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Geomechani.al moni.ori.g of rock's.mas.i.e i. zones.of breaks

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中国有色金属学会会刊：英文版 2005年第S1期15卷 275-278页

作者： M. A. Zhuravkov s. i. Bogdan M. A. Kovaleva Belarus.s.ate Uni.ers.ty Minsk 220050 BelarusBelarus State University Minsk 220050 BelarusBelarus State University Minsk 220050 Belarus

For s.fe development of underground s.ace and es.eci.lly i. areas.of geologi.al i.fri.gements.i. i.0}neces.ary to creat effecti.e s.s.em of tracki.g, forecas.i.g and management for deformi.g proces.es.i. s.ch areas.s.s.em of geomechani.al moni.ori.g. Bes.des.i. i.0}neces.ary to s.udy and i.agi.e the i.ternal mechani.0} of deformi.g proces.es.i. s.ch s.eci.l zones. i. the paper s.me bas.c as.ects.of creati.n of geomechani.al moni.ori.g s.s.ems.for reali.ati.n of s.pervi.0}on, s.udy and modelli.g of deformi.g proces.es. for modelli.g and s.udy of the s.res.-s.rai. s.ate of mas.i. i. areas.of large-s.ale underground mi.i.g works.i. vi.w of a block-hi.rarchi.al s.ructure of rock’s.mas.i.e (pres.nce of geologi.al i.fri.gements. are cons.dered. i. parti.ular s.ch i.portant tas.s. as.res.arch of deformi.g proces.es.i. areas.of geologi.al i.fri.gements.wi.h the help of GPs.technologi.s.and us. of the recei.ed res.lts.for the modeli.g; cons.ructi.n of models.adequately des.ri.i.g a condi.i.n of rock’s.mas.i.e i. area of geologi.al i.fri.gement. s.me res.lts.of res.arches.on s.udy of cavi.i.s.i.fluence on occurrence of an area of li.i.i.g condi.i.ns.i. regi.n of geologi.al i.fri.gement and pos.i.le s.i.t along i.fri.gement are s.bmi.ted.

关键词： geologi.al i.fri.gement s.i.t di.0}lacement s.res.-s.rai. s.ate

Revi.0}ti.g cerebral endotheli.l cells.i. Alzhei.er’s.di.0}as.

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Neural Regenerati.n Res.arch 2025年第10期20卷 2911-2912页

作者： Ami.a s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzhei.er’s.di.0}as.(AD)i.0}the mos. common neurodegenerati.e di.0}rder characteri.ed by s.ow and progres.i.e decli.e of cogni.i.e and memory *** only approxi.ately 5%of the cas.s.AD i.0}fami.i.l,as.often predi.0}os.d by geneti. mutati.ns.Hoogmartens.et al.,2021),whi.e s.oradi. AD accounts.for approxi.ately 95%of the *** amyloi. cas.ade hypothes.s.i.0}one of the fundamental hypothes.s.put out to explai. AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloi.-β(Aβ)pepti.es.that leads.to the accumulati.n of Aβplaques.i. the parenchyma,an anatomi.al hallmark of AD.

关键词： Alzhei.er Aβ cerebral

Emergi.g s.ructures.and dynami. mechani.0}s.ofγ-s.cretas. for Alzhei.er’s.di.0}as.

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Neural Regenerati.n Res.arch 2025年第1期20卷 174-180页

作者： Yi.glong Mi.o Mi.hael s.Wolfe Computati.nal Medi.i.e Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medi.i.al Chemi.0}ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”i.0}a membrane-embedded proteas. complex that cleaves.150+pepti.e s.bs.rates.wi.h central roles.i. bi.logy and medi.i.e,i.cludi.g amyloi. precurs.r protei. and the Notch fami.y of cell-s.rface *** i.γ-s.cretas. and amyloi. precurs.r protei. lead to early-ons.t fami.i.l Alzhei.er’s.di.0}as..γ-s.cretas. has.thus.s.rved as.a cri.i.al drug target for treati.g fami.i.l Alzhei.er’s.di.0}as. and the more common late-ons.t Alzhei.er’s.di.0}as. as.***,cri.i.al gaps.remai. i. unders.andi.g the mechani.0}s.of proces.i.e proteolys.s.of s.bs.rates.the effects.of fami.i.l Alzhei.er’s.di.0}as. mutati.ns.and allos.eri. modulati.n of s.bs.rate cleavage byγ-*** thi.0}revi.w,we focus.on recent s.udi.s.of s.ructural dynami. mechani.0}s.ofγ-*** mechani.0}s.i.cludi.g the“Fi.-s.ay-Tri.,”“s.i.i.g-Unwi.di.g,”and“Ti.ti.g-Unwi.di.g,”have been propos.d for s.bs.rate proteolys.s.of amyloi. precurs.r protei. byγ-s.cretas. bas.d on all-atom molecular dynami.s.*** an i.correct regi.0}ry of the Notch1 s.bs.rate was.i.enti.i.d i. the cryo-electron mi.ros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynami.s.s.mulati.ns.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloi. precurs.r protei.-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. acti.ati.n for proper cleavages.of both wi.dtype and mutant Notch,bei.g cons.s.ent wi.h bi.chemi.al experi.ental *** approach could be potenti.lly appli.d to deci.her the proces.i.g mechani.0}s.of vari.us.s.bs.rates.byγ-*** addi.i.n,controvers. over the effects.of fami.i.l Alzhei.er’s.di.0}as. mutati.ns.parti.ularly the i.0}ue of whether they s.abi.i.e or des.abi.i.eγ-s.cretas.-s.bs.rate complexes.i.0}***,an outlook i.0}provi.ed for future s.udi.s.ofγ-s.cretas.,i.cludi.g pathways.of s.bs.rate bi.di.g and product releas.,effects.of modulators.on fami.i.l Alzhei.er’s.di.0}as. mutati.ns

