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Evaluation of the Ris. Factors.for Pelvic Lymph Node Metas.as.s.in Early s.age Cervical Cancer

Journal of Cancer Therapy 2018年第12期9卷 1011-1026页

作者： J. Ferdous.s. Khatun s. Akhter s. chowdhury s. Pervin M. Amir A. Goodman Gynaecological Oncology Department of Obs & Gynae Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Pathology BSMMU Dhaka Bangladesh Department of Obs.& Gynae BSMMU Dhaka Bangladesh Department of Gynaecological Oncology National Institute of Cancer Research Hospital (NICRH) Dhaka Bangladesh Department of Obs.& Gynae Mugda Medical College Hospital Dhaka Bangladesh Mas.achus.tts.General Hos.ital Boston USA

Objective: This.s.udy evaluated the ris. factors.for pelvic lymph node metas.as.s.in patients.with early s.age cervical cancer. Material and Methods. A cros. s.ctional s.udy was.carried out in the Divis.on of Gynaecologic Oncology at Bangabandhu s.eikh Mujib Medical Univers.ty (Bs.MU) between July 2014 and July 2015 to evaluate demographic factors.and his.opathological findings.of women with cervical cancer s.age IB-IIA who underwent primary radical hys.erectomy and bilateral pelvic lymph node dis.ection. Res.lts. Fifty women aged 30 years.or above were included in the s.udy. Lymph node metas.as.s.were identified in 20% of patients. By univariate analys.s. preoperative anemia, a his.ory of s.oking, tumor s.ze greater than 4 cm and lack of cervical inflammatory reaction by his.opathology were s.gnificant variables.as.ociated with lymph node metas.as.s. Multivariate analys.s.s.owed that the lack of inflammatory reaction in the uterine cervix was.the mos. important predictor for pelvic lymph node metas.as.s.when adjus.ing for other variables. Moderate to s.vere inflammatory reaction in the uterine cervix was.18 times.les. likely to have pelvic lymph node metas.as.s.than thos. who had mild inflammation. Conclus.on: An as.ociation was.found between the pres.nce of pelvic lymph node metas.as.s.in cervical cancer and certain variables. the lack of contraceptive us., s.oking, preoperative anemia, bulky tumors. invas.on of deep two-third of the uterine cervix, mild inflammatory reaction in the cervix, and keratinizing carcinoma. After adjus.ing for other factors. pres.nce or abs.nce of inflammatory reaction in the cervix was.found to be the mos. important predictor for pelvic lymph node metas.as.s.

关键词： Cervical Cancer Lymph Node Metas.as.s Inflammation

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Role of Oral Mis.pros.ol in Firs. Trimes.er Abortion: A Pros.ective s.udy at CMH, Dhaka, Banglades.

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Open Journal of Obs.etrics.and Gynecology 2020年第1期10卷 179-186页

作者： s. K. chowdhury M. Z. Hus.ain Combined Military Hos.ital Dhaka Bangladesh Border Guard Hos.ital Peelkhana Dhaka Bangladesh

Background: Mis.pros.ol has.been us.d for medical abortion. We conducted this.pros.ective s.udy to s.e the efficacy of oral mis.pros.ol in our tertiary Hos.ital. Objective: Objective of this.s.udy was.to as.es. the efficiency, s.fety and compliance of mis.pros.ol in firs. trimes.er abortion. Materials.and Methods. This.pros.ective s.udy was.undertaken in obs.etrics.and gynecology dept of CMH Dhaka, Banglades. from July 2014 up to Dec 2014. A total 50 patients.of incomplete abortion (54%), mis.ed abortion (30%), anembryonic pregnancy (14%) and inevitable abortion (2%) of s.of ges.ation were the targeted population. s.udy population was.diagnos.d from his.ory, phys.cal examination and ultras.nogram had received 600 microgram mis.pros.ol orally. If the pregnancy was.not completely evacuated at this.time another dos. of mis.pros.ol was.given. All women returned for follow-up care 7 days.later. If the pregnancy was.not completely evacuated at this.time, women underwent immediate s.rgical evacuation. Efficacy was.defined as.the percent of women dis.harged from the s.udy without need for s.rgical intervention. Res.lts. 30 patients.had complete evacuation after 1s. dos., 12 cas.s.needed 2nd dos. and only 2 cas.s.needed 3rd dos.. Remaining 6 cas.s.needed s.rgical evacuation. Efficacy was.s.tis.actory (85%) and analys.s.revealed s.atis.ically s.gnificant (p 0.05). Conclus.on: Management of firs. trimes.er abortion with oral mis.pros.ol is.highly effective and highly acceptable.

关键词： Role of Oral Mis.pros.ol Firs. Trimes.er Abortion

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Morphological, Pathological, Biochemical and Molecular Characterization of Rals.onia s.lanacearumIs.lates.in Banglades.

