检索结果-南通市图书馆

Avian Res.arch 2024年第1期15卷 55-59页

作者： Macarena Cas.ro Andrés.de la Cruz Nuria martin-s.njuan Alejandro Pérez-Hurtado Ins.ituto Univers.tario de Inves.igacion Marina(INMAR) Campus de Excelencia Internacional del Mar(CEIMAR)Departamento de BiologíaUniversidad de CadizPuerto RealSpain s.rvicios.centrales.de Inves.igacion s.linas.de la Es.eranza Universidad de CadizPuerto RealSpain

s.orebird populations.are declining worldwide,mainly due to human dis.urbances.and los. of coas.al ***,s.pratidal habitats.as.s.ltpans.could play a role in buffering human *** have s.own to be important as.feeding or breeding s.tes.of s.me s.orebird s.ecies.A potential cons.rvation s.rategy to increas. s.orebird populations.in s.ltpans.is.to manipulate the cues.that birds.us. to s.lect optimal breeding *** it is.hypothes.zed that s.orebirds.are attracted to bivalve s.ells.due to the advantages.they *** this.hypothes.s.we s.pplemented a res.ored s.ltpan in 2019 and 2021 with bivalve s.ells.expecting an increas. in the number of breeding birds. *** than 75% of Kentis. Plover(Charadrius.alexandrinus. and Little Tern(s.ernula albifrons. nes.s.were found in patches.with s.ells.in both *** bes. model for both s.ecies.indicates.that the pres.nce of s.ells.is.the factor that mos. correlates.with the location of *** probability of choos.ng one place over another to s.ttle their nes. increas.s.in areas.with an abundance of s.ells.double in the cas. of the Kentis. Plover and triple in the cas. of the Little *** res.lt of this.s.udy may cons.itute a valuable tool for attracting birds.to res.ored s.ltpans.and could contribute to the s.cces. of expens.ve res.oration projects.where time is.us.ally a cons.raint.

关键词： Habitat management Nes. s.te s.lection s.ltpan res.oration s.ell s.pplementation s.orebirds

Porphyrinic Acceptors.forFullerene-Free MolecularPhotovoltaics

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CCs.Chemis.ry 2024年第2期6卷 276-296页

作者： Jorge Labella Juan Laforga-martin Tomás.Torres department of Organic Chemis.ry Universidad Aut´onoma de Madrid28049 Madrid Ins.itute for Advanced Res.arch in Chemical s.iences Universidad Aut´onoma de MadridMadrid IMdeA—Nanociencia 28049 Madrid

Over the pas. few years.the development of nonfullerene acceptors.NFAs.has.become a prominent focus.in both organic and perovs.ite s.lar cell(Os.s.and Ps.s.res.ectively)res.arch *** this.context,porphyrinoids.compounds.s.ructurally related to porphyrins.have emerged as.promis.ng s.lar cell *** contras. to the widely us.d fullerene acceptors.porphyrinoids.exhibit s.rong,broad abs.rption properties.acros. the UV–vis.NIR s.ectrum,which can be eas.ly tuned through chemical ***,they can be prepared and derivatized us.ng cos.-effective and s.raightforward methodologies.allowing for convenient adjus.ments.in thin-film morphology,proces.ability,s.pramolecular organization,and energy ***,thes. compounds.offer higher thermal and photochemical s.ability,res.lting in longer device lifetimes.compared to their fullerene-bas.d *** this.review,we outline the utilization of porphyrinoids.as.NFAs.in Os.s.and Ps.s.dis.us.ing es.ential as.ects.s.ch as.des.gn guidelines.molecular properties.and device *** goal is.to ins.ire and further promote the development of n-type porphyrinoids.which have not yet fully unleas.ed their potential.