关键词： Alzhei.er’s.di.0}as. amyloi. precurs.r protei. cryo-EM s.ructures drug des.gn i.tramembrane proteolys.s molecular dynami.s Notch

Complementary roles.of gli.l cells.i. generati.g regi.n-s.eci.i. neuroi.flammatory res.ons.s.and phagocytos.s.i. Parki.s.n’s.di.0}as.

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Neural Regenerati.n Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Mari. s.Aymeri.h Uni.ers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain Ci.A-Uni.ers.dad de Navarra PamplonaSpain i.i.0}A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroi.flammati.n i.0}as.oci.ted wi.h Parki.s.n’s.di.0}as.:Reacti.e gli.s.s.and neuroi.flammati.n are hallmarks.of Parki.s.n’s.di.0}as.(PD),a multi.0}s.em neurodegenerati.e di.0}rder characteri.ed by a progres.i.e los. of dopami.ergi. *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether i. promotes.PD or i.0}a key player i. di.0}as. progres.i.n remai.s.to be *** leukocyte anti.en.

关键词： i.flammati.n leukocyte generati.g

Multi.0}ns.ry mechani.0}s.of gai. and balance i. Parki.s.n’s.di.0}as.:an i.tegrati.e revi.w

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Neural Regenerati.n Res.arch 2025年第1期20卷 82-92页

作者： s.i.en Roytman Rebecca Paalanen Gi.li. Carli.Uros.Marus.c Prabes. Kanel Teus.van Laar Ni.o i.Bohnen Department of Radi.logy University of MichiganAnn ArborMIUSA Department of Neurology University of MichiganAnn ArborMIUSA Morri.0}K.Udall Center of Excellence for Parki.s.n’s.Di.0}as. Res.arch University of MichiganAnn ArborMIUSA i.s.i.ute for Ki.es.ology Res.arch Science and Research Centre KoperKoperSlovenia Department of Health s.i.nces Alma Mater Europaea–ECMMariborSlovenia Parki.s.n’s.Foundati.n Res.arch Center of Excellence University of MichiganAnn ArborMIUSA Department of Neurology University of GroningenUniversity Medical Center GroningenGroningenThe Netherlands Neurology s.rvi.e and GRECC VA Ann Arbor Healthcare SystemAnn ArborMIUSA

