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Blockad. of the d.ubiquitinating enzyme Us.48 d.grad.s.oncogenic HMGA2 and.inhibits.colorectal cancer invas.on and.metas.as.s

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Acta Pharmaceutica s.nica B 2024年第4期14卷 1624-1643页

作者： Can Cheng Hanhui Yao Heng Li Jingwen Liu Zhengyi Liu Yang wu Liang Zhu Hejie Hu Zhengd.ng Fang Liang wu d.partment of General s.rgery the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Anhui Province Key Laboratory of Hepatopancreatobiliary s.rgery the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China d.partment of Comprehens.ve s.rgery Anhui Provincial Cancer HospitalWest District of the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Anhui Provincial Hos.ital Health Management Center the First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China d.partment of Breas. s.rgery Henan Provincial People's HospitalPeople's Hospital of Zhengzhou UniversityPeople's Hospital of Henan UniversityZhengzhou 450003China

HMGA2,a pivotal trans.ription factor,functions.as.a vers.tile regulator implicated.in the progres.ion of d.vers. aggres.ive *** this.s.ud.,mas. s.ectrometry was.employed.to id.ntify ubiquitin-s.ecific proteas.s.that potentially interact with HMGA2,and.Us.48 was.id.ntified.as.a d.ubiquitinating enzyme of *** enforced.expres.ion of Us.48 s.gnificantly increas.d.HMGA2 protein levels.by inhibiting its.d.grad.tion,while the d.privation of Us.48 promoted.HMGA2 d.grad.tion,thereby s.ppres.ing tumor invas.on and.*** d.s.overed.that Us.48 und.rgoes.s.MOylation at lys.ne 258,which enhances.its.bind.ng affinity to *** s.bs.quent phenotypic s.reening of s.all molecules.we id.ntified.d.B-IN-2 as.a remarkably potent pharmacological inhibitor of ***,the s.all-molecule inhibitor targeting Us.48 ind.ces.d.s.abilization of ***,upregulation of Us.48 or HMGA2 in cancerous.tis.ues.is.ind.cative of poor prognos.s.for patients.with colorectal cancer(CRC).Collectively,our s.ud. not only elucid.tes.the regulatory mechanis. of d.Bs.involved.in HMGA2 s.ability and.valid.tes.Us.48 as.a potential therapeutic target for CRC,but als. id.ntifies.d.B-IN-2 as.a potent inhibitor of Us.48 and.a promis.ng cand.d.te for CRC treatment.

关键词： Colorectal cancer Invas.on and.metas.as.s Pos.-trans.ational mod.fication Ubiquitination s.MOylation Us.48 HMGA2 s.ecific inhibitors

Unraveling the role of Nis.PH@OOH/CC perovs.ite hyd.oxid. for efficient electrocatalytic oxid.tion of methanol to formate

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Nano Res.arch 2024年第4期17卷 2388-2399页

作者： Jing s.ao Yus.eng Fang Xiaobing wu Muhammad.Imran Abd.llah Youkun Tao College of Chemis.ry and.Environmental Engineering Shenzhen UniversityShenzhen 518060China s.hool of s.ience Harbin Institute of TechnologyShenzhen 518055China

The s.uggis. kinetics.of oxygen evolution reaction(OER)is.the key tailback for hyd.ogen prod.ction from the water *** OER with thermod.namically aus.icious.methanol oxid.tion reaction(MOR)can s.gnificantly boos. the H_(2) and.value-ad.ed.prod.cts.***,it is.currently challenging to achieve a s.nergis.ic manipulation of prod.ct s.lectivity and.performance for MOR ***,we report Nis.PH@OOH/CC(CC=carbon cloth)perovs.ite hyd.oxid. nanos.here as.an efficient MOR electrocatalys. with high activity,s.ability,and.s.lectivity toward.0}methanol oxid.tion to formate.A s.rface amorphous.layer of d.fect rich NiOOH was.generated.in operand. by s.lective s. leaching with s.able perovs.ite hyd.oxid. bulk s.ructure,which mitigates.the oxid.tive power and.optimizes.the local coord.nation environment of the active NiOOH *** s.tu Raman combined.with electrochemical s.ud.es.further confirm the key active s.ecies.NiOOH,generated.in operand. enhance the MOR and.blocking the over oxid.tion of methanol to CO_(2).As.a res.lt,Nis.PH@OOH/CC effectively mas.s.the OER and.attains.99%s.lectivity with 100%Farad.c efficiency for *** res.lts.of this.s.ud. s.ow the ad.ances.of Nis.PH@OOH/CC as.an efficient electrocatalys. for MOR and.als. s.gges. its.potential applications.for various.s.all organic molecules.oxid.tion.

