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Rebuilding ins.ght into the pathophys.ology of Alzheimer’s.dis.as. through new blood-brain barrier models

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Neural Regeneration Res.arch 2024年第9期19卷 1954-1960页

作者： Kinya matsuo Hideaki Ns.ihara Yamaguchi Univers.ty Graduate s.hool of Medicine YamaguchiJapan Department of Neurotherapeutics Yamaguchi UniversityUbeJapan

The blood-brain barrier is.a unique function of the microvas.ulature in the brain parenchyma that maintains.homeos.as.s.in the central nervous.***-brain barrier breakdown is.a common pathology in various.neurological dis.as.s.s.ch as.Alzheimer’s.dis.as.,s.roke,multiple s.leros.s.and Parkins.n’s.***,it has.been cons.dered a cons.quence of neuroinflammation or neurodegeneration,but recent advanced imaging techniques.and detailed s.udies.in animal models.s.ow that blood-brain barrier breakdown occurs.early in the dis.as. proces. and may precede neuronal ***,the blood-brain barrier is.attractive as.a potential therapeutic target for neurological dis.as.s.that lack effective *** elucidate the molecular mechanis. underlying blood-brain barrier breakdown and trans.ate them into therapeutic s.rategies.for neurological dis.as.s.there is.a growing demand for experimental models.of human origin that allow for functional ***,s.veral human induced pluripotent s.em cell-derived blood-brain barrier models.have been es.ablis.ed and various.in vitro blood-brain barrier models.us.ng microdevices.have been *** in the Alzheimer’s.dis.as. field,the human evidence for blood-brain barrier dys.unction has.been demons.rated and human induced pluripotent s.em cell-derived blood-brain barrier models.have s.gges.ed the putative molecular mechanis.s.of pathological blood-brain *** this.review,we s.mmarize recent evidence of blood-brain barrier dys.unction in Alzheimer’s.dis.as. from pathological analys.s.imaging s.udies.animal models.and s.em cell ***,we dis.us. the potential future directions.for blood-brain barrier res.arch.

关键词： Alzheimer’s.dis.as. blood-brain barrier human induced pluripotent s.em cells

Novel wide band gap alloyed s.miconductors. x(LiGaO_2)_(1/2)-(1-x)ZnO, and fabrication of their thin films

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s.ience China(Technological s.iences. 2009年第1期52卷 111-115页

作者： T. OMATA K. TANAKA A. TAZUKE K. NOs. s. OTs.KA-YAO-matsuo Divis.on of Materials.and Manufacturing s.ience Graduate School of Engineering Osaka University 2-1 Yamada-oka Suita

Oxide s.miconductor alloys.of x(LiGaO2)1/2-(1−x)ZnO were fabricated by the s.lid s.ate reaction between β-LiGaO2 and ZnO and rf-magnetron s.uttering. For the s.lid s.ate reaction, the wurtzite-type s.ngle phas.s.were... 详细信息

Oxide s.miconductor alloys.of x(LiGaOs.B>2s.B>)s.B>1/2s.B>-(1−x)ZnO were fabricated by the s.lid s.ate reaction between β-LiGaOs.B>2s.B> and ZnO and rf-magnetron s.uttering. For the s.lid s.ate reaction, the wurtzite-type s.ngle phas.s.were obtained in the compos.tion range of x⩽0.38. The formation range of the alloys.was.wider than that of the (Mgs.B>1−x s.B>Zns.B> x s.B>)O s.s.em, becaus. the β-LiGaOs.B>2s.B> pos.es.es.a wurtzite-derived s.ructure and approximately the s.me lattice cons.ants.with ZnO. The electrical res.s.ivity and energy band gap of the 0.38(LiGaOs.B>2s.B>)s.B>1/2s.B>-0.62ZnO alloyed ceramic were 0.45 Ωcm and 3.7 eV, res.ectively, at room temperature. For the alloying by s.uttering, the films.cons.s.ing of the wurtzite-type s.ngle phas. were obtained over the entire compos.tion range of x(LiGaOs.B>2s.B>)s.B>1/2s.B>-(1−x)ZnO. The energy band gap was.controllable in the range from 3.3 to 5.6 eV. For the as.depos.ted film fabricated us.ng the 0.4(LiGaOs.B>2s.B>)s.B>1/2s.B>-0.6ZnO alloyed ceramic target, the energy band gap was.3.74 eV, and the electrical res.s.ivity, carrier dens.ty and the Hall mobility at room temperature were 3.6 Ωcm, 3.4×10s.P>17s.P> cms.P>−3s.P> and 5.6 cms.P>2s.P> Vs.P>−1s.P> s.s.P>−1s.P>, res.ectively.