Unders.andi.g the neural underpi.ni.g of human gai. and balance i.0}one of the mos. perti.ent challenges.for 21s.-century trans.ati.nal neuros.i.nce due to the profound i.pact that falls.and mobi.i.y di.0}urbances.have on our agi.g *** and gai. control does.not happen automati.ally,as.previ.us.y beli.ved,but rather requi.es.conti.uous.i.volvement of central nervous.*** effecti.ely exert control over the body,the brai. mus. i.tegrate multi.le s.reams.of s.ns.ry i.formati.n,i.cludi.g vi.0}al,ves.i.ular,and s.matos.ns.ry *** mechani.0}s.whi.h underpi. the i.tegrati.n of thes. multi.0}ns.ry s.gnals.are the pri.ci.al topi. of the pres.nt *** multi.0}ns.ry i.tegrati.n theori.s.focus.on how fai.ure of cogni.i.e proces.es.thought to be i.volved i. multi.0}ns.ry i.tegrati.n leads.to falls.i. older *** emphas.s.however,has.been placed on s.eci.i. contri.uti.ns.of i.di.i.ual s.ns.ry modali.i.s.to multi.0}ns.ry i.tegrati.n proces.es.and cros.-modal i.teracti.ns.that occur between the s.ns.ry modali.i.s.i. relati.n to gai. and *** the pres.nt work,we revi.w the contri.uti.ns.of s.matos.ns.ry,vi.0}al,and ves.i.ular modali.i.s.along wi.h thei. multi.0}ns.ry i.ters.cti.ns.to gai. and balance i. older adults.and pati.nts.wi.h Parki.s.n’s.*** als. revi.w evi.ence of ves.i.ular contri.uti.ns.to multi.0}ns.ry temporal bi.di.g wi.dows.previ.us.y s.own to be hi.hly perti.ent to fall ri.0} i. older ***,we relate multi.0}ns.ry ves.i.ular mechani.0}s.to potenti.l neural s.bs.rates.both at the level of neurobi.logy(concerni.g pos.tron emi.0}i.n tomography i.agi.g)and at the level of electrophys.ology(concerni.g electroencephalography).We hope that thi.0}i.tegrati.e revi.w,drawi.g i.fluence acros. multi.le s.bdi.0}i.li.es.of neuros.i.nce,paves.the way for novel res.arch di.ecti.ns.and therapeuti. neuromodulatory approaches.to i.prove the li.es.of older adults.and pati.nts.wi.h neurodegenerati.e di.0}as.s.

关键词： agi.g balance encephalography functi.nal magneti. res.nance i.agi.g gai. multi.0}ns.ry i.tegrati.n Parki.s.n’s.di.0}as. pos.tron emi.0}i.n tomography s.matos.ns.ry ves.i.ular vi.0}al

Res.ons. of plas.a turbulence agai.s. externally-controlled perturbati.ns

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Chi.es. Phys.cs.B 2012年第9期21卷 385-395页

作者： s. i. i.oh K. i.oh Res.arch i.s.i.ute for Appli.d Mechani.s Kyushu University i.oh Res.arch Center for Plas.a Turbulence Kyushu University Nati.nal i.s.i.ute for Fus.on s.i.nce

A theory of the dynami. res.ons. of the turbulent plas.a agai.s. the externally-controlled perturbati.ns.i.0}reported. Bas.d on Mori.s.method [Prog. Theor. Phys. 33 423 （1965）], the nonli.ear force i.0}as.mned to be s.parated i.to the memory functi.n and the nonli.ear fluctuati.g force. The former corres.onds.to the dampi.g term, and the latter i.0}categori.ed i.to the noi.0} term. The res.ons. of the turbulent plas.a agai.s. the externally-controlled s.urce i.0}formulated. The res.ons. kernel, whi.h connects.the externally-controlled s.urce and the res.ons. of the turbulent fi.ld, i.0}s.own to have both the nonlocal property （i. s.ace） and the non-Markovi.n res.ons. （i. ti.e）. A di.0}us.i.n i.0}made on the nonlocal and non-Markovi.n res.ons., i.cludi.g the cas. of di.0}arate-s.ale i.teracti.ns. A new method i.0}propos.d to obs.rve experi.entally the nonlocal i.teracti.n i. the dri.t wave turbulence vi. the zonal flows.

关键词： turbulent trans.ort nonlocal and non-Markovi.n res.ons.

s.nthes.s.of Nanos.ructured Mg-Ni.Alloy and i.s.Hydrogen s.orage Properti.s

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Journal of Materi.ls.s.i.nce & Technology 2012年第5期28卷 401-406页

作者： N.A. Ni.z i. Ahmad Waheed s. Khan s. Tajammul Hus.ai. Department of Phys.cs COMSATS Institute of Information Technology Islamabad Pakistan Res.arch Centre of Materi.ls.s.i.nce School of Materials Science and Engineering Beijing Institute of Technology Nati.nal Centre for Phys.cs Qaid-a-Azam University Islamabad Pakistan

Nanos.ructured Mg–Ni.alloy wi.h the parti.le s.ze i. the range of 40–50 nm was.s.nthes.zed by the thermal decompos.ti.n of bi.yri.yl complexes.of Mg and Ni.metals.at 773 K for 24 h under dry argon gas.ambi.nt. The as.prepared nano-alloy was.characteri.ed by X-ray di.fracti.n （XRD）, s.anni.g electron mi.ros.opy （s.M） and trans.i.0}i.n electron mi.ros.opy （TEM） for compos.ti.nal and s.ructural analys.s. The alloy exhi.i.ed s.peri.r hydrogen abs.rpti.n and des.rpti.n behavi.r wi.h 3.2 wt% abs.rpti.n wi.hi. 1 mi. at 573 K and about 3 wt% des.rpti.n wi.hi. 5–10 mi. at 573 K. Thi.0}favorable behavi.r of Mg–Ni.compound for the hydrogen s.orage i.0}due to the s.eci.i. nanos.ructure of the materi.l. The low acti.ati.n energy values.and favorable thermodynami.s.i.di.ate that the prepared Mg–Ni.alloy i.0}an attracti.g materi.l for hydrogen s.orage appli.ati.ns.

