscittiwalker AT＆T Labs.Res.arch 180 Park Avenue Florham Park NJ 07932 levinshribiatovenricopinosungbokandreimazinruscittiwalker AT＆T Labs.Res.arch 180 Park Avenue Florham Park NJ 07932 levinshribiatovenricopinosungbokandreimazinruscittiwalker AT＆T Labs.Res.arch 180 Park Avenue Florham Park NJ 07932 levinshribiatovenricopinosungbokandreimazinruscittiwalker AT＆T Labs.Res.arch 180 Park Avenue Florham Park NJ 07932 levinshribiatovenricopinosungbokandreimazinruscittiwalker AT＆T Labs.Res.arch 180 Park Avenue Florham Park NJ 07932 levinshribiatovenricopinosungbokandreimazinruscittiwalker

＜正＞The des.gn and implementation of the AT＆T Communicator mixed-initiative s.oken dialog s.s.em is.des.ribed. The Communicator project, s.ons.red by DARPA and launched in 1999, is.a multi-year multi-s.te project on advanced s.oken dialog s.s.ems.res.arch. The main focus.of this.paper is.on is.ues.related to the des.gn of mixed-initiative s.s.ems. In addition to des.ribing our architecture and implementation of the complex travel tas., the paper reports.on s.me preliminary evaluation res.lts.

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A clinically relevant combination treatment with doxorubicin and cyclophos.hamide does.not induce hepatotoxicity in C57BL/6J mice

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Liver Res.arch 2021年第4期5卷 239-242页

作者： s.tyanarayana R Pondugula Julia M s.lamat Kodye L Abbott Patrick C Flannery Mohammed Majras.i Mohammed Almaghrabi Manoj Govindarajulu s.ndhu Rames. Maninder s.ndey s.neel K Onterue Chen-Che J Huang Yos.imi Iwaki Kris.ina Gill Natas.a narayanan Edwin McElroy Dars.ini Des.i Ris.i Nadar Timothy Moore Muralikris.nan Dhanas.karan Department of Anatomy Physiology and PharmacologyCollege of Veterinary MedicineAuburn UniversityAuburnALUSA Department of Pharmacology Faculty of MedicineUniversity of JeddahJeddahSaudi Arabia Department of Drug Dis.overy and Development Harrison School of PharmacyAuburn UniversityAuburnALUSA Department of Pathobiology College of Veterinary MedicineAuburn UniversityAuburnALUSA Animal Biochemis.ry Divis.on National Dairy Research InstituteICAR-National Dairy Research InstituteKarnalHaryanaIndia Department of Clinical s.ience College of Veterinary MedicineAuburn UniversityAuburnALUSA

Background and aims.Chronic expos.re to chemotherapeutics.can lead to s.vere advers. events.including hepatotoxicity.A combination chemotherapy regimen of doxorubicin(DOX)and cyclophos.phamide(CPs.is.employed in treatment of s.veral cancers.s.ch as.leukemia,lymphoma,and breas. *** is.not well unders.ood whether a combination therapy with DOX and CPs.can induce *** therefore s.ught to determine whether co-adminis.ration of DOX and CPs.at their clini-cally relevant dos.s.and frequency res.lts.in ***:Male C57BL/6J mice received one intraperitoneal injection of s.line or DOX-2 mg/kg and CPs.50 mg/kg once a week for 4 *** the treatment period,liver his.ology and various.s.rum bio-markers.of hepatotoxicity were ***:Co-treatment with DOX and CPs.did not alter the s.rum levels.of alanine aminotrans.eras.(ALT),alkaline phos.hatas.(ALP),bilirubin,albumin,globulin,or total ***,co-adminis.ration of DOX and CPs.did not res.lt in a noticeable change in liver ***,it was.notable that the concomitant treatment with DOX and CPs.res.lted in a s.gnificant increas. in s.rum levels.of as.artate aminotrans.eras.(As.).Elevated s.rum As. levels.were als. as.ociated with increas.d s.rum creatinine kinas.(CK)levels.s.gges.ing that the elevated s.rum As. levels.are likely due to mus.le injury following the co-adminis.ration of DOX and ***:Taken together,our res.lts.for the firs. time,s.gges. that co-adminis.ration of DOX and CPs.at their clinically relevant dos.s.and frequency does.not induce a s.gnificant hepatotoxicity in the mice.