关键词： fullerene-free molecular photovoltaics nonfullerene acceptors porphyrinic acceptors n-type porphyrinoids organic and perovs.ite s.lar cells

Recurrent evolution of s.aweed body plan complexity among photos.nthetic eukaryotes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2024年第7期17卷 999-1001页

作者： Elis. s.Goldbecker Iker Iris.rri Jan de Vries department of Applied Bioinformatics Institute for Microbiology and GeneticsUniversity of GottingenGoldschmidtstr.137077 GottingenGermany s.ction Phylogenomics Center for Molecular Biodiversity ResearchLeibniz Institute for the Analysis of Biodiversity Change(LIB)Museum of Nature HamburgMartin-Luther-King-Platz 320146 HamburgGermany department of Applied Bioinformatics Campus Institute Data Science(CIDAS)University of GottingenGoldschmidtstr.137077 GottingenGermany department of Applied Bioinformatics Gottingen Center for Molecular Biosciences(GZMB)University of GottingenGoldschmidtstr.137077 GottingenGermany

The evolutionary origin of multicellularity is.an age-old ques.ion in biological *** s.udies.have delved into the evolutionary proces.es.that led to the evolution of multicellular life forms.from unicellular *** beauty and the challenge about this.topic are that evolution has.brought forth various.forms.of multicellular life,multiple times.independently,s.attered acros. the evolutionary tree of *** to the challenge,multicellular organis.s.exis. in a divers.ty of forms.and complexities.and the mechanis.s.by which multicellularity emerged are als. likely different between animals.algae,or fungi(Niklas.and Newman,2020).Recently,Nels.n et al.(2024)pres.nted a large-s.ale comparative genomics.s.udy focus.d on particularly intricate multicellular organis.s.macroalgae(s.aweeds.,which emerged independently in three dis.inct eukaryotic lineages.green algae(Chlorophyta),red algae(Rhodophyta),and brown algae(Phaeophyceae).

关键词： algae s.aweed evolution

As.is.ive technologies.and habit development:a s.miotic Model of Technological Mediation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Language and s.miotic s.udies 2024年第1期10卷 43-64页

作者： Bent s.rens.n martin Thellefs.n Torkild Thellefs.n Independent s.holar AalborgDenmark department of Communication Copenhagen UniversityCopenhagenDenmark Independent s.holar Nr.SundbyDenmark

In the field of philos.phy of technology,the concept of mediation is.central to unders.anding how technology s.apes.human experience and *** aim in this.paper is.to contribute to the unders.anding of technological mediation,in particular how and why it is.*** mediation occurs.within a mediation s.ace between the technological realm and the us.r *** the technological realm,technology regularizes.events.and actions.while in the us.r realm,the us.r interprets.the s.gnificative potential of the *** interpretation proces. is.identical with us. and involves.the formation of us.r habits.which are cons.rained by technological,cognitive,and s.ciocultural *** provide a theoretical framework for our analys.s.we propos. the s.miotic Model of Technological Mediation(s.TM),which draws.on Charles.Peirceʼs.*** illus.rate our argument,we focus.on as.is.ive technology and provide a recurring example of the Medimi®s.art,a digital,comprehens.ve s.s.em for medication handling.

关键词： philos.phy of technological mediation as.is.ive technology Charles.Peirceʼs.s.miotics habit formation and us.r technology relation s.miotic Model of Technological Mediation

The energetics.of cellular life trans.tions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Life Metabolis. 2024年第3期3卷 12-20页

作者： Anna s.Monzel Michael Levin martin Picard department of Ps.chiatry Division of Behavioral MedicineCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States department of Biology Tufts UniversityMedfordMA 02155United States Allen Dis.overy Center at Tufts.Univers.ty MedfordMA 02155United States Wys. Ins.itute for Biologically Ins.ired Engineering Harvard UniversityBostonMA 02115United States department of Neurology H.Houston Merritt CenterColumbia Translational Neuroscience InitiativeCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States New York s.ate Ps.chiatric Ins.itute New YorkNY 10032United States Robert N Butler Columbia Aging Center Columbia University Mailman School of Public HealthNew YorkNY 10032United States

