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A modular microfluidic platform to study how fluid shear stress alters estrogen receptor phenotype in ER+breast cancer cells

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Microsystems & Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ortega Quesada Jonathan cuccia Rachael coates Blake Nassar Ethan Littlefield Elizabeth c.Martin Adam T.Melvin cain Department of chemical Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of chemical and Biological Engineering Clemson UniversityClemsonSC 29634USA Biological and Agricultural Engineering Louisiana State UniversityBaton RougeLA 70803USA Department Medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Metastatic breast cancer leads to poor prognoses and worse outcomes in patients due to its invasive behavior and poor response to *** is still unclear what biophysical and biochemical factors drive this more aggressive phenotype in metastatic cancer;however recent studies have suggested that exposure to fluid shear stress in the vasculature could cause *** this study a modular microfluidic platform capable of mimicking the magnitude of fluid shear stress(Fss)found in human vasculature was designed and *** device provides a platform to evaluate the effects of Fss on McF-7 cell line,an estrogen receptor positive(ER+)breast cancer cell line,during circulation in the *** of the effects of Fss on McF-7 cells was carried out utilizing two approaches:single cell analysis and bulk *** single cell analysis,cells were trapped in a microarray after exiting the serpentine channel and followed by immunostaining on the device(on-chip).Bulk analysis was performed after cells were collected in a microtube at the outlet of the microfluidic serpentine channel for western blotting(off-chip).It was found that cells exposed to an Fss magnitude of 10 dyn/cm^(2) with a residence time of 60 s enhanced expression of the proliferation marker Ki67 in the McF-7 cell line at a single cell *** understand possible mechanisms for enhanced Ki67 expression,on-chip and off-chip analyses were performed for pro-growth and survival pathways ERK,AKT,and JAK/*** demonstrated that after shearing the cells phosphorylation of p-AKT,p-mTOR,and p-sTAT3 were ***,there was no change in p-ERK1/*** is a mediator of ER rapid signaling,analysis of phosphorylated ERαwas carried out and no significant differences between sheared and non-sheared populations were *** together these results demonstrate that Fss can increase phosphorylation of proteins associated with a more aggressive phenotype in circulating cancer *** findin

关键词： fluid breast estrogen

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structural effects induced by dialysis-based purification of carbon nanomaterials

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Nano Materials science 2024年第4期6卷 475-483页

作者： A.D.Veloso A.M.Ferraria A.M.Botelho do Rego A.s.Viana A.J.s.Fernandes A.J.Fielding R.A.Videira M.c.Oliveira cQ-VR and chemistry Department University of Trás-os-Montes e Alto Douro BsIRG iBB-Institute for Bioengineering and BiosciencesDepartment of Chemical Engineeringand Associate Laboratory i4HB-Institute for Health and BioeconomyInstituto Superior TécnicoUniversidade de Lisboa centro de Química Estrutural Institute of Molecular SciencesDepartamento de Química e BioquímicaFaculdade de CiênciasUniversidade de Lisboa I3N and Physics Department University of AveiroCampus de Santiago Faculty of science Pharmacy and Biomolecular SchoolLiverpool John Moores University REQUIMTE/LAQV Laborat orio de FarmacognosiaDepartamento de QuímicaFaculdade de Farm aciaUniversidade do Porto

Dialysis plays a crucial role in the purification of nanomaterials but its impact on the structural properties of carbon nanomaterials was never ***,a carbon-based nanomaterial generated electrochemically in potassium phosphate buffer,was characterized before and after dialysis against pure *** is shown that dialysis affects the size of the carbon domains,structural organization,surface functionalization,oxidation degree of carbon,and grade of ***,dialysis drives the nanomaterial organization from discrete roundish carbon domains,with sizes ranging from 70 to 160 nm,towards linear stacking structures of small nanoparticles （cohol and ether （epoxide） surface groups evolve into more oxidized carbon groups （e.g.,ketone and ester groups）.Investigation of the as-prepared nanomaterial by electron paramagnetic resonance （EPR） revealed a resonance signal consistent with carbon-oxygen centred ***,this study brings to light the selective affinity of the carbon nanomaterial under study to capture Na+ions,a property greatly enhanced by the dialysis process,and its high ability to trap oxygen,particularly before *** findings open new perspectives for the application of carbon-based nanomaterials and raise awareness of the importance of structural changes that can occur during the purification of carbon-based nanomaterials.

