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Neural Regeneration Research 2024年第3期19卷 497-498页

作者： luís Gales i3s−Instituto de Investigação e Inovação em saúde Rua Alfredo AllenPortoPortugal(Gales L)IBMC−Instituto de Biologia Molecular e CelularUniversidade do PortoRua Alfredo AllenPortoPortugal ICbAs−Instituto de Ciências biomédicas Abel salazar Rua de Jorge Viterbo FerreiraPortoPortugal

Highly specific interactions between biomolecules,such as antigen-antibody,protein-ligand,or nucleic acid base pair complementary are on the basis of the organization of complex *** same principles may be tentatively used in molecular medicine for diagnosis and therapeutics.A molecule can be designed to selectively bind a protease and thereby inhibit the production of a peptide that forms toxic aggregates in the brain or an antibody may be produced to bind specifically to that peptide for detection or clearance ***,interference in biological systems is not that *** a start there is the inhibition of the physiological role of the protease;moreover,several cleavage fragments may be produced,which may continue to diverge due to putative post-translational modification and self-assembly processes,hiding the toxic target in a“soup”of peptide species varying in size,structure and chemical composition.A perspective of the current status and challenges in targeting peptide species for diagnosis and treatment in the context of Alzheimer’s disease is given.

关键词： Alzheimer diagnosis thereby

Analysis of a passive ankle exoskeleton for reduction of metabolic costs during walking

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Defence Technology（防务技术） 2024年第7期37卷 62-68页

作者： luís Quinto Pedro Pinheiro sergio b.Goncalves Ivo Roupa Paula simoes Miguel Tavares da silva CINAMIL Academia MilitarInstituto Universitario MilitarLisbonPortugal IDMEC Instituto Superior TecnicoUniversidade de LisboaLisbonPortugal

Modern conflicts demand substantial physical and psychological exertion,often resulting in fatigue and diminished combat or operational *** exoskeletons have been developed recently to address these challenges,presenting various limitations that affect their operational or everyday *** article evaluates the performance of a dual-purpose passive ankle exoskeleton developed for the reduction of metabolic costs during walking,seeking to identify a force element that could be applied to the target *** on the 6-min walk test,twenty-nine subjects participated in the study using three different force *** results indicate that it is possible to reduce metabolic expenditure while using the developed ***,the comfort and range of motion results verify the exoskeleton's suitability for use in uneven terrain and during extended ***,the choice of the force element should be tailored to each user,and the control system should be adjustable to optimise the exoskeleton's performance.

关键词： Ankle passive exoskeleton Metabolic cost reduction Dual-use exoskeleton Gait biomechanics

black hole shadows in Einstein-bel-Robinson gravity

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Chinese Physics C 2024年第5期48卷 272-283页

作者： b.Hamil b.C.Lütfüoğlu Laboratoire de Physique Mathématique et subatomique Facultédes Sciences ExactesUniversitéConstantine 1ConstantineAlgeria Department of Physics University of Hradec KrálovéRokitanského 6250003 Hradec KrálovéCzechia

Gravity models given by higher-order scalar curvature corrections are believed to bear important consequences. Einstein-bel-Robinson (EbR) gravity with quartic curvature modification motivated sajadi et al. to explore static spherically symmetric black hole solutions using perturbative methods. In this study, inspired by their work, we investigate Ads black hole shadows in EbR gravity and demonstrate how the gravity parameter alters the energy emission rate. Finally, we address the same problem in the presence of plasma, because the black holes are thought to be surrounded by a medium that changes the geodesic of photons.

关键词： black hole shadows Einstein-bel-Robinson gravity plasma

Ferroelectricity Induced by Oxygen Vacancies in Rhombohedral ZrO_(2) Thin Films

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Energy & Environmental Materials 2024年第1期7卷 229-237页

作者： Veniero Lenzi José P.b.silva břetislav Šmíd Vladimir Matoín Cosmin M.Istrate Corneliu Ghica Judith L.MacManus-Driscoll luís Marques Physics Center of Minho and Porto Universities(CF-UM-UP) University of MinhoCampus de Gualtar 4710-057Braga Portugal Laboratory of Physics for Materials and Emergent Technologies LapMETUniversity of Minho4710-057Braga Portugal Department of surface and Plasma science Faculty of Mathematics and PhysicsCharles UniversityV Holešovičkách 218000Prague 8 Czech Republic National Institute of Materials Physics 105 bis Atomistilor 077125Magurele Romania Department of Materials science and Metallurgy 27 Charles Babbage Rd.Cambridge CB3 OFSUK

Rhombohedral phase Hf_(x)Zr_(1.x)O_(2)(HZO,x from 0 to 1)films are promising for achieving robust ferroelectric polarization without the need for an initial wake-up pre-cycling,as is normally the case for the more commonly studied orthorhombic ***,a large spontaneous polarization observed in rhombohedral films is not fully understood,and there are also large discrepancies between experimental and theoretical *** this work,in rhombohedral ZrO_(2)thin films,we show that oxygen vacancies are not only a key factor for stabilizing the phase,but they are also a source of ferroelectric polarization in the *** is shown experimentally through the investigation of the structural properties,chemical composition and the ferroelectric properties of the films before and after an annealing at moderate temperature(400℃)in an oxygen environment to reduce the V_(o)concentration *** experimental work is supported by density functional theory(DFT)calculations which show that the rhombohedral phase is the most stable one in highly oxygen defective ZrO_(2)*** DFT calculations also show that V_(o)contribute to the ferroelectric *** findings reveal the importance of V_(o)for stabilizing rhombohedral ZrO_(2)thin films with superior ferroelectric properties.