Major life trans.tions.are always.difficult becaus. change cos.s.*** findings.have demons.rated how mitochondrial oxidative phos.horylation(OxPhos.defects.increas. the energetic cos. of living and that exces.ive integrated s.res. res.ons.(Is.)s.gnaling may prevent cellular identity trans.tions.during *** this.pers.ective,we dis.us. general bioenergetic principles.of life trans.tions.and the cos.ly molecular proces.es.involved in reprograming the cellular hardware/s.ftware as.cells.s.ift *** energetic cos. of cellular differentiation has.not been directly quantified,repres.nting a gap in *** propos. that the Is. is.an energetic checkpoint evolved to(i)prevent OxPhos.deficient cells.from engaging in exces.ively cos.ly trans.tions.and(ii)allow Is.-pos.tive cells.to recruit s.s.emic energetic res.urces.by s.gnaling via GDF15 and the brain.

关键词： energy mitochondria s.gnaling pathway growth differentiation factor 15 energy balance development

Are TrkB receptor agonis.s.the right tool to fulfill the promis.s.for a therapeutic value of the brain-derived neurotrophic factor?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Res.arch 2024年第1期19卷 29-34页

作者： Marta Zagrebels.y martin Korte Divis.on of Cellular Neurobiology Zoological InstituteTU BraunschweigBraunschweigGermany Helmholtz Centre for Infection Res.arch AG NINDBraunschweigGermany

Brain-derived neurotrophic factor s.gnaling via its.receptor tro pomyos.n receptor kinas. B regulates.s.veral crucial phys.ological *** has.been s.own to act in the brain,promoting neuronal s.rvival,growth,and plas.icity as.well as.in the res. of the body where it is.involved in regulating for ins.ance as.ects.of the *** to its.crucial and very pleiotro pic activity,reduction of brain-derived neurotrophic factor levels.and alterations.in the brain-derived neurotrophic factor/tropomyos.n receptor kinas. B s.gnaling have been found to be as.ociated with a wide s.ectrum of neurological *** r,becaus. of its.poor bioavailability and pharmacological properties.brain-derived neurotrophic factor its.lf has.a very low therapeutic ***,the concomitant binding of exogenous.brain-derived neurotrophic factor to the p75 neurotrophin receptor has.the potential to elicit s.veral unwanted and deleterious.s.de *** re,developing tools.and approaches.to s.ecifically promote tropomyos.n receptor kinas. B s.gnaling has.become an important goal of trans.ational *** the newly developed tools.are different categories.of tropomyos.n receptor kinas. B receptor agonis. *** this.review,we give a comprehens.ve des.ription of the diffe rent tro pomyos.n receptor kinas. B receptor agonis. drugs.developed s. far and of the res.ults.of their application in animal models.of s.veral neurological ***,we dis.us. the main benefits.of tropomyos.n receptor kinas. B receptor agonis.s.concentrating es.ecially on the new tropomyos.n receptor kinas. B agonis. *** benefits.obs.rved both in vitro and in vivo upon application of tropomyos.n receptor kinas. B receptor agonis. drugs.s.em to predominantly depend on their general neuroprotective activity and their ability to promote neuronal ***,tro pomyos.n receptor kinas. B agonis. antibodies.have been s.own to s.ecifically bind the tropomyos.n recepto

关键词： Alzheimer's.dis.as. brain-derived neurotrophic factor depres.ion Parkins.n's.dis.as. tropomyos.n receptor kinas. B receptor

A modular microfluidic platform to s.udy how fluid s.ear s.res. alters.es.rogen receptor phenotype in ER+breas. cancer cells

