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Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： siva s.v.P.sakamuri Anil sakamuri Department of Chemistry Auburn University at MontgomeryMontgomeryALUSA vascular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Discrete element method study of shear-driven granular segregation in a slowly rotating horizontal drum

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Particuology 2017年第3期15卷 89-94页

作者： Ram Chand sithi v. muniandy Chiow san Wong Jasbir singh Department of Physics Government Girls Degree College Jhudo Mirpurkhas Sindh Pakistan Center for Theoretical and Computational Physics Department of Physics Faculty of Science University of Malaya Kuala Lumpur 50603 Malaysia Plasma Technology Research Center Department of Physics Faculty of Science University of Malaya Kuala Lumpur 50603 Malaysia

segregation and mixing of granular materials are complex processes and are not fully understood. Motivated by industrial need, we performed a simulation using the discrete element method to study size segregation of a binary mixture of granular particles in a horizontal rotating drum. Particles of two dif- ferent sizes were poured into the drum until it was 50% full. shear-driven segregation was induced by rotating the side-plates of the drum in the opposite direction to that of the cylindrical wall. We found that radial segregation diminished in these systems but did not completely vanish. In an ordinary rotating drum, a radial core of smaller particles is formed in the center of the drum, surrounded by larger revolving particles. In our system, however, the smaller particles were found to migrate toward the side-plates. The shear from anti-spinning side-plates reduces the voidage and increases the bulk density. As such, smaller particles in the mixer tend to move to denser regions. We varied the shear by changing the coefficient of friction on the side-plates to study the influence of shear rate on this migration. We also compared the extent of radial segregation with stationary side-plates and with side-plates moving in different angular directions.

关键词： Granular flow Discrete element method segregation side-wall shear Rotating drum Mixing

Convergence of COvID-19 and recurrent stroke:In-hospital mortality risks explored

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World Journal of virology 2025年第1期14卷 5-8页

作者： Basavraj s Nagoba shree v Dhotre Ajay M Gavkare sachin s Mumbre Pradnya s Dhotre Department of Microbiology Maharashtra Institute of Medical Sciences and Research(Medical College)Latur 413531India Department of Microbiology Ashwini Rural Medical CollegeSolapur 413001India Department of Community Medicine Ashwini Rural Medical CollegeSolapur 413001India Department of Biochemistry Ashwini Rural Medical CollegeSolapur 413001India

This editorial comments on the article by Desai et al,which investigates the impact of coronavirus disease 2019(COvID-19)on in-hospital mortality among patients with recurrent stroke using data from the 2020 National Inpatient *** findings reveal significantly higher mortality rates in COvID-19-positive patients compared to non-COvID-19 patients,particularly among middle-aged individuals,males,and ethnic *** editorial explores the underlying mechanisms contributing to these outcomes and discusses the clinical implications for targeted management strategies in high-risk *** results emphasize the need for comprehensive approaches to mitigate the heightened risks faced by recurrent stroke patients during the COvID-19 pandemic.

关键词： Recurrent stroke COvID-19 In-hospital mortality Nationwide analysis stroke admissions Infectious diseases Chronic health conditions Hypercoagulability

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina silvera-simón Manel M.santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Ability of rotary compactor in compacting consistent slabs and effect of rotary compaction on engineering properties of stone mastic asphalt mixtures

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Journal of Central south University 2013年第12期20卷 3754-3763页

作者： Ratnasamy muniandy Hamed Haghighi salihudin bin Hassim Danial Moazami Department of Civil Engineering Universiti Putra Malaysia

A new automatic rotary compactor and its abilities in compacting stone mastic asphalt （sMA） are presented. Following an overview of the rotary compactor and the compaction procedure, it is demonstrated that the rotary compactor is able to produce uniform slabs with the desired thickness of 65 mm all over around. Furthermore, 132 cored samples from the rotary compactor had been compacted uniformly with approximately 4% optimum air void content. In addition, performance tests results indicate that the rotary compactor produces asphalt mixturures with the requirements of resilient modulus, Marshall stability and flow. A weight factor was introduced for each fraction of aggregates in the degradation analysis to compensate the crushing effect of aggregates during mixing and compacting.

关键词： stone mastic asphalt (sMA) rotary compactor sMA compaction asphalt mixture engineering properties

Microplasma direct writing for site-selective surface functionalization of carbon microelectrodes

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Microsystems & Nanoengineering 2019年第1期5卷 77-88页

作者： Aung Thiha Fatimah Ibrahim shalini muniandy Marc J.Madou Department of Biomedical Engineering Faculty of EngineeringUniversity of Malaya50603 Kuala LumpurMalaysia Centre for Innovation in Medical Engineering(CIME) Department of Biomedical EngineeringFaculty of EngineeringUniversity of Malaya50603 Kuala LumpurMalaysia Nanotechnology and Catalysis Research Centre Institute of Graduate StudiesUniversity of Malaya50603 Kuala LumpurMalaysia Department of Biomedical Engineering University of CaliforniaIrvineCA 92697USA Department of Mechanical and Aerospace Engineering University of CaliforniaIrvineCA 92697USA

