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Targeting epigenetic and.pos.trans.ational mod.fications.regulating ferroptos.s.for the treatment of d.s.as.s

s.gnal Trans.uction and.Targeted.Therapy 2024年第1期9卷 105-149页

作者： Yumin Wang Jing Hu s.uang wu Jos.ua s.Fleis.man Yulin Li Yins.i Xu Wailong Zou Jinhua Wang Yukuan Feng Jichao Chen Hongquan Wang d.partment of Res.iratory and.Critical Care Med.cine Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049PR China d.partment of Pathogen Biology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300060PR China d.partment of Neurology Zhongnan Hospital of Wuhan UniversityWuhan 430000PR China d.partment of Pharmaceutical s.iences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA d.partment of Outpatient Aerospace Center HospitalPeking University Aerospace School of Clinical MedicineBeijing 100049PR China Beijing Key Laboratory of d.ug Target and.s.reening Res.arch Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050PR China d.partment of Pancreatic Cancer Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerTianjin’s Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin 300060PR China

Ferroptos.s.a unique mod.lity of cell d.ath with mechanis.ic and.morphological d.fferences.from other cell d.ath mod.s.plays.a pivotal role in regulating tumorigenes.s.and.offers.a new opportunity for mod.lating anticancer d.ug *** epigenetic mod.fications.and.pos.trans.ational mod.fications.PTMs.promote anticancer d.ug res.s.ance,cancer progres.ion,and.*** s.ud.es.ind.cate that epigenetic mod.fications.can trans.riptionally and.trans.ationally d.termine cancer cell vulnerability to ferroptos.s.and.that ferroptos.s.functions.as.a d.iver in nervous.s.s.em d.s.as.s.Ns.s.,card.ovas.ular d.s.as.s.CVd.0},liver d.s.as.s.lung d.s.as.s.and.kid.ey *** this.review,we firs. s.mmarize the core molecular mechanis.s.of ***,the roles.of epigenetic proces.es.includ.ng his.one PTMs.d.A methylation,and.noncod.ng RNA regulation and.PTMs.s.ch as.phos.horylation,ubiquitination,s.MOylation,acetylation,methylation,and.Ad.-ribos.lation,are concis.ly *** roles.of epigenetic mod.fications.and.PTMs.in ferroptos.s.regulation in the genes.s.of d.s.as.s.includ.ng cancers.Ns.,CVd.0}liver d.s.as.s.lung d.s.as.s.and.kid.ey d.s.as.s.as.well as.the application of epigenetic and.PTM mod.lators.in the therapy of thes. d.s.as.s.are then d.s.us.ed.in *** the mechanis.s.of ferroptos.s.regulation med.ated.by epigenetic mod.fications.and.PTMs.in cancer and.other d.s.as.s.will facilitate the d.velopment of promis.ng combination therapeutic regimens.containing epigenetic or PTM-targeting agents.and.ferroptos.s.ind.cers.that can be us.d.to overcome chemotherapeutic res.s.ance in cancer and.could.be us.d.to prevent other *** ad.ition,thes. mechanis.s.highlight potential therapeutic approaches.to overcome chemores.s.ance in cancer or halt the genes.s.of other d.s.as.s.

关键词： d.s.as.s epigenetic overcome

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Aging Mongolian pine plantations.face high ris.s.of d.ought-ind.ced.growth d.cline:evid.nce from both ind.vid.al tree and.fores. s.and.meas.rements

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Journal of Fores.ry Res.arch 2024年第2期35卷 109-120页

作者： Mingyong Li Leilei Yang Yu Cao d.d.ng wu Guangyou Hao CAs.Key Laboratory of Fores. Ecology and.Management Institute of Applied EcologyChinese Academy of SciencesShenyang 110016People’s Republic of China Key Laboratory of Terres.rial Ecos.s.em Carbon Neutrality Liaoning ProvinceShenyang 110016People’s Republic of China d.qinggou Ecological Res.arch s.ation Institute of Applied EcologyChinese Academy of SciencesShenyang 110016People’s Republic of China Univers.ty of Chines. Acad.my of s.iences Beijing 100049People’s Republic of China Res.arch Ins.itute of s.nd.Control and.Utilization Liaoning ProvinceFuxin 123000People’s Republic of China

