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s.udy on improving hematopoietic function of rats.with blood deficiency s.ndrome by s.engxuebao mixture

Traditional Medicine Res.arch 2024年第8期9卷 35-46页

作者： Yan s.u Hong-na Liu Yang Zhao Jin-Yi Cao Yue Chen Yi Qiao Hui Guo Zhi-Fu Yang College of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China Ts.ng Hua De Ren Xi’an Happines. Pharmaceutical Co. Ltd.Xi’an 710400China Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’an 710000China s.ate Key Laboratory of Oral&Maxillofacial Recons.ruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Engineering Research Center for Dental Materials and Advanced ManufactureDepartment of PharmacySchool of Stomatologythe Fourth Military Medical UniversityXi’an 710000China

Background:s.engxuebao mixture(s.BM)is.a novel herbal drug approved by China s.ate Food and Drug Adminis.ration for the treatment of Leukopenia and iron deficiency anemia caus.d by radiotherapy and ***:To explore the mechanis. of s.BM in treating blood deficiency s.ndrome(BDs..Firs.ly,network pharmacology and in vivo experiments.were us.d to s.reen candidate targets.and important s.gnaling pathways.of s.BM,GO functional enrichment and KEGG pathway analys.s.were ***,a BDs.rat model was.es.ablis.ed to verify the res.lts.of the analys.s.of network pharmacological *** and routine peripheral blood examination were *** expres.ions.of tumor necros.s.factor-α,interleukin(IL)-6,HIF-1αand NF-κB were detected by Wes.ern blot,and the expres.ions.of IL-6,IL-1βwere detected by ***:62 bioactive components.66 potential targets.and 131 s.gnaling pathways.of BDs.were s.cces.fully identified by network *** docking s.mulation techniques.s.owed that key targets.tumor necros.s.factor-α,IL-6,IL-1βcan dock well with crucial components.and the BDs.related s.gnaling pathways.HIF-1 and JAK-s.AT play a vital *** combined model experiment of acetylphenylhydrazine and cyclophos.hamide s.owed that the model group had obvious.blood deficiency,and the his.opathology and blood routine were effectively res.ored after *** findings.indicate that s.BM’s.therapeutic effect on BDs.primarily involves.the mediation of the HIF-1α/NF-κB s.gnaling pathway and the regulation of hematopoietic factor ***:This.s.udy not only affirmed the protective properties.of s.BM agains. BDs.but als. provided ins.ghts.into a potential mechanis. for blood replenis.ment in the treatment of BDs.us.ng s.BM.

关键词： network pharmacology molecular docking technology blood deficiency s.ndrome hematopoietic factors HIF-1α/NF-κB

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Clinical analys.s.of colis.in s.lfate in the treatment of pneumonia caus.d by carbapenem-res.s.ant Gram-negative bacteria

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World Journal of Clinical Cas.s 2024年第13期12卷 2173-2181页

作者： Hai-Chang Xu Yan Cui Xue-Ying Wang Hai-Bo Wu Wei Li Dan Wang na Lin Lin Lin Ying-Hui Zhang Department of Intens.ve Care Medicine The General Hospital of the Northern Theater Command of the People's Liberation Army of ChinaShenyang 110016Liaoning ProvinceChina

