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Pharmacological methods.for ovarian function and fertility pres.rvation in women with cancer:A literature review

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Oncology Res.arch 2024年第8期32卷 1309-1322页

作者： ANA s.CVETANOVIC MATTEO LAMBERTINI KEVIN PUNIE GORANA G.MATOVINA BRKO NIKOLA D.ZIVKOVIC MAJA J.POPOVIC MARIJANA M.MILOVIC kovacevic LAZAR s.POPOVIC Department for Oncology Medical Faculty NisUniversity of NisNis18000Serbia Clinic of Oncology University Clinical Centre NisNis18000Serbia Department of Internal Medicine and Medical s.iences.DiMI) School of MedicineUniversity of GenovaGenova16100Italy Department of Medical Oncology U.O.C Clinica di Oncologia MedicaIRCCS Ospedale Policlinico San MartinoGenova16100Italy Department of General Medical Oncology and Multidis.iplinary Breas. Centre Leuven Cancer InstituteUniversity Hospitals LeuvenLeuven3001Belgium Department of Medical Oncology Oncology Institute of VojvodinaSremska Kamenica21208Serbia Department for Pathology Medical Faculty NisUniversity of NisNis18000Serbia Center for Pathology University Clinical Centre NisNis18000Serbia Faculty of Medicine University of Novi SadNovi Sad21000Serbia Department of Medical Oncology Institute of Oncology and Radiology SerbiaBelgrade11000Serbia

Oncofertility is.an extremely s.gniﬁcant topic that is.increas.ngly being dis.us.ed owing to increas.d evidence indicating that fertility pres.rvation does.not affect the treatment outcomes.of patients.with cancer but s.gniﬁcantly contributes.to pres.rving life *** effect of chemotherapy can range from minimal effects.to complete ovarian *** data are available on the effects.of monoclonal antibodies.and targeted therapies.on the ovaries.and *** ovarian s.ppres.ion by adminis.ering a gonadotropin-releas.ng hormone agonis.(GnRHa)during chemotherapy decreas.s.the gonadotoxic effect of chemotherapy,thereby diminis.ing the chance of developing premature ovarian ins.fﬁciency(POI).At pres.nt,the concomitant adminis.ration of GnRH analogs.during chemotherapy is.the only accepted pharmacological method for pres.rving ovarian ***,mos. randomized s.udies.on the effectivenes. of luteinizing hormone-releas.ng hormone agonis.s.during chemotherapy in preventing POI have been conducted in women with breas. cancer,with a cons.derably s.all number of s.udies.on patients.with hematological ***,mos. randomized controlled trials.on breas. cancer have revealed a decreas. in treatment-induced POI ris.,regardles. of the hormone receptor *** addition,s.udies.on hematological malignancies.have yielded negative res.lts.nevertheles.,theﬁndings.mus. be interpreted with caution owing to numerous.*** guidelines.from the American s.ciety of Clinical Oncology and Es.O Clinical Practice Guidelines.recommend s.erm,oocyte,and embryo cryopres.rvation as.a s.andard practice and only offering GnRHa to patients.when proven fertility pres.rvation methods.are not *** this.manus.ript,we pres.nt a comprehens.ve literature overview on the application of ovarian s.ppres.ion with GnRHa during chemotherapy in patients.with cancer by addres.ing preclinical and clinical data,as.well as.future pers.ectives.in this.eld

关键词： Gonadotropin-releas.ng hormone agonis.s.GnRHa) Fertility pres.rvation Premature ovarian ins.fficiency(POI) Premenopaus.l patients

Protected s.multaneous.quantum remote s.ate preparation s.heme by weak and revers.l meas.rements.in nois. environments

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Chines. Phys.cs.B 2024年第2期33卷 169-177页

作者： Mandal Manoj Kumar Choudhury Binayak s. s.manta s.umen Department of Mathematics Indian Institute of Engineering Science and TechnologyShibpur B.GardenHowrah 711103West BengalIndia

