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Performance of Crude Coagulants.from Adult Rabbit s.omach and Their Influence on the Brazilian Prato Chees. Type Compos.tion

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Food and Nutrition s.iences 2023年第5期14卷 462-479页

作者： Maximiliano s. E. jiménez Neila s. P. s. Richards Department of Food s.ience and Technology Federal University of Santa Maria Santa Maria Brazil

This.s.udy aimed to evaluate the milk clotting capacity (MCA), and cas.inolytic activity (CA) of crude coagulant from the s.omachs.of adult rabbits.(RC), and their influence on the compos.tion, proteolys.s. and texture of type Prato chees.. We tes.ed two ways.for s.lting the abomas.m and three levels.of pH and times.for enzyme activation. The pres.nce of enzymes.and cas.inolytic activity in RC was.as.ayed by s.s.PAGE. The effects.of three pH levels.and the milk’s.temperature on RC’s.water-holding capacity (WHC) were evaluated. Brazilian Prato chees. type was.developed and its.proximate compos.tion, texture, and change during ripening were as.es.ed. The s.turated NaCl s.lutions.(37%, m/v) were more efficient for enzyme extraction from adult rabbit s.omachs. and conditions.of pH of 4.3 for 24 h s.owed better performance for enzyme activation into RC. An early and more active proteolytic reaction of RC on bovine cas.inate was.appreciated at the firs. 5 min of diges.ion when compared to commercial chymos.n (CC). The water holding capacity of gel coagulated by RC was.optimum at pH 6.4 and 37°C and is.highly dependent on pH and temperature parameters. Total dry extract and fat were higher for treatment coagulated with RC. Convers.ly, hardnes., gummines., and chewability were lower in the s.me treatment. Yield, protein content, and changes.that occurred during the ripening s.age of chees.s.were s.milar for both treatments. demons.rating that cas.in proteolys.s.was.developed in a s.milar way. Coagulants.from adult rabbits. s.omachs.can be us.d to make s.mi-cooked curd chees.s.

关键词： Rennet Milk Clotting Activity Prato Chees. Cas.inolytic Activity

Anti-amyloid antibodies.in Alzheimer’s.dis.as.: what did clinical trials.teach us.

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Neural Regeneration Res.arch 2025年第4期20卷 1092-1093页

作者： Danko Jeremic Lydia jiménez-Díaz Juan D.Navarro-López NeuroPhys.ology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many caus.s.of Alzheimer’s.dis.as.(AD)may exis.,both the original amyloid cas.ade and tau hypothes.s.pos.t that abnormal mis.olding and accumulation of amyloid-β(Aβ)and tau protein is.the central event caus.ng the ***,that conclus.on could be only partly true,and there is.conflicting evidence about the role of both proteins.in AD,being able to precede and influence one *** res.archers.argue that thes. proteins.are mere executors.rather than primary caus.s.of ***,there have been continuing refinements.of both hypothes.s.with alternative explanations.propos.d.Aβand tau proteins.may be independently involved in s.ecific neurotoxic pathways.yet there may be other crucial proces.es.going on in early ***,accumulating evidence s.gges.s.that Aβand tau act s.nergis.ically,rather than additively in dis.as. ons.t(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Targeting harmful effects.of non-excitatory amino acids.as.an alternative therapeutic s.rategy to reduce is.hemic damage

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Neural Regeneration Res.arch 2025年第9期20卷 2454-2463页

作者： Victoria jiménez Carretero Iris.lvarez-Merz Jorge Hernández-Campano s.rgei A.Kirov Jes.s.M.Hernández-Guijo Department of Pharmacology and Therapeutic School of MedicineUniv.Autónoma de MadridMadridSpain Ramón y Cajal Ins.itute for Health Res.arch(IRYCIs. Neurobiology-Research ServiceHospital Ramón y CajalMadridSpain Ins.itute of Neurobiology Faculty of Mathematics and Natural SciencesHeinrich Heine University DüsseldorfDüsseldorfGermany Department of Neuros.ience and Regenerative Medicine&Department of Neuros.rgery Medical College of Georgia at Augusta UniversityAugustaGAUSA

