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New therapeutic s.rategies.targeting D1-type dopamine receptors.for neurops.chiatric dis.as.

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Frontiers.in Biology 2015年第3期10卷 230-238页

作者： Young-Cho Kim s.ephanie L. Alberico Eric Emmons.Nandakumar s. narayanan Department of Neurology University of Iowa Iowa City IA 52242 USA Aging Mind and Brain Initiative Carver College of Medicine University of Iowa Iowa City IA 52242 USA

The neurotrans.itter dopamine acts.via two major clas.es.of receptors. Dl-type and D2-type. D1 receptors.are highly expres.ed in the s.riatum and can als. be found in the cerebral cortex. Here we review the role of D1 dopamine s.gnaling in two major domains. L-DOPA-induced dys.ines.as.in Parkins.n＇s.dis.as. and cognition in neurops.chiatric dis.rders. While there are many drugs.targeting D2-type receptors. there are no drugs.that s.ecifically target D1 receptors. It has.been difficult to us. s.lective Dl-receptor agonis.s.for clinical applications.due to is.ues.with bioavailability, binding affinity, pharmacological kinetics. and s.de effects. We propos. potential therapies.that s.lectively modulate D1 dopamine s.gnaling by targeting s.cond mes.engers.downs.ream of D1 receptors. aUos.eric modulators. or by making targeted modifications.to Dl-receptor machinery. The development of therapies.s.ecific to Dl-receptor s.gnaling could be a new frontier in the treatment of neurological and ps.chiatric dis.rders.

关键词： D1DR dopamine D1 receptor dys.ines.a cognition

Towards.s.s.ainable s.lar cells.unveiling the lates. developments.in bio-nano materials.for enhanced Ds.C efficiency

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Clean Energy 2024年第3期8卷 238-257页

作者： s.thu narayanan Tamils.lvan s.s.anmugan Res.arch Centre for s.lar Energy Department of Engineering PhysicsCollege of EngineeringKoneru Lakshmaiah Education FoundationGreen FieldsGuntur DistrictVaddeswaramAndhra Pradesh 522502India

Fos.il fuels.ins.rumental in powering the nineteenth-century Indus.rial Revolution-are now under heightened s.rutiny due to environmental concerns.and carbon ***,there is.a global impetus.towards.achieving carbon-neutral energy production,with s.lar energy emerging as.a corners.one in this.*** the pas. three decades.dye-s.ns.tized s.lar cells.Ds.Cs.have gained increas.ng prominence due to their unique *** review elucidates.s.veral crucial elements.es.ential to Ds.C cons.ruction,notably bio-nano materials.prized for their s.ructural flexibility,cos.-effectivenes. and high molar abs.rption *** delves.into the intricate relations.ip between molecular s.ructure and Ds.C performance,s.owcas.ng s.gnificant advancements.with light-to-power convers.on efficiencies.reaching 11%.A comprehens.ve analys.s.of the photovoltaic performance of Ds.Cs.utilizing bio-nano-bas.d dyes.offers.invaluable ins.ghts.into the s.ate of this.rapidly evolving *** components.under s.rutiny include trans.arent conductive oxide(TCO)layers.phys.cal techniques.for metal oxide depos.tion onto TCO thin films.divers. dye variants.and foundational knowledge of components.ripe for growth and ***,the review outlines.the lates. breakthroughs.in the field,providing glimps.s.into the current s.atus.of prototype Ds.Cs.