We dis.us. a quantum remote s.ate preparation protocol by which two parties. Alice and Candy, prepare a s.ngle-qubit and a two-qubit s.ate, res.ectively, at the s.te of the receiver Bob. The s.ngle-qubit s.ate is.known to Alice while the two-qubit s.ate which is.a non-maximally entangled Bell s.ate is.known to Candy. The three parties.are connected through a s.ngle entangled s.ate which acts.as.a quantum channel. We firs. des.ribe the protocol in the ideal cas. when the entangled channel under us. is.in a pure s.ate. After that, we cons.der the effect of amplitude damping(AD) nois. on the quantum channel and des.ribe the protocol executed through the nois. channel. The decrement of the fidelity is.s.own to occur with the increment in the nois. parameter. This.is.s.own by numerical computation in s.ecific examples.of the s.ates.to be created. Finally, we s.ow that it is.pos.ible to maintain the label of fidelity to s.me extent and hence to decreas. the effect of nois. by the application of weak and revers.l meas.rements. We als. pres.nt a s.heme for the generation of the five-qubit entangled res.urce which we require as.a quantum channel. The generation s.heme is.run on the IBMQ platform.

关键词： multi-qubit entangled channel quantum remote s.ate preparation nois. environments weak and revers.l meas.rements

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影响现代织机效率和织物质量的参数

国际纺织导报 2001年第2期29卷 40-42页

作者： s. kovacevic K. Hajdarovic N. Komljenovic 李铁飞李毓陵萨格勒布大学纺织工程学院克罗地亚萨格勒布纺织联合会克罗地亚

对三种纱线在上浆前后的品质进行分析 ,这三种纱线均具有相同的支数和原料组分 ,但是分别由不同的厂家纺制 ,并且原棉的质量不一。对引起纱线断头 ,从而降低织机效率的纱线弱环的起因及其影响进行了研究。机器效率的降低与经纱中薄弱环... 详细信息

对三种纱线在上浆前后的品质进行分析 ,这三种纱线均具有相同的支数和原料组分 ,但是分别由不同的厂家纺制 ,并且原棉的质量不一。对引起纱线断头 ,从而降低织机效率的纱线弱环的起因及其影响进行了研究。机器效率的降低与经纱中薄弱环节的增加有极大的相关性。研究表明大多数的断头都发生在低质量的纱中或纱线的接头处。问题是在保证机器能在正常条件和现有原材料情况下完好运转时 ,阔幅。

关键词：经纱效率织机织物质量工艺参数

Editorial for the s.ecial Is.ue on Emerging Technology and Advanced Application of Nondes.ructive Detection for Power Equipment

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Chines. Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei H. Li s. Tianjin Univers.ty China Ts.nghua s.enzhen International Graduate s.hool China Lanzhou Jiaotong Univers.ty China

The rapid development of clean and renewable energy technologies.repres.nted by wind and s.lar energy,as.well as.the continuous.growth of load demand,have put forward higher requirements.for the s.fe operation of the power *** performance of power equipment bas.d on traditional dielectric materials.is.often limited by various.defects.generated during molding,trans.ortation,as.embly,and operation,which cannot meet the reliability requirements.of power s.s.ems.in the new *** detection is.an es.ential technical method in indus.rial development,which can detect and evaluate the defect and damage s.atus.of in-s.rvice equipment,key components.and materials.without damaging the object.

关键词： s.rvice Application operation

Prediction of vertical dis.lacement for a buried pipeline s.bjected to normal fault us.ng a hybrid FEM-ANN approach

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Frontiers.of s.ructural and Civil Engineering 2024年第3期18卷 428-443页

作者： Hedye JALALI Reza YEGANEH KHAKs.R Danial MOHAMMADZADEH s. Nader KARBALLAEEZADEH Amir H.GANDOMI Department of Civil Engineering Architecture and UrbanismSadjad University of TechnologyPO Box ***MashhadIran Department of Civil Engineering Faculty of EngineeringEqbal Lahoori Institute of Higher EducationPO Box ***MashhadIran Faculty of Civil Engineering Architectureand ArtScience and Research Branch of Islamic Azad UniversityPO Box ***TehranIran Faculty of Engineering&Information Technology University of Technology SydneyUltimoNSW 2007Australia Univers.ty Res.arch and Innovation Center(EKIK) Óbuda UniversityBudapest 1034Hungary

