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Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes

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World Journal of Hepatology 2017年第12期9卷 603-612页

作者： Michael C Hsu Charles N Weber s william stavropoulos Timothy W Clark scott O Trerotola Richard D shlansky Goldberg Michael C soulen Gregory J Nadolski Department of Radiology Division of Interventional RadiologyMount Sinai Hospital Department of Radiology Division of Interventional RadiologyHospital of the University of Pennsylvania

AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPs) and compare outcomes with maximally dilated *** Polytetrafluoroethylene covered TIPs(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPs maximally dilated to 10 mm(m TIPs), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPs portosystemic gradient(PsG), had 10 mm TIPs sub-maximally dilated to 8 mm(sm TIPs). Group characteristics(age, gender, Model for End-stage Liver Disease score, post-TIPs PsG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPs HE. A subset of fourteen patients with sm TIPs underwent follow-up computed tomography imaging after TIPs creation, and were grouped based on time of imaging( 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive *** Patient characteristics were similar between the sm TIPs and m TIPs groups, except for pre-TIPs portosystemic gradient, which was lower in the sm TIPs group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPs and m TIPs was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPs required TIPs reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPs(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPs diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPs placement compared to follow-up within 6 mo(

关键词： Variceal hemorrhage Portal hypertension Transjugular intrahepatic portosystemic shunts Ascites sub-maximal dilation Underdilated Passive expansion Hepatic encephalopathy

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Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： william J.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Universidad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Universidad de Navarra PamplonaSpain IdisNA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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Efficient differentiation of vascular smooth muscle cells from Wharton's Jelly mesenchymal stromal cells using human platelet lysate: A potential cell source for small blood vessel engineering

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World Journal of stem Cells 2020年第3期12卷 203-221页

作者： Panagiotis Mallis Aggeliki Papapanagiotou Michalis Katsimpoulas Alkiviadis Kostakis Gerasimos siasos Eva Kassi Catherine stavropoulos-Giokas Efstathios Michalopoulos Hellenic Cord Blood Bank Biomedical Research Foundation Academy of AthensAthens 11527Greece Department of Biological Chemistry Medical SchoolNational and Kapodistrian Univesity of AthensAthens 15772Greece Center of Experimental surgery Biomedical Research Foundation Academy of AthensAthens 11527Greece First Department of Cardiology “Hippokration”HospitalUniversity of Athens Medical SchoolAthens 15231Greece First Department of Internal Medicine Laiko HospitalMedical SchoolNational and Kapodistrian University of AthensAthens 11527Greece

BACKGROUND The development of fully functional small diameter vascular grafts requires both a properly defined vessel conduit and tissue-specific cellular *** stromal cells(MsCs) derived from the Wharton's Jelly(WJ) tissue can be used as a source for obtaining vascular smooth muscle cells(VsMCs),while the human umbilical arteries(h UAs) can serve as a scaffold for blood vessel *** To develop VsMCs from WJ-MsCs utilizing umbilical cord blood platelet *** WJ-MsCs were isolated and expanded until passage(P) 4. WJ-MsCs were properly defined according to the criteria of the International society for Cell and Gene Therapy. Then, these cells were differentiated into VsMCs with the use of platelet lysate from umbilical cord blood in combination with ascorbic acid,followed by evaluation at the gene and protein levels. specifically, gene expression profile analysis of VsMCs for ACTA2, MYH11, TGLN, MYOCD, sOX9,NANOG homeobox, OCT4 and GAPDH, was performed. In addition,immunofluorescence against ACTA2 and MYH11 in combination with DAPI staining was also performed in VsMCs. HUAs were decellularized and served as scaffolds for possible repopulation by VsMCs. Histological and biochemical analyses were performed in repopulated h *** WJ-MsCs exhibited fibroblastic morphology, successfully differentiating into"osteocytes", "adipocytes" and "chondrocytes", and were characterized by positive expression(> 90%) of CD90, CD73 and CD105. In addition, WJ-MsCs were successfully differentiated into VsMCs with the proposed differentiation protocol. VsMCs successfully expressed ACTA2, MYH11, MYOCD, TGLN and sOX9. Immunofluorescence results indicated the expression of ACTA2 and MYH11 in VsMCs. In order to determine the functionality of VsMCs, h UAs were isolated and decellularized. Based on histological analysis, decellularized h UAs were free of any cellular or nuclear materials, while their extracellular matrix retained intact. Then, repopulat

关键词： Vascular smooth muscle cells Decellularized umbilical arteries Mesenchymal stromal cells MYOCD Cardiovascular disease Blood vessels

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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

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Measurement invariance of maternal ratings of ADHD symptoms across clinic referred children’s with and without ADHD

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Advances in Developmental and Educational Psychology 2019年第1期1卷 7-17页

作者： Rapson Gomez Alasdair Vance Vasileios stavropoulos Royal Childrens Hospital and The University of Melbourne VictoriaAustralia Cairnmillar Institute Australia

The study examined the measurement invariance (configural,metric,scalar,and error variances) and factor mean scores equivalencies of a modified version of the strengths and Weaknesses of ADHDsymptoms and Normal Behavior scale (sWAN-M) across ratings provided by mothers of clinic-referred children and adolescents,diagnosed with (N = 666) and without (N = 202) ADHD. Confirmatory factor analysis (CFA) of these ratings provided support for the bi-factor model of ADHD [orthogonal general and specific factors for inattention (IA) and hyperactivity/impulsivity (HI) symptoms]. Multiple-group confirmatory factor analysis (CFA) of the bi-factor model supported full measurement invariance. Findings also showed that for latent mean scores,the ADHD group had higher scores than the non-ADHD group for the ADHD general and IA specific factors. The findings indicate that observed scores (based on maternal ratings of the sWAN-M) are comparable,as they have the same measurement properties. The theoretical,psychometric and clinical implications of the findings are discussed.

关键词： strengths and weaknesses of ADHD-symptoms and Normal Behavior scale factor structure measurement invariance children and adolescents mother ratings

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Rethinking the definition of the word‘map’:an evaluation of Beck’s representation of the London Underground through a qualitative expert survey

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International Journal of Digital Earth 2015年第7期8卷 522-537页

作者： william Cartwright school of Mathematical and Geospatial sciences RMIT UniversityMelbourneVICAustralia

This paper reports on the results from a qualitative expert survey of members of the international geospatial community to elicit their view of Henry(Harry)Beck’s iconic 1931 representation of the London *** begins by providing a background to the publishing era when Beck’s representation was developed under the‘umbrella’of the design style adopted by the London Passenger Transport Board to promote the image of‘the new’and contemporary *** then outlines Beck’s representation and his quest to develop a clearer and more understandable graphic information *** is followed by an overview of representative views from the design community about Beck’s ***,it provides the results of research undertaken with an informed international cartographic community to determine whether they viewed the product as a map or a *** is important to understand how Beck’s representation is viewed from the perspective of the geospatial *** it works as a map,albeit one where geography is generally abandoned,relative positions are favoured over the absolute and azimuth is distorted,then the view that successful(geo)communication artefacts must be linked to map designs that focus on precise and true representations of geographic information can be questioned.

关键词： maps diagrams design

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

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