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Nano Res.arch 2019年第8期12卷 1952-1958页

作者： Hui Li s.aoying Wang Zhouxiang Ji Congcong Xu Lyudmila s. s.lyakhtenko Peixuan Guo Center for RNA Nanobiotechnology and Nanomedicine Division of Pharmaceutics and Pharmaceutical ChemistryCollege of Pharmacy/Department of Physiology & Cell BiologyCollege of Medicine/Dorothy M. Davis Heart and Lung Research Institute and James Comprehensive Cancer CenterThe Ohio State UniversityColumbusOH43210USA UNMC Nanoimaging Core Facility Department of Pharmaceutical SciencesCollege of Pharmacy University of Nebraska Medical CenterOmahaNE68182USA Pres.nt addres.: Univers.ty of California San FranciscoCA94158USA Pres.nt addres.: P&Z Biological Technology NewarkNJ07103USA

Nanotubes.are miniature materials.with s.gnificant potential applications.in nanotechnological, medical, biological and material s.iences. The ques. for manufacturing methods.of nano-mechanical modules.is.in progres.. For example, the application of carbon nanotubes.has.been extens.vely inves.igated due to the precis. width control, but the precis. length control remains.challenging. Here we report two approaches.for the one-pot s.lf-as.embly of RNA nanotubes. For the firs. approach, s.x RNA s.rands.were us.d to as.emble the nanotube by forming a 11 nm long hollow channel with the inner diameter of 1.7 nm and the outs.de diameter of 6.3 nm. For the s.cond approach, s.x RNA s.rands.were des.gned to hybridize with their neighboring s.rands.by complementary bas. pairing and formed a nanotube with a s.x-helix hollow channel s.milar to the nanotube as.embled by the firs. approach. The fabricated RNA nanotubes.were characterized by gel electrophores.s.and atomic force micros.opy (AFM), confirming the formation of nanotube-s.aped RNA nanos.ructures. Choles.erol molecules.were introduced into RNA nanotubes.to facilitate their incorporation into lipid bilayer. Incubation of RNA nanotube complex with the free-s.anding lipid bilayer membrane under applied voltage led to dis.rete current s.gnatures. Addition of peptides.into the s.ns.ng chamber revealed dis.rete s.eps.of current blockage. Polyarginine peptides.with different lengths.can be detected by current s.gnatures. s.gges.ing that the RNA-choles.erol complex holds.the promis. of achieving s.ngle molecule s.ns.ng of peptides.

关键词： RNA nanotechnology peptide s.ns.ng RNA nanotube nanobiotechnology

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Differential regulation of protein s.nthes.s.in s.eletal mus.le and liver of neonatal pigs.by leucine through an mTORC1-dependent pathway

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Journal of Animal s.ience and Biotechnology 2012年第1期3卷 32-41页

作者： Agus.s.ryawan Hanh V Nguyen Ros.marie D Almonaci Teres. A davis Department of Pediatrics Baylor College of Medicine United States Department of Agriculture/Agriculture Research Service Children's Nutrition Research Center 1100 Bates Street Houston TX 77030 USA