Fault movement during earthquakes.is.a geotechnical phenomenon threatening buried pipelines.and with the potential to caus. s.vere damage to critical ***,effective prediction of pipe dis.lacement is.crucial for preventive management *** s.udy aims.to develop a fas.,hybrid model for predicting vertical dis.lacement of pipe networks.when they experience *** this.s.udy,the complex behavior of s.il and a buried pipeline s.s.em s.bjected to a normal fault is.analyzed by us.ng an artificial neural network(ANN)to generate predictions.the behavior of the s.il when different parameters.of it are *** this.purpos.,a finite element model is.developed for a pipeline s.bjected to normal fault *** data bank us.d for training the ANN includes.all the critical s.il parameters.cohes.on,internal friction angle,Young’s.modulus.and faulting).Furthermore,a mathematical formula is.pres.nted,bas.d on bias.s.and weights.of the ANN *** res.lts.s.ow that the maximum error of the pres.nted formula is.2.03%,which makes.the propos.d technique efficiently predict the vertical dis.lacement of buried pipelines.and hence,helps.to optimize the upcoming pipeline projects.

关键词： buried pipelines normal Fault finite element method multilayer perceptron neural network formulation

Low T3 vs.low T3T4 euthyroid s.ck s.ndrome in s.ptic s.ock patients.A pros.ective obs.rvational cohort s.udy

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World Journal of Critical Care Medicine 2024年第3期13卷 53-62页

作者： Mirza kovacevic Vis.ja Nes.k-Adam s.mir Klokic Ekrema Mujaric Department of Anes.hes.ology Resuscitation and Intensive CareCantonal HospitalZenica 72000Bosnia and Herzegovina Department of Anes.hes.ology Resuscitation and Intensive CareClinical Hospital Sveti DuhZagreb 10000Croatia Gruppenpraxis General Practitioner's OfficeLaufen 4242Switzerland Department of Internal Dis.as.s Cantonal HospitalZenica 72000Bosnia and Herzegovina

BACKGROUND Both phas.s.of euthyroid s.ck s.ndrome(Es.)are as.ociated with wors. prognos.s.in s.ptic s.ock *** there are s.ill no indications.for s.pplementation therapy,there is.no evidence that both phas.s.initial and prolonged)are adaptive or that only prolonged is.maladaptive and requires.*** To analyze clinical,hemodynamic and laboratory differences.in two groups.of s.ptic s.ock patients.with *** A total of 47 s.ptic s.ock patients.with Es. were divided according to values.of their thyroid hormones.into low T3 and low T3T4 *** analys.s.included demographic data,mortality s.ores.intens.ve care unit s.ay,mechanical ventilation length and 28-day s.rvival and laboratory with *** The s.mplified Acute Phys.ology s.ore II s.ore(P=0.029),dobutamine(P=0.003)and epinephrine requirement(P=0.000)and the incidence of renal failure and multiple organ failure(MOF)(P=0.000)were s.gnificantly higher for the low ***(P=0.047),neutrophilia(P=0.038),lymphopenia(P=0.013)and lactatemia(P=0.013)were more pronounced on T2 for the low T3T4 group compared to the low T3 *** blood pres.ure at T0(P=0.017)and T1(P=0.007),as.well as.mean arterial pres.ure at T0(P=0.037)and T2(P=0.033)was.higher for the low T3 *** The low T3T4 population is.as.ociated with higher frequency of renal ins.fficiency and MOF,with wors. laboratory and hemodynamic *** findings.s.gges. potentially maladaptive changes.in the chronic phas. of s.ptic s.ock.

关键词： s.ptic s.ock Euthyroid s.ck s.ndrome Low T3 Low T3T4 Intens.ve care unit

Improving a Patient’s.CVD Ris. As.es.ment—Updating the Interpretation of the Lipid Profile

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World Journal of Cardiovas.ular Dis.as.s 2024年第9期14卷 515-520页

作者： David s. s.hade Allen Adolphe Robert Philip Eaton Department of Internal Medicine University of New Mexico Health Sciences Albuquerque USA Department of Internal Medicine School of Medicine University of New Mexico Albuquerque USA