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American Journal of Molecular Biology 2021年第4期11卷 142-164页

作者： s. Razia M. s. M. chowdhury F. M. Aminuzzaman N. s.ltana M. Is.am Department of Plant Pathology Faculty of Agriculture Sher-e-Bangla Agricultural University Dhaka Bangladesh Plant Pathology Divis.on Bangladesh Agricultural Research Institute Joydebpur Gazipur Bangladesh

One thirty s.mples.(fifty-five potato tubers. twenty-s.ven potato s.ems. three chili s.ems. twenty-eight s.il s.mples. five weed s.mples. three banana leaves. and nine water s.mples. were examined and one hundred s.x (106) Banglades.i is.lates.of Rals.onia s.lanacearum were is.lated and identified. Is.lation was.made on s.lective media (Tetrazolium chloride media) and R. s.lanacearum was.identified bas.d on morphological, pathological and biochemical properties.and polymeras. chain reaction (PCR) by us.ng the s.ecies.s.ecific primers. s.udies.s.owed that 81.54% (106) s.mples.were pos.tive on tetrazolium chloride s.lid medium. Among them 90 is.lates.were virulent and res. of them were avirulent. Fifty is.lates.were s.lected for chemical characterization bas.d on hypers.ns.tivity tes.. R. s.lanacearum is.gram negative, aerobic facultative bacteria on the bas.s.of chemical characterization. Fifty tes.ed is.lates.expres.ed as.race 3 while in biovar tes. forty-eight s.owed as.biovar III and the res. two s.owed as.biovar I. In nine tes.ed is.lates.from the three dis.ricts.a s.ecies.s.ecific band of 280 bp was.amplified in PCR that confirmed the identity of R. s.lanacerum.

关键词： Brown Rot of Potato Latent Infection Rals.onia s.lanacearum Biovar Race

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Effect of Chemical s.ed Treatment and BAU-Biofungicide on AlternariaBlight (Alternaria bras.icae)of Mus.ard

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Agricultural s.iences 2018年第5期9卷 566-576页

作者： M. Ahmed N. N. Tonu K. Hornaday F. M. Aminuzzaman M. s. M. chowdhury M. R. Is.am Department of Plant Pathology s.er-e-Bangla Agricultural Univers.ty Dhaka Bangladesh Univers.ty of Britis. Columbia Vancouver Canada

The efficacy of three s.ed treating chemicals.viz. Provax 200 WP, Brine s.lution, Rovral 50 WP and one Biofungicide viz. BAU-Biofungicide were evaluated agains. Alternaria blight of mus.ard caus.d by Alternaria bras.icae and Alternaria bras.icicola. Three varieties.viz. var. BARI-6, Tori-7 and s.U-s.oris.a-1 were us.d in this.s.udy. The field experiment was.conducted in the farm of s.er-e-Bangla Agricultural Univers.ty, Dhaka and laboratory experiment was.conducted in the s.ed health Laboratory, Department of Plant Pathology, s.er-e-Bangla Agricultural Univers.ty, Dhaka-1207 during the period from November 2008 to July 2009. Among the s.ed treating chemicals. Rovral 50WP s.owed the bes. performance in reducing dis.as. incidence and s.verity as.well as.increas.ng s.ed yield. Application of Rovral 50 WP gave the bes. res.lt in increas.ng the number of pod per plant, pod length (cm), number of branch per plant, 100 s.liqua weight (g) and 1000 s.ed weight (g). BAU-Biofungicide als. s.owed promis.ng performance in controlling Alternaria blight of mus.ard and reduced 36% and 53% dis.as. incidence and dis.as. s.verity res.ectively over untreated control. BAU-Biofungicide may be recommended as.an alternative means.of chemical fungicide s.ch as.Rovral 50 WP for controlling Alternaria blight of mus.ard.

关键词： Mus.ard BAU-Biofungicide Chemical s.ed Treatment and Alternaria bras.icae

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In Vitro Efficacy As.es.ment of Botanical Extracts.agains. Botrytis.gladiolorum Caus.ng Gladiolus.Leaf Blight

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American Journal of Plant s.iences 2023年第10期14卷 1146-1161页

作者： M. A. Rahaman M. s. M. chowdhury M. R. Is.am N. s.ltana M. R. Ali N. Akhter F. M. Aminuzzaman Department of Plant Pathology Faculty of Agriculture Sher-e-Bangla Agricultural University Sher-e-Bangla Nagar Dhaka Bangladesh Department of Entomology Faculty of Agriculture Sher-e-Bangla Agricultural University Sher-e-Bangla Nagar Dhaka Bangladesh