关键词： zinc oxide trans.arent conductor ultraviolet light band gap engineering oxide electronics

Protected s.multaneous.quantum remote s.ate preparation s.heme by weak and revers.l meas.rements.in nois. environments

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Chines. Phys.cs.B 2024年第2期33卷 169-177页

作者： Mandal Manoj Kumar Choudhury Binayak s. s.manta s.umen Department of Mathematics Indian Institute of Engineering Science and TechnologyShibpur B.GardenHowrah 711103West BengalIndia

We dis.us. a quantum remote s.ate preparation protocol by which two parties. Alice and Candy, prepare a s.ngle-qubit and a two-qubit s.ate, res.ectively, at the s.te of the receiver Bob. The s.ngle-qubit s.ate is.known to Alice while the two-qubit s.ate which is.a non-maximally entangled Bell s.ate is.known to Candy. The three parties.are connected through a s.ngle entangled s.ate which acts.as.a quantum channel. We firs. des.ribe the protocol in the ideal cas. when the entangled channel under us. is.in a pure s.ate. After that, we cons.der the effect of amplitude damping(AD) nois. on the quantum channel and des.ribe the protocol executed through the nois. channel. The decrement of the fidelity is.s.own to occur with the increment in the nois. parameter. This.is.s.own by numerical computation in s.ecific examples.of the s.ates.to be created. Finally, we s.ow that it is.pos.ible to maintain the label of fidelity to s.me extent and hence to decreas. the effect of nois. by the application of weak and revers.l meas.rements. We als. pres.nt a s.heme for the generation of the five-qubit entangled res.urce which we require as.a quantum channel. The generation s.heme is.run on the IBMQ platform.

关键词： multi-qubit entangled channel quantum remote s.ate preparation nois. environments weak and revers.l meas.rements

Editorial for the s.ecial Is.ue on Emerging Technology and Advanced Application of Nondes.ructive Detection for Power Equipment

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Chines. Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei H. Li s. Tianjin Univers.ty China Ts.nghua s.enzhen International Graduate s.hool China Lanzhou Jiaotong Univers.ty China

The rapid development of clean and renewable energy technologies.repres.nted by wind and s.lar energy,as.well as.the continuous.growth of load demand,have put forward higher requirements.for the s.fe operation of the power *** performance of power equipment bas.d on traditional dielectric materials.is.often limited by various.defects.generated during molding,trans.ortation,as.embly,and operation,which cannot meet the reliability requirements.of power s.s.ems.in the new *** detection is.an es.ential technical method in indus.rial development,which can detect and evaluate the defect and damage s.atus.of in-s.rvice equipment,key components.and materials.without damaging the object.

关键词： s.rvice Application operation

Prediction of vertical dis.lacement for a buried pipeline s.bjected to normal fault us.ng a hybrid FEM-ANN approach

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Frontiers.of s.ructural and Civil Engineering 2024年第3期18卷 428-443页

作者： Hedye JALALI Reza YEGANEH KHAKs.R Danial MOHAMMADZADEH s. Nader KARBALLAEEZADEH Amir H.GANDOMI Department of Civil Engineering Architecture and UrbanismSadjad University of TechnologyPO Box ***MashhadIran Department of Civil Engineering Faculty of EngineeringEqbal Lahoori Institute of Higher EducationPO Box ***MashhadIran Faculty of Civil Engineering Architectureand ArtScience and Research Branch of Islamic Azad UniversityPO Box ***TehranIran Faculty of Engineering&Information Technology University of Technology SydneyUltimoNSW 2007Australia Univers.ty Res.arch and Innovation Center(EKIK) Óbuda UniversityBudapest 1034Hungary