关键词： charged defects ferroelectric polarization rhombohedral phase stability zirconia

Quantized autoencoder(QAE)intrusion detection system for anomaly detection in resource-constrained loT devices using RT-loT2022 dataset

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Cybersecurity 2024年第2期7卷 13-27页

作者： b s sharmila Rohini Nagapadma Depatment of Electronics and Communication Engineering The National Institute of EngineeringMysoreKarnataka 570008India

In recent years,many researchers focused on unsupervised learning for network anomaly detection in edge devices to identify *** deployment of the unsupervised autoencoder model is computationally expensive in resource-constrained edge *** study proposes quantized autoencoder(QAE)model for intrusion detection systems to detect *** is an optimization model derived from autoencoders that incorporate pruning,clustering,and integer quantization *** autoencoder uint8(QAE-u8)and quantized autoencoder float16(QAE-f16)are two variants of QAE built to deploy computationally expensive Al models into Edge ***,we have generated a Real-Time Internet of Things 2022 dataset for normal and attack *** autoencoder model operates on normal traffic during the training *** same model is then used to reconstruct anomaly traffic under the assumption that the reconstruction error(RE)of the anomaly will be high,which helps to identify the ***,we study the performance of the autoencoders,QAE-u8,and QAE-f16 using accuracy,precision,recall,and F1 score through an extensive experimental *** showed that QAE-u8 outperforms all other models with a reduction of 70.01%in average memory utilization,92.23%in memory size compression,and 27.94%in peak CPU ***,the proposed QAE-u8 model is more suitable for deployment on resource-constrained IoT edge devices.

关键词： IoT constrained system

Research onManeuver Decision-Making ofMulti-Agent Adversarial Game in a Random Interference Environment

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Computers, Materials and Continua 2024年第1期81卷 1879-1903页

作者： Hu s. Ru L. lu b. Wang Z. Zhao X. Wang W. Xi H. Equipment Management and UAV Engineering College Air Force Engineering University Xi'an 710051 China National Key Laboratory of Unmanned Aerial Vehicle Technology Xi'an 710051 China College of Information Technology Nanjing Police University Nanjing 210023 China

The strategy evolution process of game players is highly uncertain due to random emergent situations and other external disturbances. This paper investigates the issue of strategy interaction and behavioral decision-making among game players in simulated confrontation scenarios within a random interference environment. It considers the possible risks that random disturbances may pose to the autonomous decision-making of game players, as well as the impact of participants' manipulative behaviors on the state changes of the players. A nonlinear mathematical model is established to describe the strategy decision-making process of the participants in this scenario. subsequently, the strategy selection interaction relationship, strategy evolution stability, and dynamic decision-making process of the game players are investigated and verified by simulation experiments. The results show that maneuver-related parameters and random environmental interference factors have different effects on the selection and evolutionary speed of the agent's strategies. Especially in a highly uncertain environment, even small information asymmetry or miscalculation may have a significant impact on decision-making. This also confirms the feasibility and effectiveness of the method proposed in the paper, which can better explain the behavioral decision-making process of the agent in the interaction process. This study provides feasibility analysis ideas and theoretical references for improving multi-agent interactive decision-making and the interpretability of the game system model. © 2024 The Authors. Published by Tech science Press.

关键词： behavior decision-making maneuver multi-agent nonlinear mathematical modeling stochastic evolutionary game

Fuzzy Reliability and Availability of system under a Calendar-based Inspection Involving Multiple Failures and Its Application to Wind Turbine system

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Journal of systems science and systems Engineering 2024年第2期33卷 187-206页

作者： Mintu Kumar Himani Pant s.b.singh Department of Mathematics statistics and Computer science G.B.Pant University of AgricultureTechnologyPantnagarUttarakhandIndia

Uncertainty is an important factor that needs to be considered while analyzing the performance of any engineering *** order to quantify uncertainty,fuzzy set theory is frequently used by most of researchers,including energy system *** to the classical reliability theory,component lifetimes have crisp parameters,but due to uncertainty and inaccuracy in data,it is sometimes very difficult to determine the exact values of these parameters in real-world *** overcome this difficulty in the current research,failure and repair rates were taken as triangular fuzzy numbers to determine the fuzzy availability of a system undergoing calendar-based periodic inspection subject to multiple failure modes(FMs).It was assumed that each component in the system had an exponential failure rate and repair rate with fuzzy *** FMs were explicitly taken into account when a functional state of the system was *** FM had a random failure *** the occurrence of any failure,a random time was selected for the relevant corrective repair *** proposed research was studied for one of the major sources of green energy,namely a wind turbine system wherein all the derived propositions have been implemented on it.