d.s.erning vulnerability d.fferences.among d.fferent aged.trees.to d.ought-d.iven growth d.cline or to mortality is.critical to implement age-s.ecific countermeas.res.for fores. management in water-limited.*** important s.ecies.for affores.ation in d.y environments.of northern China,Mongolian pine(Pinus.s.lves.ris.*** Litv.)has.recently exhibited.growth d.cline and.d.eback on many s.tes.particularly pronounced.in old.growth ***,changes.in res.ons. to d.ought s.res. by this.s.ecies.with age as.well as.the und.rlying mechanis.s.are poorly *** this.s.ud.,tree-ring d.ta and.remotely s.ns.d.vegetation d.ta were combined.to inves.igate variations.in growth at ind.vid.al tree and.s.and.s.ales.for young(9-13 years.and.aging(35-52 years.plantations.of Mongolian pine in a water-limited.area of northern China.A recent d.cline in tree-ring wid.h in the old.r plantation als. had.lower values.in s.tellited.d.rived.normalized.d.fference vegetation ind.ces.and.normalized.d.fference water ind.ces.relative to the younger *** ad.ition,all meas.red.growth-related.metrics.were s.rongly correlated.with the s.lf-calibrating Palmer d.ought s.verity ind.x d.ring the growing s.as.n in the old.r *** of growth to d.ought of the old.r plantation might be attributed.to more s.vere hyd.aulic limitations.as.reflected.by their lower s.pwood.and.leaf-s.ecific hyd.aulic *** s.ud. pres.nts.a comprehens.ve view on changes.of growth with age by integrating multiple method.0}and.provid.s.an explanation from the pers.ective of plant hyd.aulics.for growth d.cline with *** res.lts.ind.cate that old.growth Mongolian pine plantations.in water-limited.environments.may face increas.d.growth d.clines.und.r the context of climate warming and.d.ying.

关键词： Tree age d.ought s.res. Mongolian pine plantation Tree rings Remote s.ns.ng Plant hyd.aulics

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Frus.rated.s.percond.ctivity and.s.xtetting ord.r

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s.ience China(Phys.cs.Mechanics.& As.ronomy) 2024年第8期67卷 168-176页

作者： Zhiming Pan Chen Lu Fan Yang Congjun wu Ins.itute for Theoretical s.iences Westlake UniversityHangzhou 310024China New Corners.one s.ience Laboratory Department of PhysicsSchool of ScienceWestlake UniversityHangzhou 310024China s.hool of Phys.cs Beijing Institute of TechnologyBeijing 100081China Key Laboratory for Quantum Materials.of Zhejiang Province School of ScienceWestlake UniversityHangzhou 310024China Ins.itute of Natural s.iences Westlake Institute for Advanced StudyHangzhou 310024China

The s.percond.cting s.ate typically favors.a uniform s.atial d.s.ribution akin to ***,the pair-d.ns.tywave s.ate exhibits.s.gn changes.in the pairing ord.r,lead.ng to potential frus.rations.in phas. *** propos. a mechanis. to the s.xtetting ord.r s.emming from the frus.rations.in the phas. coherence of a pair-d.ns.ty-wave s.ate,whos. s.atial mod.lation manifes.s.a vortex-antivortex honeycomb *** clas.ical ground.s.ate configurations.are mapped.to Baxter's.three-coloring mod.l,revealing a macros.opic d.generacy accompanied.by extens.ve *** phas. coherence problem intertwines.the U(1)phas.s.and.the vorticity *** the res.ltant color and.phas. fluctuations.s.ppres. the pair-d.ns.tywave ord.r,they maintain the s.xtetting ord.r above the s.percond.cting trans.tion temperature(T_(c)).The 1/3-fractional vortex emerges.as.the fund.mental topological d.fect in the s.xtetting *** novel mechanis. of frus.rated.s.percond.ctivity provid.s.an alternative explanation for the experimental obs.rved.fractional os.illations.in Cs._(3)s._(5).

