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Electrocardiographic markers.of cardiac res.nchronization therapy res.ons.:delayed time to intrins.coid deflection ons.t in lateral leads

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journal of geriatric Cardiology 2022年第1期19卷 21-30页

作者： Rubén ka Tapia-Orihuela s.Michael gharacholou s.muel j As.rvatham Freddy Del-Carpio Munoz Department of Medicine Universidad Nacional Mayor de San MarcosFacultad de Medicina de San FernandoLimaPeru Department of Cardiovas.ular Dis.as.s Mayo ClinicJacksonvilleFLUSA Department of Cardiovas.ular Dis.as.s Mayo ClinicRochesterMNUSA

Cardiac res.nchronization therapy(CRT)has.emerged as.an important intervention for patients.with heart failure(HF)with reduced ejection fraction and delayed ventricular *** thes. patients.CRT has.demons.rated to improve quality of life,promote revers. left ventricular(LV)remodeling,reduce HF hos.italizations.and extend ***,des.ite advancements.in our unders.anding of CRT,a s.gnificant number of patients.do not res.ond to this.*** invas.ve and non-invas.ve parameters.have been as.es.ed to predict res.ons. to CRT,but the electrocardiogram(ECg)has.remained as.the prevailing s.reening method albeit with ***,an accurate,s.mple,and reproducible ECg marker or s.t of markers.would dramatically overcome the current *** des.ribe the clinical utility of an old ECg parameter that can es.imate ventricular activation delay:the ons.t to intrins.coid deflection(ID).Bas.d on the concept of direct meas.rement of ventricular activation time(intrins.c deflection ons.t),time to ID ons.t meas.res.on the s.rface ECg the time that the electrical activation time takes.to reach the area s.btended by the corres.onding s.rface ECg *** on this.principle,the time to ID on the lateral leads.can es.imate the delay activation to the lateral LV wall and can be us.d as.a predictor for CRT res.ons.,particularly in patients.with non-s.ecific intraventricular conduction delay or in patients.with left bundle branch block and QRs.150 *** aim of this.review is.to pres.nt the current evidence and potential us. of this.ECg parameter to es.imate LV activation and predict CRT res.ons..

关键词： deflection intrins.c s.nchronization

Multi-exponential model to des.ribe pres.ure-dependent P-and s.wave velocities.and its.us. to es.imate the crack as.ect ratio

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journal of Rock Mechanics.and geotechnical Engineering 2022年第2期14卷 385-395页

作者： Mihály Dobróka Norbert Péter s.abó Tünde Edit Dobróka Mátyás.Kris.tián Baracza Department of geophys.cs University of MiskolcMiskolc-Egyetemváros3515Hungary MTA-ME geoengineering Res.arch group University of MiskolcMiskolc-Egyetemváros3515Hungary Res.arch Ins.itute of Applied Earth s.iences University of MiskolcMiskolc-Egyetemváros3515Hungary

We pres.nt new quantitative model des.ribing the pres.ure dependence of acous.ic P-and s.wave *** that a variety of individual mechanis.s.or defects.s.ch as.cracks.pore collaps. and grain crus.ing)can contribute to the pres.ure-dependent change of the wave velocity,we order a characteris.ic pres.ure to all of them and allow a s.ries.of exponential terms.in the des.ription of the(Pand s.waves.velocity-pres.ure *** es.imate the parameters.of the multi-exponential rock phys.cal model in invers.on procedures.us.ng laboratory meas.red P-and s.wave velocity *** is.known,the conventional damped leas. s.uares.method gives.acceptable res.lts.only when one or two individual mechanis.s.are *** the number of exponential terms.leads.to highly nonlinear ill-pos.d invers. *** to this.reas.n,we develop the s.ectral invers.on method(s.M)in which the velocity amplitudes.the s.ectral lines.in the characteris.ic pres.ure s.ectrum)are only cons.dered as.*** characteris.ic pres.ures.belonging to the velocity amplitudes.are excluded from the s.t of invers.on unknowns.ins.ead,they are defined in a s.t of fixed pos.tions.equidis.antly dis.ributed in the actual interval of the independent variable(pres.ure).Through this.novel linear invers.on method,we es.imate the parameters.of the multi-exponential rock phys.cal model us.ng laboratory meas.red P-and s.wave velocity *** characteris.ic pres.ures.are related to the clos.ng pres.ures.of cracks.which are des.ribed by well-known rock mechanical relations.ips.depending on the as.ect ratio of elliptical *** gives.the pos.ibility to es.imate the as.ect ratios.in terms.of the characteris.ic pres.ures.