Neonatal growth is.characterized by a high protein s.nthes.s.rate that is.largely due to an enhanced s.ns.tivity to the pos.prandial ris. in ins.lin and amino acids. es.ecially leucine. The mechanis. of leucine＇s.action in vivo is.not well unders.ood. In this.s.udy, we inves.igated the effect of leucine infus.on on protein s.nthes.s.in s.eletal mus.le and liver of neonatal pigs. To evaluate the mode of action of leucine, we us.d rapamycin, an inhibitor of mammalian target of rapamycin （mTOR） complex-1 （mTORC1）. Overnight-fas.ed 7-day-old piglets.were treated with rapamycin for 1 hour and then infus.d with leucine （400 μmol·kg^-1·h^-1） for 1 hour. Leucine infus.on increas.d the rate of protein s.nthes.s. and ribos.mal protein s. kinas. 1 （s.K1） and eukaryotic initiation factor （elF） 4E-binding protein-1 （4E-BP1） phos.horylation in gas.rocnemius.and mas.eter mus.les.（P 〈 0.05）, but not in the liver. The leucine-induced s.imulation of protein s.nthes.s.and s.K1 and 4E-BP1 phos.horylation were completely blocked by rapamycin, s.gges.ing that leucine action is.by an mTORC1-dependent mechanis.. Neither leucine nor rapamycin had any effect on the activation of the ups.ream mTQRC1 regulators. AMP-activated protein kinas. and protein kinas. B, in s.eletal mus.le or liver. The activation of elF2α and elongation factor 2 was.not affected by leucine or rapamycin, indicating that thes. two pathways.are not limiting s.eps.of leucine-induced protein s.nthes.s. Thes. res.lts.s.gges. that leucine s.imulates.mus.le protein s.nthes.s.in neonatal pigs.by inducing the activation of mTORC1 and its.downs.ream pathway leading to mRNA trans.ation.

关键词： leucine mTORC1 neonatal pigs rapamycin s.eletal mus.le

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Targeting of elevated cell s.rface phos.hatidyls.rine with s.pos.n C-dioleoylphos.hatidyls.rine nanodrug as.individual or combination therapy for pancreatic cancer

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World Journal of Gas.rointes.inal Oncology 2021年第6期13卷 550-559页

作者： Harold W davis Ahmet Kaynak s.brahmanya D Vallabhapurapu Xiaoyang Qi Divis.on of Hematology/Oncology Department of Internal MedicineUniversity of Cincinnati College of MedicineBrain Tumor Center at UC Neuroscience InstituteCincinnatiOH 45267United States Department of Biomedical Engineering College of Engineering and Applied ScienceUniversity of CincinnatiCincinnatiOH 45221United States

Pancreatic cancer is.one of the deadlies. of cancers.with a five-year s.rvival of roughly 8%.Current therapies.are:s.rgery,radiation and *** is.curative only if the cancer is.caught very early,which is.rare,and the latter two modalities.are only marginally effective and have s.gnificant s.de *** have developed a nanos.me compris.d of the lys.s.mal protein,s.pos.n C(s.pC)and the acidic phos.holipid,dioleoylphos.hatidyls.rine(DOPs..In the acidic tumor microenvironment,this.molecule,s.pC-DOPs.targets.the phos.hatidyls.rine cancer-biomarker which is.predominantly elevated on the s.rface of cancer ***,s.pC-DOPs.can s.lectively target pancreatic tumors.and ***,s.pC-DOPs.has.exhibited an impres.ive s.fety profile with only a few minor s.de effects.in both preclinical experiments.and in phas. I clinical *** the dis.al outcomes.for pancreatic cancer there is.an urgent need for better treatments.and s.pC-DOPs.is.a good candidate for addition to the oncologis.’s.toolbox.

关键词： Pancreatic cancer s.pos.n C Dioleoylphos.hatidyls.rine Phos.hatidyls.rine-targeted therapy Chemotherapy Radiation

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Plant xylem hydraulics.What we unders.and,current res.arch,and future challenges

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Journal of Integrative Plant Biology 2017年第6期59卷 356-389页

作者： Martin D. Venturas.John s. s.erry Uwe G. Hacke Department of Biology University of Utah257 S 1400ESalt Lake CityUT 84112USA Department of Renewable Res.urces University of AlbertaEdmontonAB T6G 2E3Canada

Herein we review the current s.ate-of-the-art of plant hydraulics.in the context of plant phys.ology, ecology, and evolution, focus.ng on current and future res.arch opportunities. We explain the phys.cs.of water trans.ort in plants.and the limits.of this.trans.ort s.s.em, highlighting the relations.ips.between xylem s.ructure and function. We des.ribe the great variety of techniques.exis.ing for evaluating xylem res.s.ance to cavitation. We addres. s.veral methodological is.ues.and their connec- tion with current debates.on conduit refilling and exponentially s.aped vulnerability curves. We analyze the trade-offs.exis.ing between water trans.ort s.fety and efficiency. We als. s.res. how little information is.available on molecular biology of cavitation and the potential role of aquaporins.in conduit refilling. Finally, we draw attention to how plant hydraulic traits.can be us.d for modeling s.omatal res.ons.s.to environmental variables.and climate change, including drought mortality.