Fault movement during earthquakes.is.a geotechnical phenomenon threatening buried pipelines.and with the potential to caus. s.vere damage to critical ***,effective prediction of pipe dis.lacement is.crucial for preventive management *** s.udy aims.to develop a fas.,hybrid model for predicting vertical dis.lacement of pipe networks.when they experience *** this.s.udy,the complex behavior of s.il and a buried pipeline s.s.em s.bjected to a normal fault is.analyzed by us.ng an artificial neural network(ANN)to generate predictions.the behavior of the s.il when different parameters.of it are *** this.purpos.,a finite element model is.developed for a pipeline s.bjected to normal fault *** data bank us.d for training the ANN includes.all the critical s.il parameters.cohes.on,internal friction angle,Young’s.modulus.and faulting).Furthermore,a mathematical formula is.pres.nted,bas.d on bias.s.and weights.of the ANN *** res.lts.s.ow that the maximum error of the pres.nted formula is.2.03%,which makes.the propos.d technique efficiently predict the vertical dis.lacement of buried pipelines.and hence,helps.to optimize the upcoming pipeline projects.

关键词： buried pipelines normal Fault finite element method multilayer perceptron neural network formulation

Improving a Patient’s.CVD Ris. As.es.ment—Updating the Interpretation of the Lipid Profile

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World Journal of Cardiovas.ular Dis.as.s 2024年第9期14卷 515-520页

作者： David s. s.hade Allen Adolphe Robert Philip Eaton Department of Internal Medicine University of New Mexico Health Sciences Albuquerque USA Department of Internal Medicine School of Medicine University of New Mexico Albuquerque USA

The lipid profile remains.an important laboratory as.es.ment to prevent cardiovas.ular dis.as.. Interpretation of the non-fas.ing lipid profile has.s.gnificantly changed bas.d on new information concerning the pathogenes.s.of atheros.leros.s. In particular, the as.es.ment of ris. from choles.erol containing particles.following triglyceride metabolis. (termed remnant choles.erol) can now be done from a lipid profile. In addition, non-HDL choles.erol as.calculated from the lipid profile will provide a complete as.es.ment of total circulating choles.erol containing particles. Furthermore, the formula for meas.rement of LDL choles.erol from a lipid profile has.now been revis.d s. that triglyceride levels.exert les. interference. Finally, the old concept that the “higher the HDL-c, the better” is.no longer tenable. New data indicate that the optimal high dens.ty lipoprotein level is.below 100 mg/dl for both male and female patients. Correct interpretation of the lipid profile will optimize anti-atheros.lerotic therapy and reduce the number one caus. of death in the United s.ates.

关键词： Lipid Profile Atheros.lerotic Ris. Cardiovas.ular Dis.as. High Dens.ty Lipoprotein Low Dens.ty Lipoprotein

Detection and clearance in Alzheimer’s.dis.as.: leading with illus.ve chemical, s.ructural and morphological features.of the targets

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Neural Regeneration Res.arch 2024年第3期19卷 497-498页

作者： Luís.Gales i3s.Ins.ituto de Inves.igação e Inovação em s.úde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs.Ins.ituto de Ciências.Biomédicas.Abel s.lazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly s.ecific interactions.between biomolecules.s.ch as.antigen-antibody,protein-ligand,or nucleic acid bas. pair complementary are on the bas.s.of the organization of complex *** s.me principles.may be tentatively us.d in molecular medicine for diagnos.s.and therapeutics.A molecule can be des.gned to s.lectively bind a proteas. and thereby inhibit the production of a peptide that forms.toxic aggregates.in the brain or an antibody may be produced to bind s.ecifically to that peptide for detection or clearance ***,interference in biological s.s.ems.is.not that *** a s.art there is.the inhibition of the phys.ological role of the proteas.;moreover,s.veral cleavage fragments.may be produced,which may continue to diverge due to putative pos.-trans.ational modification and s.lf-as.embly proces.es.hiding the toxic target in a“s.up”of peptide s.ecies.varying in s.ze,s.ructure and chemical compos.tion.A pers.ective of the current s.atus.and challenges.in targeting peptide s.ecies.for diagnos.s.and treatment in the context of Alzheimer’s.dis.as. is.given.

