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Treatment of laryngopharyngeal reflux disease: A systematic review

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World Journal of Clinical Cases 2019年第19期7卷 2995-3011页

作者： Jerome R Lechien Francois Mouawad Maria R Barillari Andrea Nacci seyyedeh Maryam Khoddami Necati Enver sampath Kumar Raghunandhan Christian Calvo-Henriquez Young-Gyu Eun sven saussez Laboratory of Anatomy and Cell Biology Faculty of MedicineUMONS Research Institute for Health Sciences and TechnologyUniversity of MonsMons 7000Belgium Laryngopharyngeal Reflux study Group of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological societies Paris 75000France Department of Otolaryngology-Head and Neck surgery CHU de LilleLille 59000France Division of Phoniatrics and Audiology Department of Mental and Physical Health and Preventive MedicineUniversity of L.VanvitelliNaples 80100Italy ENT Audiology and Phoniatric Unit University of PisaPisa 56100Italy Larynx Function and Acoustic Voice Laboratory Department of Speech TherapySchool of RehabilitationTehran 11369Iran Department of Otolaryngology Marmara University Pendik Training and Research HospitalIstanbul 34722Turkey Department of Otology Neurotology and Skullbase SurgeryMadras ENT Research FoundationTamil Nadu 60028India Department of Otorhinolaryngology and Head and Neck surgery Hospital Complex of Santiago de CompostelaSantiago de Compostela 15700Spain Department of Otorhinolaryngology and Head and Neck surgery Kyung Hee University Medical CenterSeoul 130702Korea

BACKGROUNG For a long time,laryngopharyngeal reflux disease(LPRD)has been treated by proton pump inhibitors(PPIs)with an uncertain success *** To shed light the current therapeutic strategies used for LPRD in order to analysis the rationale in the LPRD *** Three authors conducted a PubMed search to identify papers published between January 1990 and February 2019 about the treatment of *** prospective or retrospective studies had to explore the impact of medical treatment(s)on the clinical presentation of suspected or confirmed *** criteria for considering studies for the review were based on the population,intervention,comparison,and outcome *** The search identified 1355 relevant papers,of which 76 studies met the inclusion criteria,accounting for 6457 patients.A total of 64 studies consisted of empirical therapeutic trials and 12 were studies where authors formally identified LPRD with pH-monitoring or multichannel intraluminal impedance-pH monitoring(MII-pH).The main therapeutic scheme consisted of once or twice daily PPIs for a duration ranged from 4 to 24 *** most used PPIs were omeprazole,esomeprazole,rabeprazole,lansoprazole and pantoprazole with a success rate ranging from 18%to 87%.Other composite treatments have been prescribed including PPIs,alginate,prokinetics,and H2 Receptor *** Regarding the development of MII-pH and the identification of LPRD subtypes(acid,nonacid,mixed),future studies are needed to improve the LPRD treatment considering all subtypes of reflux.

关键词： Laryngopharyngeal Reflux Laryngitis Treatment Proton pump inhibitors

GIs-Based situational Analysis of Cutaneous Leishmaniasis Disease (CLD) in sri Lanka

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Journal of Geoscience and Environment Protection 2023年第3期11卷 70-86页

作者： sampath Arunashantha Mangala Jayarathne saseeka Wijesekera Nishan sakalasooriya Charuni Kottage Department of Geography University of Kelaniya Kelaniya Sri Lanka Regional Health services Office Polonnaruwa Sri Lanka

Cutaneous Leishmaniasis (CL) is a severe health problem and a parasitic disease on human dermal and widely pervades tropical and subtropical developing counties. The study is mainly focused on Geographic Information system (GIs) based situational Analysis (sA). The clinically recorded 394 CL patients’ information was obtained from the District General Hospital of Polonnaruwa (DGHP) for 2017 and 2018. The spatial distribution of these patients was collected using Global Positing system (GPs). Moran’s I Index spatial autocorrelation technique and Getis-Ord Gi were used to identify the study site’s hot spot and cold spot areas. More than 75% of the CL patients’ population were highly involved with agricultural activities, and they are the highly exposed group of the CL in the study area. Also, 75% of the CL population were men, and the highly vulnerable age group was 35 - 39 men and 40 - 44 women. The generated Moran’s I Index indicates 0.0321, representing a randomly distributed pattern of CL patients over the District, and the Getis-Ord Gi Z score value was >1.96 (p s revealed that, during and in the post-harvesting periods of paddy cultivation, farmers are highly exposed to sandflies becoming CL patients. Due to this situation, the researchers observed that the highest number of patients have reported in May of both years and the infection period is two to four weeks earlier than the reported month. Hence to prevent the disease spread, it is essential to implement an awareness program regarding sandflies’ behaviour and CLD.

关键词： sandflies Disease Geoinformatics Techniques Environmental Factors Dry Zone

Efficient Power Conditioner for a Fuel Cell stack-Ripple Current Reduction Using Multiphase Converter

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smart Grid and Renewable Energy 2013年第1期4卷 53-56页

作者： sampath Naveen Kumar Natarajan Rajalakshmi Kaveripatnam samban Dhathathreyan Centre for Fuel Cell Technology ARCI IIT Madras Research Park Chennai India.