关键词： perovs.ite hyd.oxid. s.all organic molecules nickel oxy(hyd.oxid.) value-ad.ed.prod.cts methanol oxid.tion reaction

Hybrid.d.namic Variables.d.pend.nt Event-Triggered.Fuzzy Mod.l Pred.ctive Control

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IEEE/CAA Journal of Automatica s.nica 2024年第3期11卷 723-733页

作者： Xiongbo Wan Chaoling Zhang Fan Wei Chuan-Ke Zhang Min wu IEEE the s.hool of Automation China University of Geosciencesthe Hubei Key Laboratory of Advanced Control and Intelligent Automation for Complex Systemsand the Engineering Research Center of Intelligent Technology for Geo-ExplorationMinistry of EducationWuhan 430074China

This.article focus.s.on d.namic event-triggered.mechanis.(d.TM)-bas.d.mod.l pred.ctive control(MPC) for T-s.fuzzy s.s.ems.A hybrid.d.namic variables.d.pend.nt d.TM is.carefully d.vis.d.which includ.s.a multiplicative d.namic variable and.an ad.itive d.namic *** ad.res.ed.d.TM-bas.d.fuzzy MPC is.ue is.d.s.ribed.as.a “min-max” optimization problem(OP).To facilitate the co-d.s.gn of the MPC controller and.the weighting matrix of the d.TM,an auxiliary OP is.propos.d.bas.d.on a new Lyapunov function and.a new robus. pos.tive invariant(RPI) s.t that contain the members.ip functions.and.the hybrid.d.namic variables.A d.namic event-triggered.fuzzy MPC algorithm is.d.veloped.accord.ngly,whos. recurs.ve feas.bility is.analys.d.by employing the RPI *** the d.s.gned.controller,the involved.fuzzy s.s.em is.ens.red.to be as.mptotically *** examples.s.ow that the new d.TM and.d.TM-bas.d.MPC algorithm have the ad.antages.of red.cing res.urce cons.mption while yield.ng the anticipated.performance.

关键词： d.namic event-triggered.mechanis.(d.TM) hybrid.d.namic variables mod.l pred.ctive control(MPC) robus. pos.tive invariant(RPI)s.t T-s.fuzzy s.s.ems

Food.orne toxin Aflatoxin B_(1)ind.ced.glomerular pod.cyte inflammation through proteolys.s.of RelA,d.wnregulation of miR-9 and.CXCR4/TXNIP/NLRP3 pathway

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Food.s.ience and.Human Wellnes. 2024年第4期13卷 2289-2309页

作者： Jie Zhang s.uang Yang Baocai Xu Zihui Qin Xinyi Guo Ben Wei Qinghua wu Kamil Kuca Tus.uai Li Wend. wu s.hool of Biology and.Food.Engineering Changshu Institute of TechnologySuzhou 215500China Center for Clinical Mas. s.ectrometry School of Pharmaceutical SciencesSoochow UniversitySuzhou 215123China s.hool of Food.and.Biological Engineering Hefei University of TechnologyHefei 230009China MOE Joint International Res.arch Laboratory of Animal Health and.Food.s.fety College of Veterinary MedicineNanjing Agricultural UniversityNanjing 210095China d.partment of Chemis.ry Faculty of ScienceUniversity of Hradec KraloveHradec Kralove 50003Czech Republic College of Life s.ience Yangtze UniversityJingzhou 434025China wuxi Med.cal College Jiangnan UniversityWuxi 214122China wuxi Trans.ational Med.cine Res.arch Center and.Jiangs. Trans.ational Med.cine Res.arch Ins.itute wuxi Branch Wuxi 214013China

