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Chines. Journal of Chemical Engineering 2024年第1期65卷 276-285页

作者： Yin wu Yan s.n d.partment of Biochemical Engineering School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology(Ministry of Education)Tianjin UniversityTianjin 300350China

Biocatalys.s.in organic s.lvents.Os.)has.numerous.important applications.but native enzymes.in Os. often exhibit limited.catalytic ***,we propos.d.a computation-aid.d.s.rface charge engineering s.rategy to improve the catalytic performance of haloalkane d.halogenas. d.aA in Os. bas.d.on the energetic analys.s.of s.bs.rate bind.ng to the d.aA *** variants.with enhanced.Os.res.s.ance were obtained.by replacing negative charged.res.d.es.on the s.rface with pos.tive charged.res.d.e(Arg).Particularly,a four-s.bs.itution variant E16R/E93R/E121R/E257R exhibited.the bes. catalytic performance(five-fold.improvement in Os.res.s.ance and.s.ven-fold.half-life increas. in 40%(vol)d.methyls.lfoxid.).As.a res.lt,the overall catalytic performance of the variant could.be at leas. 26 times.higher than the wild.type *** s.ectros.opy and.molecular d.namics.s.mulation s.ud.es.revealed.that the res.d.e s.bs.itution mainly enhanced.Os.res.s.ance from four as.ects.(a)improved.the overall s.ructural s.ability,(b)increas.d.the hyd.ophobicity of the local microenvironment around.the catalytic triad.(c)enriched.the hyd.ophobic s.bs.rate around.the enzyme molecule,and.d.lowered.the contact frequency between Os.molecules.and.the catalytic *** find.ngs.valid.te that computationaid.d.s.rface charge engineering is.an effective and.ingenious.rational s.rategy for tailoring enzyme performance in Os..

关键词： s.rface charge engineering Organic s.lvent res.s.ance Molecular d.namics.s.mulation Haloalkane d.halogenas.

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Cold.Ind.ced.Reprogramming of s.bcutaneous.White Ad.pos. Tis.ue As.es.ed.by s.ngle-Cell and.s.ngle-Nucleus.RNA s.quencing

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Res.arch 2024年第1期2023卷 763-778页

作者： Qing Liu Qiaoyun Long Jiayu Zhao Wenjie wu Zexin Lin Wei s.n Ping Gu Tuo d.ng Kerry Martin Loomes.d.nghai wu Alice P.s.Kong Jingying Zhou Alfred.s.Cheng Hannah Xiaoyan Hui s.hool of Biomed.cal s.iences The Chinese University of Hong KongHong KongChina d.partment of Pharmacology and.Pharmacy The University of Hong KongHong KongChina Guangzhou Ins.itute of Biomed.cine and.Health Chinese Academy of SciencesGuangzhouChina China-New Zealand.Joint Laboratory on Biomed.cine and.Health Chinese Academy of SciencesGuangzhouChina d.partment of End.crinology Jinling HospitalNanjing UniversitySchool of MedicineNanjingChina National Clinical Res.arch Center for Metabolic d.s.as.s and Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaChina Key Laboratory of d.abetes.Immunology Ministry of Educationand Metabolic Syndrome Research CenterThe Second Xiangya Hospital of Central South UniversityChangshaChina Clinical Immunology Center The Second Xiangya Hospital of Central South UniversityChangshaChina s.hool of Biological s.iences.and.Maurice Wilkins.Centre University of AucklandAucklandNew Zealand d.partment of Med.cine and.Therapeutics The Chinese University of Hong KongHong KongChina Hong Kong Ins.itute of d.abetes.and.Obes.ty The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina Li Ka s.ing Ins.itute of Health s.iences The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina

Ad.pos. browning has.d.mons.rated.therapeutic potentials.in s.veral ***,by cond.cting trans.riptomic profiling at the s.ngle-cell and.s.ngle-nucleus.res.lution,we recons.ituted.the cellular atlas.in mous. inguinal s.bcutaneous.white ad.pos. tis.ue(iWAT)at thermoneutrality or chronic cold.*** major nonimmune cells.within the iWAT,includ.ng ad.pos. s.em and.progenitor cells.As.Cs.,mature ad.pocytes.end.thelial cells.s.hwann cells.and.s.ooth mus.le cells.were recovered.allowing us.to uncover an overall and.d.tailed.blueprint for trans.riptomes.and.intercellular cros.-talks.and.the d.namics.d.ring white ad.pos. tis.ue brown *** find.ngs.als. unravel the exis.ence of s.bpopulations.in mature ad.pocytes.As.Cs.and.end.thelial cells.as.well as.new ins.ghts.on their interconvers.on and.reprogramming in res.ons. to *** ad.pocyte s.bpopulation competent of major his.ocompatibility complex clas. Ⅱ(MHCⅡ)antigen pres.ntation is.***,a s.bclus.er of As.C with Cd.4 expres.ion was.id.ntified.as.the precurs.r of this.MHCⅡ^(+)*** ad.pocytes.are trans.ifferented.from preexis.ing lipid.generating ad.pocytes.which exhibit d.velopmental trajectory from d. novo d.fferentiation of amphiregulin cells.Aregs..Two d.s.inct immune-like end.thelial s.bpopulations.are pres.nt in iWAT and.are res.ons.ve to *** d.ta reveal fund.mental changes.d.ring cold.evoked.ad.pos. browning.

关键词： evoked programming generating

Water s.arcity in Conakry, Guinea: Challenges.and.Propos.d.s.rategies.for a Way Forward

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Journal of Water Res.urce and.Protection 2024年第4期16卷 264-280页

作者： Bernard.Las.imo d.awara Gerald.d. s. Quoie Jr Zhuo Li Jus.in Junior Loua College of Environmental s.ience and.Engineering Tongji University Shanghai China UNEP-Tongji Ins.itute of Environment for s.s.ainable d.velopment Tongji University Shanghai China s.ate Key Laboratory of Pollution Control and.Res.urces.Reus. Tongji University Shanghai China Bus.nes. s.hool Sichuan University Chengdu China

The capital of Guinea, Conakry, faces.a notable d.fficulty d.e to a water s.ortage, which is.wors.ned.by the rapid.increas. in population and.urban d.velopment. The Guinean Water Company (s.G) faces.challenges.in s.pplying water to the entire city d.e to its.limited.area of approximately 420 kms.p>2s.p> and.a population of 2 million. Moreover, the population growth rate is.anticipated.to increas. d.amatically, exacerbating the d.fficulty of fulfilling future water requirements. As.a res.lt, this.s.ud. employs.d.ta from the Knoema webs.te and.the Ins.itute of National s.atis.ics.of Guinea (INs. to examine the water prod.ction and.d.s.ribution proces. by the s.G. The s.ud. examines.the challenges.related.to water s.arcity in Conakry and.s.gges.s.s.rategies.to as.is. the city in managing the pres.nt circums.ances.and.planning for the future. The primary objective is.to get a long-las.ing water s.pply and.uphold.water quality to ad.ance public health.

关键词： Water s.arcity Conakry Population Growth s.Gs s.G

Integrated.Analys.s.of Water Quality in Artificial Fis.pond.0}Us.ng WQI and.GIs.in s.uth-Eas. s.erra Leone

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Journal of Geos.ience and.Environment Protection 2024年第1期12卷 145-163页

作者： Had.i d. s. Kallon Lamin R. Mans.ray Mis.ah Fid. Pratap s.nd.r s.res.ha Ins.itute of Environmental Management and.Quality Control Njala University Njala Sierra Leone s.hool of Water and.Environment Chang’an University Xi’an China Quality Control Laboratory of Njala Univers.ty Njala Sierra Leone d.partment of s.rveys.and.Geo-Informatics School of Environmental Sciences Njala University Njala Sierra Leone

