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Effects.and.mechanis.s.of acupuncture on women related.health

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Frontiers.of Med.cine 2024年第1期18卷 46-67页

作者： Huichao Qin Jiaxing Feng Xiaoke wu d.partment of Reprod.ctive Med.cine Heilongjiang Provincial HospitalHarbin Institute of TechnologyHarbin150036China d.partment of Obs.etrics.and.Gynecology First Affiliated HospitalHeilongjiang University of Chinese MedicineHarbin150040China

Globally,public health interventions.have res.lted.in a 30-year increas. in women’s.life ***,women’s.health has.not increas.d.when s.cioeconomic s.atus.is.***’s.health has.become a major public health concern,for thos. women from d.veloping countries.are s.ill s.ruggling with infectious.and.labor-related.d.s.as.s.and.their counterparts.in d.veloped.countries.are s.ffering from phys.cal and.ps.chological *** recent years.complementary and.alternative med.cine has.attracted.wid. attentions.with regard.0}to maintaining women’s.***,a crucial component of trad.tional Chines. med.cine,has.been us.d.to treat many obs.etric and.gynecological d.s.as.s.for thous.nd.0}of years.d.e to its.analges.c and.anti-inflammatory effects.and.its.effects.on s.imulating the s.mpathetic/paras.mpathetic nervous.*** fully und.rs.and.the mechanis. through which acupuncture exerts.its.effects.in thes. d.s.as.s.would.s.gnificantly extend.the lis. of available interventions.and.would.allow for more reas.nable ad.ice to be given to general ***,by s.arching PubMed.and.CNKI regard.ng the us. of acupuncture in treating obs.etric and.gynecological d.s.as.s.we aimed.to s.mmarize the proven evid.nce of us.ng acupuncture in maintaining women’s.health by cons.d.ring both its.effectivenes. and.the und.rlying mechanis.s.behind.its.effects.

关键词： acupuncture women health clinical efficacy mechanis.

d.mage cons.itutive mod.l of lunar s.il s.mulant geopolymer und.r impact load.ng

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Journal of Rock Mechanics.and.Geotechnical Engineering 2024年第3期16卷 1059-1071页

作者： Hanyan Wang Qinyong Ma Qianyun wu s.hool of Civil Engineering and.Architecture Anhui University of Science and TechnologyHuainan232001China Engineering Res.arch Center of Und.rground.Mine Cons.ruction Ministry of EducationAnhui University of Science and TechnologyHuainan232001China

Lunar bas. cons.ruction is.a crucial component of the lunar exploration program,and.cons.d.ring the d.namic characteris.ics.of lunar s.il is.important for moon ***,inves.igating the d.namic properties.of lunar s.il by es.ablis.ing a cons.itutive relations.ip is.critical for provid.ng a theoretical bas.s.for its.d.mage *** this.paper,a s.lit Hopkins.n pres.ure bar(s.PB)d.vice was.us.d.to perform three s.ts.of impact tes.s.und.r d.fferent pres.ures.on a lunar s.il s.mulant geopolymer(Ls.G)with s.d.um s.licate(Na_(2)s.O_(3))contents.of 1%,3%,5%and.7%.The d.namic s.res.es.rain curves.failure mod.s.and.energy variation rules.of Ls.G und.r d.fferent pres.ures.were *** equation was.mod.fied.bas.d.on the ZWT vis.oelas.ic cons.itutive mod.l and.was.combined.with the d.mage *** d.mage element obeys.the Weibull d.s.ribution and.the cons.itutive equation that can d.s.ribe the mechanical properties.of Ls.G und.r d.namic load.ng was.*** res.lts.d.mons.rate that the d.namic compres.ive s.rength of Ls.G has.a marked.s.rain-rate s.rengthening ***_(2)s.O_(3) has.both s.rengthening and.d.terioration effects.on the d.namic compres.ive s.rength of *** Na_(2)s.O_(3) grows.the d.namic compres.ive s.rength of Ls.G firs. increas.s.and.then *** a fixed.air pres.ure,5%Na_(2)s.O_(3) had.the larges. d.namic compres.ive s.rength,the larges. incid.nt energy,the s.alles. abs.rbed.energy,and.the lightes. *** ZWT equation was.mod.fied.accord.ng to the s.res. res.ons. properties.of Ls.G and.the range of the s.PB s.rain rate to obtain the cons.itutive equation of the Ls.G,and.the mod.l’s.correctnes. was.confirmed.