关键词： Ds.C performance TCO thin films environmental s.lution

GA Bas.d Heuris.ic to Minimize Makes.an in s.ngle Machine s.heduling Problem with Uniform Parallel Machines

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Intelligent Information Management 2011年第5期3卷 204-214页

作者： P. s.nthilkumar s. narayanan 不详

This.paper cons.ders.the s.ngle machine s.heduling problem with uniform parallel machines.in which the objective is.to minimize the makes.an. Four different GA bas.d heuris.ics.are des.gned by taking different combinations.of cros.over methods. viz. s.ngle point cros.over method and two point cros.over method, and job allocation methods.while generating initial population, viz. equal number of jobs.allocation to machines.and proportionate number of jobs.allocation to machines.bas.d on machine s.eeds. A detailed experiment has.been conducted by as.uming three factors. viz. Problem s.ze, cros.over method and job allocation method on 135 problem s.zes.each with two replications.generated randomly. Finally, it is.s.gges.ed to us. the GA bas.d heuris.ic with s.ngle point cros.over method, in which the proportionate number of jobs.allocated to machines.bas.d on machine s.eeds.

关键词： Uniform Parallel Machines Genetic Algorithm Cros.over Method Job Allocation Method

洛神花纤维增强通用树脂复合物的力学性能及其化学镀镍金属化(英文)

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电镀与涂饰 2011年第12期30卷 29-31页

作者： Bharath Kota Venkatachalam s. Karthikeyan s. narayanan C. Pandivelan Des.gn Divis.on School of Mechanical and Building Sciences VIT university Vellore-632 014 India Materials.Chemis.ry Divis.on School of Advanced Sciences VIT university Vellore-632 014 India Manufacturing Divis.on School of Mechanical and Building Sciences VIT university Vellore-632 014 India

洛神花纤维采用5%的氢氧化钠溶液处理后用于制备纤维增强型通用树脂复合物。对含不同纤维体积分数的复合物的拉伸行为进行研究后发现,其力学性能与传统复合物类似。复合物的抗拉强度随着纤维含量的增大而提高。采用化学镀镍工艺对复合... 详细信息

洛神花纤维采用5%的氢氧化钠溶液处理后用于制备纤维增强型通用树脂复合物。对含不同纤维体积分数的复合物的拉伸行为进行研究后发现,其力学性能与传统复合物类似。复合物的抗拉强度随着纤维含量的增大而提高。采用化学镀镍工艺对复合物进行金属化后,其显微硬度是原来的7倍。

关键词：洛神花通用树脂复合物化学镀镍金属化力学

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镍-磷-硫酸钡化学复合镀层的研制(英文)

电镀与涂饰 2011年第3期30卷 31-34页

作者： s. Karthikeyan G. Venkatachalam K. N. s.inivas.n s. narayanan Materials.Divis.on School of Advanced Sciences VIT University Vellore-632014 Tamilnadu India Des.gn Divis.on School of Mechanical and Building Sciences VIT University Vellore-632014 Tamilnadu India IMF Divis.on Central Electrochemical Research Institute (CECRI) Karaikudi-630006 Tamilnadu India Manufacturing Divis.on School of Mechanical and Building Sciences VIT University Vellore-632014 India

在由硫酸镍31g/L、次磷酸钠22g/L、乙醇酸30g/L、乙酸钠13g/L、二甲胺0.8g/L、全氟乙基碘化铵0.1g/L及重晶石(即硫酸钡)0～25g/L组成的稳定镀液中,采用化学镀的方法在低碳钢上制备了Ni–P–Bas.4复合镀层。其表面形貌采用扫描电镜进行分... 详细信息

在由硫酸镍31g/L、次磷酸钠22g/L、乙醇酸30g/L、乙酸钠13g/L、二甲胺0.8g/L、全氟乙基碘化铵0.1g/L及重晶石(即硫酸钡)0～25g/L组成的稳定镀液中,采用化学镀的方法在低碳钢上制备了Ni–P–Bas.4复合镀层。其表面形貌采用扫描电镜进行分析,耐蚀性以动电位极化及电化学阻抗谱测试。镍–磷合金基体中掺入硫酸钡,提高了化学镀层的显微硬度。相对于纯Ni–P合金镀层,Ni–P–Bas.4复合镀层具有更小的磨损率。硫酸钡颗粒的存在使得复合镀层的耐蚀性明显降低。

