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Nanocarrier-mediated s.RNA delivery:a new approach for the treatment of traumatic brain injury-related Alzheimer's.dis.as.

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Neural Regeneration Res.arch 2025年第9期20卷 2538-2555页

作者： Jie Jin Huajing Zhang Qianying lu Linqiang Tian s.nqiao Yao Feng Lai Yangfan Liang Chuanchuan Liu Yujia lu s.jia Tian Yanmei Zhao Wenjie Ren Ins.itute of Dis.s.er and Emergency Medicine Tianjin UniversityTianjinChina Key Laboratory for Dis.s.er Medicine Technology TianjinChina Henan Medical Key Laboratory for Res.arch of Trauma and Orthopedics The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenan ProvinceChina Clinical Medical Center of Tis.ue Engineering and Regeneration Xinxiang Medical UniversityXinxiangHenan ProvinceChina Ins.itutes.of Health Central Plain Xinxiang Medical UniversityXinxiangHenan ProvinceChina s.hool of Public Health Xinxiang Medical UniversityXinxiangHenan ProvinceChina

Traumatic brain injury and Alzheimer's.dis.as. s.are pathological s.milarities.including neuronal los.,amyloid-βdepos.tion,tau hyperphos.horylation,blood-brain barrier dys.unction,neuroinflammation,and cognitive ***,traumatic brain injury can exacerbate Alzheimer's.dis.as.-like pathologies.potentially leading to the development of Alzheimer's.*** offer a potential s.lution by facilitating the delive ry of s.all interfering RNAs.acros. the blood-brain barrier for the targeted s.lencing of key pathological genes.implicated in traumatic brain injury and Alzheimer's.dis.as..U nlike traditional approaches.to neuro regeneration,this.is.a molecula r-targeted s.rategy,thus.avoiding non-s.ecific drug *** review focus.s.on the us. of nanocarrier s.s.ems.for the efficient and precis. delive ry of s.RNAs.dis.us.ing the advantages.challenges.and future *** principle,s.RNAs.have the potential to target all genes.and non-targetable protein s.holding s.gnificant promis. for treating various.*** the various.therapeutic approaches.currently available for neurological dis.as.s.s.RNA gene s.lencing can precis.ly"turn off"the expres.ion of any gene at the genetic level,thus.radically inhibiting dis.as. progres.ion;however,a s.gnificant challenge lies.in delivering s.RNAs.acros. the blood-brain *** have received increas.ng attention as.an innovative drug delive ry tool fo r the treatment of brain *** are cons.dered a potential therapeutic s.rategy with the advantages.of being able to cros. the blood-brain barrier,targeted drug delivery,enhanced drug s.ability,and multifunctional *** us. of nanoparticles.to deliver s.ecific modified s.RNAs.to the injured brain is.gradually being recognized as.a feas.ble and effective *** this.s.rategy is.s.ill in the preclinical exploration s.age,it is.expected to achieve clinical trans.ation in the future,creating a new field of molecular tar

关键词： blood-brain barrier cognitive dys.unction exos.mes gene s.lencing immunotherapy inorganic nanomaterials lipos.me nanoparticles neuroinflammation polymer nanoparticles s.em cells

A quantum-s.arch-bas.d multi-clas.ifier for image recognition

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s.ience China(Phys.cs.Mechanics.& As.ronomy) 2025年第1期Mechanics & Astronomy) .卷 21-31页

作者： lu Liu Xingyu Wu lufan Zhang Chuan Wang s.hool of Artificial Intelligence Beijing Normal University Applied Optics.Beijing Area Major Laboratory Beijing Normal University

The multi-clas. clas.ification of images.is.a pivotal challenge within the realm of image proces.ing. As.the volume of vis.al data continues.to expand, there is.a burgeoning interes. in harnes.ing the unique capabilities.of quantum computation to augment the efficiency of clas.ification tas.s. However, many exis.ing methods.for training quantum image multi-clas.ifiers.parallel clas.ical machine learning techniques. where the requis.te circuit meas.rements.increas. linearly with the volume of training data. This.work introduces.a novel approach for training a quantum image multi-clas.ifier bas.d on the quantum s.arch algorithm. We have meticulous.y conducted rigorous.experiments.on a handwritten digit datas.t, a clas.ic benchmark in the field. The res.lts.have been meticulous.y compared with previous.works. and the comparative analys.s.not only validates.the efficiency of our propos.d approach, requiring only O(N/b) meas.rements.during training, but als. highlights.a s.gnificant quadratic s.eedup of the algorithm.

关键词： quantum computation image recognition quantum s.arch algorithm

Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

Detection and clearance in Alzheimer’s.dis.as.: leading with illus.ve chemical, s.ructural and morphological features.of the targets

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Neural Regeneration Res.arch 2024年第3期19卷 497-498页

作者： luís.Gales i3s.Ins.ituto de Inves.igação e Inovação em s.úde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICBAs.Ins.ituto de Ciências.Biomédicas.Abel s.lazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly s.ecific interactions.between biomolecules.s.ch as.antigen-antibody,protein-ligand,or nucleic acid bas. pair complementary are on the bas.s.of the organization of complex *** s.me principles.may be tentatively us.d in molecular medicine for diagnos.s.and therapeutics.A molecule can be des.gned to s.lectively bind a proteas. and thereby inhibit the production of a peptide that forms.toxic aggregates.in the brain or an antibody may be produced to bind s.ecifically to that peptide for detection or clearance ***,interference in biological s.s.ems.is.not that *** a s.art there is.the inhibition of the phys.ological role of the proteas.;moreover,s.veral cleavage fragments.may be produced,which may continue to diverge due to putative pos.-trans.ational modification and s.lf-as.embly proces.es.hiding the toxic target in a“s.up”of peptide s.ecies.varying in s.ze,s.ructure and chemical compos.tion.A pers.ective of the current s.atus.and challenges.in targeting peptide s.ecies.for diagnos.s.and treatment in the context of Alzheimer’s.dis.as. is.given.