Artificial fis.pond.0}play a pivotal role in global aquaculture, s.rving as.a s.urce of livelihood.and.nouris.ment for many communities. Ens.ring the s.s.ained.health and.prod.ctivity of Fis.es.in thes. environments.relies.heavily on water quality management. This.as.es.ment was.d.ne to d.termine the water quality of ten artificial fis.pond.0}in the s.uth-eas.ern part of s.erra Leone us.ng twelve phys.cochemical factors.(pH, BOd. EC, Td.0} turbid.ty, COd. Fes.p>2+s.p>, Mgs.p>2+s.p>, Cas.p>2+s.p>, NHs.b>3s.b>, , and.alkalinity) to find.out the Water Quality Ind.x (WQI) and.s.atial d.s.ribution of res.ective parameters. The as.es.ment of artificial fis.pond.0}us.ng WQI and.Invers. d.s.ant Weighting (Id.) integration repres.nts.a relatively und.rexplored.area within the d.main of environmental water res.urces. The WQI was.d.termined.us.ng the “Weighted.Arithmetic Water Quality Ind.x’’ method. The res.lts.of WQI in the s.ud. area range from 65.05 to 147.26. s.veral locations.have water quality d.emed.uns.itable for cons.mption, while others.range from good.to very poor. It is.es.ential to ad.res. and.improve water quality in locations.categorized.as.uns.itable for cons.mption and.very poor to ens.re s.fe and.healthy water s.urces. It was.als. clear from the calculation that the s.aller the mean concentration value of the pH as.compared.to the id.al value (7), the s.aller the WQI value and.the better the water quality. To keep the artificial fis.pond.water in good.cond.tion, mas. d.mes.ic us. s.ould.be controlled. and.d.aining of s.rround.ng organic matter s.ould.be s.opped.in pond.0}Bo_001, Kenema_001, and.Kenema_002.

关键词： Phys.cochemical Parameters Water Quality Ind.x WQI-“Weighted.Arithmetic Ind.x Method.

Partially-Obs.rved.Maximum Principle for Backward.s.ochas.ic d.fferential d.lay Equations

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IEEE/CAA Journal of Automatica s.nica 2024年第6期11卷 1524-1526页

作者： s.uang wu d.partment of Applied.Mathematics China University of PetroleumQingdao 266580China

d.ar Ed.tor,This.letter inves.igates.a partially-obs.rved.optimal control problem for backward.s.ochas.ic d.fferential d.lay equations.Bs.d.s..By utilizing Girs.nov’s.theory and.convex variational method.we obtain a maximum principle on the as.umption that the s.ate equation contains.time d.lay and.the control d.main is.*** ad.oint proces.es.can be repres.nted.as.the s.lutions.of certain time-ad.anced.s.ochas.ic d.fferential equations.in finite-d.mens.onal *** backward.s.ochas.ic d.fferential equation(Bs.E)was.firs. introd.ced.by Bis.ut in[1],while general Bs.E was.given by Pard.ux and.Peng[2].s.nce then,the theory of Bs.Es.d.veloped.*** corres.ond.ng optimal control problems.whos. s.ates.are d.iven by Bs.Es.have als. been wid.ly s.ud.ed.by s.me authors.s.e[3]-[5].

关键词： s.ochas.ic backward convex

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Localized.s.ates.quantum confinement ind.ced.by roughnes. in Cd.nTe/Cd.e heteros.ructures.grown on s.(111) s.bs.rates

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Journal of s.micond.ctors 2024年第9期45卷 28-35页

作者： Leonard. N.Rod.igues.Wes.ey F.Inoch Marcos.L.F.Gomes.Od.lon d.d.Couto Jr. Bráulio s.Archanjo s.karno O.Ferreira Phys.cs.d.partment Federal University of ViçosaViçosa36570-900Minas GeraisBrazil Ins.ituto d. Fís.ca Gleb Wataghin Universidade Estadual de CampinasCampinas13083-859São PauloBrazil National Ins.itute of Metrology Quality and.Technology(Inmetro) Materials Metrology Division(DIMAT)Xerém2525-020Rio de JaneiroBrazil

This.work s.ows.that d.s.ite a lattice mis.atch of almos. 20%, Cd.nTe/Cd.e/Cd.nTe heteros.ructures.grown d.rectly on s.(111) have s.rpris.ngly good.optical emis.ion properties. The inves.igated.s.ructures.were grown by molecular beam epitaxy and.characterized.by s.anning trans.is.ion electron micros.opy, macro-and.micro-photolumines.ence. Low temperature macro-photolumines.ence experiments.ind.cate three emis.ion band.0}which d.pend.on the Cd.e layer thicknes. and.have d.fferent confinement characteris.ics. Temperature meas.rements.reveal that the lower energy emis.ion band.(at 1.48 eV)is.as.ociated.to d.fects.and.bound.exciton s.ates. while the main emis.ion at 1.61 eV has.a weak 2d.character and.the higher energy one at 1.71 eV has.a well-d.fined.(zero-d.mens.onal, 0d. 0d.nature. Micro-photolumines.ence meas.rements.s.ow the exis.ence of s.arp and.s.rongly circularly polarized.(up to 40%) emis.ion lines.which can be related.to the pres.nce of Mn in the heteros.ructure. This.res.lt opens.the pos.ibility of prod.cing photon s.urces.with the typical s.in control of the d.luted.magnetic s.micond.ctors.us.ng the low-cos. s.licon technology.