关键词： frus.rated.s.percond.ctivity pair d.ns.ty wave charge-6e ord.r

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Collaborative integration of Fe-N_(x)active center into d.fective s.lfur/s.lenium-d.ped.carbon for efficient oxygen electrocatalys.s.in liquid.and.flexible Zn-air batteries

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Chines. Chemical Letters 2024年第9期35卷 421-425页

作者： Yufeng wu Mingjun Jing Juan Li Wenhui d.ng Mingguang Yi Zhanpeng Chen Meixia Yang Jinyang wu Xinkai Xu Yans.n Bai Xiaoqing Zou Tianjing wu Xianyou Wang National Bas. for International s.ience&Technology Cooperation National Local Joint Engineering Laboratory for Key Materials of New Energy Storage BatteryKey Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationXiangtan UniversityXiangtan 411105China

s.rategic active s.te organization is.imperative for the ad.ancement of effective and.long-las.ing catalys.s.of oxygen red.ction ***,the controllable multi-active s.te d.s.gn is.a highly intricate topic for catalys. *** pre-trapping and.pos.-activation s.rategy,Fe-N bond.ng s.ructure and.s.s. functionalized.heteroatom are integrated.into a cond.ctive porous.*** this.proces.,the nitrogen-abund.nt polymer 1,3,5-triformylbenzene-tris.4-aminophenyl)benzene(Tf-TAPA)ad.0}rbs.Fe^(3+)und.r the intrins.cally metal anchoring ability of N atoms.and.s.multaneous.y in-s.tu as.embles.longchain ***,the Fe^(3+)is.trans.ormed.into Fe-N_(x)moieties.with the convers.on of the organic chain to incompletely graphitized.***,the alteration of the electronic configuration achieved.through the introd.ction of d.al-atom s.and.s. lead.0}to a pronounced.enhancement in catalytic *** from the Fe-N_(x)bond.ng s.ructure,d.ns. s.ructural d.fects.and.cond.ctive carbon networks.the res.ltant Fe-s.s./NCNs.pos.es.es.a pos.tive half-wave potential of 0.86 V and.a 90%current retention rate,outs.ripping the Pt/C ***,the liquid.and.flexible ZAB d.iven by Fe-s.s./NCNs.achieves.large power d.ns.ties.of 259.7 and.164.7 m W/cm^(2),*** s.ud. provid.s.a new comprehens.on in d.veloping an efficient and.s.able M-N-C oxygen electrocatalys..

关键词： Atomic regulation Chalcogens.co-d.ped Catalytic performance Noble metal-free electrocatalys. Zn-air battery

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Recent Ad.ances.in d.uteration Reactions

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Chines. Journal of Chemis.ry 2024年第10期42卷 1145-1156页

作者： Hao Li Muhammad.s.abbir wu Li Aiwen Lei Ins.itutefor Ad.anced.s.ud.es.IAs. Collegeof Chemistry and Molecular SciencesWuhan UniversityWuhanHubei 430072China

The d.uteration of organic compound.0}has.attracted.more attentions.in recent years.for the potential applications.in new d.ug d.s.overy and.s.nthetic *** this.purpos.,many efficient d.uterium labeling method.logies.have been d.veloped.includ.ng hyd.ogen is.tope exchange(HIE),red.ctive d.uteration,and.d.halogenative d.uteration that allow for the s.nthes.s.of s.lectively d.uterated.*** the las. few years.great breakthroughs.in s.lective is.tope labeling have been achieved.and.the interes. in new method.logies.for the d.uteration of organic molecules.is.*** this.review,we s.mmarized.the recent d.velopments.in the s.lective d.uteration of organic molecules.s.nce *** types.of key proces.es.in d.uterium incorporation reactions.includ.ng H/d.exchange,red.ctive d.uteration and.d.halogenative d.uteration,are introd.ced.and.d.s.us.ed.

关键词： d.uterated.compound. H/d.exchange Red.ctive d.uterations d.halogenative d.uterations d.uterium C-Hactivation s.nthetic method.

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Jiangs.n Mao:a pioneer in Chines. hepatitis.A vaccine and.interferon res.arch,a virologis. at the forefront of times

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Protein & Cell 2024年第1期15卷 1-5页

作者： Huan Liu Kunlan Zuo Zongzhen wu Hao Cheng Univers.ty of s.ience and.Technology of China Hefei 230026China s.ate Key Laboratory of Virology Wuhan 430072China Ins.itute of Microbiology Chinese Academy of SciencesBeijing 100101China

There is.a renowned.virologis. who d.d.cated.his.life to virology and.med.cine *** has.mad. important contributions.to the s.ud. of Chines. polio and.hepatitis.A vaccines.interferons.and.the theory of viral revers. *** invented.a live attenuated.vaccine for hepatitis.A(H2 s.rain)in the late 1970s.which contributed.to the prevention of hepatitis.A epid.mics.in China and.earned.him the title"Hepatitis.A Erad.cator"He s.id.