关键词： Nanocarbon surface functionalization NMR XPs Hydrophilic carbon Paramagnetic

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Ipsilateral fractures of the acromion and coracoid processes of the scapula

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chinese Journal of Traumatology 2024年第2期27卷 121-124页

作者： Yusuf Omar Qalib srinivasa reddy Medagam sunil Dachepalli Department of Orthopaedics The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai519000GuangdongChina Department of Orthopaedics Yashoda HospitalsSomajigudaHyderabadTelangana500082India

A fracture of the acromion and coracoid processes of scapula is rarely seen in the outpatient clinic,due to the acromion's anatomical position and shape,as well as the strong ligaments and muscles that are attached to *** fractures are caused by either direct or indirect high-energy trauma injuries to the shoulder joint,leading to severe pain and a grossly restricted range of *** acromial classifications were reported,but this type of longitudinal plane fracture of the acromion process in our case is yet to be described in the current *** present a rare combination of the coracoid process and unstable acromion bony projection fractures that have not previously been noted for this type of *** closest to this is Kuhn's type III classification.A 51-year-old male presented to our emergency department complaining of the right shoulder pain and difficulty raising his arm following a 2-wheeler *** patient was managed by open reduction and internal fixation with 3 cannulated cancellous screws fixation and progressed well with no postoperative *** was asymptomatic postoperatively and regained full range of motion after 4 months.

关键词： Acromion scapular fracture coracoid process

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Efficacy of a Diabetes specific Nutritional supplement (DsNs) on Glycemic Response in Prediabetic Adults: A Two-Armed, Open-Labelled Randomized controlled study

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Food and Nutrition sciences 2024年第7期15卷 612-643页

作者： Deepti Khanna Kejal Joshi reddy Hema s. Gopalan Jaladhi Bhatt Jayanti Gupta simran sethi Parth Joshi Manoj Pareek Department of R&D Hindustan Unilever Limited Gurugram India Mumbai India cliantha Research Ahmedabad India

It is well known that Diabetes specific Nutritional supplements (DsNss) are linked to improved glycemic control in individuals with diabetes. However, data on efficacy of DsNss in prediabetics is limited. This was a two-armed, open-labelled, randomized controlled six-week study on 199 prediabetics [30 - 65 years;Glycosylated Hemoglobin (HbA1c) 5.7% - 6.4% and/or Fasting Blood Glucose (FBG) 100-125 mg/dl]. Two parallel phases were conducted: Acute Blood Glucose Response (ABGR) and Intervention phase. Prediabetic participants were randomized into test (n = 100) and control (n = 99). The primary objective was to assess the ABGR of DsNs versus an isocaloric snack, measured by incremental Area under the curve (iAUc). Test and control received 60 g of DsNs and 56 g of isocaloric snack (cornflakes) respectively, both in 250 ml double-toned milk on visit days 1, 15, 29 and 43. Postprandial Blood Glucose (PPG) was estimated at 30, 60, 90, 120, 150 and 180 minutes. During the 4 weeks intervention phase, the test group received DsNs with lifestyle counselling (DsNs + Lc) and was compared with the control receiving lifestyle counselling alone (Lc alone). Impact was studied on FBG, HbA1c, anthropometry, body composition, blood pressure, nutrient intake, and physical activity. The impact of DsNs was also studied using cGM between two 14-day phases: cGM1 baseline (days 1 - 14) and cGM2 endline (days 28 - 42). DsNs showed significantly lower PPG versus isocaloric snack at 30 (p 12, and chromium were reported by DsNs + Lc versus Lc alone. No other significant changes were reported between groups. It may be concluded that DsNs may be considered as a snack for prediabetic or hyperglycemic individuals requiring nutritional support for improved glycemic control.