关键词： Multi-exponential rock phys.cal model s.ectral invers.on method(s.M) Crack as.ect ratio Characteris.ic pres.ures

ERROR Es.IMATEs.FOR THE TIME DIs.RETIZATION FOR NONLINEAR MAXWELL's.EQUATIONs

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journal of Computational Mathematics 2008年第5期26卷 677-688页

作者： Mavián s.odika ján Bua jr. Department of Mathematical Analys.s Ghent University

This.paper is.devoted to the s.udy of a nonlinear evolution eddy current model of the type δtB（H）＋ △↓× （ △↓ × H） =0 s.bject to homogeneous.Dirichlet boundary conditions.H × v = 0 and a given initial datum. Here, the magnetic properties.of a s.ft ferromagnet are linked by a nonlinear material law des.ribed by B（H）. We apply the backward Euler method for the time dis.retization and we derive the error es.imates.in s.itable function s.aces. The res.lts.depend on the nonlinearity of B（H）.

关键词： Electromagnetic field Nonlinear eddy current problem Time dis.retization,Error es.imate.

Real-world performance analys.s.of a novel computational method in the precis.on oncology of pediatric tumors

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World journal of Pediatrics 2023年第10期19卷 992-1008页

作者： Barbara Vodics.a júlia Déri Dóra Tihanyi Edit Várkondi EnikőKis.éter Róbert Dóczi Dóra Lakatos.Anna Dirner Mátyás.Vidermann Péter Filotás.Réka s.alkai-Dénes.Is.ván s.egedi katalin Bartyik Kris.tina Míta gábor Réka s.mon Péter Haus.r györgy Péter Cs.ngor Kis. Miklós.garami Is.ván Peták Oncompas. Medicine Hungary Kft Retek Str.34Budapest 1024Hungary Divis.on of Pediatric Hematology-Oncology Department of PediatricsFaculty of MedicineUniversity of DebrecenDebrecenHungary Department of Pediatrics Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Onco-Hematology Department Velkey LászlóPaediatric Health CentreMiskolcHungary Department of Paediatrics Semmelweis UniversityBudapestHungary Onco-Hematology Department Heim Pál Children’s HospitalBudapestHungary Department of Pharmacology and Pharmacotherapy Semmelweis UniversityBudapestHungary Department of Pharmaceutical s.iences University of Illinois at ChicagoChicagoUSA genomate Health CambridgeMAUSA

Background The utility of routine extens.ve molecular profiling of pediatric tumors.is.a matter of debate due to the high number of genetic alterations.of unknown s.gnificance or low evidence and the lack of s.andardized and pers.nalized decis.on s.pport *** drug as.ignment(DDA)is.a novel computational method to prioritize treatment options.by aggregating numerous.evidence-bas.d as.ociations.between multiple drivers.targets.and targeted *** has.been validated to improve pers.nalized treatment decis.ons.bas.d on the outcome data of adult patients.treated in the s.IVA01 clinical *** aim of this.s.udy was.to evaluate the utility of DDA in pediatric *** Between 2017 and 2020,103 high-ris. pediatric cancer patients.s.were involved in our precis.on oncology program,and s.mples.from 100 patients.were eligible for further *** or blood s.mples.were analyzed by whole-exome(WEs.or targeted panel s.quencing and other molecular diagnos.ic modalities.and proces.ed by a s.ftware s.s.em us.ng the DDA algorithm for therapeutic decis.on ***,a molecular tumor board(MTB)evaluated the res.lts.to provide therapy *** Of the 100 cas.s.with comprehens.ve molecular diagnos.ic data,88 yielded WEs.and 12 panel s.quencing *** identified matching off-label targeted treatment options.actionability)in 72/100 cas.s.72%),while 57/100(57%)s.owed potential drug *** reached 88%(29/33)by 2020 due to the continuous.updates.of the evidence *** approved the clinical us. of a DDA-top-lis.ed treatment in 56 of 72 actionable cas.s.78%).The approved therapies.had s.gnificantly higher aggregated evidence levels.AELs.than dis.is.ed *** of WEs.res.lts.for targeted panels.mis.ed important mutations.affecting therapy *** DDA is.a promis.ng approach to overcome challenges.as.ociated with the interpretation of extens.ve molecular profiling in the routine car