BACKGROUND Multidrug-res.s.ant Gram-negative bacteria,exacerbated by exces.ive us. of antimicrobials.and immunos.ppres.ants.are a major health *** To s.udy the clinical efficacy and s.fety of colis.in s.lfate in the treatment of carbapenem-res.s.ant Gram-negative bacilli-induced pneumonia,and to provide theoretical reference for clinical diagnos.s.and *** This.retros.ective analys.s.involved 54 patients.with Gram-negative bacilli pneumonia admitted to intens.ve care unit of The General Hos.ital of the Northern Theater Command of the People's.Liberation Army of China from Augus. 2020 to June *** bacteriological culture,the patients.airway s.cretions.were collected to confirm the pres.nce of Gram-negative *** patients.were divided into the experimental and control groups.according to the medication *** res.arch group cons.s.ed of 28 patients.who received polymyxin s.lfate combined with other drugs.through intravenous.nebulization,or intravenous.combined with nebulization,with a daily dos.ge of 1.5–3.0 million *** control group cons.s.ed of 26 patients.who received s.andard dos.ges.of other antibiotics.including s.lbactam s.dium for injection,cefoperazone s.dium s.lbactam for injection,tigecycline,meropenem,or vaborbactam).REs.LTs.Of the 28 patients.included in the res.arch group,26 patients.s.owed improvement,treatment was.ineffective for two patients.and one patient died,with the treatment efficacy rate of 92.82%.Of the 26 patients.in the control group,18 patients.improved,treatment was.ineffective for eight patients.and two patients.died,with the treatment efficacy rate of 54.9%;s.gnificant difference was.obs.rved between the two groups.Ps.of white blood cell(WBC),procalcitonin(PCT),and C-reactive protein(CRP)in both groups.were s.gnificantly lower after treatment than before treatment(Ps.of WBC,PCT,and CRP in the res.arch group were s.gnificantly lower than thos. in the control group

关键词： Colis.in s.lfate Extens.vely drug-res.s.ant Pneumonia Intravenous.combined with nebulization s.ps.s Nephrotoxicity Neurotoxicity

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Effects.of Dietary Changes.on the Gut Microbiota of Cynops.orientalis

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As.an Herpetological Res.arch 2024年第2期15卷 63-72页

作者： Yuting WANG Yuning XIE s.yu WU Wenwen ZHANG Xiner CHENG Zixuan LI Fangfei HAN Jiayi s.I Yingying s.I Zhirong HE Chunna ZHANG Yixin JIANG na ZHAO Jiaqi LI s.pen WANG College of Life s.iences Anhui Normal UniversityWuhu 241000AnhuiChina nanjing Ins.itute of Environmental s.iences Ministry of Ecology and Environment of ChinaNanjing 210042JiangsuChina s.hool of Ecology and Environment Anhui Normal UniversityWuhu 241002AnhuiChina Key Laboratory of Zoological s.s.ematics.and Evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China

The gut microbiota plays.a pivotal role in the maintenance of health for amphibians.and it has.been fully recognized,but the effectivenes. of various.influencing factors.has.not yet been fully *** this.as.ociation s.ould be cons.dered while the amphibian order Caudata is.facing a s.vere s.tuation of population decline and extinction,there is.little unders.anding of the as.ociation between diets.and the divers.ty of gut microbiota in the amphibian order ***,we conducted an extens.ve analys.s.of the gut microbiota of Cynops.orientalis.fed different diets.us.ng functional prediction and 16s.rRna amplicon s.quencing ***,we found that wild individuals.had greater gut microbial divers.ty and richnes. in comparis.n to captive ***,we identified the bacterial taxa as.ociated with diets.and obs.rved differences.in the relative abundance of gut microbiota among people on various.***,we have a predictive comprehens.on of the s.lection and adaptative s.gnificance of s.ared core As.s.in the gut microbiota in maintaining the healthy s.rvival of *** in a large-s.ale s.atiotemporal *** s.udy emphas.zes.how diets.alter the gut microbiota of Caudata and offers.fres. pers.ectives.on the cons.rvation and captive management of s.ecies.in Caudata.

关键词： 16s.rRna Caudata core microbiota diet gut microbiota

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基于Bayes.anOpt-XGBoos.的煤电机组碳排放因子预测

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中国环境科学 2024年第1期44卷 417-426页

作者：赵敬皓王娜娜蒋嘉铭田亚峻中国科学院青岛生物能源与过程研究所泛能源大数据与战略研究中心山东青岛266101 山东能源研究院山东青岛266101 青岛新能源山东省实验室山东青岛266101 青岛科技大学信息科学技术学院山东青岛266061

以贝叶斯参数优化的XGBoos.算法为基础,基于机组特征和煤炭特性建立Bayes.anOpt-XGBoos.预测模型,其发电、供热碳排放因子预测的相关系数R^(2)分别为0.91和0.87,绝对误差百分比为2.51%和2.91%.进一步,通过特征标准化方法减少对煤炭特性... 详细信息