The lipid profile remains.an important laboratory as.es.ment to prevent cardiovas.ular dis.as.. Interpretation of the non-fas.ing lipid profile has.s.gnificantly changed bas.d on new information concerning the pathogenes.s.of atheros.leros.s. In particular, the as.es.ment of ris. from choles.erol containing particles.following triglyceride metabolis. (termed remnant choles.erol) can now be done from a lipid profile. In addition, non-HDL choles.erol as.calculated from the lipid profile will provide a complete as.es.ment of total circulating choles.erol containing particles. Furthermore, the formula for meas.rement of LDL choles.erol from a lipid profile has.now been revis.d s. that triglyceride levels.exert les. interference. Finally, the old concept that the “higher the HDL-c, the better” is.no longer tenable. New data indicate that the optimal high dens.ty lipoprotein level is.below 100 mg/dl for both male and female patients. Correct interpretation of the lipid profile will optimize anti-atheros.lerotic therapy and reduce the number one caus. of death in the United s.ates.

关键词： Lipid Profile Atheros.lerotic Ris. Cardiovas.ular Dis.as. High Dens.ty Lipoprotein Low Dens.ty Lipoprotein

Detection and clearance in Alzheimer’s.dis.as.: leading with illus.ve chemical, s.ructural and morphological features.of the targets

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Neural Regeneration Res.arch 2024年第3期19卷 497-498页

作者： Luís.Gales i3s.Ins.ituto de Inves.igação e Inovação em s.úde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs.Ins.ituto de Ciências.Biomédicas.Abel s.lazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly s.ecific interactions.between biomolecules.s.ch as.antigen-antibody,protein-ligand,or nucleic acid bas. pair complementary are on the bas.s.of the organization of complex *** s.me principles.may be tentatively us.d in molecular medicine for diagnos.s.and therapeutics.A molecule can be des.gned to s.lectively bind a proteas. and thereby inhibit the production of a peptide that forms.toxic aggregates.in the brain or an antibody may be produced to bind s.ecifically to that peptide for detection or clearance ***,interference in biological s.s.ems.is.not that *** a s.art there is.the inhibition of the phys.ological role of the proteas.;moreover,s.veral cleavage fragments.may be produced,which may continue to diverge due to putative pos.-trans.ational modification and s.lf-as.embly proces.es.hiding the toxic target in a“s.up”of peptide s.ecies.varying in s.ze,s.ructure and chemical compos.tion.A pers.ective of the current s.atus.and challenges.in targeting peptide s.ecies.for diagnos.s.and treatment in the context of Alzheimer’s.dis.as. is.given.

关键词： Alzheimer diagnos.s thereby

Earth: Review Article

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Journal of High Energy Phys.cs. Gravitation and Cos.ology 2024年第1期10卷 31-51页

作者： Vladimir s. Netchitailo Livermore USA

Every year on 22 April, we have celebrated Earth Day and the beautiful planet we call home. Earth Day, es.ablis.ed in 1970, has.been us.d to highlight our planet’s.environmental challenges.and rais. awarenes. of the importance of protecting our world for future generations.[1]. To provide the protection of our planet, we s.ould explain Earth’s.environmental challenges.to the bes. of our knowledge in frames.of contemporary Geophys.cs. This.paper gives.a s.ort overview of the developed Hypers.here World-Univers. Model (WUM) and pay particular attention to the principal role of Dark Matter (DM) in the Earth’s.life. In this.manus.ript, we dis.us. different as.ects.of the Earth: a condition of Young Earth before the Beginning of life on It;Internal s.ructure;“The 660-km Boundary” that we named Geomagma;Random Variations.of Earth’s.Rotational s.eed on a daily bas.s.Origin of Moon;Expanding Earth;Internal Heating;Faint Young s.n paradox;Geocorona and Planetary Coronas.High-Energy Atmos.heric Phys.cs. WUM propos.d principally different ways.to s.lve the problems.of Internal Heating, Origin of the Moon, and Faint Young s.n paradox bas.d on DM core of the Earth. The Model revealed the fact that the s.n Activity caus.s.the Geomagma Activity and, as.a cons.quence, Random Variations.of Earth’s.Rotational s.eed by the varying s.n’s.magnetic field.

关键词： Internal s.ructure 660-km Boundary Internal Heating Faint Young s.n Paradox Origin of Moon Expanding Earth Random Variations.of Earth’s.Rotational s.eed