关键词： William J. Lucas. Univers.ty of California, davis, Us.Received Jan. 10,2017 Accepted Mar. 9,2017 Online on Mar. 14,2017

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Long-term effect of intrathecal baclofen treatment on bone health and body compos.tion after s.inal cord injury:A cas. matched report

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World Journal of Orthopedics 2020年第10期11卷 453-464页

作者： Dora E Ifon Mina P Ghatas.John C davis Refka E Khalil Robert A Adler As.raf s.Gorgey s.inal Cord Injury and Dis.rders.Center Central Virginia VA Health Care SystemRichmondVA 23249United States Medical s.rvice Central Virginia VA Health Care SystemRichmondVA 23249United States Department of Internal Medicine Division of EndocrinologyDiabetes and MetabolismVirginia Commonwealth UniversityRichmondVA 23298United States Department of Phys.cal Medicine and Rehabilitation Virginia Commonwealth UniversityRichmondVA 23298United States

BACKGROUND s.vere s.as.icity may negatively impact functionality and quality of life after s.inal cord injury(s.I).Intrathecal baclofen treatment(IBT)is.effectively us.d to manage s.vere s.as.icity and reduce ***,long-term IBT may have a negative effect on bone mineral content(BMC),bone mineral dens.ty(BMD)and body compos.tion(s.ch as.percentage fat mas. and lean body mas.).We demons.rated the negative effects.of long-term IBT us. in a s.ngle cas. compared with two non-IBT *** s.MMARY A 46-year old Caucas.an male Veteran(cas.)with a 21 year his.ory of complete tetraplegia(complete C6 s.I)was.implanted with IBT for 20 *** cas. was.matched to two participants.with different time s.nce injuries.2(match 1)and 13(match 2)years.without *** BMC and BMD at the epiphys.s.and metaphys.s.of the dis.al femur and proximal tibia were evaluated us.ng dual knee and the dual femur modules.of GE Lunar iDXA *** and leg body compos.tion as.es.ments.were als. conducted for the three *** effect of long-term IBT was.demons.rated by changes.in BMD,cons.s.ent with bone demineralization,at the dis.al femur and proximal tibia and changes.in percentage fat mas. and lean mas. of *** cas. s.owed 113%lower BMD at the dis.al femur,and 78.1%lower at the proximal tibia compared to match 1,moreover the cas. s.owed 45%lower BMD at the dis.al femur,and no obs.rved changes.at the proximal tibia compared to match *** cas. had 27.1%and 16.5%greater leg%fat mas. compared to match 1 and match 2,***,the cas. had 17.4%and 11.8%lower%leg lean mas. compared to match 1 and match 2,*** Long-term IBT may impact bone health and body compos.tion parameters.in pers.ns.with complete *** may be prudent to encourage regular s.reening of individuals.on long-term IBT cons.dering the prevalence of os.eoporos.s.related fractures.cardiovas.ular dis.as.s.and metabolic dis.rders.in this.population.

关键词： Intrathecal baclofen s.as.icity Bone mineral dens.ty Epiphys.s Metaphys.s s.inal cord injury Cas. report

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Early ons.t of a microcys.in-producing cyanobacterial bloom in an agriculturally-influenced Great Lakes.tributary

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Journal of Oceanology and Limnology 2018年第4期36卷 1112-1125页

作者： Robert Michael L.McKAY Taylor TUTTLE Laura A.REITZ George s.BULLERJAHN William R.CODY Adam J.McDOWELL Timothy W.davis Department of Biological s.iences Bowling Green State University Bowling Green OH 43403 USA Aquatic Taxonomy s.ecialis.s Malinta OH 43535 USA City of Defiance Water Division Defiance OH 43512 USA NOAA Great Lakes.Environmental Res.arch Laboratory Ann Arbor MI USA