关键词： Diabetes specific Nutritional supplement Prediabetes Acute Blood Glucose Response Incremental Area under curve Lifestyle counselling

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Polio eradication surveillance in sri Lanka,2019-2023

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Asian Pacific Journal of Tropical Medicine 2024年第6期17卷 268-272页

作者： M.A.Y.Fernando N.s.Madarasinghe c.Rangana N.Weerasinghe D.c.U.D.Weligamage J.I.Abeynayake Department of Medical Microbiology and Immunology Faculty of MedicineUniversity of ColomboSri Lanka Department of Virology Medical Research InstituteColombo 08Sri Lanka Medical Research Institute Colombo 08Sri Lanka

Objective:To evaluate the polio laboratory surveillance carried out from January,2019 to May,2023 by the Polio Regional Reference Laboratory,sri ***:This retrospective study analyzed all stool samples received under the acute flaccid paralysis(AFP)and immunodeficient vaccine-derived poliovirus(VDPV)surveillance at Polio Regional Reference Laboratory,sri Lanka from January,2019 to May,*** results of the testing methodologies were extracted from the laboratory data system,i.e.,poliovirus virus isolation,intra-typic differentiation/VDPV real time reverse transcriptase polymerase chain reaction(ITD/VDPV rRTPcR)and sequencing,along with the data on timing of reporting results,stool adequacy and *** was analyzed using descriptive ***:A total of 2141 stool samples from 1644 cases were received for AFP surveillance from sri Lanka(93.61%),Maldives(1.52%),and immunodeficient VDPV(4.86%)*** polioviruses(19/1644,1.15%)and non-polio enteroviruses(73/1644,4.44%)were isolated,while sabin-like 3 virus was detected in majority(12/19,63.15%)among the poliovirus *** polioviruses or circulating VDPVs were not detected among the *** all years of the study,the non-polio AFP detection rate was>1/100000 in children aged less than 15 years,whereas stool adequacy rate was>80%.All results were reported within 14 days of receipt,ensuring timely reporting as per global ***:The Polio Regional Reference Laboratory,sri Lanka plays a vital role in maintaining the polio-free status in the country through its robust laboratory surveillance,while adhering to the surveillance ***-detection of wild polioviruses and circulating VDPV during the study period reinforces the polio-free status in the country.

关键词： Poliovirus Polio laboratory surveillance Regional reference laboratory Polio eradication

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Generalized autoencoder-based fault detection method for traction systems with performance degradation

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High-speed Railway 2024年第3期2卷 180-186页

作者： cheng c. Liu W. Di L. Wang s. changchun University of Technology Changchun 130012 China Jilin Institute of Electronics Information Products Inspection Changchun 130012 China

Fault diagnosis of traction systems is important for the safety operation of high-speed trains. Long-term operation of the trains will degrade the performance of systems, which decreases the fault detection accuracy. To solve this problem, this paper proposes a fault detection method developed by a Generalized Autoencoder (GAE) for systems with performance degradation. The advantage of this method is that it can accurately detect faults when the traction system of high-speed trains is affected by performance degradation. Regardless of the probability distribution, it can handle any data, and the GAE has extremely high sensitivity in anomaly detection. Finally, the effectiveness of this method is verified through the Traction Drive control system (TDcs) platform. At different performance degradation levels, our method's experimental results are superior to traditional methods. © 2024 Beijing Jiaotong University

关键词： Fault detection Generalized autoencoder High-speed trains Performance degradation Traction control systems

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The ccD instrument background of the sMILE sXI

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Earth and Planetary Physics 2024年第1期8卷 15-24页

作者： M.W.J.Hubbard O.Hetherington D.J.Hall T.W.Buggey s.Parsons T.Arnold A.Holland c.Pagani s.sembay centre for Electronic Imaging The Open UniversityMilton KeynesMK76AAUK X-ray and Observational Astronomy Group Department of Physics&AstronomyUniversity of LeicesterLE17RHUK