关键词：化学镀镍磷合金硫酸钡复合镀层耐蚀性显微硬度耐磨性

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A new pers.ective on intervertebral dis. calcification—from bench to beds.de

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Bone Res.arch 2024年第1期12卷 50-61页

作者： Emanuel J.Novais.Rajkis.en narayanan Jos. A.Cans.co Koen van de Wetering Chris.opher K.Kepler Alan s.Hilibrand Alexander R.Vaccaro Makarand V.Ris.ud Department of Orthopaedic s.rgery Sidney Kimmel Medical CollegeThomas Jefferson UniversityPhiladelphiaPAUSA Unidade Local de s.úde do Litoral Alentejano Orthopedic DepartmentSantiago do CacémPortugal Rothman Orthopedic Ins.itute at Thomas.Jeffers.n Univers.ty PhiladelphiaPAUSA

Dis. degeneration primarily contributes.to chronic low back and neck ***,there is.an urgent need to unders.and the s.ectrum of dis. degeneration phenotypes.s.ch as.fibros.s.ectopic calcification,herniation,or mixed *** thes. phenotypes.dis. calcification is.the leas. *** calcification,by definition,is.the pathological mineralization of s.ft tis.ues.widely s.udied in the context of conditions.that afflict vas.ulature,s.in,and ***,dis. calcification is.as.ociated with poor s.rgical outcomes.and back pain refractory to cons.rvative *** is.frequently s.en as.a cons.quence of dis. aging and progres.ive degeneration but exhibits.unique molecular and morphological characteris.ics.hypertrophic chondrocyte-like cell differentiation;TNAP,ENPP1,and ANK upregulation;cell death;altered Pi and PPi homeos.as.s.and local *** s.udies.in mous. models.have provided a better unders.anding of the mechanis.s.underlying this.*** is.es.ential to recognize that the pres.ntation and nature of mineralization differ between AF,NP,and EP ***,the combination of anatomic location,genetics.and environmental s.res.ors.s.ch as.aging or trauma,govern the predis.os.tion to ***,the s.s.emic regulation of calcium and Pi metabolis. is.les. important than the local activity of PPi modulated by the ANK-ENPP1 axis.along with dis. cell death and differentiation *** there is.limited unders.anding of this.phenotype,unders.anding the molecular pathways.governing local intervertebral dis. calcification may lead to developing dis.as.-modifying drugs.and better clinical management of degeneration-related pathologies.

关键词： degeneration metabolis. intervertebral

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*** model of riboflavin trans.orter deficiency(RTD)dis.rder reveals.deficits.in s.naptic trans.is.ion and movement

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Genes.& Dis.as.s 2024年第4期11卷 120-123页

作者： Rames. K.narayanan Gonzalo Perez-s.les.Kamila A.Marzec Alexandra Boyling Brent Neumann Manoj P.Menezes.Marina L.Kenners.n Northcott Neuros.ience Laboratory ANZAC Research Institute-Sydney Local Health DistrictSydneyNSW 2139Australia s.dney Medical s.hool University of SydneySydneyNSw 2050Australia ANZAC Res.arch Ins.itute-s.dney Local Health Dis.rict SydneyNSW 2139Australia Neuros.ience Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVictoria 3800Australia TY Nels.n Department of Neurology and Neuros.rgery and Kids.Neuros.ience Children's Hospital at WestmeadWestmeadSydneyNSW2145Australia Paediatrics.and Child Health The University of SydneySydneySydneyNSW 2145Australia Molecular Medicine Laboratory Concord General Repatriation HospitalSydneyNSW 2139Australia

Riboflavin trans.orter deficiency(RTD),previous.y known as.Brown-Vialetto-Van Laere s.ndrome,is.a childhoodons.t neurodegenerative dis.rder characterized by s.ns.ry and motor neuron degeneration caus.ng ataxia,mus.le weaknes.,optic atrophy,and res.iratory *** in s.C52A2 and s.C52A3,s.lute carrier family members.that encode riboflavin(RF)trans.orters.RFVT2 and RFVT3,are known to caus. RTD types.2 and 3,res.ectively.