关键词： prevention hepatitis vaccine

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High-throughput and.s.multaneous.inertial s.paration of tumor cells.and.clus.ers.from malignant effus.ons.us.ng s.iral-contraction-expans.on channels

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Micros.s.ems.& Nanoengineering 2024年第2期10卷 91-99页

作者： Zhixian Zhu Hui Ren d.n wu Zhonghua Ni Nan Xiang s.hool of Mechanical Engineering and Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical InstrumentsSoutheast University211189NanjingChina s.hool of Mechanical Technology Wuxi Institute of TechnologyNo.1600 Gaolang West Road214129WuxiChina d.partment of Oncology Jiangyin People’s Hospital214400JiangyinChina

Tumor cell clus.ers.are regard.d.as.critical factors.in cancer pathophys.ology,and.increas.ng evid.nce of their higher treatment res.s.ance and.metas.as.s.compared.to s.ngle tumor cells.has.been ***,exis.ing cell s.paration method.0}that are d.s.gned.for s.ngle tumor cells.cannot be us.d.to s.multaneous.y purify tumor cell *** ad.res. this.problem,we d.mons.rated.a microfluid.c approach for the high-throughput,continuous.flow ternary s.paration of s.ngle tumor cells.tumor cell clus.ers.and.WBCs.from clinical pleural or abd.minal effus.ons.by coupling s.anted.s.iral channels.and.period.c contraction-expans.on *** firs. s.s.ematically explored.the influence of particle s.ze and.flow rate on particle *** s.paration performance ind.cated.that 94.0%of WBCs.were removed.and.more than 97%of Md.-MB-231 tumor cells.were recovered.at a high flow rate of 3500µL/***,more than 90%of tumor cell clus.ers.were effectively pres.rved.after ***,we s.cces.fully applied.our d.vice for the ternary s.paration of s.ngle tumor cells.tumor cell clus.ers.and.WBCs.from d.fferent malignant effus.ons.collected.from patients.with metas.atic ***,our s.iral-contraction-expans.on d.vice has.potential as.a s.mple pretreatment tool for the cytological d.agnos.s.of malignant effus.ons.

关键词： s.paration contraction removed

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Ald.hyd. oxid.s. med.ated.enantios.lective metabolic health ris. of d.notefuran

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s.ience China Chemis.ry 2024年第6期67卷 2079-2091页

作者： Liwei Xu Xinxin Xu Hua Kuang Chuanlai Xu Xiaoling wu s.ate Key Laboratory of Food.s.ience and.Res.urces Jiangnan UniversityWuxi214122China International Joint Res.arch Laboratory for Biointerface and.Biod.tection and.s.hool of Food.s.ience and.Technology Jiangnan UniversityWuxi214122China Collaborative Innovation center of Food.s.fety and.Quality Control in Jiangs. Province Jiangnan UniversityWuxi214122China

Chiral pollutants.often pos. s.gnificant d.fferential environmental health *** this.s.ud.,the biotrans.ormation of chiral d.notefuran(d.N)and.its.enantios.lective metabolic toxicity mechanis.s.have been s.s.emically ***,revers.d.has. chromatography-high res.lution mas. s.ectrometry was.d.veloped.to quantify the content of d.N R/s.chiral enantiomer with pg level s.ns.tivity,revealing a lower elimination rate cons.ant(K_(e))of s.d.N(0.730 h^(-1))than R-d.N(0.746 h^(-1)).s.cond.y,the interaction mechanis. between d.N metabolis. and.important end.genous.bioactive molecules.s.ch as.ald.hyd. oxid.s.(AOX)and.neurotrans.itters.was.*** d.N nitro-group was.converted.into a guanid.ne group by the red.cing s.te of nearby flavin ad.nine d.nucleotid.(FAd.in AOX with the preferred.higher affinity of ***,the end.genous.tryptophan(Trp)ald.hyd. metabolic intermed.ate,5-hyd.oxyind.leacetald.hyd.(5-HIAL),provid.s.a pers.s.ent electron d.nor for d.N red.ction via the oxid.tion-catalyzed.s.te in AOX,res.lting in remarkable up-regulation of monoamine neurotrans.itters.s.ch as.s.rotonin and.***,the higher level of neurotrans.itters.further med.ated.d.s.egulation of oxylipin homeos.as.s.via the s.rotonergic pathway,where s.d.N exhibited.more pronounced.liver lipid.d.mage and.environmental health ris. with the accumulated.lipid.biomarkers.oxid.zed.triglycerid.(OxTG)and.oxid.zed.s.hingomyelin(Oxs.).This.s.ud. elucid.tes.the AOX-med.ated.enantios.lectivity metabolic pathway of d.N,provid.ng a new analytical method.for chiral pollutants.and.paves.the way for their health ris. as.es.ments.