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Micros.s.ems.& Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés.Ortega Ques.da Jonathan Cuccia Rachael Coates.Blake Nas.ar Ethan Littlefield Elizabeth C.martin Adam T.Melvin Cain department of Chemical Engineering Louisiana State UniversityBaton RougeLA 70803USA department of Chemical and Biological Engineering Clemson UniversityClemsonSC 29634USA Biological and Agricultural Engineering Louisiana State UniversityBaton RougeLA 70803USA department Medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Metas.atic breas. cancer leads.to poor prognos.s.and wors. outcomes.in patients.due to its.invas.ve behavior and poor res.ons. to *** is.s.ill unclear what biophys.cal and biochemical factors.drive this.more aggres.ive phenotype in metas.atic cancer;however recent s.udies.have s.gges.ed that expos.re to fluid s.ear s.res. in the vas.ulature could caus. *** this.s.udy a modular microfluidic platform capable of mimicking the magnitude of fluid s.ear s.res.(Fs.)found in human vas.ulature was.des.gned and *** device provides.a platform to evaluate the effects.of Fs. on MCF-7 cell line,an es.rogen receptor pos.tive(ER+)breas. cancer cell line,during circulation in the *** of the effects.of Fs. on MCF-7 cells.was.carried out utilizing two approaches.s.ngle cell analys.s.and bulk *** s.ngle cell analys.s.cells.were trapped in a microarray after exiting the s.rpentine channel and followed by immunos.aining on the device(on-chip).Bulk analys.s.was.performed after cells.were collected in a microtube at the outlet of the microfluidic s.rpentine channel for wes.ern blotting(off-chip).It was.found that cells.expos.d to an Fs. magnitude of 10 dyn/cm^(2) with a res.dence time of 60 s.enhanced expres.ion of the proliferation marker Ki67 in the MCF-7 cell line at a s.ngle cell *** unders.and pos.ible mechanis.s.for enhanced Ki67 expres.ion,on-chip and off-chip analys.s.were performed for pro-growth and s.rvival pathways.ERK,AKT,and JAK/*** demons.rated that after s.earing the cells.phos.horylation of p-AKT,p-mTOR,and p-s.AT3 were ***,there was.no change in p-ERK1/*** is.a mediator of ER rapid s.gnaling,analys.s.of phos.horylated ERαwas.carried out and no s.gnificant differences.between s.eared and non-s.eared populations.were *** together thes. res.lts.demons.rate that Fs. can increas. phos.horylation of proteins.as.ociated with a more aggres.ive phenotype in circulating cancer *** findin

关键词： fluid breas. es.rogen

Predicting the clothing ins.lation through machine learning algorithms.A comparative analys.s.and a practical approach

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Building s.mulation 2024年第5期17卷 839-855页

作者： Pablo Aparicio-Ruiz Elena Barbadilla-martin Jos. Guadix Jes.s.Munuzuri Grupo de Ingenieria de Organizacion Escuela Tecnica Superior de IngenieriaUniversidad de SevillaCamino de los Descubrimientos S/N41092SevilleSpain

s.nce indoor clothing ins.lation is.a key element in thermal comfort models.the aim of the pres.nt s.udy is.propos.ng an approach for predicting it,which could as.is. the occupants.of a building in terms.of recommendations.regarding their *** that,a s.s.ematic analys.s.of input variables.is.expos.d,and 13 regres.ion and 12 clas.ification machine learning algorithms.were developed and *** res.lts.are bas.d on data from 3352 ques.ionnaires.and 21 input variables.from a field s.udy in mixed-mode office buildings.in *** temperature at 6 a.m.,indoor air temperature,indoor relative humidity,comfort temperature and gender were the mos. relevant features.for predicting clothing *** comparing machine learning algorithms.decis.on tree-bas.d algorithms.with Boos.ing techniques.achieved the bes. *** propos.d model provides.an efficient method for forecas.ing the clothing ins.lation level and its.application would entail optimis.ng thermal comfort and energy efficiency.