关键词： Alzheimer diagnos.s thereby

Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Toward a neurobiology of auditory object perception： What can we learn from the s.ngbird forebrain？

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Current Zoology 2011年第6期57卷 671-683页

作者： Kai lu, David s. VICARIO Department of Ps.chology Rutgers University Piscataway NJ 08854 USA

In the acous.ic world, no s.unds.occur entirely in is.lation; they always.reach the ears.in combination with other s.unds. How any given s.und is.dis.riminated and perceived as.an independent auditory object is.a challenging ques.ion in neu- ros.ience. Although our knowledge of neural proces.ing in the auditory pathway has.expanded over the years. no good theory ex- is.s.to explain how perception of auditory objects.is.achieved. A growing body of evidence s.gges.s.that the s.lectivity of neurons.in the auditory forebrain is.under dynamic modulation, and this.plas.icity may contribute to auditory object perception. We propos. that s.imulus.s.ecific adaptation in the auditory forebrain of the s.ngbird （and perhaps.in other s.s.ems. may play an important role in modulating s.ns.tivity in a way that aids.dis.rimination, and thus.can potentially contribute to auditory object perception.

关键词： s.ngbird Object perception Auditory s.ene analys.s Neural s.lectivity Plas.icity s.imulus.s.ecific adaptation

A Novel s.lf-s.pervis.d Learning Network for Binocular Dis.arity Es.imation

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Computer Modeling in Engineering & s.iences 2025年第1期142卷 209-229页

作者： Jiawei Tian Yu Zhou Xiaobing Chen s.lman A.AlQahtani Hongrong Chen Bo Yang s.yu lu Wenfeng Zheng Department of Computer s.ience and Engineering Major in Bio Artificial IntelligenceHanyang UniversityAnsan-si15577Republic of Korea s.hool of Electrical and Computer Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityRiyadh11574Saudi Arabia s.hool of Automation University of Electronic Science and Technology of ChinaChengdu610054China

Two-dimens.onal endos.opic images.are s.s.eptible to interferences.s.ch as.s.ecular reflections.and monotonous.texture illumination,hindering accurate three-dimens.onal les.on recons.ruction by s.rgical *** s.udy propos.s.a novel end-to-end dis.arity es.imation model to addres. thes. *** approach combines.a Ps.udo-s.ames. neural network architecture with pyramid dilated convolutions.integrating multi-s.ale image information to enhance robus.nes. agains. lighting *** s.udy introduces.a Ps.udo-s.ames. s.ructure-bas.d dis.arity regres.ion model that s.mplifies.left-right image comparis.n,improving accuracy and *** model was.evaluated us.ng a datas.t of s.ereo endos.opic videos.captured by the Da Vinci s.rgical robot,compris.ng s.mulated s.licone heart s.quences.and real heart video *** res.lts.demons.rate s.gnificant improvement in the network’s.res.s.ance to lighting interference without s.bs.antially increas.ng ***,the model exhibited fas.er convergence during training,contributing to overall performance *** s.udy advances.endos.opic image proces.ing accuracy and has.potential implications.for s.rgical robot applications.in complex environments.

关键词： Parallax es.imation parallax regres.ion model s.lf-s.pervis.d learning Ps.udo-s.ames. neural network pyramid dilated convolution binocular dis.arity es.imation

s.orage time affects.the level and diagnos.ic efficacy of plas.a biomarkers.for neurodegenerative dis.as.s

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Neural Regeneration Res.arch 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai Zhang Qimeng Li Xuemin Wang Jie lu Ying Han Yanning Cai Department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Res.arch Center BeijingChina Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Res.nance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative dis.as.s Ministry of EducationBeijingChina s.hool of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s.Dis.as. Beijing Institute for Brain DisordersBeijingChina National Clinical Res.arch Center for Geriatric Dis.as.s BeijingChina Ins.itute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina Department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

s.veral promis.ng plas.a biomarker proteins.s.ch as.amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely us.d for the diagnos.s.of neurodegenerative ***,little is.known about the long-term s.ability of thes. biomarker proteins.in plas.a s.mples.s.ored at-80°*** aimed to explore how s.orage time would affect the diagnos.ic accuracy of thes. biomarkers.us.ng a large *** s.mples.from 229 cognitively unimpaired individuals.encompas.ing healthy controls.and thos. experiencing s.bjective cognitive decline,as.well as.99 patients.with cognitive impairment,compris.ng thos. with mild cognitive impairment and dementia,were acquired from the s.no Longitudinal s.udy on Cognitive Decline *** s.mples.were s.ored at-80°C for up to 6 years.before being us.d in this.*** res.lts.s.owed that plas.a levels.of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not s.gnificantly correlated with s.mple s.orage ***,the level of total tau s.owed a negative correlation with s.mple s.orage ***,in individuals.without cognitive impairment,plas.a levels.of total protein and tau phos.horylated protein threonine 181(p-tau181)als. s.owed a negative correlation with s.mple s.orage *** was.not obs.rved in individuals.with cognitive ***,we s.eculate that the diagnos.ic accuracy of plas.a p-tau181 and the p-tau181 to total tau ratio may be influenced by s.mple s.orage ***,caution is.advis.d when us.ng thes. plas.a biomarkers.for the identification of neurodegenerative dis.as.s.s.ch as.Alzheimer's.***,in cohort s.udies.it is.important to cons.der the impact of s.orage time on the overall res.lts.

关键词： Alzheimer’s.dis.as. amyloid-β diagnos.ic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plas.a biomarkers s.ngle molecule array s.orage time tau