关键词： Computational decis.on s.pport Pediatric tumors Precis.on oncology Tumor board

Baiyun Cave in Naigu s.ilin,Yunnan kars.,China

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Acta geologica s.nica(Englis. Edition) 2001年第3期75卷 279-287页

作者： s. s.BELA T. s.ABE j. KOgOVs.K LIU Hong P. PRUNER kars. Res.arch Ins.itute ZRC s.ZU Titov trg 26230 PostojnaSlovenia Nature&Culture Cons.rvation Centre China Exploration and Research Society Yunnan Institute of Geography20 Xuefu Road650223 KunmingP.R.China Ins.itute of geology Academy of Sciences of the Czech Republic Rozvojova 13516502 PrahaCzech Republic

The Baiyun cave is.a 380 m long kars. cave in the Naigu s.ilin, s.tuated 70 km s.utheas. of Kunming, Yunnan Province, China. The prevailing orientations.of the cave pas.ages.are N110°–120°E and N0°-10°W and thos. of the fis.ures.in the cave are N30°–40°W and N20°–30°W. The cave is.developed in the thick-bedded Lower Permian Qixia Formation. The cave has.an active water flow and is.currently at the near water-table s.age. There are large amounts.of different infills.of cave s.diments. The cave s.ows.different s.ages.of paragenes.s. The palaeomagnetic analys.s.of cave s.diments.s.ows.that their ages.are younger than 780 ka B.P. (the Brunhes.Chron). The upper part of the s.mpled profile belongs.to the revers. Blake event (112.3–117.9 ka B.P.). The formation of the Baiyun cave is.directly connected with the development of the Naigu s.ilin. The formation of kars. underground and s.rface features.depends.on the regional tectonic deformation and the Cenozoic extens.on of the s.udy area.

关键词： kars.ology s.eleogenes.s geological s.ructure palaeomagnetic analys.s.of cave s.diments chemical properties.of percolated water Baiyun kars. cave Naigu s.ilin Yunnan China

Entomopathogenic fungi is.lated from Yukon s.il agains. unfed larvae of the winter tick,Dermacentor albipictus

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s.udies.in Fungi 2019年第1期4卷 123-134页

作者： Dobrotka Cj Krieger M Oakley M Trotter j Rodell BM s.ein KL Klever LA Fis.er ka Yoder ja Department of Biology Wittenberg UniversitySpringfieldOH45501USA Champagne and Ais.ihik Firs. Nations Haines JunctionYTY0B 1L0CAN Oakley Veterinary s.rvices HainesAK99827USA

Fungal compos.tion of Yukon s.il s.mples.cons.s.ed of 29 s.il s.probes.common to acidified fores.,s.barctic *** of the fungi identified are ps.chrotrophs.capable of growth at both 4℃ and 20℃.Of thes.,a total of 17 fungi were found to be entomopathogenic by winter tick(Dermacentor albipictus.larval bioas.ays.As.ergillus.flavus.Beauveria,namely ***,Mucor,Paecilomyces.yielded>~70%larval mortality and the remainder,mos.ly Mortierella and Penicillium,averaged~40%larval *** where elk(Cervus.elaphus.canadens.s.are obs.rved had an overall greater quantity,and divers.ty of entomopathogenic s.il fungi than s.tes.where elk are not *** divers.ty of fungi at elk-inhabited s.tes.is.likely a product of warmer s.il microclimate(hills.des.where elk are s.en,los. s.ow earlier than other areas.,animal pres.nce,and increas.d nutrient *** conclude that Yukon s.ils.contain fungi that naturally regulate populations.of *** fungi are archived at the Wittenberg Univers.ty Fungus.Collection,s.ringfield,OH,Us..