Aflatoxin B_(1)(AFB_(1))is.a naturally-occurring mycotoxin and.recognized.as.the mos. toxic food.orne toxin,particularly caus.ng d.mages.to *** pod.cytes.are terminally d.fferentiated.epithelial ***_(1)ind.ces.pod.cyte inflammation,proteinuria and.renal *** the mechanis. of AFB_(1)-ind.ced.pod.cyte inflammation and.murine kid.ey d.s.unction,we d.tected.that AFB_(1)increas.d.ubiquitind.pend.nt d.grad.tion of the trans.ription factor RelA through enhanced.interaction of RelA with E3 ubiquitin ligas. tripartite motif containing 7(TRIM7)in mous. pod.cyte clone-5(MPC-5)and.mous. *** of RelA res.lted.in d.creas.ng microRNA-9(miR-9)and.activating the chemokine receptor 4(CXCR4),thiored.xin interacting protein(TXNIP),and.NOd.like receptor pyrin d.main-containing 3(NLRP3)s.gnaling axis.CXCR4/TXNIP/NLRP3 pathway),lead.ng to pod.cyte *** als. d.termined.that d.wnregulation of miR-9 led.to CXCR4 expres.ion and.the d.wns.ream TXNIP/NLRP3 pathway *** of miR-9 or d.letion of CXCR4 s.ppres.ed.AFB_(1)-ind.ced.CXCR4/TXNIP/NLRP3 pathway,res.lting in alleviating pod.cyte inflammation and.kid.ey *** find.ngs.ind.cated.that ubiquitin-d.pend.nt proteolys.s.of RelA,d.wnregulation of miR-9,and.activation of CXCR4/TXNIP/NLRP3 pathway played.an es.ential role in AFB_(1)-ind.ced.glomerular pod.cyte *** s.ud. revealed.a novel mechanis.,via RelA,for the control of AFB_(1)’s.nephrotoxicity,lead.ng to an effective protection of food.s.fety and.public health.

关键词： Aflatoxin B_(1) Pod.cyte inflammation miRNA-9 Chemokine(C-X-C motif)receptor 4 RelA ubiquitin-d.pend.nt d.grad.tion

Metal complexes.of bipyrid.ne-functionalized.covalent organic frameworks.as.efficient electrocatalys.s.for oxygen evolution reaction

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Rare Metals 2024年第7期43卷 3096-3106页

作者： Zhuang-Zhuang wu Tian Xia Ying Liang Yong-Peng Li Zhu-Yin s.i Li-Juan Feng d.o-Xiong wu Xin-Long Tian Qi Chen s.ate Key Laboratory of Marine Res.urce Utilization in s.uth China s.a School of Marine Science and EngineeringHainan UniversityHaikou 570228China s.hool of Chemis.ry and.Chemical Engineering Yantai UniversityZhuhai519041China s.hool of Bioengineering Zhuhai Campus of Zunyi Medical UniversityZhuhai519041China

Electrocatalytic water s.litting is.cons.d.red.a clean and.practic al method.for prod.cing *** this.s.ud.,COF-Bpy,a bipyrid.ne-functionalized.covalent organic framework(COF),was.prepared.via pos.-s.nthetic mod.fication,after which electrocatalys.s.for the oxygen evolution reactions.OER)were formed.through coord.nation to s.ngle-or d.uble-trans.tion metals.Fe,Co,Ni,FeCo,FeNi or CoNi).COF-Bpy@FeNi d.livered.the bes. OER performance among the s.ud.ed.electrocatalys.s.with an overpotential of 399 mV at 10 mA·cm^(-2)in an alkaline electrolyte(1.0 mol·L^(-1)KOH aqueous..Notably,the electrocatalytic performance of COF-Bpy@FeNi s.owed.s.ight d.grad.tion d.ring d.rability tes.ing,which is.as.ribable to its.irrevers.ble benzoquinoline s.ructure and.s.rong metal *** expected.COF-Bpy@FeNi exhibited.a low overpotential of 347 mV at a turnover frequency(TOF)of 0.1 s.(-1),which s.gges.s.that COF-Bpy@FeNi pos.es.es.excellent intrins.c electroc atalytic OER ***,d.ns.ty functional theory(d.T)calculations.reveal that the Ni s.te plays.a major role,while the Fe s.te ad.us.s.the electronic s.ructure of the Ni ions.which rationalizes.the excellent OER properties.of COF-Bpy@*** s.ud. not only provid.s.a s.mple and.efficient method.for complexing COFs.with trans.tion metals.but als. offers.a novel s.rategy for d.s.gning porous.organic polymer electrocatalys.s.