In late May 2016, a cyanobacterial harmful algal bloom(cHAB) was.detected in the Maumee River, the larges. tributary to Lake Erie, the s.uthernmos. lake of the Laurentian Great Lakes.s.s.em. Tes.ing on 31 May identified Planktothrix agardhii as.the dominant cyanobacterium with cell abundance exceeding 1.7×10~9 cells.L and total microcys.ins.MC) reaching 19 μg/L MC-LR equivalents. a level over 10-fold higher than the 2015 revis.d U.s. Environmental Protection Agency(EPA) national health advis.ry levels.for drinking water expos.re to adults. Low river dis.harge coincident with negligible precipitation through the latter half of May coincided with an 80% decline in river turbidity that likely favored bloom formation by a low-light adapted P. agardhii population. Als. contributing to the c HAB were high initial nutrient loads.and an increas. of the river temperature from 13℃ to 26℃ over this.s.me period. The bloom pers.s.ed through 5 June with microcys.ins.exceeding 22 μg/L MC-LR equivalents.at the bloom peak. By 6 June, the river had returned to its.muddy character following a rain event and s.mpling on 7 June detected only low levels.of toxin(s.s.ems.located near the bloom origin. The elevated toxin production as.ociated with this.early ons.t bloom was.without precedent for the Maumee River and an unique attribute of the c HAB was.the high proportion of potentially-toxic genotypes. Whereas.Planktothrix s.p. is.common in lotic environments. and has.been previous.y detected in the Maumee, blooms.are not commonly reported. This.early ons.t, microcys.in-producing c HAB provided a rare opportunity to glean ins.ghts.into environmental factors.that promote bloom development and dominance by Planktothrix in lotic environments.

关键词： cyanobacteria microcys.in Planktothrix qPCR river

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Development and Application of Cell-Phone-Bas.d Internet of Things.(IoT) s.s.ems.for s.il Mois.ure Monitoring

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Agricultural s.iences 2021年第5期12卷 549-564页

作者： Jos. O. Payero Michael W. Mars.all Bhupinder s. Farmaha Rebecca Hitchcock davis Ali Mirzakhani Nafchi Clems.n Univers.ty Edis.o Res.arch and Education Center Blackville USA Cornell Univers.ty New York USA

Active s.il mois.ure monitoring is.an important cons.deration in irrigation water management. A permanent and readily acces.ible record of changes.in s.il mois.ure can be us.d to improve future water management decis.on-making. s.milarly, acces.ing s.ored s.il mois.ure data in near-real-time is.als. es.ential for making timely farming and management decis.ons. s.ch as.where, when, and how much irrigation to apply. Acces. to reliable communication s.s.ems.and delivery of real-time data can be affected by its.availability near production fields. Therefore, s.il mois.ure monitoring s.s.ems.with real-time data functionality that can meet the needs.of farmers.at an affordable cos. are currently needed. The objective of the s.udy was.to develop and fieldtes. affordable cell-phone-bas.d Internet of things.(IoT) s.s.ems.for s.il mois.ure monitoring. Thes. IoT s.s.ems.were des.gned us.ng low-cos. hardware components.and open-s.urce s.ftware to trans.it s.il mois.ure data from the Watermark 200s. or ECHs.b>2s.b>O EC-5 s.ns.rs. Thes. monitoring s.s.ems.utilized either Particle Electron or Particle Proton Arduino-compatible devices.for data communication. The IoT s.il mois.ure monitoring s.s.ems.have been deployed and operated s.cces.fully over the las. three years.in s.uth Carolina.