Carbon micro-and nanoelectrodes fabricated by carbon microelectromechanical systems(carbon MEMs)are increasingly used in various biosensors and supercapacitor *** modification of as-produced carbon electrodes with oxygen functional groups is sometimes necessary for biofunctionalization or to improve electrochemical ***,conventional surface treatment methods have a limited ability for selective targeting of parts of a surface area for surface modification without using complex photoresist ***,we report microplasma direct writing as a simple,low-cost,and low-power technique for site-selective plasma patterning of carbon MEMs electrodes with oxygen *** microplasma direct writing,a high-voltage source generates a microplasma discharge between a microelectrode tip and a target surface held at atmospheric *** our setup,water vapor acts as an ionic precursor for the carboxylation and hydroxylation of carbon surface *** direct writing increases the oxygen content of an sU-8-derived pyrolytic carbon surface from~3 to 27%while reducing the carbon-to-oxygen ratio from 35 to ***,a microplasma treatment increases the number of carbonyl,carboxylic,and hydroxyl functional groups with the largest increase observed for carboxylic ***,water microplasma direct writing improves the hydrophilicity and the electrochemical performance of carbon electrodes with a contact-angle change from~90°to~20°,a reduction in the anodic peak to cathodic peak separation from 0.5 v to 0.17 v,and a 5-fold increase in specific capacitance from 8.82 mF∙cm−2 to 46.64 mF∙cm^(−2).The plasma direct-writing technology provides an efficient and easy-to-implement method for the selective surface functionalization of carbon MEMs electrodes for electrochemical and biosensor applications.

关键词： properties. carbon surface

Bio-analysis of saliva Using Paper Devices and Colorimetric Assays

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Journal of Analysis and Testing 2024年第1期8卷 114-132页

作者： Adhan Narasimhan Harshil Jain Kowshika muniandy Raja Chinnappan Naresh Kumar Mani Microfluidics Sensors and Diagnostics(μSenD)LaboratoryCentre for MicrofluidicsBiomarkersPhotoceutics&Sensors(μBioPS)Department of BiotechnologyManipal Institute of TechnologyManipal Academy of Higher EducationManipalKarnataka 576104India College of Medicine Alfaisal UniversityRiyadh 11533SaudiArabia Tissue/Organ Bioengineering&BioMEMs Lab Organ Transplant Centre of ExcellenceTransplant Research&Innovation DepartmentKing Faisal Specialist Hospital and Research CentreRiyadhSaudi Arabia

In light of the evolving nature of various diseases,time becomes a crucial factor in diagnosis and identifying the underlying causes.A point-of-care device provides a rapid diagnosis of a disease without using complex and advanced instruments,which are costly and difficult to transport.A paper-based device is a relatively frugal solution wherein the paper is used as a substratum in which the reactions are carried *** methods are non-invasive,and the sample collection is relatively *** is one such body fluid in which various biomarkers are present for numerous *** of saliva has attracted more attention recently due to its non-invasiveness and *** the discovery of clinical biomarkers from salivary analysis has the potential to revolutionize the healthcare sector by providing crucial information to monitor the health status of individuals and disease progression which enables personalized *** review provides the limitation of the traditional methods in clinical applications and highlights the significance of saliva as a non-invasive biological fluid that is a source of multiple biomarkers associated with various *** also provides insights into the different paper-based colorimetric microfluidic devices developed against salivary biomarkers in the past *** major challenges in the point-of-care application and the future prospects have been discussed as ***,we also emphasize the importance of this approach in dental disease diagnosis which is least explored and holds potential applications.

关键词： Paper-based assay salivary analysis Non-invasive Point-of-care Body fluids Biomarkers Qualitative detection

Controversies in fecal incontinence

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World Journal of Gastroenterology 2025年第3期31卷 113-119页

作者： Andreia Albuquerque satish s C Rao school of Medicine and Biomedical sciences Fernando Pessoa UniversityGondomar 4420-096PortoPortugal Precancerous Lesions and Early Cancer Management Research Group RIsE@CI-IPO(Health Research Network) Portuguese Oncology Institute of PortoPorto 4200-072Portugal Division of Gastroenterology and Hepatology Department of Internal MedicineAugusta UniversityAugustaGA 30912United States

Fecal incontinence is a common condition that can significantly impact patients’quality of *** anal sphincter injury and anorectal surgeries are common *** ultrasound and anorectal manometry are important diagnostic tools for evaluating *** are various treatment options,including diet,lifestyle modifications,drugs,biofeedback therapy,tibial and sacral nerve neuromodulation therapy,and *** this editorial,we will discuss current controversies and novel approaches to fecal *** for asymptomatic anal sphincter defects after obstetric anal sphincter injury and in patients with inflammatory bowel disease is not generally recommended,but may be helpful in selected *** Garg incontinence score is a new score that includes the assessment of solid,liquid,flatus,mucous,stress and urge fecal *** tests such as translumbosacral anorectal magnetic stimulation and novel therapies such as translumbosacral neuromodulation therapy are promising diagnostic and treatment options,for both fecal incontinence and *** biofeedback therapy can overcome some limitations of the office-based *** muscle-derived cell implantation of the external anal sphincter has been further studied as a possible treatment *** neuromodulation may be useful in scleroderma,congenital fecal incontinence and inflammatory bowel disease but merits further study.

关键词： Fecal incontinence Endoanal ultrasound Anal sphincter defects Biofeedback Neuropathy sacral neuromodulation

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第01期 81-100页

作者： s.sAURABH R.KIRAN D.sINGH R.vAIsH v.s.CHAUHAN school of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHsDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(Hs), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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