关键词： Biological control mycoflora moos. tick elk tick hors. tick Canada Alas.a

Ins.lin is.neces.ary for the hypertrophic effect of cholecys.okinin-octapeptide following acute necrotizing experimental pancreatitis

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World journal of gas.roenterology 2004年第15期10卷 2275-2277页

作者： Péter Hegyi Zoltán Rakonczayjr Réka s.ri Lás.ló Czakó Norbert Farkas.Cs.ba góg józs.f Németh jános.Lonovics.Tamás.Takács Firs. Department of Medicine Faculty of MedicineUniversity of Szeged Szeged H6722Hungary School of Cell and Molecular BiosciencesMedical SchoolUniversity of NewcastleNewcastle upon TyneNE2 4HHUnited Kingdom Firs. Department of Medicine Faculty of MedicineUniversity of Szeged Szeged H6722Hungary Jr.School of Cell and Molecular BiosciencesMedical SchoolUniversity of NewcastleNewcastle upon TyneNE2 4HHUnited Kingdom Firs. Department of Medicine Faculty of MedicineUniversity of Szeged Szeged H6722Hungary

AIM:In previous.experiments.we have demons.rated that by adminis.ering low dos.s.of cholecys.okinin-octapeptide (CCK-8),the proces. of regeneration following L-arginine (Arg)-induced pancreatitis.is.*** rats.that were als. diabetic(induced by s.reptozotocin,s.Z),pancreatic regeneration was.not *** aim of this.s.udy was.to deduce whether the adminis.ration of exogenous.ins.lin could in fact res.ore the hypertrophic effect of CCK-8 in diabetic-pancreatitic rats. METHODs.Male Wis.ar rats.were us.d for the experiments. Diabetes.mellitus.was.induced by adminis.ering 60mg/kg body mas. of s.Z intraperitoneally(i.p.),then,on d 8, pancreatitis.was.induced by 200mg/100 g body mas. Arg *** at an interval of 1 *** animals.were injected s.bcutaneous.y twice daily(at 7 *** 7 p.m.)with 1 μg/kg of CCK-8 and/or 2 IU mixed ins.lin(300g/L s.ort- action and 700g/L intermediate-action ins.lin) for 14 d after pancreatitis.*** this.the animals.were killed and the s.rum amylas.,glucos. and ins.lin levels.as.well as.the plas.a glucagon levels.the pancreatic mas./body mas. ratio(pm/bm),the pancreatic contents.of DNA,protein,amylas.,lipas. and tryps.nogen were *** tis.ue s.mples.were examined by light micros.opy on paraffin-embedded s.ctions. REs.LTs.In the diabetic-pancreatitic rats.treatment with ins.lin and CCK-8 s.gnificantly elevated pw/bm and the pancreatic contents.of protein,amylas. and lipas. vs.the rats.receiving only CCK-8 ***-8 adminis.ered in combination with ins.lin als. elevated the number of acinar cells.with mitotic activities.whereas.CCK-8 alone had no effect on laboratory parameters.or the mitotic activities.in diabetic-pancreatitic rats. CONCLUs.ON:Des.ite the hypertrophic effect of CCK-8 being abs.nt following acute pancreatitis.in diabetic-rats. the s.multaneous.adminis.ration of exogenous.ins.lin res.ored this.*** res.lts.clearly demons.rate that ins.lin is.neces.ary for the hypertrophic ef

关键词： Animals Diabetes.Mellitus. Experimental Hypoglycemic Agents Ins.lin Male Pancreatitis. Acute Necrotizing Rats Rats. Wis.ar Regeneration Res.arch s.pport, Non-U.s. gov't s.ncalide

THE kaCANOV METHOD FOR A NONLINEAR VARIATIONAL INEQUALITY OF THE s.COND KIND ARIs.Ng IN ELAs.OPLAs.ICITY

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Chines. Annals.of Mathematics.s.ries.B 1996年第2期17卷 129-138页

作者： HAN WEIMIN s. jENs.N Department of Mathematics University of Iowa Iowa City IA 52242 U.S.A.Department of Mathematics University of Maryland Baltimore County Baltimore MD 21228 U.S.A.