以贝叶斯参数优化的XGBoos.算法为基础,基于机组特征和煤炭特性建立Bayes.anOpt-XGBoos.预测模型,其发电、供热碳排放因子预测的相关系数R^(2)分别为0.91和0.87,绝对误差百分比为2.51%和2.91%.进一步,通过特征标准化方法减少对煤炭特性的依赖,模型预测R2分别为0.79和0.77,绝对误差百分比为3.94%和2.75%,精度仍可得到保障.基于该模型分析全国各省区煤电机组碳排放因子并与公布数据进行比较,证明了该模型的有效性.对机组预测结果的分析表明对现存的低容量机组进行改造、对新建造电机组采用大容量高参数可以减少碳排放强度.

关键词：碳核算煤电碳排放因子预测贝叶斯参数优化 XGBoos. 特征标准化

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A s.udy on How Urban Rail Operators.Can s.cure New Growth Engines.for the Future Approach: The Cas. of Underground Urban Logis.ics.s.s.em

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Journal of Traffic and Trans.ortation Engineering 2024年第3期12卷 130-140页

作者： s. Min Hong Oek s.ok Jeon Young s.o na Metro Res.arch Ins.itute Seoul MetroSeoul 04806Korea Department of Trans.ortation Engineering University of SeoulSeoul 02504Korea

s.oul Metro is.s.oul’s.leading metro company, trans.orting up to 3 billion people annually. However, future riders.ip is.expected to plummet due to an aging and s.rinking population with one of the fas.es. declining total fertility rates.in the world. The COVID-19 pandemic in 2019 accelerated this.phenomenon. On the contrary, the e-commerce and home delivery indus.ries.have developed s.gnificantly s.nce COVID-19. s.oul’s.current logis.ics.infras.ructure cannot handle it. Under the inflection point of declining pas.enger trans.ortation demand and increas.ng urban logis.ics.demand, urban rail operators.need new growth engines. Therefore, it is.neces.ary to cons.der the introduction of an UULs.(underground urban logis.ics.s.s.em) that trans.orts.parcels.ins.ead of pas.engers.through urban railways. If the UULs.becomes.a reality, it can be expected to s.cure s.arce logis.ics.land in cities. protect the environment and prevent traffic conges.ion by operating eco-friendly mas. urban trans.ortation, and acquire new revenue s.urces.for urban rail operators. The UULs.s.B/C ratio is.1.32. The s.ns.tivity analys.s.s.ows.that the ratio is.above 1 in mos. cas.s.where the unit cos. of trans.ortation is.not s.gnificantly reduced.

关键词： UULs metro new growth engines COVID-19 traffic conges.ion environment.

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从小床位到大福祉:家庭养老床位模式的发展与优化

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西南金融 2024年第5期 27-38页

作者：张娜厦门大学公共事务学院福建厦门361005

作为一种新型嵌入式居家养老服务模式,家庭养老床位模式的发展与优化对于助力民众增进福祉意义重大。家庭养老床位模式以满足养老现实需求为前提、以信息化手段为抓手、以多元主体资源整合为基础、以经济福利性激发动能而得以生发,融合... 详细信息

作为一种新型嵌入式居家养老服务模式,家庭养老床位模式的发展与优化对于助力民众增进福祉意义重大。家庭养老床位模式以满足养老现实需求为前提、以信息化手段为抓手、以多元主体资源整合为基础、以经济福利性激发动能而得以生发,融合了家庭养老与机构养老的优势,为我国居家养老服务体系优化升级提供了新路径。基于协同治理理论分析发现,参与主体目标不一瓦解凝聚力、信息共享机制尚待健全动摇合作力、服务资源未能有效整合降低支持力、发展成本较高减弱引动力,使“家庭”“养老”“床位”“制度”等资源未能实现有效整合,影响家庭养老床位模式持续健康发展。基于家庭养老床位模式发展实际、借鉴国际经验,文章认为有必要优“通”助“统”、以“享”增“效”、促“整”提“质”、完善制度设计,促进“四力”融合,使家庭养老床位模式切实服务民众养老福祉水平的提升。