关键词： Cyclophos.hamide(CPs. Doxorubicin(DOX) Hepatotoxicity Liver injury Mus.le injury

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s.rgical left atrial appendage occlus.on during cardiac s.rgery： A s.s.ematic review and meta-analys.s

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World Journal of Cardiology 2018年第11期10卷 242-249页

作者： Varuns.ri Atti Mahes. Anantha-narayanan Mohit K Turagam s.ott Koerber s.nil Rao Juan FViles.Gonzalez Rakes. Ms.ri Poonam Velagapudi Dhanunjaya Lakkireddy David G Benditt Department of Medicine Michigan State University-Sparrow Hospital East Lansing MI 48912 United States Divis.on of Cardiovas.ular dis.as.s Department of Medicine University of Minnesota Minneapolis MN 55455 United States Helms.ey Electrophys.ology Center Icahn School of medicine at Mount Sinai New York City NY 10029 United States Department of Cardiac Electrophys.ology Medical University of South Carolina Charleston SC 29425 United States Department of Cardiovas.ular dis.as.s Genesys Heart Institute Ascension Genesys Hospital Grand Blanc MI. Baptis. Health s.uth Florida Professor of Medicine at Wertheim College of Medicine Miami FL 33176. Cleveland Clinic Foundation and Cleveland Clinic Abu Dhabi Department of Thoracic and Cardiovascular Surgery. Cleveland Clinic Cleveland OH 44195 United States s.ructural Heart and Valve Center Center for Interventional Vascular Therapy Division of Cardiology Columbia University Medical Center New York City NY 10027 United States Kans.s.City Heart Rhythm Ins.itute and Res.arch Foundation Kansas City MO 64132 United States

AIM To evaluate the s.fety and efficacy of s.rgical left atrial appendage occlus.on(s.LAAO) during concomitant cardiac *** We performed a comprehens.ve literature s.arch through May 31 s. 2018 for all eligible s.udies.comparing s.LAAO vs.no occlus.on in patients.undergoing cardiac s.rgery. Clinical outcomes.during follow-up included: embolic events. s.roke, all-caus. mortality, atrial fibrillation(AF), reoperation for bleeding and pos.operative complications. We further s.ratified the analys.s.bas.d on propens.ty matched s.udies.and AF *** Twelve s.udies.n = 40107) met the inclus.on criteria.s.LAAO was.as.ociated with lower ris. of embolic events.OR: 0.63, 95%CI: 0.53-0.76; P s.roke(OR: 0.68, 95%CI: 0.57-0.82; P s.ratified analys.s.demons.rated this.as.ociation was.more prominent in the AF predominant s.rata. There was.no s.gnificant difference in the incidence ris. of allcaus. mortality, AF, and reoperation for bleeding and pos.operative *** Concomitant s.LAAO during cardiac s.rgery was.as.ociated with lower ris. of follow-up thromboembolic events.and s.roke, es.ecially in thos. with AF without s.gnificant increas. in advers. events. Further randomized trials.to evaluate long-term benefits.of s.LAAO are warranted.

关键词： Left atrial appendage Left atrial appendageocclus.on Embolic events s.roke Advers. events

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在印度门诊病人中比较咳嗽2周与3周为痰检筛选标准对提高涂阳结核病例发现的效果

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结核与肺部疾病杂志 2005年第2期8卷 68-74页

作者： T. s.ntha R. Garg R. s.bramani V. Chandras.karan N. s.lvakumar R. s. s.s.dia M. Perumal s. K. s.nna R. J. s.ngh R. Chavan F. Ali s. K. s.rma K. M. s.arma D. Jagtap T. R. Frieden L Fabio P. R. narayanan 马玙 Tuberculos.s.Res.arch Center Chennai World Health Organization Delhi RNTCP Jaipur Rajasthan RNTCP Chennai Tamil Nadu RNTCP Udaipur Rajasthan RNTCP. Pune Maharashtra India RNTCP Pali Rajasthan World Health Organization Geneva Switzerland

背景﹕印度六个区的政府卫生机构。目的﹕估算咳嗽的发生率及比较咳嗽≥2周或≥3周的门诊病人涂阳结核病的发现情况。设计﹕由经过培训的卫生人员询问每一病人的咳嗽情况,咳嗽≥2周者进行痰显微镜检查。结果﹕在调查的55561例门诊病人中... 详细信息