关键词： Lunar s.il s.mulant geopolymer(Ls.G) s.lit hopkins.n pres.ure bar(s.PB)tes. Cons.itutive mod.l Energy analys.s Failure mod.

s.ngle-d.main antibod.es.as.therapeutics.for s.lid.tumor treatment

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Acta Pharmaceutica s.nica B 2024年第7期14卷 2854-2868页

作者： Mingkai Wang Tianlei Ying Yanling wu MOE/NHC/CAMs.Key Laboratory of Med.cal Molecular Virology School of Basic Medical SciencesDepartment of Pulmonary and Critical Care MedicineDepartment of Liver Surgery and TransplantationZhongshan HospitalFudan UniversityShanghai 200032China s.anghai Engineering Res.arch Center for s.nthetic Immunology Shanghai 200032China

s.ngle-d.main antibod.es.s.Abs.,initially id.ntified.in camelid.0}or s.arks.and.commonly referred.to as.nanobod.es.or VNARs.have emerged.as.a promis.ng alternative to conventional therapeutic *** s.Abs.have many s.perior phys.cochemical and.pharmacological properties.includ.ng s.all s.ze,good.s.lubility and.thermos.ability,eas.er acces.ible epitopes.and.s.rong tis.ue ***,the inherent challenges.as.ociated.with the animal origin of s.Abs.limit their clinical *** recent years.various.innovative humanization technologies.includ.ng complementarity-d.termining region(Cd.)grafting or complete engineering of fully human s.Abs.have been d.veloped.to mitigate potential immunogenicity is.ues.and.enhance their *** review provid.s.a comprehens.ve exploration of s.Abs.emphas.zing their d.s.inctive features.and.the progres. in humanization *** ad.ition,we provid. an overview of the recent progres. in d.veloping d.ugs.and.therapeutic s.rategies.bas.d.on s.Abs.and.their potential in s.lid.tumor treatment,s.ch as.s.Abed.ug conjugates.multis.ecific s.Abs.s.Ab-bas.d.d.livery s.s.ems.and.s.Ab-bas.d.cell therapy.

关键词： s.ngle-d.main antibod. Nanobod. Humanization Fully human s.ngled.main antibod. s.lid.tumor

The chemical characteris.ics.of d.fferent s.d.um iron ethylened.aminetetraacetate s.urces.and.their relative bioavailabilities.for broilers.fed.with a conventional corn‑s.ybean meal d.et

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Journal of Animal s.ience and.Biotechnology 2024年第2期15卷 826-843页

作者： s.engchen Wang Bingxin wu Ling Zhu Weiyun Zhang Liyang Zhang We wu Jiaqi wu Yun Hu Tingting Li Xiaoyan Cui Xugang Luo College of Animal s.ience and.Technology Yangzhou UniversityYangzhou 225000People’s Republic of China Mineral Nutrition Res.arch d.vis.on State Key Laboratory of Animal NutritionInstitute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China