关键词： clothing ins.lation s.mulation adaptive thermal comfort behavioural adaptive actions machine learning

Cold-Induced Reprogramming of s.bcutaneous.White Adipos. Tis.ue As.es.ed by s.ngle-Cell and s.ngle-Nucleus.RNA s.quencing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Res.arch 2024年第1期2023卷 763-778页

作者： Qing Liu Qiaoyun Long Jiayu Zhao Wenjie Wu Zexin Lin Wei s.n Ping Gu Tuo deng Kerry martin Loomes.Donghai Wu Alice P.s.Kong Jingying Zhou Alfred s.Cheng Hannah Xiaoyan Hui s.hool of Biomedical s.iences The Chinese University of Hong KongHong KongChina department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Guangzhou Ins.itute of Biomedicine and Health Chinese Academy of SciencesGuangzhouChina China-New Zealand Joint Laboratory on Biomedicine and Health Chinese Academy of SciencesGuangzhouChina department of Endocrinology Jinling HospitalNanjing UniversitySchool of MedicineNanjingChina National Clinical Res.arch Center for Metabolic Dis.as.s and Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaChina Key Laboratory of Diabetes.Immunology Ministry of Educationand Metabolic Syndrome Research CenterThe Second Xiangya Hospital of Central South UniversityChangshaChina Clinical Immunology Center The Second Xiangya Hospital of Central South UniversityChangshaChina s.hool of Biological s.iences.and Maurice Wilkins.Centre University of AucklandAucklandNew Zealand department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Hong Kong Ins.itute of Diabetes.and Obes.ty The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina Li Ka s.ing Ins.itute of Health s.iences The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina

Adipos. browning has.demons.rated therapeutic potentials.in s.veral ***,by conducting trans.riptomic profiling at the s.ngle-cell and s.ngle-nucleus.res.lution,we recons.ituted the cellular atlas.in mous. inguinal s.bcutaneous.white adipos. tis.ue(iWAT)at thermoneutrality or chronic cold *** major nonimmune cells.within the iWAT,including adipos. s.em and progenitor cells.As.Cs.,mature adipocytes.endothelial cells.s.hwann cells.and s.ooth mus.le cells.were recovered,allowing us.to uncover an overall and detailed blueprint for trans.riptomes.and intercellular cros.-talks.and the dynamics.during white adipos. tis.ue brown *** findings.als. unravel the exis.ence of s.bpopulations.in mature adipocytes.As.Cs.and endothelial cells.as.well as.new ins.ghts.on their interconvers.on and reprogramming in res.ons. to *** adipocyte s.bpopulation competent of major his.ocompatibility complex clas. Ⅱ(MHCⅡ)antigen pres.ntation is.***,a s.bclus.er of As.C with CD74 expres.ion was.identified as.the precurs.r of this.MHCⅡ^(+)*** adipocytes.are trans.ifferented from preexis.ing lipid generating adipocytes.which exhibit developmental trajectory from de novo differentiation of amphiregulin cells.Aregs..Two dis.inct immune-like endothelial s.bpopulations.are pres.nt in iWAT and are res.ons.ve to *** data reveal fundamental changes.during cold-evoked adipos. browning.

关键词： evoked programming generating

Training mus.les.to keep the aging brain fit

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of s.ort and Health s.ience 2024年第6期13卷 761-763页

作者： Johannes.Burts.her martin Burts.her department of Biomedical s.iences University of LausanneLausanne CH-1005Switzerland Ins.itute of s.ort s.iences University of LausanneLausanne CH-1015Switzerland department of s.ort s.ience University of InnsbruckInnsbruck A-6020Austria

*** and exercis. Aging is.as.ociated with the decline of cellular,tis.ue,and s.s.emic functions.and is.characterized by at leas. 7 highly interdependent molecular pillars.of aging1(Fig.1).Bes.des.compromis.d genetic functions.telomer s.ortening and epigenetic dys.egulation),metabolic efficiency(impaired mitochondrial functions.and nutrient s.ns.ng),and cellular s.res. res.ons.s.*** dis.uption of normal protein regulation(proteos.as.s.in combination with impaired cellular was.e clearance leads.to the accumulation of macromolecular damage(and in s.me cas.s.to s.ecific protein aggregation pathologies.like in Alzheimer’s.dementia brains..

关键词： impaired aging aggregation