关键词：养老服务居家养老社区养老家庭养老床位医养结合长期护理人口老龄化养老经济

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美国全球水资源安全战略分析

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亚太安全与海洋研究 2024年第2期 72-88,I0003,I0004页

作者：任娜中国社会科学院亚太与全球战略研究院北京100007

由于相对实力下降,美国的霸权正面临“碎片化”与“议题化”转型。在众多涉及安全的议题中,水资源议题因为自身的敏感性,成为美国国家安全的重要组成部分。2022年美国相继发布《全球水安全行动计划》和第二个《美国全球水战略》文件,明... 详细信息

由于相对实力下降,美国的霸权正面临“碎片化”与“议题化”转型。在众多涉及安全的议题中,水资源议题因为自身的敏感性,成为美国国家安全的重要组成部分。2022年美国相继发布《全球水安全行动计划》和第二个《美国全球水战略》文件,明确了未来一段时期美国在全球水资源领域的战略目标、原则、优先方向、实施路径以及项目规划。其在优先方向、重点地区以及实施路径等方面的新变化,不但会对中美在水资源领域的竞争产生重要影响,更可能干扰中国与周边国家在水资源领域的合作。中国需加强跟踪研判和科学谋划,不断调整和优化与周边国家开展水资源合作及治理的政策和路径,化解美国对华开展水资源竞争所带来的风险。

关键词：美国水资源水资源合作中美博弈安全战略国家安全

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s.nthes.s.of highly s.able Ni nanoparticles.via electros.atic s.lf-as.embly for enhanced hydrogen s.orage of MgH2

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Rare Metals 2024年第9期43卷 4356-4366页

作者： Qin-Ke Tang Jiang-Chuan Liu Rui s.i Yun-Feng Zhu Ji-Guang Zhang Ya-na Liu Jun Wang Yao Zhang Xiao-Hui Hu Zhi-Bin Liu Li-Quan Li College of Materials.s.ience and Engineering Jiangsu Collaborative Innovation Centre for Advanced Inorganic Function CompositesNanjing Tech University s.hool of Materials.s.ience and Engineering Southeast University

Magnes.um-bas.d hydrides.have been widely recognized as.an appropriate choice for s.lid-s.ate hydrogen ***,its.undes.rable thermodynamics.and s.uggis. hydrogenation/dehydrogenation kinetics.are major bottlenecks.for its.***,a highly s.able and highly dis.ers.d Ni-bas.d catalys. （Ni/Al2O3/GN） was.fabricated to promote the hydrogen s.orage performance of MgH2via the electros.atic effect of NiAl-LDH/GN precurs.r with a co-calcination reduction ***2-5wt % Ni/Al2O3/GN exhibits.excellent hydrogen s.orage performance,releas.ng about 5.7 wt % hydrogen in 3500 s.at 250℃,and can reach a s.turation hydrogen abs.rption of about 6.15 wt% in 3000 s.at 100℃.Furthermore,it als. s.ows.low dehydrogenation apparent activation energy of 89.1 and 118.2 kJ·***,the catalys. ens.res.the s.ability of both the phys.cal phas. and s.ructure during ball milling and cycling *** role of each phas. in Ni/Al2O3/GN on the hydrogen s.orage performance of MgH2was.als. dis.us.ed through experiments.and theoretical calculation,and the s.nergis.ic catalytic mechanis. of Ni/Al2O3/GN was.clearly *** work provides.a unique pers.ective for the preparation of highly s.able and highly dis.ers.ble catalys.s.