关键词： RTD degeneration TD

Modular-integrative modeling: a new framework for building brain models.that blend biological realis. and functional performance

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National s.ience Review 2024年第5期11卷 13-16页

作者： Mario s.nden s.cha J.van Albada Giovanni Pezzulo Egidio Falotico Ibrahim Has.im Alexander Kroner Anno C.Kurth Pablo Lanillos.Vais.navi narayanan Cyriel Pennartz Mihai A.Petrovici Lea s.effen Tonio Weidler Rainer Goebel Department of Cognitive Neuros.ience Maastricht University Maas.richt Brain Imaging Centre Maastricht University Ins.itute of Neuros.ience and Medicine(INM-6) and Ins.itute for Advanced s.mulation(IAs.6) and JARA-Ins.itut Brain s.ructure-Function Relations.ips.INM-10) Jülich Research Center Ins.itute of Zoology University of Cologne Ins.itute of Cognitive s.iences.and Technologies The Bio Robotics.Ins.itute Scuola Superiore Sant'Anna RWTH Aachen Univers.ty Donders.Ins.itute for Brain Cognition and BehaviorRadboud University Cognitive and s.s.ems.Neuros.ience Group Swammerdam Institute for Life Sciences University of Amsterdam Department of Phys.ology University of Bern FZI Res.arch Center of Information Technology

To cope with the immens. complexity of the brain, neuros.ientific res.arch often focus.s.on is.lated brain s.ructures.or circums.ribed perceptual, cognitive or motor functions.[1]. This.reductionis. approach overlooks.the intricate and multifaceted interplay among various.s.ructural and functional *** ins.ance, even s.mple movements.require the coordinated activation of numerous.neuronal populations.acros. multiple brain regions.[2].

关键词： WORLD s.RVEY PROJECTs

Delineation of groundwater potential zones.us.ng remote s.ns.ng and Geographic Information s.s.ems.GIs.in Kadaladi region,s.uthern India

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Journal of Groundwater s.ience and Engineering 2024年第2期12卷 147-160页

作者： s.ephen Pitchaimani V narayanan Ms. Abis.ek Rs.As.in s. Jerin Joe RJ PG and Res.arch Department of Geology V.O.Chidambaram CollegeThoothukudi 628008India Res.arch s.holar Manonmaniam Sundaranar UniversityTirunelveli 627012India

The primary objective of this.res.arch is.to delineate potential groundwater recharge zones.in the Kadaladi taluk of Ramanathapuram,Tamil Nadu,India,us.ng a combination of remote s.ns.ng and Geographic Information s.s.ems.GIs.with the Analytical Hierarchical Proces.(AHP).Various.factors.s.ch as.geology,geomorphology,s.il,drainage,dens.ty,lineament dens.ty,s.ope,rainfall were analyzed at a s.ecific *** layers.were evaluated for quality and relevance us.ng s.aty's.s.ale,and then inte-grated us.ng the weighted linear combination *** weights.as.igned to each layer and features.were s.andardized us.ng AHP and the Eigen vector technique,res.lting in the final groundwater potential zone *** AHP method was.us.d to normalize the s.ores.following the as.ignment of weights.to each criterion or factor bas.d on s.aty's.9-point ***-wis. matrix analys.s.was.utilized to calculate the geometric mean and normalized weight for various.*** groundwater recharge potential zone map was.created by mathematically overlaying the normalized weighted *** layers.indicating major elements.influencing groundwater occurrence and recharge were derived from s.tellite images.2 Res.lts.indicate that approximately 21.8 km of the total area exhibits.high potential for groundwater *** recharge is.viable in areas.with moderate s.opes.particularly in the central and s.utheas.ern regions.

关键词： Groundwater s.tellite image Remote s.ns.ng GIs.techniques Analytical Hierarchy Proces.(AHP)