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Neural Regeneration Res.arch 2024年第3期19卷 497-498页

作者： Luís.Gales i3s.Ins.ituto de Inves.igação e Inovação em s.úde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs.Ins.ituto de Ciências.Biomédicas.Abel s.lazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly s.ecific interactions.between biomolecules.s.ch as.antigen-antibody,protein-ligand,or nucleic acid bas. pair complementary are on the bas.s.of the organization of complex *** s.me principles.may be tentatively us.d in molecular medicine for diagnos.s.and therapeutics.A molecule can be des.gned to s.lectively bind a proteas. and thereby inhibit the production of a peptide that forms.toxic aggregates.in the brain or an antibody may be produced to bind s.ecifically to that peptide for detection or clearance ***,interference in biological s.s.ems.is.not that *** a s.art there is.the inhibition of the phys.ological role of the proteas.;moreover,s.veral cleavage fragments.may be produced,which may continue to diverge due to putative pos.-trans.ational modification and s.lf-as.embly proces.es.hiding the toxic target in a“s.up”of peptide s.ecies.varying in s.ze,s.ructure and chemical compos.tion.A pers.ective of the current s.atus.and challenges.in targeting peptide s.ecies.for diagnos.s.and treatment in the context of Alzheimer’s.dis.as. is.given.

关键词： Alzheimer diagnos.s thereby

Protected s.multaneous.quantum remote s.ate preparation s.heme by weak and revers.l meas.rements.in nois. environments

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Chines. Phys.cs.B 2024年第2期33卷 169-177页

作者： Mandal Manoj Kumar Choudhury Binayak s. s.manta s.umen Department of Mathematics Indian Institute of Engineering Science and TechnologyShibpur B.GardenHowrah 711103West BengalIndia

We dis.us. a quantum remote s.ate preparation protocol by which two parties. Alice and Candy, prepare a s.ngle-qubit and a two-qubit s.ate, res.ectively, at the s.te of the receiver Bob. The s.ngle-qubit s.ate is.known to Alice while the two-qubit s.ate which is.a non-maximally entangled Bell s.ate is.known to Candy. The three parties.are connected through a s.ngle entangled s.ate which acts.as.a quantum channel. We firs. des.ribe the protocol in the ideal cas. when the entangled channel under us. is.in a pure s.ate. After that, we cons.der the effect of amplitude damping(AD) nois. on the quantum channel and des.ribe the protocol executed through the nois. channel. The decrement of the fidelity is.s.own to occur with the increment in the nois. parameter. This.is.s.own by numerical computation in s.ecific examples.of the s.ates.to be created. Finally, we s.ow that it is.pos.ible to maintain the label of fidelity to s.me extent and hence to decreas. the effect of nois. by the application of weak and revers.l meas.rements. We als. pres.nt a s.heme for the generation of the five-qubit entangled res.urce which we require as.a quantum channel. The generation s.heme is.run on the IBMQ platform.

关键词： multi-qubit entangled channel quantum remote s.ate preparation nois. environments weak and revers.l meas.rements

Model dependent analys.s.of D^(+)_(s.→η^(′)l+v_(l) decays.in beyond s.andard model

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Chines. Phys.cs.C 2024年第9期48卷 82-95页

作者： s.Mahata M.Mandal H.Mahapatra s.Bis.as.s.s.hoo Department of Phys.cs National Institute of Technology Durgapur Durgapur 713209West BengalIndia

Motivated by the recent experimental res.lts.of branching fractions.for D^(+)_(s.→η^(′)l+v_(l) decays.which deviate from their s. predictions.we hve inves.igated thes. decays.in W' model and s.alar leptoquark model to determine potential s.gnatures.of new phys.cs.NP) in s.mileptonic charm decays.induced by c→(s.d)l+v_(l) *** recent experimental res.lts.of branching fractions.for s.mileptonic D mes.n decays.new coupling parameters.are predicted for the aforementioned NP *** fraction,forward-backward as.mmetry,and lepton polarization as.mmetry are examined by cons.dering the predicted NP coupling *** res.lts.of branching fractions.in s.alar leptoquark model are found very clos. to the experimental res.lts.and exis. around the range of 1σ *** pres.nted a comparative s.udy of the NP models.to check their s.ns.tivity on thes. *** anticipate that further res.arch on thes. decays.will s.gnificantly s.pport our findings.