关键词： Covalent organic framework Oxygen evolution reactions.OER)electrocatalys. Nickel-iron s.nergy Water s.litting

d.namic emis.ion characteris.ics.and.control s.rategies.of air pollutants.from motor vehicles.in d.wntown Beijing,China

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Journal of Environmental s.iences 2024年第2期136卷 637-646页

作者： Yan s.en Tongran wu Aiping Lian Jie Gao Fei Peng Guohua s.ng Xuefang wu Yangyang Cui Xinyu Liu Yunfei Wan Jing Yan Yifeng Xue National Engineering Res.arch Center of Urban Environmental Pollution Control Beijing Municipal Research Institute of Eco-Environmental ProtectionBeijing 100037China Beijing Municipal Ecology and.Environment Bureau Beijing 100048China Beijing Jiaotong Univers.ty Beijing 100091China

This.s.ud. combined.the real-time monitoring and.inves.igation of traffic flows.to comprehens.vely analyze the road.traffic flow and.vehicle s.ructure in d.wntown Beijing.A d.namic emis.ion inventory of motor vehicle air pollutants.in d.wntown Beijing in 2021 was.es.ablis.ed.and.the impact of thes. emis.ions.on air quality was.s.mulated.and.quantified.and.d.fferent emis.ion red.ction control s.enarios.were propos.d.to evaluate their environmental improvement effects.and.explore meas.res.to mitigate the impact of pollution *** res.lts.s.ow that the high traffic flow and.the s.ructure of the motor vehicle emis.ions.in d.wntown Beijing are the main caus.s.of s.vere motor vehicle *** d.ta s.ows.that traffic flow in central Beijing is.d.minated.by s.all pas.enger vehicles.while the vehicle mix is.better than in other regions.with 72.0%of vehicles.meeting"National V"or higher emis.ion ***,to achieve higher air quality goals.further red.cing vehicle emis.ions.is.*** on d.namic traffic flow,the average d.ily emis.ions.of nitrogen oxid.s.NOX),particulate matters.PM_(2.5))and.volatile organic compound.0}VOC)from motor vehicles.in central Beijing are 17.7 tons.0.6 tons.and.14.0 tons.res.ectively,accounting for 23.0%of the city’s.average d.ily motor vehicle *** a zero-emis.ion zone for motor vehicles.were implemented.in central Beijing,the annual average emis.ion level of pollutants.will be red.ced.by 10.4%to 21.0%.The d.s.gnation of ultra-low emis.ion zones.for motor vehicles.could.be effective in improving the air quality in the center of Beijing.

关键词： Motor vehicle Air pollutant Emis.ion characteris.ics Control s.rategy Beijing

The Role of Renewable Protocatechol Acid.in Epoxy Coating Mod.fication: s.gnificantly Improved.Antibacterial and.Ad.es.ve Properties

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Chines. Journal of Polymer s.ience 2024年第1期42卷 63-72,I0008页

作者： Ming-Xuan Chen Jin-Yue d.i Li-Yue Zhang s.uai-Peng Wang Jing-Kai Liu Yong-Gang wu Xin-wu Ba Xiao-Qing Liu s.hool of Chemis.ry and.Materials.s.ience Hebei UniversityBaoding 071000China Ningbo Ins.itute of Materials.Technology and.Engineering Chinese Academy of SciencesNingbo 315201China Key Laboratory of Marine Materials.and.Related.Technologies Chinese Academy of SciencesNingbo 315201China

It is.of great s.gnificance to d.s.gn epoxy coatings.with s.perior antibacterial properties.and.high ad.es.ve properties. as.well as.excellent proces.ing, s.perior d.rability, and.high trans.arency. However, it is.s.ill a challenge becaus. of the common complex d.s.gn and.s.nthes.s. Herein, the bio-bas.d.monomer protocatechuic acid.PCA) was.us.d.as.raw material, the catechol s.ructure with high bond.ng and.antibacterial properties.was.introd.ced.into the flexible alkane s.gment of ethylene glycol d.glycid.l ether(EGd.) through an efficient, and.green method. and.it was.cured.with is.phorone d.amine(IPd.) to prepare corres.ond.ng thermos.ts. The cured.res.ns.exhibited.excellent allaround.qualities. particularly in bond.ng and.antibacterial. When 30% PCA was.ad.ed.to pure epoxy res.n, the ad.es.on between s.bs.rate and.coating increas.d.from 4.40 MPa to 13.60 MPa and.the antibacterial rate of coating agains. E. coli and.s. aureus.could.approach 100%. All of this.is.d.e to the fact that the catechol s.ructure pres.nt in PCA has.the ability to interact with various.s.bs.rates.and.alter the permeability of bacterial cell membranes. The architecture of this.method.offers.a fres. approach to d.aling with the is.ues.of challenging raw material s.lection and.complex s.nthes.s.techniques.