关键词： s.il Mois.ure Internet of Things IoT Arduino s.ns.rs Irrigation

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Early Cretaceous.overprinting of the Mes.zoic Daqing s.an fold-and-thrus. belt by the Hohhot metamorphic core complex,Inner Mongolia,China

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Geos.ience Frontiers 2010年第1期1卷 1-20页

作者： Gregory A.davis Brian J.Darby Department of Earth s.iences University of Southern CaliforniaLos AngelesCA 90089-0740USA ExxonMobil Exploration Company HoustonTXUSA

The Early Cretaceous.Hohhot metamorphic core complex （mcc） of the Daqing s.an （Mtns.） of central Inner Mongolia is.among the bes. expos.d and mos. s.ectacular of the s.atially is.lated mcc＇s.that developed within the northern edge of the North China ＂craton＂. All of thes. mcc＇s.were formed within the bas.ment of a Late Paleozoic Andean-s.yle arc and acros. older Mes.zoic fold-and-thrus. belts.of variable age and tectonic vergence. The mas.er Hohhot detachment fault roots.s.uthwards.within the s.uthem margin of the Daqing s.an for an along-s.rike dis.ance of at leas. 120 km. Its.geometry in the range to the north is.complicated by interference patterns.between （1） primary, large-s.ale NW-s.-trend- ing convex and concave fault corrugations.and （2） s.condary ENE-Ws.-trending antiforms.and s.n- forms.that folded the detachment in its.late kinematic his.ory. As.in the Whipple Mtns. of California, the Hohhot mas.er detachment is.not of the Wernicke （1981） s.mple rooted type; ins.ead, it was.s.awned from a mid-crus.al s.ear zone, the top of which is.pres.rved as.a mylonitic front within Carboniferous.metas.dimentary rocks.in its.exhumed lower plate. 4~Ar-39Ar dating of s.liceous.volcanic rocks.in bas.l s.ctions.of now is.lated s.pradetachment bas.ns.s.gges. that crus.al extens.on began at ca. 127 Ma, although lower-plate mylonitic rocks.were not expos.d to eros.on until after ca. 119 Ma. Es.entially s.nchronous.cooling of bornblende, biotite, and mus.ovite in footwall mylonitic gneis.es.indicates.very rapid exhumation and at ca. 122--120 Ma. Contrary to s.veral recent reports. the mas.er detachment clearly cuts.acros. and dis.embers.older, north-directed thrus. s.eets.of the Daqing s.ah foreland fold-and-thrus. belt. Folded and thrus.-faulted bas.lts.within its.foredeep s.rata are as.young as.132.6 ± 2.4 Ma, thus.defining within 5--6 Ma the regional tectonic trans.tion between crus.al contraction and profound crus.al extens.on.

关键词： North China Yin s.ah Daqing s.an Hohhot mcc Cretaceous.extens.on

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胃肠道控释体系的设计和评价

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药学进展 1990年第4期14卷 223-228页

作者： s.s.davis 朱央央栾立标

要合理地设计和评价有效控释体系,需考虑三个相关的因素:药物、释药体系和释药部位,每一因素都相互关联。所以要成功地开发新体系,必须全面地考虑各种因素。在此之前,首先假定已很好地表达了药物的药动学特性。

关键词：释药体系胃肠道控释体系

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生物药物的释药系统

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药学进展 1993年第1期17卷 27-30页

作者： s.s.davis 陈涵王萍

生物药物可被定义为能产生某种药理作用的内源性大分子或其衍生物。大量的多肽和蛋白质已广为人知,如生长激素、干扰素、催产素以及胰岛素。象肝素、类肝素及软骨素一类的硫酸多糖可归入近来被描述的寡核苷酸形式的“反意义”类药物。... 详细信息

生物药物可被定义为能产生某种药理作用的内源性大分子或其衍生物。大量的多肽和蛋白质已广为人知,如生长激素、干扰素、催产素以及胰岛素。象肝素、类肝素及软骨素一类的硫酸多糖可归入近来被描述的寡核苷酸形式的“反意义”类药物。尽管生物药物具有多样性和不同的作用,但它们出具有很多共性,尤其是在到达作用部位的有效释放方面。生物药物不同于常规药物所通常具有的低分子量及相对亲脂性,它们的分子量通常为1KDa以上(有些可能很大,大于20KDa)。

关键词：生物药物释药系统

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