关键词： Catalytic mechanis. Hydrogen s.orage performance Magnes.um hydride Ni/Al2O3/GN

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N-acetyls.rotonin alleviates.retinal is.hemia-reperfus.on injury via HMGB1/RAGE/NF-κB pathway in rats

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International Journal of Ophthalmology(Englis. edition) 2024年第2期17卷 228-238页

作者： Yu-Ze Zhao Xue-Ning Zhang Yi Yin Pei-Lun Xiao Meng Gao Lu-Ming Zhang s.uan-Hu Zhou s.u-na Yu Xiao-Li Wang Yan-s.ng Zhao Department of Ophthalmology Affiliated Hospital of Weifang Medical UniversityWeifang 261031Shandong ProvinceChina s.hool of Medical Imaging Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Department of Anatomy Weifang Medical UniversityWeifang 261053Shandong ProvinceChina Departments.of Orthopedic s.rgery Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115USA

AIM:To obs.rve the effects.of N-acetyls.rotonin(nas.adminis.ration on retinal is.hemia-reperfus.on(Rir)injury in rats.and explore the underlying mechanis.s.involving the high mobility group box 1(HMGB1)/receptor for advanced glycation end-products.RAGE)/nuclear factor-kappa B(NF-κB)s.gnaling ***:A rat model of Rir was.developed by increas.ng the pres.ure of the anterior chamber of the *** male s.rague Dawley were randomly divided into five groups.s.am group(n=8),Rir group(n=28),Rir+nas.group(n=28),Rir+FPs.ZM1 group(n=8)and Rir+nas.FPs.ZM1 group(n=8).The therapeutic effects.of nas.were examined by hematoxylin-eos.n(H&E)s.aining,and retinal ganglion cells.RGCs.*** expres.ion of interleukin 1 beta(IL-1β),HMGB1,RAGE,and nod-like receptor 3(NLRP3)proteins.and the phos.horylation of nuclear factorkappa B(p-NF-κB)were analyzed by immunohis.ochemis.ry s.aining and Wes.ern blot *** expres.ion of HMGB1 protein was.als. detected by enzyme-linked immunos.rbent as.ay(ELIs.).REs.LTs.H&E s.aining res.lts.s.owed that nas.s.gnificantly reduced retinal edema and increas.d the number of RGCs.in Rir *** nas.therapy,the HMGB1 and RAGE expres.ion decreas.d s.gnificantly,and the activation of the NF-κB/NLRP3 pathway was.antagonized along with the inhibition of p-NF-κB and NLRP3 protein ***,nas.exhibited an anti-inflammatory effect by reducing IL-1β*** inhibitory of RAGE binding to HMGB1 by RAGE inhibitor FPs.ZM1 led to a s.gnificant decreas. of p-NF-κB and NLRP3 expres.ion,s. as.to the IL-1βexpres.ion and retinal edema,accompanied by an increas. of RGCs.in Rir ***:nas.may exhibit a neuroprotective effect agains. Rir via the HMGB1/RAGE/NF-κB s.gnaling pathway,which may be a us.ful therapeutic target for retinal dis.as..

关键词： retinal dis.as.s retinal is.hemia—reperfus.on injury N-acetyls.rotonin high mobility group box 1 receptor for advanced glycation end-products nuclear factor-κB rats

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新中式家具设计的原则与策略研究

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包装工程 2024年第16期45卷 366-369页

作者：杨娜四川艺术职业学院成都611131

目的详细探究新中式家具设计的原则与设计策略,为新中式家具设计提供参考,以便设计出更符合用户需求、更具文化性特色的新中式家具。方法采用理论研究法,从新中式家具的内涵入手,分析新中式家具的设计原则,并对新中式家具设计的策略展... 详细信息

目的详细探究新中式家具设计的原则与设计策略,为新中式家具设计提供参考,以便设计出更符合用户需求、更具文化性特色的新中式家具。方法采用理论研究法,从新中式家具的内涵入手,分析新中式家具的设计原则,并对新中式家具设计的策略展开论述。结论在新中式家具设计中,要遵从创新性、和谐性、舒缓性原则,设计策略上要注重功能上的扩展与适应;不拘泥于传统材质,融合传统与现代工艺材料;根据现代人审美优化与简化新中式家具造型;把握“中式”核心,积极融入传统文化,抓住传统文化精髓,将其作为最本质的内容融入到新中式家具设计中;根据实际需求对新中式家具样式进行改良。

关键词：新中式家具设计传统文化结构特性

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