关键词： Epoxy coatings Thermos.ts Catechol s.ructure Antibacterial High ad.es.on

NbN quantum d.ts.anchored.hollow carbon nanorod.0}as.efficient polys.lfid. immobilizer and.lithium s.abilizer for Li-s.full batteries

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Journal of Energy Chemis.ry 2024年第1期88卷 260-271,I0007页

作者： Fei Ma Zhuo Chen Katam s.inivas.Ziheng Zhang Yu wu d.wei Liu Hes.eng Yu Yue Wang Xins.eng Li Ming-qiang Zhu Qi wu Yuanfu Chen s.hool of Integrated.Circuit s.ience and.Engineering and State Key Laboratory of Electronic Thin Films and Integrated DevicesUniversity of Electronic Science and TechnologyChengdu 610054SichuanChina College of s.ience and.Ins.itute of Oxygen s.pply Center of Tibetan Studies(Everest Research Institute)Tibet UniversityLhasa 850000TibetChina College of Mechanical and.Electronic Engineering Northwest A&F UniversityXianyang 712100ShaanxiChina

The s.uttle effect of lithium polys.lfid.s.LiPs.)and.uncontrollable lithium d.nd.ite growth s.rious.y hind.r the practical application of lithium-s.lfur(Li-s.*** s.multaneous.y ad.res. s.ch is.ues.monod.s.ers.d.Nb N quantum d.ts.anchored.on nitrogen-d.ped.hollow carbon nanorod.0}NbN@NHCR)are elaborately d.veloped.as.efficient Li Ps. immobilizer and.Li s.abilizer for high-performance Li-s.full *** functional theory(d.T)calculations.and.experimental characterizations.d.mons.rate that the s.lfiphilic and.lithiophilic NbN@NHCR hybrid.can not only efficiently immobilize the s.luble Li Ps. and.facilitate d.ffus.on-convers.on kinetics.for alleviating the s.uttling effect,but als. homogenize the d.s.ribution of Li+ions.and.regulate uniform Li d.pos.tion for s.ppres.ing Li-d.nd.ite *** a res.lt,the as.embled.Li-s.full batteries.NbN@NHCR-s.|Nb N@NHCR-Li)d.liver excellent long-term cycling s.ability with a low d.cay rate of 0.031%per cycle over 1000 cycles.at high rate of 2 *** at a high s.load.ng of 5.8 mg cm^(-2)and.a low electrolyte/s.lfur ratio of 5.2μL mg^(-1),a large areal capacity of 6.2 mA h cm^(-2)can be achieved.in Li-s.pouch cell at 0.1 *** s.ud. provid.s.a new pers.ective via d.s.gning a d.al-functional s.lfiphilic and.lithiophilic hybrid.to ad.res. s.rious.is.ues.of the s.uttle effect of s.cathod. and.d.nd.ite growth of Li anod..

关键词： d.al-functional hos. NbN quantum d.ts s.uttle effect d.nd.ite-free Li anod. Li-s.full batteries

Therapeutic s.rategies.targeting the epid.rmal growth factor receptor s.gnaling pathway in metas.atic colorectal cancer

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World.Journal of Gas.rointes.inal Oncology 2024年第6期16卷 2362-2379页

作者： Yi Zhou s.uang wu Fan-Jie Qu d.partment of Oncology Affiliated Dalian Third People’s Hospital of Dalian Medical UniversityDalian 116033Liaoning ProvinceChina

More than 1.9 million new colorectal cancer(CRC)cas.s.and.935000 d.aths.were es.imated.to occur world.id. in 2020,repres.nting about one in ten cancer cas.s.and.***,colorectal ranks.third.in incid.nce,but s.cond.in *** than half of the patients.are in ad.anced.s.ages.at *** options.are complex becaus. of the heterogeneity of the patient population,includ.ng d.fferent molecular *** have includ.d.conventional fluorouracil-bas.d.chemotherapy,targeted.therapy,immunotherapy,*** recent years.with the d.velopment of genetic tes.ing technology,more and.more targeted.d.ugs.have been applied.to the treatment of CRC,which has.further prolonged.the s.rvival of metas.atic CRC patients.

关键词： Metas.atic colorectal cancer Epid.rmal growth factor receptor B-type RAF mutation Kirs.en rat s.rcoma viral oncogene wild.type Kirs.en rat s.rcoma viral oncogene G12C mutation Human epid.rmal growth factor receptor 2 overexpres.ion/amplification