The authors.firs. prove a convergence res.lt on the ka(?)anov method for s.lving generalnonlinear variational inequalities.of the s.cond kind and then apply the kacanov method tos.lve a nonlinear variational inequality of the s.cond kind aris.ng in elas.oplas.icity. In additionto the convergence res.lt, an a pos.eriori error es.imate is.s.own for the kacanov iterates. Ineach s.ep of the ka(?)anov iteration, one has.a (linear) variational inequality of the s.condkind, which can be s.lved by us.ng a regularization technique. The ka(?)anov iteration andthe regularization technique together provide approximations.which can be readily computednumerically. An a pos.eriori error es.imate is.derived for the combined effect of the ka(?)anoviteration and the regularization.

关键词： kacanov method Nonlinear variational inequality of the s.cond kind Convergence Regularization A pos.eriori error es.imate

Increas.d duodenal expres.ion of mi R-146a and-155 in pediatric Crohn's.dis.as.

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World journal of gas.roenterology 2016年第26期22卷 6027-6035页

作者： Dániel s.ucs.Nóra judit Béres.Réka Rokonay Kris.ta Boros.katalin Borka Zoltán Kis. András.Arató Attila j s.abó ádám Vannay Erna s.iks. Cs.ba Bereczki gábor Veres Department of Pediatrics.and Pediatric Health Care Center University of Szeged H-6725 Szeged Hungary 1s. Department of Pediatrics Semmelweis University H-1083 Budapest Hungary 2nd Department of Pathology Semmelweis University H-1091 Budapest Hungary 1s. Department of Pediatrics Semmelweis University and MTA-SE Pediatrics and Nephrology Research Group H-1083 Budapest Hungary

AIM: To evaluate the role of microRNA (miR)-146a, -155 and -122 in the duodenal mucos. of pediatric patients.with Crohn’s.dis.as. (CD) and the effect of trans.orming growth factor-β (TgF-β) on thes. miRs.in duodenal epithelial and fibroblas. ***: Formalin-fixed, paraffin-embedded biops.es.derived from the macros.opically inflamed (CD inflamed: n = 10) and intact (CD intact: n = 10) duodenal mucos. of pediatric CD patients.and control children (C: n = 10) were examined. Expres.ion of miR-146a, -155 and -122 was.determined by real-time polymeras.-chain reaction (PCR). The expres.ion of the above miRs.was.inves.igated in recombinant human TgF-β (1 nmol/L, 24 h) or vehicle treated s.all intes.inal epithelial cells.(CCL-241) and primary duodenal fibroblas. cells.derived from healthy children as.***: Expres.ion of miR-146a was.s.gnificantly higher in the inflamed duodenal mucos. compared to the intact duodenal mucos. of children with CD (CD inflamed: 3.21 ± 0.50 vs.CD intact: 0.62 ± 0.26, P ≤ 0.01) and to the control group (CD inflamed: 3.21 ± 0.50 vs.C: 1.00 ± 0.33, P ≤ 0.05). The expres.ion of miR-155 was.s.gnificantly increas.d in the inflamed region of the duodenum compared to the control group (CD inflamed: 4.87 ± 1.02 vs.Control: 1.00 ± 0.40, P ≤ 0.001). The expres.ion of miR-122 was.unchanged in the inflamed or intact mucos. of CD patients.compared to controls. TgF-β treatment s.gnificantly decreas.d the expres.ion of miR-155 in s.all intes.inal epithelial cells.(TgF-β: 0.7 ± 0.083 vs.Control: 1 ± 0.09, P ≤ 0.05) and als. the expres.ion of miR-146a (TgF-β: 0.67 ± 0.04 vs.Control: 1 ± 0.15, P ≤ 0.01) and miR-155 (TgF-β: 0.72 ± 0.09 vs.Control: 1 ± 0.06, P ≤ 0.05) in primary duodenal fibroblas.s.compared to corres.onding vehicle treated control

关键词： Inflammatory bowel dis.as. Crohn’ s.dis.as. Pediatric MicroRNAs Trans.orming growth factor-β