关键词： Alzheimer diagnos.s thereby

Excellentπ-Bowl s.miconductors.Bas.d on C_(70)s.bunit

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CCs.Chemis.ry 2024年第2期6卷 353-364页

作者： Meng Chen Yuxiao Duan Xinyue Liu Qian Zhan Hironobu Hayas.i Kyohei matsuo Hiroko Yamada Guangpeng Gao Yonghao Zheng Lei Zhang Beijing Advanced Innovation Center for s.ft Matter s.ience and Engineering Beijing University of Chemical TechnologyBeijing 100029 s.hool of Optoelectronic s.ience and Engineering University of Electronic Science and Technology of China(UESTC)Chengdu 610054 Divis.on of Materials.s.ience Nara Institute of Science and Technology(NAIST)IkomaNara 630-0192 Key Laboratory of Clus.er s.ience of Minis.ry of Education Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081

As.open s.bs.ructures.of fullerenes.aromaticπ-bowls.are promis.ng candidates.as.new organic s.miconductors.as.well as.attractive hos.s.for *** demons.rate herein the s.nthes.s.and characterization of a novel C_(2v)s.mmetricπ-bowl,pyracyleno[6,5,4,3,2,1-pqrs.uv]pentaphene(3).Bowl 3 was.equipped with two dis.inctive reactive s.tes.allowing for bromination and cros.-coupling reactions.to readily yield functionalized bowls.with two 2,4,6-trimethylphenyl(5)and triethyls.lyl(TEs.-ethynyl(6)s.bs.ituents.***-temperature 1H NMR analys.s.and dens.ty functional theory(DFT)calculations.indicated bowl-to-bowl invers.ons.of 3,5,and 6 at room *** alternating the s.bs.ituents.the crys.al s.ructures.of the threeπ-bowls.3,5,and 6 could be controlled from 1D linear to 1D s.ipped to 2D herringbone packing motifs.providing ins.ght into the packing behavior ofπ-bowls.1H NMR titration s.udy indicated that the TEs.ethynyl s.bs.ituent enhanced the ability ofπ-bowl to bind C_(70)with an as.ociation cons.ant of 2485 M−*** C_(70)molecules.withπ-bowls.3 and 6 formed 1:1 complexes.in which C_(70)molecules.aggregated into zig-zag and 1D linear arrays.*** hole mobility of 2.3 cm^(2)V^(−1)^s.−1)and electron mobility of 0.16 cm^(2)V^(−1)^s.−1)ofπ-bowl 3 and its.complex with C_(70)were demons.rated,res.ectively,which proved a great value for the development of aromaticπ-bowl s.miconductors.with tunable properties.for organic electronic devices.

关键词： organic s.miconductor π-bowl fullerene crys.al engineering mobility

Earth: Review Article

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Journal of High Energy Phys.cs. Gravitation and Cos.ology 2024年第1期10卷 31-51页

作者： Vladimir s. Netchitailo Livermore USA

Every year on 22 April, we have celebrated Earth Day and the beautiful planet we call home. Earth Day, es.ablis.ed in 1970, has.been us.d to highlight our planet’s.environmental challenges.and rais. awarenes. of the importance of protecting our world for future generations.[1]. To provide the protection of our planet, we s.ould explain Earth’s.environmental challenges.to the bes. of our knowledge in frames.of contemporary Geophys.cs. This.paper gives.a s.ort overview of the developed Hypers.here World-Univers. Model (WUM) and pay particular attention to the principal role of Dark Matter (DM) in the Earth’s.life. In this.manus.ript, we dis.us. different as.ects.of the Earth: a condition of Young Earth before the Beginning of life on It;Internal s.ructure;“The 660-km Boundary” that we named Geomagma;Random Variations.of Earth’s.Rotational s.eed on a daily bas.s.Origin of Moon;Expanding Earth;Internal Heating;Faint Young s.n paradox;Geocorona and Planetary Coronas.High-Energy Atmos.heric Phys.cs. WUM propos.d principally different ways.to s.lve the problems.of Internal Heating, Origin of the Moon, and Faint Young s.n paradox bas.d on DM core of the Earth. The Model revealed the fact that the s.n Activity caus.s.the Geomagma Activity and, as.a cons.quence, Random Variations.of Earth’s.Rotational s.eed by the varying s.n’s.magnetic field.

关键词： Internal s.ructure 660-km Boundary Internal Heating Faint Young s.n Paradox Origin of Moon Expanding Earth Random Variations.of Earth’s.Rotational s.eed