The EsA and cAs sMILE mission orbit is highly elliptical and will pass through multiple radiation *** soft X-ray Imager(sXI)instrument aboard has a radiation shutter door designed to close when the surrounding radiation flux is *** shutter door will close when passing below an altitude threshold to protect against trapped particles in the Earth’s Van Allen ***,two radiation environments can be approximated based on the shutter door position:open and *** instrument background for the ccDs(charge-coupled Devices)that form the focal plane array of the sXI were evaluated for the two *** to the correlation of the space environment with the solar cycle,the solar minima and maxima,the background was also evaluated at these two *** results demonstrated that the highest instrument background will occur during solar minima due to the main contributing source being Galactic cosmic Rays(GcRs).It was also found that the open background was highest for solar minima and that the closed background was highest during solar *** is due to the radiation shutter door acting as a scattering centre and the changes in the energy flux distribution of the GcRs between the two solar extremes.

关键词： instrument background X-ray astronomy space radiation

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Laparoscopic management of remnant gall bladder with stones: Lessons from a tertiary care centre's experience

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Laparoscopic, Endoscopic and Robotic surgery 2024年第1期7卷 27-33页

作者： Gilbert samuel Jebakumar Jeevanandham Muthiah Loganathan Jayapal R.santhosh Kumar siddhesh Tasgaonkar K.s.santhosh Anand J.K.A.Jameel sudeepta Kumar swain K.J.Raghunath Prasanna Kumar reddy Tirupporur Govindaswamy Balachandar Department of surgical Gastroenterology Apollo HospitalsChennai 600006India Department of General surgery Apollo HospitalsChennai 600006India Department of Minimal Access surgery Apollo HospitalsChennai 600006India

Objective:Laparoscopic cholecystectomy is currently the gold standard for treating symptomatic gallstone *** its success,approximately 10%of patients may experience persistent biliary symptoms,leading to the post-cholecystectomy syndrome.A remnant gallbladder with cystic duct or bile duct stones is one of the causes of this *** objective of this study was to shed light on the clinical manifestations,evaluation,therapeutic strategies,and outcomes associated with laparoscopic management of symptomatic remnant ***:This was a retrospective study,conducted over a five-year period(January 2017 to December 2022)at Apollo Hospitals in south *** patients who underwent laparoscopic completion cholecystectomy for a remnant gall bladder were *** following data were collected:patient demographics,symptoms,preoperative investigations,intraoperative details and post operative ***:In total,36 patients were included and *** majority of patients were male(25,69.4%),with a mean age of 50.7±12.1 *** most common presentation was pain in the upper abdomen or right upper quadrant region(24,66.7%).The laparoscopic approach was attempted in all patients,with a success rate of 94.4%.Two patients required conversion to open *** fistula to the colon was observed in one *** was observed in 7 patients(19.4%),and stone clearance was successfully achieved using endoscopic retrograde cholangiopancreatography in all patients ***:Incomplete gall bladder removal either intentionally or unintentionally leaves a remnant gall bladder that is at risk for stone formation and *** who have this clinical entity with symptoms require a redo or complete cholecystectomy,a complex procedure associated with certain *** study highlights the feasibility and safety of laparoscopic completion cholecystectomy for the management of remnant gallbladder

关键词： Remnant gall bladder stump cholecystitis subtotal cholecystectomy Laparoscopic completion cholecystectomy

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Tilted global solar irradiance in Bahrain: an experimental study

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cLEAN ENERGY 2024年第2期8卷 27-34页

作者： Vasilikos, N. Georgantopoulou, c. Alajaimi, H. Almajed, s. H. Ahmed, M. Mathioulakis, D. Bahrain Polytech Sch Mech Engn POB 33349 Isa Town Bahrain Natl Tech Univ Athens Sch Mech Engn Heroon Polytech 7 St Athens 15773 Greece