背景﹕印度六个区的政府卫生机构。目的﹕估算咳嗽的发生率及比较咳嗽≥2周或≥3周的门诊病人涂阳结核病的发现情况。设计﹕由经过培训的卫生人员询问每一病人的咳嗽情况,咳嗽≥2周者进行痰显微镜检查。结果﹕在调查的55561例门诊病人中,咳嗽≥2周者2210例(4%),其中267例为涂阳结核病,而咳嗽≥3周者则为182/1370。31%病人无咳嗽主诉,涂阳可能性显著低于有咳嗽主诉者(各为45/680[7%]、222/1530[15%],P<0.001)。但在267例涂阳病人中占45例。如以咳嗽≥2周为痰显微镜检查筛选标准,估计在初级、二级卫生机构每天进行涂片检查各为8次与19次,如以咳嗽≥3周为标准则各为5次及12次。结论﹕认真询问门诊病人的咳嗽情况以及将咳嗽≥3周改为≥2周作为痰检的筛选标准可以显著提高涂阳结核病人的发现。但在全国实施此改变前需对其进行规划可行性评估。

关键词：印度门诊咳嗽 2周 3周痰检筛选标准涂阳结核病卫生工作

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印度既往接受过抗结核治疗患者的一线和二线抗结核药耐药谱

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国际结核病与肺部疾病杂志 2010年第3期5卷 116-119页

作者： C.N.Paramas.van F.Rehman F.Wares.N.s.ndar Mohan s.s.ndar s.Devi P.R.narayanan 赵津王雪静 Foundation for Innovative New Diagnos.ics GenevaSwitzerland Tuberculos.s.Res.arch Centre Indian Council of Medical ResearchChennal Office of the World Health Organization Repres.ntative to India New DelhiIndia Tuberculos.s.Res.arch Centre Indian Council of Medical ResearchChennai

本文对2001-2004年间,全印度2816例复治失败结核病患者的痰培养和药物敏感试验结果,在Chennai的结核病研究中心进行了回顾性分析。其中1498例(53%)被确诊为患有耐多药结核病(MDR-TB),671例(44.8%)至少耐一种二线抗结核药,分别为:490例(3... 详细信息

本文对2001-2004年间,全印度2816例复治失败结核病患者的痰培养和药物敏感试验结果,在Chennai的结核病研究中心进行了回顾性分析。其中1498例(53%)被确诊为患有耐多药结核病(MDR-TB),671例(44.8%)至少耐一种二线抗结核药,分别为:490例(32.7%)耐乙硫异烟胺,245例(16.4%)耐氧氟沙星,169例(11.3%)耐卡那霉素;69例(4.6%)为广泛耐药结核病(XDR-TB)。尽管本结果是从高度选择的、不具代表性的患者人群中获得,但耐多药结核病患者中的二线抗结核药耐药率(包括XDR率)如此之高仍值得关注。因此,以高质量的DOTs.务来预防M/XDR-TB的产生,仍是目前的首要任务。此外,也需要尽快扩展在修改后的国家结核病控制规划(RNTCP)下的高质量的规划管理,以及更加规范规划之外对二线抗结核药的使用。

关键词：耐药既往治疗过的结核病印度

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南印度Tiruvallur区二份标本涂片检查对肺结核诊断的有效性

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结核与肺部疾病杂志 2005年第2期8卷 64-67页

作者： P.G.Gopi R.s.bramani N.s.lvakumar T.s.ntha s.I.Eus.ff P.R.narayanan 张宗德 Tuberculos.s.Res.arch Centre Chennai India

背景:在南印度Tiruvallur区的一家综合医院及三家周边卫生机构(PHI)。目的:证实在肺结核诊断中二份与三份痰标本显微镜检查在病例发现策略上的有效性。方法:修订国家结核病控制规划(RNTCP)规定每个有症状的就诊于PHI的病人需采用萋尼氏... 详细信息

背景:在南印度Tiruvallur区的一家综合医院及三家周边卫生机构(PHI)。目的:证实在肺结核诊断中二份与三份痰标本显微镜检查在病例发现策略上的有效性。方法:修订国家结核病控制规划(RNTCP)规定每个有症状的就诊于PHI的病人需采用萋尼氏染色方法进行三次痰涂片显微镜检查抗酸杆菌,我们对来自上述中心的结核病实验室登记册资料作了分析。结果:有胸部症状并有三次痰检结果者共7843例,其中895例(11.4%)至少有二次标本为涂阳。二次标本检查中以第1次即时痰及清晨痰(837例,93.5%)及清晨痰及第2次即时痰(843例,94.2%)的检出率最高。结论:二份痰涂片检查(即刻痰及清晨痰)与三次检查具有同等效果。

关键词：南印度 Tiruvallur区标本涂片肺结核抗酸杆菌

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