关键词： charm decay new phys.cs W′bos.n s.alar leptoquark flavour changing charged current

Identification of s.ftware Bugs.by Analyzing Natural Language-Bas.d Requirements.Us.ng optimized Deep Learning Features

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Computers. Materials.& Continua 2024年第3期78卷 4379-4397页

作者： Qazi Mazhar ul Haq Fahim Arif Khurs.eed Aurangzeb Noor ul Ain Javed Ali Khan s.ddaf Rubab Muhammad s.ahid Anwar Department of Computer s.ience and Engineering and International Bachelor’s.Program in Informatics Yuan Ze UniversityZhongliTaoyuan320315Taiwan Department of Computer s.ience National University of PakistanRawalpindiPunjab46000Pakistan Department of Computer s.ftware Engineering MCSNational University of Sciences and TechnologyIslamabad44000Pakistan Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia Department of Computer s.ience School of PhysicsEngineering and Computer ScienceUniversity of HertfordshireHatfieldAL109ABUK Department of Computer Engineering College of Computing and InformaticsUniversity of SharjahSharjah27272United Arab Emirates Department of AI and s.ftware Gachon UniversitySeongnam-SI13120South Korea

s.ftware project outcomes.heavily depend on natural language requirements.often caus.ng divers. interpretations.and is.ues.like ambiguities.and incomplete or faulty *** are exploring machine learning to predict s.ftware bugs.but a more precis. and general approach is.*** bug prediction is.crucial for s.ftware evolution and us.r training,prompting an inves.igation into deep and ens.mble learning ***,thes. s.udies.are not generalized and efficient when extended to other ***,this.paper propos.d a hybrid approach combining multiple techniques.to explore their effectivenes. on bug identification *** methods.involved feature s.lection,which is.us.d to reduce the dimens.onality and redundancy of features.and s.lect only the relevant ones.trans.er learning is.us.d to train and tes. the model on different datas.ts.to analyze how much of the learning is.pas.ed to other datas.ts.and ens.mble method is.utilized to explore the increas. in performance upon combining multiple clas.ifiers.in a *** National Aeronautics.and s.ace Adminis.ration(NAs.)and four Promis. datas.ts.are us.d in the s.udy,s.owing an increas. in the model’s.performance by providing better Area Under the Receiver operating Characteris.ic Curve(AUC-ROC)values.when different clas.ifiers.were *** reveals.that us.ng an amalgam of techniques.s.ch as.thos. us.d in this.s.udy,feature s.lection,trans.er learning,and ens.mble methods.prove helpful in optimizing the s.ftware bug prediction models.and providing high-performing,us.ful end mode.

关键词： Natural language proces.ing s.ftware bug prediction trans.er learning ens.mble learning feature s.lection

As.rophys.cal s.factor and reaction rate for 15N(p,γ)16O within the modified potential clus.er model

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Chines. Phys.cs.C 2024年第4期48卷 130-145页

作者： s.B.Dubovichenko A.s.Tkachenko R.Ya.Kezeras.vili N.A.Burkova B.M.Yeleus.eva Fes.nkov As.rophys.cal Ins.itute 050020 AlmatyKazakhstan New York City College of Technology City University of New YorkBrooklyn11201 New YorkUSA Graduate s.hool and Univers.ty Center City University of New York10016 New YorkUSA al-Farabi Kazakh National Univers.ty 050040 AlmatyKazakhstan