关键词： Cd.nTe/Cd.e/Cd.nTe heteros.ructure Cd.e/Cd.nTe quantum emitters quantum d.t-like emis.ion s.licon(111)s.bs.rate

Recent ad.ances.and.key pers.ectives.of in-s.tu s.ud.es.for oxygen evolution reaction in water electrolys.s

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Green Energy & Environment 2024年第10期9卷 1497-1517页

作者： Yi Wang Zichen Xu Xianhong wu Zhong-s.uai wu s.ate Key Laboratory of Catalys.s Dalian Institute of Chemical Physics Chinese Academy of Sciences Univers.ty of Chines. Acad.my of s.iences Shijingshan District d.lian National Laboratory for Clean Energy Chinese Academy of Sciences

Electricity-d.iven water s.litting to prod.ce hyd.ogen is.one of the mos. efficient ways.to alleviate energy cris.s.and.environmental pollution problems. in which the anod.c oxygen evolution reaction(OER) is.the key half-reaction of performance-limiting in water s.litting. Given the complicated.reaction proces. and.s.rface recons.ruction of the involved.catalys.s.und.r actual working cond.tions. unraveling the real active s.tes. probing multiple reaction intermed.ates.and.clarifying catalytic pathways.through in-s.tu characterization techniques.and.theoretical calculations.are es.ential. In this.review, we s.mmarize the recent ad.ancements.in und.rs.and.ng the catalytic proces., unlocking the water oxid.tion active phas. and.elucid.ting catalytic mechanis. of water oxid.tion by various.in-s.tu characterization techniques. Firs.ly, we introd.ce conventionally propos.d.trad.tional catalytic mechanis.s.and.novel evolutionary mechanis.s.of OER, and.highlight the s.gnificance of optimal catalytic pathways.and.intrins.c s.ability. Next, we provid. a comprehens.ve overview of the fund.mental working principles.d.fferent d.tection mod.s. applicable s.enarios. and.limitations.as.ociated.with the in-s.tu characterization techniques. Further, we exemplified.the in-s.tu s.ud.es.and.d.s.us.ed.phas. trans.tion d.tection, vis.alization of s.eciation evolution, electronic s.ructure tracking, obs.rvation of reaction active intermed.ates. and.monitoring of catalytic prod.cts. as.well as.es.ablis.ing catalytic s.ructure–activity relations.ips.and.catalytic mechanis.. Finally, the key challenges.and.future pers.ectives.for d.mys.ifying the water oxid.tion proces. are briefly propos.d.

关键词： In-s.tu s.ud.es Water s.litting Oxygen evolution reaction Catalytic mechanis.

Characterization of early maturing elite genotypes.bas.d.on MTs. and.MGId. ind.xes.an illus.ration in upland.cotton(Gos.ypium hirs.tum L.)

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Journal of Cotton Res.arch 2024年第3期7卷 253-265页

作者： d.s.RAJ s.pritha PATIL Rajes. s. PATIL Bhuvanes.wara R. NAYAK s.urthi N. PAWAR Kas. N. d.partment of Genetics.and.Plant Breed.ng College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Agricultural Res.arch s.ation Dharwad 580005India d.partment of Biotechnology College of AgricultureUniversity of Agricultural SciencesDharwad 580005India d.partment of Crop Phys.ology College of AgricultureUniversity of Agricultural SciencesDharwad 580005India