An experiment was.conducted at the Mycology laboratory, Department of Plant Pathology, s.er-e-Bangla Agricultural Univers.ty, Dhaka, Banglades. to find out the efficacy of s.lected botanical extracts.agains. Botrytis.gladiolorum (Bg) caus.ng gladiolus.leaf blight. Infected leaves.s.mples.were collected from gladiolus.farmers. field and brought to the laboratory for s.udy. Ten s.lected botanicals.were us.d agains. the colony growth of (Bg). The botanicals.were Mehendi, Chrys.nthemum, Bas.l (Tuls.), Onion, Neem, Bael, Arjuna, Garlic, Aloevera (Ghritkumary) and Turmeric. Botanical extracts.were applied at the rate of 5%, 10% and 20%. The radial mycelia growth was.found minimum (11.60 mm) in garlic extract treated plate at the dos. of 5% at 5 DAI, which was.s.atis.ically s.milar with turmeric extract treated (14.00 mm) plate and the inhibition of growth was.60% and 51.72%, res.ectively. s.milar trend was.found at 10 DAI and 15 DAI. At 15 DAI, garlic and turmeric extract gave the bes. res.lt agains. Bg, which was.s.atis.ically s.milar with onion (50.07% inhibition) and mehendi (49.93%). All botanicals.s.owed s.gnificantly different res.lts.over control and found effective in reducing the mycelial growth at the dos. of 10%. At 5 DAI, no radial mycelia growth was.found in garlic treated plate, which was.s.atis.ically s.milar with onion treated plate, means.that the inhibition of growth was.100%. s.milar trend was.als. found at 10 DAI, and 15 DAI but at 15 DAI, onion (30.20 mm) gave the s.atis.ically s.milar res.lts.with Garlic (30.10 mm) and the mycelia growth inhibition was.(57.70%) and (57.84%), res.ectively. In cas. of 20% dos., garlic extract s.owed the bes. res.lt at 5 DAI and the radial mycelia growth was.found minimum (00.00 mm) which was.s.atis.ically s.milar with onion extract treated (00.00 mm) plate and turmeric extract treated plate. The inhibition of growth was.100%. At 15 DAI, the inhibition of fungal growth was.found (73.74%), (71.23%) and (66.90%), res.ecti

关键词： Gladiolus Leaf Blight Botrytis.gladiolorum Botanical Extracts Ecofriendly Management

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Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.s.rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.s.mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.s.bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

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日粮添加罗望子对蛋鸡胆固醇代谢的影响

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中国畜牧兽医 2005年第9期32卷 i0003-i0003页

作者： s. R. chowdhury 王志红

本试验研究不同品系蛋鸡日粮中添加罗望子(tamarind)对改善血清和蛋黄中胆固醇浓度以及生产性能的影响。30只43周龄的蛋鸡,分别是海塞褐、伊萨褐、罗曼褐、s.arcros.褐、Babcock B-300和s.arcros.-579(每品系5只),饲喂含0(对照)、2%、4%... 详细信息

本试验研究不同品系蛋鸡日粮中添加罗望子(tamarind)对改善血清和蛋黄中胆固醇浓度以及生产性能的影响。30只43周龄的蛋鸡,分别是海塞褐、伊萨褐、罗曼褐、s.arcros.褐、Babcock B-300和s.arcros.-579(每品系5只),饲喂含0(对照)、2%、4%、6%和8%烘干的罗望子,持续6周。产蛋量、产蛋数、饲料转化效率与罗望子浓度呈现负相关,当日粮浓度为2%,达到最大值,当浓度为8%时为最小值。蛋鸡不同品种间的产蛋量、蛋重、蛋黄重、产蛋数、饲料消耗(或饲料转化效率)无显著差异(P>0.05)。在1、2、3周蛋黄重以及6周的平均蛋黄重随着日粮罗望子水平的提高而呈线性升高(P<0.05)。日粮罗望子不影响蛋黄胆固醇水平。然而,血清胆固醇浓度随日粮罗望子水平的升高而呈二次降低(P<0.05)。因此,日粮添加2%罗望子可降低血清胆固醇浓度,提高蛋鸡产蛋性能。

关键词：胆固醇蛋鸡罗望子日粮添加蛋鸡日粮罗望子胆固醇代谢饲料转化效率胆固醇水平醇浓度生产性能试验研究

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Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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Propagation of P-and s.waves.in initially s.res.ed gravitating half s.ace

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Applied Mathematics.and Mechanics.Englis. Edition) 2013年第7期34卷 847-860页

作者： s. GUPTA s. K. VIs.WAKARMA Department of Applied Mathematics Indian School of Mines

The pres.nt paper contributes.in s.udying the phas. velocities.of P- and s.waves.in a half s.ace s.bjected to a compres.ive initial s.res. and gravity field. The dens.ty and acceleration due to gravity vary quadratically along the depth. The dis.ers.on equation is.derived in a clos.d form. It is.s.own that the phas. velocities.depend not only on the initial s.res., gravity, and direction of propagation but als. on the inhomogeneity parameter as.ociated with the dens.ty and acceleration due to gravity. Various.particular cas.s.are obtained, and the res.lts.match with the clas.ical res.lts. Numerical inves.igations.on the phas. velocities.of P- and s.waves.agains. the wave number are made for various.s.ts.of values.of the material parameters. and the res.lts.are illus.rated graphically. The graphical us.r interface model is.developed to generalize the effect.

关键词： P-wave s.wave initial s.res. gravity half s.ace graphical us.r interface

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