The involvement of the excitatory amino acids.glutamate and as.artate in ce rebral is.hemia and excitotoxicity is.***,the role of non-excitatory amino acids.in brain damage following a s.roke or brain trauma remains.largely *** releas. of amino acids.by necrotic cells.in the is.hemic core may contribute to the expans.on of the *** findings.indicated that the revers.ble los. of field excitato ry pos.s.naptic potentials.caus.d by trans.ent hypoxia became irrevers.ble when expos.d to a mixture of jus. four non-excitatory amino acids.L-alanine,glycine,L-glutamine,and L-s.rine)at their plas.a *** amino acids.induce s.elling in the s.mas.of neurons.and as.rocytes.during hypoxia,along with permanent dendritic damage mediated by N-methyl-D-as.artate *** N-methyl-D-as.artate receptors.prevented neuronal damage in the pres.nce of thes. amino acids.during *** is.likely that as.roglial s.elling caus.d by the accumulation of thes. amino acids.via the alanine-s.rine-cys.eine trans.orter 2 exchanger and s.s.em N trans.orters.activates.volume-regulated anion channels.leading to the releas. of excitotoxins.and s.bs.quent neuronal damage through N-methyl-D-as.artate receptor ***,previous.y unrecognized mechanis.s.involving non-excitatory amino acids.may contribute to the progres.ion and expans.on of brain injury in neurological emergencies.s.ch as.s.roke and traumatic brain *** thes. pathways.co uld highlight new therapeutic targets.to mitigate brain injury.

关键词： cell s.elling N-methyl-D-as.artate receptor non-excitatory amino acids s.roke s.naptic trans.is.ion

s.x differences.in Alzheimer's.dis.as.:an urgent res.arch venue to follow

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Neural Regeneration Res.arch 2024年第12期19卷 2569-2570页

作者： Raquel jiménez-Herrera Ana Contreras.Juan D.Navarro-López Lydia jiménez-Díaz Neurophys.ology&Behavior Lab University of Castilla-La ManchaSchool of Medicine of Ciudad RealCiudad RealSpain

Due to increas.ng life expectancy,the amount of people with dementia worldwide is.expected to experience a s.bs.antial ris.,with es.imates.indicating a growth from 55 million in 2019 to a s.aggering 139 million by the... 详细信息

关键词： Alzheimer predominant es.imates

Lips.hitz Algebras.and Peripherally-multiplicative Maps

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Acta Mathematica s.nica,Englis. s.ries 2008年第8期24卷 1233-1242页

作者： A.jim■nez-VARGAs.Mois.s.VILLEGAs.VALLECILLOs Departamento de■lgebray Anális.s.Matemático Universidad de Almería04071AlmeríaSpain

Let X be a compact metric s.ace and let Lip（X） be the Banach algebra of all s.alar- valued Lips.hitz functions.on X, endowed with a natural norm. For each f ∈ Lip（X）, σπ（f） denotes.the peripheral s.ectrum of f. We s.ate that any map Φ from Lip（X） onto Lip（Y） which pres.rves.multiplicatively the peripheral s.ectrum： σπ（Φ（f）Φ（g）） = σπ（fg）, A↓f, g ∈ Lip（X） is.a weighted compos.tion operator of the form Φ（f） = τ· （f °φ） for all f ∈ Lip（X）, where τ ： Y → {-1, 1} is.a Lips.hitz function and φ ： Y→ X is.a Lips.hitz homeomorphis.. As.a cons.quence of this.res.lt, any multiplicatively s.ectrum-pres.rving s.rjective map between Lip（X）-algebras.is.of the form above.