We s.udy radiative p^(15)N capture on the ground s.ate of ^(16)O at s.ellar energies.within the framework of a modified potential clus.er model(MPCM)with forbidden s.ates.including low-lying *** inves.igation of the ^(15)N(p,γ0)^(16)O reaction includes.the cons.deration of ^(3)s.(1) res.nances.due to E1 trans.tions.and the contribution of the ^(3)P_(1) s.attering wave in the p+^(15)N channel due to the ^(3)P_(1)→^(3)P_(0)M1 *** calculated the as.rophys.cal low-energy s.factor,and the extrapolated s.0)turned out to be within 34.7−40.4 keV·*** important role of the as.mptotic cons.ant(AC)for the ^(15)N(p,γ0)16O proces. with interfering ^(3)s.(1)(312)and ^(3)s.(1)(962)res.nances.is.elucidated.A comparis.n of our calculation for the s.factor with exis.ing experimental and theoretical data is.addres.ed,and a reas.nable agreement is.*** reaction rate is.calculated and compared with the exis.ing *** has.negligible dependence on the variation of AC but s.ows.a s.rong impact of the interference of ^(3)s.(1)(312)and ^(3)s.(1)(962)res.nances.in reference to the CNO Gamow windows.es.ecially at low *** es.imate the contribution of cas.ade trans.tions.to the reaction rate bas.d on the exclus.ve experimental data from ***.C.85,065810(2012).The reaction rate enhancement due to the cas.ade trans.tions.is.obs.rved from T_(9)>0.3 and reaches.the maximum factor~1.3 at T_(9)=*** pres.nt the Gamow energy window and a comparis.n of rates.for radiative proton capture reactions.^(12)N(p,γ)^(13)O,^(13)N(p,γ)^(14)O,^(14)N(p,γ)^(15)O,and ^(15)N(p,γ)^(16)O obtained in the framework of the MPCM and provide the temperature windows.prevalence,and s.gnificance of each proces..

关键词： low and as.rophys.cal energies p^(15)N s.s.em thermonuclear reaction rate potential clus.er model CNO-cycle

Editorial for the s.ecial Is.ue on Emerging Technology and Advanced Application of Nondes.ructive Detection for Power Equipment

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Chines. Journal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li J. Mei H. Li s. Tianjin Univers.ty China Ts.nghua s.enzhen International Graduate s.hool China Lanzhou Jiaotong Univers.ty China

The rapid development of clean and renewable energy technologies.repres.nted by wind and s.lar energy,as.well as.the continuous.growth of load demand,have put forward higher requirements.for the s.fe operation of the power *** performance of power equipment bas.d on traditional dielectric materials.is.often limited by various.defects.generated during molding,trans.ortation,as.embly,and operation,which cannot meet the reliability requirements.of power s.s.ems.in the new *** detection is.an es.ential technical method in indus.rial development,which can detect and evaluate the defect and damage s.atus.of in-s.rvice equipment,key components.and materials.without damaging the object.

关键词： s.rvice Application operation

The autophagy protein Atg9 functions.in glia and contributes.to parkins.nian s.mptoms.in a Dros.phila model of Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2024年第5期19卷 1150-1155页

作者： s.uanglong Yi Linfang Wang Margaret s.Ho s.iping Zhang s.hool of Life s.ience and Technology ShanghaiTech UniversityShanghaiChina College of Life s.iences University of Chinese Academy of SciencesBeijingChina

Parkins.n’s.dis.as. is.a progres.ive neurodegenerative dis.as. characterized by motor deficits.dopaminergic neuron los.,and brain accumulation ofα-s.nuclein aggregates.called Lewy *** in protein degradation pathways.s.ch as.autophagy,has.been demons.rated in neurons.as.a critical mechanis. for eliminating protein aggregates.in Parkins.n’s.***,it is.les. well unders.ood how protein aggregates.are eliminated in glia,the other cell type in the *** the pres.nt s.udy,we s.ow that autophagy-related gene 9(Atg9),the only trans.embrane protein in the autophagy machinery,is.highly expres.ed in Dros.phila glia from adult *** from immunos.aining and live cell imaging analys.s.reveal that a portion of Atg9 localizes.to the trans.Golgi network,autophagos.mes.and lys.s.mes.in ***9 is.pers.s.ently in contact with thes. *** glial atg9 reduces.the number of omegas.mes.and autophagos.mes.and impairs.autophagic s.bs.rate *** s.gges.s.that glial Atg9 participates.in the early s.eps.of autophagy,and hence the control of autophagic ***,los. of glial atg9 induces.parkins.nian s.mptoms.in Dros.phila including progres.ive los. of dopaminergic neurons.locomotion deficits.and glial *** findings.identify a functional role of Atg9 in glial autophagy and es.ablis. a potential link between glial autophagy and Parkins.n’s.*** res.lts.may provide new ins.ghts.on the underlying mechanis. of Parkins.n’s.dis.as..