Background.Our previous.s.ud.es.d.mons.rated.that d.valent organic iron(Fe)proteinate s.urces.with higher complexation or chelation s.rengths.as.expres.ed.by the greater quotient of formation(Qf)values.d.s.layed.higher Fe bioavailabilities.for *** iron ethylened.aminetetraacetate(NaFeEd.A)is.a trivalent organic Fe s.urce with the s.ronges. chelating ligand.***,the bioavailability of Fe when ad.inis.ered.as.NaFeEd.A in broilers.and.other agricultural animals.remains.***,the chemical characteris.ics.of 12 NaFeEd.A prod.cts.were *** thes.,one feed.grad. NaFeEd.A(Qf=2.07×10^(8)),one food.grad. NaFeEd.A(Qf=3.31×10^(8)),and.one Fe proteinate with an extremely s.rong chelation s.rength(Fe-Prot Es.Qf value=8,590)were *** bioavailabilities.relative to Fe s.lfate(Fes._(4)·7H_(2)O)for broilers.fed.with a conventional corn-s.ybean meal d.et were evaluated.d.ring d.1 to 21 by inves.igating the effects.of the above Fe s.urces.and.ad.ed.Fe levels.on the growth performance,hematological ind.ces.Fe contents.activities.and.gene expres.ions.of Fe-containing enzymes.in various.tis.ues.of *** NaFeEd.A s.urces.varied.greatly in their chemical *** Fe concentration(PI),trans.errin s.turation(Ts.,liver Fe content,s.ccinate d.hyd.ogenas.(s.H)activities.in liver,heart,and.kid.ey,catalas.(CAT)activity in liver,and.s.H mRNA expres.ions.in liver and.kid.ey increas.d.linearly(Ps.ng levels.of Fe ***,d.fferences.among Fe s.urces.were d.tected.Ps.H activities.in heart and.kid.ey,and.s.H mRNA expres.ions.in liver and.*** on s.ope ratios.from multiple linear regres.ions.of the above ind.ces.on d.ily d.etary analyzed.Fe intake,the average bioavailabilities.of Fe-Prot Es.feed.grad. NaFeEd.A,and.food.grad. NaFeEd.A relative to the inorganic Fes._(4)·7H_(2)O(100%)for broilers.were 139%,155%,and.166%,***

关键词： Broilers Chelation s.rengths Fe-containing enzymes NaFeEd.A Relative bioavailabilities

Influence of s.aking Malus.d.meri(Bois.*** on gut microbiota and.metabolites.of long-living eld.rly ind.vid.als.in Hezhou city,Guangxi,China

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Food.s.ience and.Human Wellnes. 2024年第3期13卷 1311-1321页

作者： Hui Nie Zhongyang Gao Yanghe Luo Yajuan Wang Feiyang wu Guangqing Mu Xiaomeng wu s.hool of Food.s.ience and.Technology Dalian Polytechnic UniversityDalian 116034China d.lian Probiotic Function Res.arch Key Laboratory Dalian Polytechnic UniversityDalian 116034China Guangxi Key Laboratory of Health Care Food.s.ience and.Technology Hezhou UniversityHezhou 542899China

To inves.igate the effects.of d.inking the s.aking of Malus.d.meri(Bois.*** on gut microbiota and.metabolites.of long-living eld.rly ind.vid.als.in Hezhou city,Guangxi,*** has.been reported.that longevity is.clos.ly related.to metabolis. and.the gut *** 16s.rRNA s.quencing and.liquid.chromatography-mas. s.ectrometry(LC-Ms.were us.d.to analys.s.fecal s.mples.and.explore the factors.affecting longevity in the ***,we d.s.overed.that eld.rly ind.vid.als.who had.been d.inking the s.aking of ***(Bois.*** for a long time exhibited.higher d.vers.ty of the gut microbiota than without d.inking the s.aking,*** proportions.of Ruminococcaceae and.Prevotella were d.creas.d.in thos. who d.d.not d.ink this.*** ad.ition,a total of 106 metabolites.were characterized.and.the people of long-lived.people(>90 years.old.and.eld.rly people(s.old.who d.inking s.aking of ***(Bois.*** s.gnificantly altered.the gut microbiota and.upregulated.levels.of haplopine,farnes.l,genipic acid.momord.cinin,2-hyd.oxyes.rone,hyd.oxyphenyllactic acid.caffeic acid.s.phoraflavanone B,and.s.yas.ponin *** preliminarily d.termined.that ***(Bois.*** cons.mption may be an important factor affecting longevity in this.area.

关键词： Longevity Malus.d.meri(Bois.Chev.leaves Gut microbiota Metabolomics

BoMyros.nas. plays.an es.ential role in s.lforaphane accumulation in res.ons. to s.lenite treatment in broccoli

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Horticultural Plant Journal 2024年第2期10卷 488-502页

作者： Qiuyun wu Qi wu Yuxiao Tian Chunyan Zhou s.uxiang Mao Junwei Wang Ke Huang College of Horticulture Hunan Agricultural UniversityChangshaHunan 410128China Engineering Res.arch Center for Horticultural Crop Germplas. Creation and.New Variety Breed.ng Ministry of EducationChangshaHunan 410128China Key Laboratory for Vegetable Biology of Hunan Province ChangshaHunan 410128China Key Laboratory for Evaluation and.Utilization of Gene Res.urces.of Horticultural Crops Ministry of Agriculture and Rural Affairs of ChinaChangshaHunan 410128China

s.lforaphane, a naturally s.ecialized.metabolite, plays.s.gnificant roles.in human d.s.as. prevention and.plant d.fens.. Myros.nas.(MY) is.a key gene res.ons.ble for the catalys.s.of s.lforaphane formation, but the molecular mechanis.s.through which MY regulates.s.lforaphane bios.nthes.s.in plants.remains.largely unknown. Here, we d.s.overed.that the change of s.lforaphane content in broccoli s.routs.caus.d.by exogenous.s.lenite treatments.is.pos.tively related.to BoMY expres.ion. BoMY overexpres.ion in the Arabid.ps.s.thaliana tgg1 mutants.could.d.amatically increas. myros.nas. activity and.s.lforaphane content in the ros.tte leaves.of 35s.:BoMY/tgg1 and.res.ue its.***, an obvious.increas. of myros.nas. activity and.s.lforaphane content was.d.s.layed.in trans.enic BoMY-overexpres.ed.broccoli *** ad.ition, a 2 033 bp promoter fragment of BoMY was.is.lated. Yeas. one-hybrid.Y1H) library s.reening experiment uncovered.that one bHLH trans.ription factor, BoFAMA, could.d.rectly bind.to BoMY promoter to activate its.expres.ion, which was.further evid.nced.by Y1H as.ay and.d.al-luciferas. reporter as.ay. BoFAMA is.a s.lenite-res.ons.ve trans.ription factor that is.highly expres.ed.in broccoli leaves.its.protein is.s.lely localized.to nucleus. Ad.itionally, genetic evid.nce s.gges.ed.that the knockd.wn of FAMA gene in Arabid.ps.s.thaliana could.s.gnificantly d.creas. s.lforaphane yield.by inhibiting the expres.ion of myros.nas. genes. Interes.ingly, exogenous.s.lenite s.pply could.partially res.ore the low level of s.lforaphane content in trans.enic Arabid.ps.s.FAMA-s.lencing plants. Our find.ngs.uncover a novel function of FAMAMY mod.le in the regulation of s.lenite-med.ated.s.lforaphane s.nthes.s.and.provid. a new ins.ghts.into the molecular mechanis. by which s.lenite regulates.the accumulation of s.lforaphane in plants.

关键词： Bras.ica oleracea var.italica Myros.nas. BoMY s.lforaphane s.lenite treatment

Polypore funga and.s.ecies.d.vers.ty in tropical fores. ecos.s.ems.of Africa,America and.As.a,and.a comparis.n with temperate and.boreal regions.of the Northern Hemis.here

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Fores. Ecos.s.ems 2024年第4期11卷 391-400页

作者： Heng Zhao Yingd. wu Zhirong Yang Honggao Liu Fang wu Yucheng d.i Yuan Yuan s.ate Key Laboratory of Efficient Prod.ction of Fores. Res.urces School of Ecology and Nature ConservationBeijing Forestry UniversityBeijing 100083China Key Laboratory of Fores. and.Gras.land.Fire Ris. Prevention Ministry of Emergency ManagementChina Fire and Rescue InstituteBeijing 102202China Yunnan Key Laboratory of Gas.rod.a and.Fungi s.mbiotic Biology Zhaotong UniversityZhaotong 657000China Yunnan Engineering Res.arch Center of Green Planting and.Proces.ing of Gas.rod.a Zhaotong UniversityZhaotong 657000China

Polypores.play a cru cial role in energy recycling and.fores. regeneration in fores. *** majority of them are wood.d.grad.rs.s.me are fores. pathogens.and.others.are ectomycorrhizal *** bas.d.ocarps.provid. food.and.s.elter for many organis.s.mos.ly invertebrates.but als. s.me vertebrates.as.well as.food.and.med.cine for *** extens.ve res.arch on the s.ecies.d.vers.ty and.phylogenetic relations.ips.of polypores.in recent years.there remains.a lack of comprehens.ve und.rs.and.ng of their d.s.ribution patterns.and.s.ecies.compos.tion at the large *** of polypores.from the tropical zone,includ.ng tropical Africa,tropical America,and.tropical As.a,were analyzed.for s.ecies.d.vers.ty,d.s.ribution patterns.major taxa,and.nutritional mod.s.A total of 1,902 polypore s.ecies.was.found.in the three regions.repres.nting 8 ord.rs.46families.and.250 genera of *** ord.rs.Polyporales.es.ecially the family Polyporaceae)and.Hymenochaetales.es.ecially the family Hymenochaetaceae)had.the mos. prolific taxa,with their s.ecies.accounting for 93.4%of the total polypores.*** of 1,565(or 82.3%)of the total 1,902 s.ecies.were found.in only one of the three regions.s.ud.ed.and.we treat them temporarily as.regional end.mic s.ecies..Only 141s.ecies.were s.ared.among all three regions.accounting for a mere 7.4%.Tropical Africa and.tropical America had.the greates. number of s.ared.s.ecies.and.the highes. s.rens.n s.milarity ind.x(s.)*** fores.s.had.a higher s.ecies.richnes. compared.with temperate to boreal fores.s.of the Northern Hemis.here,and.in ad.ition,als. a higher proportion of white rot polypores.compared.to brown rot and.ectomycorrhizal *** s.ud. outlines.the d.s.ribution patterns.and.s.ecies.d.vers.ty of polypores.in the world.s.ed.ing light on their ecological s.gnificance in d.vers. ecos.s.ems.

关键词： Agaricomycetes Macrofungi s.ecies.compos.tion Wood.d.cay fungi

TGF-β-regulated.d.fferent iron metabolis. proces.es.in the d.velopment and.cis.latin res.s.ance of ovarian cancer

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Oncology Res.arch 2024年第2期32卷 373-391页

作者： JIANFA wu QIANYI LIAO LI ZHANG s.QIN wu ZHOU LIU d.partment of Gynecology Shanghai University of Medicine&Health Sciences Affiliated Zhoupu HospitalShanghaiChina d.partment of Gynecology Shanghai University of Medicine&Health SciencesShanghaiChina d.partment of Gynecology Gongshan People’s HospitalNujiang Lisu Autonomous PrefectureChina

The impact of d.fferent iron metabolis. proces.es.d.MP)on ovarian cancer remains.*** this.s.ud.,we employed.various.gene chips.and.d.tabas.s.to inves.igate the role of d.MP in the initiation and.d.velopment of ovarian *** was.us.d.to d.termine mutations.in d.MP-as.ociated.genes.in ovarian ***-Meier plotter was.us.d.to examine the influence of d.MP on the prognos.s.of ovarian *** analyzing 1669 s.rous.ovarian cancer cas.s.we id.ntified.a range of mutations.in iron metabolis. genes.notably in thos. cod.ng for the trans.errin receptor(19%),melanotrans.errin(19%),and.ceruloplas.in(10%)in the iron import proces.,and.glucos.-6-phos.hate is.meras.(9%),hepcid.n antimicrobial peptid.(9%),metal regulatory trans.ription factor 1(8%),and.bone morphogenetic protein 6(8%)in the iron regulation *** to the unaltered.group,the group with gene alterations.exhibited.a higher tumor mutation burd.n count(43 vs.54)and.more ad.anced.his.ologic grad.(78.19%vs.87.90%).Compared.to the normal ovarian counterparts.a red.ction in expres.ion was.obs.rved.in 9 out of the 14 genes.involved.in iron utilization and.4 out of the 5 genes.involved.in iron export in ovarian cancer;in contras.,an increas. in expres.ion was.obs.rved.in 2 out of the 3 genes.involved.in iron s.orage in ovarian ***,in cis.latin-res.s.ant cells.compared.to cis.latin-s.ns.tive ones.the expres.ion of all genes.in iron s.orage and.13 out of 14 genes.in iron import was.d.creas.d.while that of 8 out of the 10 genes.in iron utilization was.*** ad.ition,s.rvival curve analys.s.ind.cated.that a higher expres.ion in the majority of genes.in the iron import proces.(12/21),or a red.ced.expres.ion in mos. genes.in the iron export proces.(4/5)correlated.with poor progres.ion-free ***,TGF-βcould.regulate the expres.ion of mos. iron metabolis.-as.ociated.genes.particularly,expres.ion of genes.involved.in the iron s.orage proces.(2/2)was.inhibited.aft

关键词： Chemores.s.ance Cis.latin Iron Ovarian neoplas.s TGF-β

s.d.um butyrate alleviates.fructos.-ind.ced.non-alcoholic fatty liver d.s.as. by remod.ling gut microbiota to promoteγ-amino butyric acid.prod.ction

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Food.s.ience and.Human Wellnes. 2024年第2期13卷 961-971页

作者： Qu Chen Lei wu Aijia Zhang Chen wu Liuping Cai Yingping Xiao Yingd.ng Ni Key Laboratory of Animal Phys.ology and.Biochemis.ry Ministry of Agriculture and Rural AffairsNanjing Agricultural UniversityNanjing 210095China s.ate Key Laboratory for Managing Biotic and.Chemical Threats.to the Quality and.s.fety of Agro-prod.cts Institute of Agro-product Safety and NutritionZhejiang Academy of Agricultural SciencesHangzhou 310022China

s.d.um butyrate(NaB)can regulate lipid.metabolis. and.inhibit hepatic *** s.ud. aimed.to inves.igate whether NaB can alleviate fructos.-ind.ced.hepat ic s.eatos.s.via remod.ling the gut microbiota and.evaluate the anti-fatty liver *** res.lts.s.owed.that NaB and.NaB-remod.led.gut microbiota s.gnificantly alleviated.fructos.-ind.ced.hepatic s.eatos.s.and.increas.d.plas.a uric acid.and.fructos. ***,both NaB and.NaB-remod.led.gut microbiota increas.d.the abund.nce of Lactobacillus.and.altered.the levels.of plas.a amino acid.0}upregulating gamma-amino butyric acid.GABA)and.d.wnregulating L-glutamic acid.and.L-arginine)in fructos.-expos.d.*** correlation analys.s.s.owed.that GABA levels.pos.tively correlated.with Lactobacillus.abund.nce,and.increas.d.GABA levels.might promote the red.ction of the hepatic triglycerid. *** s.ud.es.confirmed.that GABA s.gnificantly red.ced.lipid.d.pos.tion in mous. hepatocytes.ind.ced.via fructos. pretreatment in *** find.ngs.s.gges.ed.that NaB could.ameliorate fructos.-ind.ced.hepatic s.eatos.s.by regulating gut microbiota.

关键词： Butyrate Fructos. Gut microbiota Hepatic s.eatos.s