关键词： Fuzzy reliability fuzzy availability wind turbine system multiple failure modes triangular fuzzy number

Rotating effects on the photoionization cross-section of a 2D quantum ring

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Communications in Theoretical Physics 2024年第10期76卷 153-159页

作者： Carlos Magno O Pereira Frankbelson dos s Azevedo luís Fernando C Pereira Edilberto O silva Departamento de Física Universidade Federal do Maranh?o

In this article, we investigate the nonrelativistic quantum motion of a charged particle within a rotating frame, taking into account the Aharonov–bohm(Ab) effect and a uniform magnetic field. Our analysis entails the derivation of the equation of motion and the corresponding radial equation to describe the system. solving the resulting radial equation enables us to determine the eigenvalues and eigenfunctions, providing a clear expression for the energy levels. Furthermore,our numerical analysis highlights the substantial influence of rotation on both energy levels and optical properties. specifically, we evaluate the photoionization cross-section with and without the effects of rotation. To elucidate the impact of rotation on the photoionization process of the system, we present graphics that offer an appealing visualization of the intrinsic nature of the physics involved.

关键词： Aharonov-bohm effect photoionization cross-section quantum ring rotating effect

Effects of freeze-thaw cycles on sandstone in sunny and shady slopes

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第7期16卷 2503-2515页

作者： Dian Xiao Xiaoyan Zhao Corrado Fidelibus Roberto Tomás Qiu lu Hongwei Liu Academy of Railway sciences Corporation Limited BeijingChina Faculty of Geosciences and Environmental Engineering Southwest Jiaotong UniversityChengduChina Department of Civil Engineering University of AlicanteAlicanteSpain Department of Innovation Engineering University of SalentoLecceItaly Department of Earth and Environmental sciences University of Milano BicoccaMilanItaly

A growing rock engineering activity in cold regions is facing the threat of freeze-thaw(FT)weathering,especially in high mountains where the sunny-shady slope effects strongly control the difference in weathering behavior of *** this paper,an investigation of the degradation of petrophysical characteristics of sandstone specimens subjected to FT cycle tests to simulate the sunny-shady slope effects is *** this aim,non-destructive and repeatable testing techniques including weight,ultrasonic waves,and nuclear magnetic resonance methods on standard specimens were *** the sunny slope specimens,accompanied by the enlargement of small pores,100 FT cycles caused a significant decrease in P-wave velocity with an average of 23%,but a consistent rise of 0.18%in mass loss,34%in porosity,67%in pore geometrical mean radius,and a remarkable 14.5-fold increase in ***,slight changes with some abnormal trends in physical parameters of the shady slope specimens were observed during FT cycling,which can be attributed to superficial granular disaggregation and pore throat *** shocks enhance rock weathering on sunny slopes during FT cycles,while FT weathering on shady slopes is restricted to the small pores and the superficial *** two factors are primarily responsible for the differences in FT weathering intensity between sunny and shady *** conclusions derived from the interpretation of the experimental results may provide theoretical guidance for the design of slope-failure prevention measures and the selection of transportation routes in cold mountainous regions.

关键词： sunny-shady slope Freeze and thaw Pore structure Tight rocks Talus slope Cold regions

Collective Molecular Machines: Multidimensionality and Reconfigurability

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Nano-Micro Letters 2024年第8期16卷 309-340页

作者： bin Wang Yuan lu Department of Chemical Engineering Tsinghua UniversityBeijing 100084People’s Republic of China Key Laboratory of Industrial biocatalysis Ministry of EducationTsinghua UniversityBeijing 100084People’s Republic of China

Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical *** the last 60 years,designing molecular structures capable of generating unidirectional mechanical motion at the nanoscale has been the topic of intense *** progress has been made,attributed to advances in various fields such as supramolecular chemistry,biology and nanotechnology,and ***,individual molecular machines are only capable of producing nanometer work and generally have only a single *** order to address these problems,collective behaviors realized by integrating several or more of these individual mechanical units in space and time have become a new *** this review,we comprehensively discuss recent developments in the collective behaviors of molecular *** particular,collective behavior is divided into two *** is the appropriate integration of molecular machines to efficiently amplify molecular motions and deformations to construct novel functional *** other is the construction of swarming modes at the supramolecular level to perform nanoscale or microscale *** discuss design strategies for both modes and focus on the modulation of features and ***,in order to address existing challenges,the idea of transferring experience gained in the field of micro/nano robotics is presented,offering prospects for future developments in the collective behavior of molecular machines.

关键词： Molecular machines Collective control Collective behaviors DNA biomolecular motors