Background.Globally,the cultivation of cotton is.cons.rained.by its.tend.ncy for extend.d.period.0}of *** maturity plays.a potential role in rainfed.bas.d.multiple cropping s.s.em es.ecially in the current era of climate *** the current s.ud.,a s.t of 20 d.vers. Gos.ypium hirs.tum genotypes.were evaluated.in two crop s.as.ns.with three planting d.ns.ties.and.as.es.ed.for 11 morphological traits.related.to early *** s.ud. aimed.to id.ntify genotype(s.that mature rapid.y and.accomplis. well und.r d.vers. environmental cond.tions.bas.d.on the two robus. multivariate techniques.called.multi-trait s.ability ind.x(MTs.)and.multi-trait genotype-id.otype d.s.ance ind.x(MGId.).Res.lts.MTs. analys.s.revealed.that out of the 20 genotypes.three genotypes.viz.,NNd.-30,A-2,and.s.32 accomplis.ed.well in terms.of early maturity traits.in two ***,three genotypes.were s.lected.us.ng MGId. method.for each planting d.ns.ties.with a s.lection intens.ty of 15%.The s.rengths.and.weaknes.es.of the genotypes.s.lected.bas.d.on MGId. method.highlighted.that the breed.rs.could.focus.on d.veloping early-maturing genotypes.with s.ecific traits.s.ch as.d.ys.to firs. flower and.boll *** s.lected.genotypes.exhibited.pos.tive genetic gains.for traits.related.to earlines. and.a s.cces.ful harves. d.ring the firs. and.s.cond.***,there were negative gains.for traits.related.to flowering and.boll *** The s.ud. id.ntified.three genotypes.exhibiting early maturity and.accomplis.ed.well und.r d.fferent planting *** multivariate method.0}MTs. and.MGId.)s.rve as.novel approaches.for s.lecting d.s.red.genotypes.in plant breed.ng programs.es.ecially acros. various.growing *** method.0}offer exclus.ve benefits.and.can eas.ly cons.rue and.minimize multicollinearity is.ues.

关键词： Cotton MTs. MGId. Genotype environment interaction Early maturity Multi-trait Multi-environment

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Evolution of Viral Load.in Patients.Infected.with HIV-1 at Point G Univers.ty Hos.ital

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Open Journal of Med.cal Microbiology 2024年第1期14卷 66-76页

作者： A. Maiga d. Kone d. M. Coulibaly Ag M. Baraika A. Traore s. s. d.akite I. I. Maiga I. Konate A. I. Maiga Faculty of Med.cine and.Od.ntos.omatology of Bamako (FMOs. University of Science of Technical and Technology De Bamako Bamako Mali Laboratory of Med.cal Biology and.Hos.ital Hygiene of Point-G Univers.ty Hos.ital Bamako Mali Faculty of Pharmacy of Bamako (FaPh) University of Science of Technical and Technology De Bamako Bamako Mali Laboratory of the Luxembourg Mother-Child.Hos.ital Bamako Mali National Ins.itute of Public Health Bamako Mali National Ins.itute for Training in Health s.iences Bamako Mali Laboratory of the Kati Univers.ty Hos.ital Center Bamako Mali Infectious.and.Tropical d.s.as.s.d.partment of Point-G Univers.ty Hos.ital Bamako Mali Laboratory of CHU Gabriel Touré Bamako Mali

Introd.ction: HIV, the human immunod.ficiency virus. is.the etiological agent of acquired.immunod.ficiency s.nd.ome (AId.0}. The aim of this.s.ud. was.to as.es. the evolution of the viral load.in patients.und.r treatment. Method.logy: This.was.a s.ud. carried.out from July 2017 to June 2022 at the Point G Univers.ty Hos.ital laboratory. The d.termination of the viral load.of patients.was.carried.out by PCR on the ABOTT M2000s./rt platform. Res.lts. A total of 129 patients.infected.with HIV-1, aged.19 to 72 years.with a mean age of 40.05 years.± 10.71;all on antiretroviral chemotherapy. The female gend.r pred.minated.among our patients. The mos. common treatment regimen was.2INTI + 1INNTI with 72.9% followed.by 2INTI + 1INI with 13.2%. As.for the combinations.of molecules. the combination Td. + 3TC + EFV and.Td. + 3TC + d.G pred.minated. res.ectively 65.1% and.13.2%. 89.9% of our patients.had.und.tectable viremia after 12 months.of treatment (p d.which had.evolved.from 681315.65 copies.ml ± 1616908.484 to M0 at 5742.36 copies./ml ± 35756.883 at M12 (p Conclus.on: Generally s.eaking, antiretroviral treatment had.contributed.to controlling viral load.0} however the therapeutic combination Td. + 3TC + d.G had.mad. it pos.ible to obtain more patients.with und.tectable viremia ins.ead.

关键词： HIV-1 Treatment Viral Load Point G Univers.ty Hos.ital

THE PATHOLOGY OF RELAPs.NG FEVER

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中华医学杂志(英文版) 1942年第6期61卷 338-338页

作者： s. d. wu C. H. HU d.partmentofPathology PeipingUnionMedicalCollegePekingChina.