In the present work, tilted global solar irradiance data are presented and analysed, measured for a period of 1 year on the campus of Bahrain Polytechnic, Kingdom of Bahrain, from both a fixed photovoltaic panel and a moving one via a two-axis solar tracker. The fixed panel faces south with an angle of 26 degrees with respect to the horizontal, coinciding with the local geographical latitude. The second panel is moved by two motors, controlled by a global positioning system and suitable software so that the sun's rays are perpendicular to the panel surface. A pyranometer is installed on each panel, recording the tilted global solar irradiance, stored by using a data logger. The analysis of the data obtained shows a 33% solar energy gain on an annual basis for the moving panel (2780 versus 2088 kWh/m2 on the fixed panel). More importantly, in June, when the energy demand in Bahrain is elevated due to the increased residential cooling loads, the solar energy received by the moving panel is 54.7% higher compared with that of the fixed panel. On a percentage basis, the increase in solar energy from the moving panel is profound in the early morning and late evening hours. Moreover, the reduction in the solar energy received by the fixed panel from May to June does not appear in the moving panel because of the adjustable orientation of the latter. Throughout the year, the mean daily solar power varies between 0.37 and 0.56 kW/m2 for the fixed panel, and 0.45 and 0.70 kW/m2 for the moving panel. In winter, solar energy fluctuations are elevated due to erratic weather conditions that present a peak standard deviation of 28% of the corresponding mean. The data presented are useful for potential solar investments in Gulf countries. Tilted global solar irradiance data are measured and analysed for a period of 1 year on the campus of Bahrain Polytechnic, Kingdom of Bahrain, from both a fixed photovoltaic panel and a moving one via a two-axis solar tracker. Graphical Abstract

关键词： tilted solar irradiance renewable energy solar tracking photovoltaic Gulf cooperation council countries sUN TRAcKING ENERGY sYsTEMs PANELs WORLD

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Magnesium oxide(MgO)nanoadsorbents in wastewater treatment:A comprehensive review

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Journal of Magnesium and Alloys 2024年第5期12卷 1709-1773页

作者： H.c.s.Perera V.Gurunanthanan Anoop singh M.M.M.G.P.G.Mantilaka G.Das sandeep Arya Department of Physics Khalifa UniversityAbu Dhabi12788United Arab Emirates Postgraduate Institute of science University of PeradeniyaPeradeniyaSri Lanka Department of Humanities and sciences Guru Nanak Institutions Technical CampusIbrahimpatnamHyderabad501506India centre for Global Health Research Saveetha Medical College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai602105Tamil NaduIndia Department of Physics University of JammuJammu and Kashmir180006India

Wastewater contamination by heavy metals and synthetic dyes presents a significant environmental challenge,necessitating effective and sustainable separation *** review article provides a detailed examination of magnesium oxide(MgO)nanoparticles as an innovative nanoadsorbent for wastewater treatment,with a specific focus on heavy metal and dye *** review comprehensively explores various aspects of MgO nanoparticles,including their structural characteristics and synthesis *** article delves into the morphology and crystallographic arrangement of MgO nanoparticles,offering insights into their structural *** the complexity of adsorption processes,the review identifies and analyzes parameters influencing the adsorption efficiency of MgO nanoparticles,such as temperature,pH,contact time,initial concentration,and co-existing *** interplay between these parameters and the adsorption capability of MgO nanoparticles emphasizes the importance of optimizing operational ***,the review assesses various synthesis methods for MgO nanoparticles,including sol-gel,hydrothermal,precipitation,green synthesis,solvothermal,and template-assisted *** discusses the advantages,limitations,and resulting nanoparticle characteristics of each method,enabling readers to grasp the implications of synthesis processes on adsorption *** comprehensive review consolidates current insights into the effectiveness of MgO nanoparticles as a potent nanoadsorbent for removing heavy metals and dyes from wastewater covering a wide spectrum of aspects related to MgO ***,there is a need to investigate the use of MgO in the treatment of actual wastewater or river water,in order to leverage its cost-effectiveness and high efficiency for practical water treatment applications in real-time.

关键词： MgO nanoparticles Nanoadsorbent Wastewater treatment Heavy metals Dye separation Adsorption synthesis methods

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