关键词： neonicotinoid.d.notefuran enantiomer ald.hyd. oxid.s. metabolomics health ris.

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d.fined.hyd.ogels.for s.inal cord.organoid.0}challenges.and.potential applications

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Neural Regeneration Res.arch 2024年第11期19卷 2329-2330页

作者： Wai Hon Chooi Yuewen wu s.i-Yan Ng Ins.itute of Molecular and.Cell Biology(IMCB) Agency for ScienceTechnology and Research(A*STAR)SingaporeSingapore d.partment of Phys.ology Yong Loo Lin School of MedicineNational University of Singapore(NUS)SingaporeSingapore

Organoid.0}of the central nervous.s.s.em,primarily d.rived.from pluripotent s.em cells.or neural s.em cells.are three-d.mens.onal tis.ue cultures.with s.lf-organizing *** expos.d.to the right combinations.of s.gnals.they d.fferentiate into a 3d.tis.ue cons.s.ing of complex cytoarchitecture and.native cell types.includ.ng various.neuron s.btypes.and.glial *** features.clos.ly mimic native tis.ues.making them invaluable for d.velopmental s.ud.es.and.d.s.as. *** recent years.s.inal cord.organoid.0}s.Os.have been d.veloped.to inves.igate s.inal cord.d.velopment,injuries.and.various.neurological *** an integral part of the central nervous.s.s.em,s.Os.play a vital role and.s.rve as.a s.te for s.ud.ing both neurod.velopment and.neurod.generative d.s.as.s.

关键词： properties injuries primarily

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Cyber-phys.cal Collaborative Res.oration s.rategy for Power Trans.is.ion s.s.em Cons.d.ring Maintenance s.hed.ling

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Cs.E Journal of Power and.Energy s.s.ems 2024年第3期10卷 1331-1341页

作者： Baozhong Ti Chuanyun Zhang Jingfei Liu Zhaoyuan wu Ziyang Huang North China Branch of s.ate Grid.Corporation of China Beijing 100053China s.ate Grid.Beijing Electric Power Company Beijing 100031China s.ate Key Laboratory of Alternate Electrical Power s.s.em with Renewable Energy s.urces School of Electrical and Electronic EngineeringNorth China Electric Power UniversityBeijing 102206China IEEE Cs.E

In ord.r to improve the ability of power trans.is.ion s.s.em to cope with compound.faults.on the communication s.d. and.power s.d.,a cyber-phys.cal collaborative res.oration s.rategy is.***,accord.ng to the information s.s.em’s.role in fault d.agnos.s.remote control of equipment maintenance and.automatic output ad.us.ment of generator res.oration,a cyber-phys.cal coupling mod.l is.*** this.bas.s.a collaborative res.oration mod.l of power trans.is.ion s.s.em is.es.ablis.ed.by s.ud.ing interactions.among maintenance s.hed.le paths.information s.s.em operation,and.power s.s.em *** on power flow linearization and.the large M-ε method.the above mod.l is.trans.ormed.into a mixed.integer linear programming mod.l,whos. computational burd.n is.red.ced.further by the clus.ering *** to the parameters.of IEEE39 New England.s.s.em,the geographic wiring d.agram of the cyber-phys.cal s.s.em is.*** res.lts.s.ow the propos.d.res.oration s.rategy can cons.d.r the s.pport function of the information s.s.em and.s.ace-time coord.nation of equipment maintenance at both s.d.s.comprehens.vely to s.eed.up load.recovery progres..

关键词： Clus.ering method collaborative res.oration cyber-phys.cal power s.s.em maintenance s.hed.ling power trans.is.ion s.s.em res.oration

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