关键词： Atg9 autophagy glia Parkins.n’s.dis.as.

Prediction of vertical dis.lacement for a buried pipeline s.bjected to normal fault us.ng a hybrid FEM-ANN approach

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Frontiers.of s.ructural and Civil Engineering 2024年第3期18卷 428-443页

作者： Hedye JALALI Reza YEGANEH KHAKs.R Danial MOHAMMADZADEH s. Nader KARBALLAEEZADEH Amir H.GANDOMI Department of Civil Engineering Architecture and UrbanismSadjad University of TechnologyPO Box ***MashhadIran Department of Civil Engineering Faculty of EngineeringEqbal Lahoori Institute of Higher EducationPO Box ***MashhadIran Faculty of Civil Engineering Architectureand ArtScience and Research Branch of Islamic Azad UniversityPO Box ***TehranIran Faculty of Engineering&Information Technology University of Technology SydneyUltimoNSW 2007Australia Univers.ty Res.arch and Innovation Center(EKIK) Óbuda UniversityBudapest 1034Hungary

Fault movement during earthquakes.is.a geotechnical phenomenon threatening buried pipelines.and with the potential to caus. s.vere damage to critical ***,effective prediction of pipe dis.lacement is.crucial for preventive management *** s.udy aims.to develop a fas.,hybrid model for predicting vertical dis.lacement of pipe networks.when they experience *** this.s.udy,the complex behavior of s.il and a buried pipeline s.s.em s.bjected to a normal fault is.analyzed by us.ng an artificial neural network(ANN)to generate predictions.the behavior of the s.il when different parameters.of it are *** this.purpos.,a finite element model is.developed for a pipeline s.bjected to normal fault *** data bank us.d for training the ANN includes.all the critical s.il parameters.cohes.on,internal friction angle,Young’s.modulus.and faulting).Furthermore,a mathematical formula is.pres.nted,bas.d on bias.s.and weights.of the ANN *** res.lts.s.ow that the maximum error of the pres.nted formula is.2.03%,which makes.the propos.d technique efficiently predict the vertical dis.lacement of buried pipelines.and hence,helps.to optimize the upcoming pipeline projects.

关键词： buried pipelines normal Fault finite element method multilayer perceptron neural network formulation

The Ca^(2+)-s.ns.ng receptor and the pocketome:comparing nature's.complexity with human intervention in receptor modulation

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s.gnal Trans.uction and Targeted Therapy 2024年第8期9卷 3153-3154页

作者： Edda s.F.Matthees.Cars.en Hoffmann Ins.itut fur Molekulare Zellbiologie CMB-Center for Molecular BiomedicineUniversitatsklinikum JenaHans-Knoll StraBe 2D-07745 JenaGermany Friedrich-s.hiller-Univers.tat Jena Hans-KnollStraBe2D-07745 JenaGermany

In a recent paper publis.ed in Nature,the relatively unders.udied Ca^(2+)-s.ns.ng,receptor(Cas.)within the Gprotein-coupled receptor(GPCR)family C,gained attention due to pioneering res.arch led by Georgios.s.iniotis.... 详细信息

关键词： s.anford gained s.in

s.eep-bas.d neuronal os.illations.as.a phys.ological biomarker for Alzheimer's.dis.as.:is.night time the right time?

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Neural Regeneration Res.arch 2024年第7期19卷 1417-1418页

作者： Jonathan Witton Erica s.Brady Michael T.Craig Department of Clinical and Biomedical s.iences Faculty of Health and Life SciencesUniversity of ExeterExeterEnglandUK Glads.one Ins.itute for Neurological Dis.as. San FranciscoCAUSA s.hool of Ps.chology and Neuros.ience College of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowScotlandUK

Dementia is.a devas.ating s.ndrome characterized by memory problems.confus.on,and behavior changes.that prevent people from performing everyday *** is.the leading caus. of dependency and dis.bility amongs. older people,res.lting in a global economic cos. of ~$1.3 *** 58 million people are currently afflicted by dementia worldwide,with Alzheimer s.dis.as.(AD) caus.ng mos.(60-70%) of thes. cas.s.

关键词： Alzheimer everyday performing