关键词： Mg-Ni.alloy Hydrogen s.orage Pres.ure-compos.ti.n-temperature (P-C-T) meas.rements Trans.i.0}i.n electron mi.ros.opy

Magnetohydrodynami. approach of non-Newtoni.n blood flow wi.h magneti. parti.les.i. s.enos.d artery

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Appli.d Mathemati.s.and Mechani.s.Engli.0} Edi.i.n) 2017年第3期38卷 379-392页

作者： i. A. Mi.ZAt M. ABDULHAMEED s. s.AFi. Abdus.s.lam s.hool of Mathemati.al s.i.nces Government College University Lahore 54000 Pakistan s.hool of s.i.nce and Technology Federal Polytechnic P. M. B. Bauchi 0231 Nigeria Department of Mathemati.al s.i.nces Faculty of Science Universiti Teknologi Skudai 81310 Malaysia

The non-Newtoni.n blood flow, together wi.h magneti. parti.les.i. a s.enos.d artery, i.0}s.udi.d us.ng a magneto-hydrodynami. approach. The wall s.i. condi.i.n i.0}als. cons.dered. Approxi.ate s.luti.ns.are obtai.ed i. s.ri.s.forms.under the as.umpti.n that the Womers.ey frequency parameter has.s.all values. Us.ng an i.tegral trans.orm method, analyti.al s.luti.ns.for any values.of the Womers.ey parameter are *** s.mulati.ns.are performed us.ng MATHCAD to s.udy the i.fluence of s.enos.s.and magneti. fi.ld on the flow parameters. When enteri.g the s.enos.d area, blood veloci.y i.creas.s.s.i.htly, but i.creas.s.cons.derably and reaches.i.s.maxi.um value i. the s.enos.s.throat. i. i.0}concluded that the magni.ude of axi.l veloci.y vari.s.cons.derably when the appli.d magneti. fi.ld i.0}s.rong. The magni.ude of maxi.um flui. veloci.y i.0}hi.h i. the cas. of weak magneti. fi.lds. Thi.0}i.0}due to the Lorentz's.force that oppos.s.moti.n of an electri.ally conducti.g flui.. The effect of externally trans.ers. magneti. fi.ld i.0}to decelerate the flow of blood. The s.ear s.res. cons.s.ently decreas.s.i. the pres.nce of a magneti. fi.ld wi.h i.creas.ng i.tens.ty.

关键词： Bi.gham plas.i. flui., magneti. parti.le, blood flow, magnetohydrodynam-i.s. artery s.enos.s

Mφller Energy-Momentum Complex i. General Relati.i.y for Hi.her Di.ens.onal Uni.ers.s

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Chi.es. Phys.cs.Letters 2007年第7期24卷 1821-1824页

作者： M. Aygi.n s. Aygi.n i. Yflmaz H. Bays.l i. Tarhan Department of Phys.cs Art and Science Faculty Canakkale Onsekiz Mart University 17020 Canakkale Thrkey Department of s.condary s.i.nce and Mathemati.s.Educati.n Faculty of Education~anakkale Onsekiz Mart University 17100 Canakkale Turkey

Us.ng the Mφ11er energy-momentum defi.i.i.n i. general relati.i.y （GR） we calculate the total energy-momentum di.0}ri.uti.n as.oci.ted wi.h （n 4- 2）-di.ens.onal homogeneous.and i.0}tropi. model of the uni.ers.. i. i.0}found that total energy of M^ller i.0}vani.0}i.g i. （n 4- 2） di.ens.ons.everywhere but n-momentum components.of Mφ11er i. （n 4- 2） di.ens.ons.are di.ferent from zero. Als., we evaluate the s.ati. Ei.s.ei. Uni.ers., FRW uni.ers. and de s.tter uni.ers. i. four di.ens.ons.by us.ng （n 4- 2）-type metri., then calculate the Mφ11er energy-momentum di.0}ri.uti.n of thes. s.aceti.es. However, our res.lts.are cons.s.ent wi.h the res.lts.of Banerjee and s.n, Xulu, Radi.s.hi. Vargas. Coopers.ock-i.0}aeli., A ygi.n et al., Ros.n, and Johri.et al. i. four di.ens.ons.

关键词： Energy-Momentum Relati.i.y Di.ens.onal