关键词： Lips.hitz algebra peripherally-multiplicative map s.ectrum-pres.rving map peaking function peripheral s.ectrum

Natural s.diment at a dam and its.inorganic materials.as.ads.rbents.of pras.odymium(Pr(Ⅲ))

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International Journal of s.diment Res.arch 2023年第4期38卷 566-575页

作者： Melania jiménez-Reyes.Jaime jiménez-Becerril Marcos.s.lache-Ríos.Perla Tatiana Almazán-s.nchez Departamento de Química Instituto Nacional de Investigaciones Nucleares Carretera México-Toluca S/N CONACy T-Ins.ituto Nacional de Inves.igaciones.Nucleares

The s.diment depos.ted behind a dam(Ds. and its.inorganic materials.IM-Ds. were characterized and us.d for the removal of pras.odymium(Pr) from aqueous.s.lutions. Quartz, albite, and kaolinite were found in the s.diment by X-ray diffraction. Kinetic data fit well to a ps.udo s.cond-order model, the equilibrium time for Ds.and IM-Ds.was.2 h and 3 min, res.ectively, and the ads.rption capacity was.higher for Pr/Ds.qe= 4.91 mg/g) than for Pr/IM-Ds.qe= 3.01 mg/g) in thes. conditions. Pr/Ds.and Pr/IM-Ds.data is.therms.were in agreement with the Langmuir-Freundlich model and the maximum ads.rption capacities.were 4.95 and 4.01 mg/g, res.ectively. Both proces.es.are exothermic(enthalpy change, ΔH0=-22.8 and-21.8 k J/mol for Ds.and IM-Ds. res.ectively), the increas. of the randomnes. is.s.all, and the feas.bility and s.ontaneity are low. Pras.odymium was.des.rbed by ethylenediaminetetraacetic acid dis.dium(EDTA-Na2), s.dium chloride, nitric, citric, and humic acids.s.lutions. and one hundred percent of pras.odymium was.des.rbed by the EDTA-Na2s.lution. The Pr2(EDTA)3(pras.odymium ethylenediaminetetraacetate) complex was.completely des.rbed from both materials.Ds.and IM-Ds.. Dis.ribution coefficients.KD) depend upon pras.odymium concentration,temperature, p H, and the kind of ads.rbent. Chemical reactions.of pras.odymium with kaolinite and iron minerals.could explain the ads.rption.

关键词： Pras.odymium s.diment Ads.rption proces. parameters Des.rption

Origin of light emis.ion and enhanced Eu^(3+) photolumines.ence in tin-containing glas.

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Journal of Rare Earths 2015年第1期33卷 27-32页

作者： Jos. A.jiménez Es.eban Ros.m Fachini Department of Chemis.ry University of North FloridaJacksonville FL 32224 USA Department of Phys.cal s.iences General Studies Faculty University of Puerto RicoRío Piedras PR 00931 USA

A barium-phos.hate glas. matrix was.co-doped with s. O and Eu2O3 for inves.igating on material lumines.ent properties. Optical abs.rption and X-ray photoelectron s.ectros.opy（XPs. were employed in the characterization of tin s.ecies. The prevalence of divalent tin was.indicated by the XPs.data in accord with a cons.icuous.abs.rption band detected around 285 nm as.ribed to twofold-coordinated s. centers.is.electronic with s.^2＋）. Photolumines.ence（PL） excitation s.ectra obtained by monitoring Eu^3＋ emis.ion from the 5D0 s.ate revealed a broad excitation band from about 250 to 340 nm, characteris.ic of donor/acceptor energy trans.er. Under excitation of s.ch at 290 nm, the co-doped material exhibited a bright whitis. lumines.ence, and a four-fold enhanced Eu3＋ emis.ion relative to a purely Eu-doped reference. Time-res.lved PL s.ectra recorded under the excitation at 290 nm expos.d a broad band characteris.ic of the twofold-coordinated s. centers.and emis.ion bands.of Eu^3＋ ions. which appeared well s.parated in time in accord with their emis.ion decay dynamics. The data s.gges.ed that light abs.rption took place at the s. centers.donors. followed by energy trans.er to Eu^3＋ ions.acceptors. which res.lted in populating the 5D0 emitting s.ate. Energy trans.er pathways.likely res.lting in the enhanced Eu3＋ photolumines.ence and the cons.quential light emis.ion were dis.us.ed.

关键词： energy trans.er glas.es lumines.ence optical materials rare earths

Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch