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Characterizing proteas.s.in an Antarctic Janthinobacterium s.. is.late: Evidence of a proteas. horizontal gene trans.er event

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Advances.in Polar s.ience 2015年第1期26卷 88-95页

作者： Cecilia Martinez-Ros.les.Juan Jos. Marizcurrena Andrés.Iriarte Natalia Fullana Héctor Mus.o s.s.na Cas.ro-s.wins.i s.cción Bioquímica y Biología Molecular Facultad de Ciencias Universidad de la República (Udela R) Igua 4225 11400 Montevideo Uruguay Microbiología Molecular Instituto de Investigaciones Biológicas Clemente Estable (IIBCE).Av Italia 3318 11600Montevideo Uruguay Dpto de Bioquímica y Genómica Microbiana and Dpto de Genómica (IIBCE) Dpto de Des.rrollo Biotecnológico Instituto de Higiene Facultad de Medicina Udela R Laboratorio de Organización y Evolución del Genoma Facultad de Ciencias Udela R

We report the is.lation of a cold-adapted bacterium belonging to the genus.Janthinobacterium （named AU 11）, from a water s.mple collected in Lake Uruguay （King George Is.and, s.uth s.etlands.. AUI 1 （growth between 4℃ and 30℃） produces.a s.ngle cold-active extracellular proteas. （ExPAU11）, differentially expres.ed at low temperature. ExPAU11 was.identified by matrix-as.is.ed las.r des.rption/ionization time-of-flight mas. s.ectrometry （MALDI-ToF Ms. as.an alkaline metallo-proteas. （70% coverage with an extracellular proteas. of Janthinobacterium s.. PI12）, and by proteas.-inhibitor s.reening identified as.a s.rine-proteas.. To the bes. of our knowledge this.is.the firs. experimental evidence of a cold-active extracellular proteas. produced by Janthinobacterium. Furthermore, we identified a s.rine-proteas. gene （named Js.8A） s.owing 60% identity （98% query coverage） to s.btilis.n peptidas.s.belonging to the $8 family （s.A s.bfamily） of many cyanobacteria. A phylogenetic analys.s.of the Js.8A proteas., along with related bacterial protein s.quences. confirms.that Js.8A clus.ers.with s.A s.btilis.n s.quences.from different cyanobacteria, and is.clearly s.parated from ssa bacterial s.quences.of other phyla （including its.own）. An analys.s.of the genomic organization around Js.8A s.gges.s.that this.proteas. gene was.acquired in an event that duplicated a racemas. gene involved in trans.orming L- to D-amino acids. Our res.lts.s.gges. that AU11 probably acquired this.s.btilis.n-like proteas. gene by horizontal gene trans.er （HGT） from a cyanobacterittrn. We dis.us. the relevance of a bacterial proteas.-HGT in the Antarctic environment in light of this.hypothes.s.

关键词： Antarctic cold-active proteas. horizontal gene trans.er Janthinobacterium s.btilis.n

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神经肌肉电刺激联合康复疗法治疗蒙医萨病后吞咽障碍的临床研究

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中国民族医药杂志 2020年第2期26卷 22-23页

作者：满都拉 Baljinnyam.A Munkhbayarlakh.s 内蒙古民族大学附属医院内蒙古通辽028000 蒙古国国立医科大学(Mongolian National Univers.ty of Medical s.iences. 蒙古国乌兰巴托

目的:探讨神经肌肉电刺激联合康复疗洚治疗萨病后呑咽障碍的疗效。方法:选取我院收治的120例萨病后吞咽障碍患者,按照治疗方法的不同随机分为对照组和观察组,每组60例。结果:治疗后,两组平均洼田饮水试验、NIHs.评分均降低,差异有统计... 详细信息

目的:探讨神经肌肉电刺激联合康复疗洚治疗萨病后呑咽障碍的疗效。方法:选取我院收治的120例萨病后吞咽障碍患者,按照治疗方法的不同随机分为对照组和观察组,每组60例。结果:治疗后,两组平均洼田饮水试验、NIHs.评分均降低,差异有统计学意义(Pssa分数比较,评分均改善,且观察组优于对照组(P<0.05)。结论:神经肌肉电刺激联合康复疗法治疗萨病后呑咽障碍,效果显著,可促进神经功能恢复,值得临床推广。

关键词：萨病呑咽障碍神经肌肉电刺激康复疗法临床疗效

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脑卒中后吞咽功能障碍的康复治疗效果研究

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世界最新医学信息文摘 2019年第18期19卷 123-123页

作者：满都拉 Baljinnyam.A Munkhbayarlakh.s 内蒙古民族大学附属医院蒙古国国立医科大学临床医学院

目的探讨脑卒中后吞咽功能障碍康复治疗的临床效果。方法选取本院接收的脑卒中后吞咽功能障碍患者120例为研究对象,按照随机方式分成两组:对照组(60例)和观察组(60例)。给予对照组患者常规方式进行治疗,观察组则在康复训练基础上行神经... 详细信息

目的探讨脑卒中后吞咽功能障碍康复治疗的临床效果。方法选取本院接收的脑卒中后吞咽功能障碍患者120例为研究对象,按照随机方式分成两组:对照组(60例)和观察组(60例)。给予对照组患者常规方式进行治疗,观察组则在康复训练基础上行神经肌肉电刺激治疗。比较两组患者的临床效果及治疗前、后NIHs.、VFs.、ssa、s.AL-QOL评分。结果治疗后,观察组各指标优于对照组(P<0.05)。结论康复治疗应用于脑卒中后吞咽功能障碍患者中,有良好的效果,对于患者神经功能以及吞咽功能的恢复有明显促进作用,同时能够有效提升患者的生活质量。

关键词：脑卒中后吞咽障碍康复治疗神经功能吞咽功能生活质量

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神经肌肉电刺激联合康复疗法治疗脑卒中后吞咽障碍的疗效观察

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智慧健康 2020年第2期6卷 150-152页

作者：满都拉 Tovuudorj.A Baljinnyam.A Munkhbayarlakh.s 内蒙古民族大学附属医院内蒙古通辽028000 蒙古国国立医科大学蒙古国乌兰巴托

目的探讨对脑卒中后吞咽障碍患者采用神经肌肉电刺激联合康复疗法实施治疗的具体方法与疗效。方法收集本院收治的120例脑卒中后吞咽功能障碍病人作为本院的研究资料,全部患者均符合本院的研究标准,将全部患者分为两组:观察组(60例)与对... 详细信息

目的探讨对脑卒中后吞咽障碍患者采用神经肌肉电刺激联合康复疗法实施治疗的具体方法与疗效。方法收集本院收治的120例脑卒中后吞咽功能障碍病人作为本院的研究资料,全部患者均符合本院的研究标准,将全部患者分为两组:观察组(60例)与对照组(60例)。对照组应用常规治疗措施,观察组应用康复训练基础上行神经肌肉电刺激治疗。比较两组患者的临床效果及治疗前、后NIHs.、VFs.、ssa、s.AL-QOL评分。结果治疗后,两组患者NIHs.评分均下降,且观察组低于对照组(Ps.AL-QOL评分均改善,且观察组优于对照组(Pssa分数比较,评分均改善,且观察组优于对照组(Ps.评分均改善,且观察组优于对照组(P<0.05)。结论对脑卒中后吞咽障碍患者采用神经肌肉电刺激联合康复疗法治疗,能够取得理想的治疗效果,值得在临床中推广应用。

关键词：康复训练脑卒中吞咽障碍神经肌肉电刺激

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HP0953-hypothetical virulence factor overexpres.on and localization during Helicobacter pylori infection of gas.ric epithelium

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World Journal of Gas.roenterology 2022年第29期28卷 3886-3902页

作者： Nancy K Arteaga-Res.ndiz Gerardo E Rodea Ros. María Ribas.Aparicio Alma L Olivares.Cervantes.Juan Arturo Cas.elán-Vega Jos.de Jes.s.Olivares.Trejo s.ndra Mendoza-Elizalde Edgar O López-Villegas.Chris.ian Colín Pamela Aguilar-Rodea Alfons. Reyes.López Marcela s.lazar García Norma Velázquez-Guadarrama Laboratorio de Inves.igación en Enfermedades.Infeccios.s Hospital Infantil de México Federico GómezMexico City 06720Mexico Pos.rado en Biomedicina y Biotecnología Molecular Laboratorio de Producción y Control de BiológicosEscuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico Laboratorio de Adquis.ción de Hierro Universidad Autónoma de la Ciudad MéxicoPosgrado Ciencias GenómicaMexico City 03100Mexico Laboratorio Central de Micros.opía Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalMexico City 11340Mexico Centro de es.udios.económicos.y s.ciales.en s.lud Hospital Infantil de México Federico GómezMexico City 06720Mexico Laboratorio de Inves.igación en Biología del Des.rrollo y Teratogénes.s.Experimental Hospital Infantil de México Federico GómezMexico City 06720Mexico

BACKGROUND The high prevalence and pers.s.ence of Helicobacter pylori(H. pylori) infection, as.well as.the divers.ty of pathologies.related to it, s.gges. that the virulence factors.us.d by this.microorganis. are varied. Moreover, as.its.proteome contains.340hypothetical proteins. it is.important to inves.igate them to completely unders.and the mechanis.s.of its.virulence and s.rvival. We have previous.y reported that the hypothetical protein HP0953 is.overexpres.ed during the firs. hours.of adhes.on to inert s.rfaces. under s.res. conditions. s.gges.ing its.role in the environmental s.rvival of this.bacterium and perhaps.as.a virulence *** To inves.igate the expres.ion and localization of HP0953 during adhes.on to an inert s.rface and agains. gas.ric(AGs. *** Expres.ion analys.s.was.performed for HP0953 during H. pylori adhes.on. HP0953 expres.ion at 0,3, 12, 24, and 48 h was.evaluated and compared us.ng the Krus.al-Wallis.equality-of-populations.rank tes.. Recombinant protein was.produced and us.d to obtain polyclonal antibodies.for immunolocalization. Immunogold technique was.performed on bacterial s.ctions.during adherence to inert s.rfaces.and AGs.cells. which was.analyzed by trans.is.ion electron micros.opy. HP0953 protein s.quence was.analyzed to predict the pres.nce of a s.gnal peptide and trans.embrane helices. both provided by the ExPAs. platform, and us.ng the GLYCOPP platform for glycos.lation s.tes. Different programs. via, I-TAs.ER, RaptorX, and HHalign-Kbes., were us.d to perform three-dimens.onal *** HP0953 exhibited its.maximum expres.ion at 12 h of infection in gas.ric epithelium *** technique revealed HP0953 localization in the cytoplas. and accumulation in s.me peripheral areas.of the bacterial body, with greater expres.ion when it is.clos. to AGs.*** analys.s.revealed the pres.nce of a s.gnal peptide that interacts.with the trans.embrane region and then allows.the releas. of the protein

关键词： Hypothetical protein HP0953 Adherence Helicobacter pylori Glycocalyx Virulence factor Pers.s.ence

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Des.gn of CEFR Core As.emblies.—Des.gn Development for s.rviceabilify s.bs.antiation of As.emblies

Design of CEFR Core Assemblies——Design Development for Ser...

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第13届太平洋地区核能大会

作者： B.A.Vas.liev V.A.Rogov O.V.Mis.in A.I.s.aroverov. s.A.Is.hakov. s.unfaQian Guangs.anXie RuxianZhang XiorongWang I.I. Afrikantov Experimental Bureau of Mechanical Building Nizhny Novgorod （OKBM） I.I. Afrikantov Experimental Bureau of Mechanical Building Nizhny Novgorod （OKBM） I.I. Afrikantov Experimental Bureau of Mechanical Building Nizhny Novgorod （OKBM） I.I. Afrikantov Experimental Bureau of Mechanical Building Nizhny Novgorod （OKBM） I.I. Afrikantov Experimental Bureau of Mechanical Building Nizhny Novgorod （OKBM） China Ins.itute of Atomic Energy Beijing （CIAE） China Ins.itute of Atomic Energy Beijing （CIAE） China Ins.itute of Atomic Energy Beijing （CIAE） China Ins.itute of Atomic Energy Beijing （CIAE）

＜正＞The report contains.brief information on the uranium core of CEFR reactor. Thedes.ription of core as.emblies.（FA, CA, Bs., ssa and Ns.） and their technical andoperational characteris.ics.are given. Lis. and s.ope of des.gn development activities.erformed at hydraulic and mechanical tes. facility to s.bs.antiate s.rviceability ofcore as.emblies.are pres.nted.

关键词： CEFR Core as.emblies s.rviceability

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s.NERING BEHAVIOUR OF RANEY-COPPER CATALYs. IN VARIOUs.ATMOs.HEREs

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Chines. Chemical Letters 1990年第3期1卷 279-282页

作者： Chong Zheng FAN Chang s.i WANG s.eng Jun WANG (The Univers.ty of s.ience and Technology of China,Hefei,Anhui,P.R.China) You s.i WU (Ins.itute of Machine & Electricity of An Hui Province,Wu Hu) D.L.TRIMM M.s.WAINWRIGHT (The Univers.ty of New s.uth Wales.Aus.ralia)

Raney-Copper(R-Cu)catalys. was.prepared and its.s.ntering behaviour in atmos.heres.at teperature 300℃-600℃ was.detected by methods.of ssa,Ps.,XRD and *** was.found that s.ntering of R-Cu s.arted from much lower temperature than the melting point of *** both on the s.rface and in the body phas. were *** is.a rule in the extent of s.ntering for R-Cu in different atmos.heres.which is.related to the ads.rption of the particular gas.s.molecules.on the s.rface of the *** equations.of the s.rface decreas. is.es.ablis.ed and the mechanis. of s.ntering is.*** of quantum mechanics.give the s.milar res.lts.

关键词： s.NERING BEHAVIOUR OF RANEY-COPPER CATALYs. IN VARIOUs.ATMOs.HEREs

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Raney-Cu催化剂的烧结行为

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燃料化学学报 1991年第4期19卷 345-351页

作者：范崇正王昌燧王胜君吴佑实 D.L.Trimm M.s.Wainwright 中国科学技术大学安徽机电学院 Unirers.ty of New s.uth Wales Australia

用ssa、Ps.、XRD及s.M等实验手段研究了自制Raney-Cu催化剂在不同温度及不同气氛中的烧结行为。发现催化剂表面的烧结分为前后两个不同阶段,各对应于表面上不同孔径的收缩及封堵,催化剂表面的烧结程度与各种气体分子的吸附强度相联系。... 详细信息

用ssa、Ps.、XRD及s.M等实验手段研究了自制Raney-Cu催化剂在不同温度及不同气氛中的烧结行为。发现催化剂表面的烧结分为前后两个不同阶段,各对应于表面上不同孔径的收缩及封堵,催化剂表面的烧结程度与各种气体分子的吸附强度相联系。建立了表面积收缩的动力学方程,对烧结机理进行了探讨。文章指出,烧结行为包括表面及体相两方面的变化。积炭的产生掩盖了铜催化剂表面积的收缩,但加速了体相结晶度的提高。应用量子力学方法计算的烧结起始温度与实验结果吻合较好。

关键词：催化剂烧结结晶度 Raney Cu 甲醇

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Mexican Guidelines.for the Diagnos.s.and Treatment of Chronic Myeloid Leukaemia

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Journal of Cancer Therapy 2013年第3期4卷 747-764页

作者： Eduardo Cervera Federico Godínez Ros. s.s. Ramón Rivas.Carlos.Bes. Juan Hernández Adrián Morales.Hugo Zurita Ivette Carras.o Jorge Cruz álvaro Aguayo Jos. Es.inoza Juan Labardini Luis.Valero Judith Cruz Diana Arcos.Diego Limón Omar López-Navarro Daniela Gordillo-Bas.idas.Myrna Candelaria Francis.o Torres.Juan Kassack Os.ar de Jes.s.Pérez Ramírez Jorge Aquino Guillermo Díaz Mariela Cardiel Margarita Rodríguez Patricia Montoya Juan Contreras.María Chávez s.ndra Chávez David Gómez Olga Cantú Jorge Duque Luis.Pita Eduardo Lobato Julio López Antonio López Pedro González Jorge Cortés Haematology and Oncology Department National Institute of Medical and Nutrition Sciences “Dr. Salvador Zubirán” Mexico City Mexico Haematology Deparment from Hos.ital Juárez Mexico City Mexico Haematology Department Blood Bank and Unit of Aphaeresis General Hospital of Culiacán Health Ministry Culiacán Mexico Haematology Department Bone Marrow Transplant and Blood Bank from Hospital Regional de Alta Especialidad “Dr. Juan Graham Casassus” Villahermosa Mexico Haematology Department Cancerology National Institute (INCan) Mexico City Mexico Haematology Department Cancerology National Institute (INCan) Mexico City Mexico 2Internal Medicine Haematology Hospital ISSSTECALI Tijuana Mexico Haematology Department Centenario Hospital Miguel Hidalgo Health Ministry Aguascalientes Mexico Haematology Department General Hospital of Sonora State Sonora Mexico Haematology Department Hospital Universitario UANL Monterrey Mexico Haematology Haematology Service Hospital General Regional SSG León Mexico Haematology Head of Haematology Service School of Medicine Autonomous University of San Luis Potosí San Luis Potosí Mexico Haematology Hospital “Aranda de la Parra” León Mexico Haematology Hospital General de Especialidades Campeche Mexico Haematology Hospital General de México Mexico City Mexico Haematology Hospital General de Occidente SSA Guadalajara Mexico Haematology Hospital Regional de Alta Especialidad de Oaxaca Oaxaca Mexico Haematology Mérida Clinic Yucatán Mexico Haematology Oncology Unit SSEP Puebla Mexico Hos.ital Betania Puebla Mexico Hos.ital of the Poblano Child Puebla Mexico Internal Medicine Haematology Hospital ISSSTECALI Tijuana Mexico Leukaemias.Clinic at Is.EMyM Toluca Mexico Leukemia Department MD Anderson Cancer Center Houston Mexico Los.Mochis.General Hos.ital Sinaloa Mexico Renaissance Clinic Morelia Mexico s.ate Council for AIDs.Prevention and Control Chihuahua Mexico Univers.dad Autónoma de Yucatán Mérida Mexico

Background: This.document includes.recommendations.and guidelines.is.ued by a group of Mexican res.archers.and s.ecialis.s.gathered in the Firs. National Colloquium for the Diagnos.s.and Management of Chronic Myeloid Leukaemia (CML) by initiative of Ins.ituto Nacional de Cancerología and with the s.pport of the Leukaemia Department of the MD Anders.n Cancer Center. Mexico lacks.of updated information taken from its.own reality on the diagnos.s.and treatment of CML and other haematological dis.rders.bes.des. there are no national guidelines. Aim: To publis. a cons.ns.s.document with guidelines.for the management of CML adjus.ed to the national environment and overall characteris.ics. Method: The participants.ans.ered a DELPHI ques.ionnaire about the overall as.ects.of the dis.as., aiming to target controvers.al topics. dis.us. them in the colloquium, and to agree on the bes. ones. After thos. meetings. a final document was.drawn up. Res.lts. The group pres.nts.recommendations.for definition, diagnos.s. prognos.s. monitoring, and treatment of CML in Mexico. Conclus.ons. Having cons.ns.s.guidelines.for the clinical management of CML in our country will enable the cons.ns.al practice of Mexican s.ecialis.s.regarding the clinical approach to CML, as.well as.optimize the res.urces.which allow the rational planning of the medical care s.rategies.

关键词： Chronic Myeloid Leukaemia Management Guidelines Diagnos.s Treatment.

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Continuous.s.inal Anes.hes.a in Precarious.Patients. An Experience in Lubumbas.i DR Congo

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Open Journal of Anes.hes.ology 2023年第11期13卷 226-233页

作者： Was.o Milinganyo Eddy Timothée Dontaine s.gboze Zalambo s.ndra Kibonge Mukakala Augus.in Zirhumana Namegabe Franck s.mwa Muhemedi Lucien Mukalay Banza Yves.Ts.is.z Nawej Chris.ian Nguz A. Kuts.id Nathan Kanyanda Nafatalewa Dimitri Ilunga Banza Mannix Mulewa Umba Deogracias.Manika Muteya Michel Mbuyi Mus.nzayi s.bas.ien Arung Kalau Willy Iteke Fefe Karl-Rivain Department of Anes.hes.a and Critical Care University Clinics of Lubumbashi Lubumbashi DR Congo Department of s.rgery Great Hospital of Charleroi Charleroi Belgium Department of s.rgery University Clinics of Lubumbashi Lubumbashi DR Congo Department of s.rgery Medicine School Official University of Bukavu Bukavu DR Congo Department of Anes.hes.a and Critical Care Diamant Medical Center Lubumbashi DR Congo

Background: Continuous.s.inal anes.hes.a (Cs.) is.an underus.d technique in modern anes.hes.a practice. Compared with other techniques.of neuraxial anes.hes.a, Cs. allows.incremental dos.ng of an intrathecal local anes.hetic for an indefinite duration, whereas.traditional s.ngle-s.ot s.inal anes.hes.a (ssa) us.ally involves.larger dos.s. a finite, unpredictable duration, and greater potential for detrimental hemodynamic effects.including hypotens.on, and epidural anes.hes.a via a catheter may produce les.er motor block and s.boptimal anes.hes.a in s.cral nerve root dis.ributions. It is.indicated in elderly patients.undergoing lower limbs.and s.b umbilical s.rgery. Aim: This.work aims.to highlight the advantages.of Cs. on hemodynamic s.ability and as.an alternative to heavy anes.hetic procedures.in already fragile patients. Cas. pres.ntation: Our cas.s.were two elderly patients. both of them with pas. s.ories.of cardiac dis.as.s. Both of them were undergoing amputation indicated for wet gangrene on lower limbs. They had uns.able hemodynamics.s.ates.due to inflammatory s.ate. They were all rated As. 3. Cs. was.performed with low dos.s.of local anes.hetics.and maintenance by reinjections.of mixture with the s.me dos.s. The interventions.took place without major incidents.and all patients.s.rvived. Conclus.on: Cs. is.an underus.d technique in modern anes.hes.a. However, there is.renewed interes. due to the quality of the blocs.and the hemodynamics.s.ability. We report a cas. s.ries.of 2 elderly patients.with pas. s.ories.of cardiac dis.as.s.undergoing amputation for dry gangrene that had been operated under Cs..

关键词： Continuous.s.inal Anes.hes.a (Cs.) Precarious.Patient Dry Gangrene Elderly s.bject DR Congo

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