Integration of fuel cell stack with an inverter is complex in nature. A number of factors have to be taken into account in designing the inverter as well as during the integration. One of these factors is ripple current which could affect the life of the fuel cell stack if there is fuel and/or oxidant starvation. In this paper an inverter topology is investigated which significantly reduces or even nullifies the ripple content in the fuel cell system. The investigations have been carried out using indigenously developed 1 KW PEMFC stack and a 4 kW PEMFC stack with single and multi phase inverter. The results are presented here.

关键词： Fuel Cell stack Ripple Current Reduction Multiphase Inverter

腹腔巨噬细胞功能平衡对小鼠异位子宫内膜细胞清除的影响

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基础医学与临床 2006年第9期26卷 993-998页

作者：曹绚杨冬梓刘梅谢梅青 Parthasarathy sampath 中山大学第二医院妇产科广东广州510120 海珠区第一人民医院药剂科广东广州510100 路易斯安那州大学健康科技中心病理科

目的探讨腹腔巨噬细胞功能平衡对小鼠腹腔微环境和腹腔异位子宫内膜细胞清除的影响。方法给小鼠、裸鼠腹腔注射子宫内膜上皮和间质细胞,不同时间观察腹腔募集巨噬细胞数,D iI-Ac-LDL鉴定分化巨噬细胞吞噬功能的清道夫受体(sR-A1)。同步... 详细信息

目的探讨腹腔巨噬细胞功能平衡对小鼠腹腔微环境和腹腔异位子宫内膜细胞清除的影响。方法给小鼠、裸鼠腹腔注射子宫内膜上皮和间质细胞,不同时间观察腹腔募集巨噬细胞数,D iI-Ac-LDL鉴定分化巨噬细胞吞噬功能的清道夫受体(sR-A1)。同步反转录-聚合酶链技术(Real-Tim e RT-PCR)检测巨噬细胞的MCP-1/JE和IL-1αmRNA表达。结果腹腔注射子宫内膜细胞后的小鼠、裸鼠募集巨噬细胞增多,上皮细胞的刺激作用强于间质细胞。24 h点为腹腔巨噬细胞募集高峰、MCP-1/JE和IL-1α的基因表达高峰,免疫正常小鼠表达反应吞噬功能的巨噬细胞清道夫受体(sR-A1)强于免疫缺陷裸鼠。结论子宫内膜细胞募集腹腔巨噬细胞为一独立免疫防御反应,募集巨噬细胞的清道夫功能和细胞因子分泌功能的平衡可能对维持正常腹腔微环境和有效清除异位子宫内膜细胞起重要作用,这在内异症的发病机制中具有重要意义。

关键词：子宫内膜异位症巨噬细胞清道夫受体白介素单核细胞趋化蛋白-1

Acaricidal activity of synthesized titanium dioxide nanoparticles using Calotropis gigantea against Rhipicephalus microplus and Haemaphysalis bispinosa

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Asian Pacific Journal of Tropical Medicine 2013年第9期6卷 682-688页

作者： sampath Marimuthu Abdul Abdul Rahuman Chidambaram Jayaseelan Arivarasan Vishnu Kirthi Thirunavukkarasu santhoshkumar Kanayairam Velayutham Asokan Bagavan Chinnaperumal Kamaraj Gandhi Elango Moorthy Iyappan Chinnadurai siva Loganathan Karthik Kokati Venkata Bhaskara Rao Unit of Nanotechnology and Bioactive Natural Products Post Graduate and Research Department of ZoologyCAbdul Hakeem College Environmental Biotechnology Division School of Bio Sciences and TechnologyVIT University

Objective:To assess the acaricidal activity of titanium dioxide nanoparticles(TiO_2 NPs)synthesized from flower aqueous extract of Calotropis gigantea(***)against the larvae of Rhipicephalus(Boophilus)microplus[R.(B.)microplus]and the adult of Haemaphrysalis bispinosa(***).Methods:The lyophilized *** flower aqueous extract of 50 mg was added with 100 mL of TiO(OH_2)(10 mM)and magnetically stirred for 6 *** TiO_2 NPs were characterized by X-ray diffraction(XRD).Fourier transform infrared spectroscopy(FTIR),scanning electron microscopy(sEM),and Energy dispersive X-ray spectroscopy(EDX).The synthesised TiO_2 NPs were tested against the larvae of R(B.)microplus and adult of *** were exposed to filter paper impregnated ***:XRD confirmed the crystalline nature of the nanoparticles with the mean size of 10.52 *** functional groups for synthesized TiO_2NPs were 1405.19,and 1053.45 cm^(-1)for-NH_2 bending,primary amines and amides and 1053.84and 1078.45 cm^(-1)for *** micrographs of the synthesized TiO_2 NPs showed the aggregated and spherical in *** maximum efficacy was observed in the aqueous flower extract of *** and synthesized TiO_2 NPs against R.(B.)microplus(LC_(50)=24.63 and 5.43 mg/L and r^2=0.960 and 0.988)and against ***(LC_(50)=35.22 and 9.15 mg/L and r^2=0.969 and 0.969).***:The synthesized TiO_2 NPs were highly stable and had significant acaricidal activity against the larvae of R.(B.)microplus and adult of *** study provides the first report of synthesized TiO_2 NPs and possessed excellent anti-parasitic activity.

关键词： Rhipicephalus(Boophilus) microplus Haemaphysalis bispinosa Calotropis gigantean Titanium dioxide nanoparticles X-ray diffraction techniques Electron microscopic study

A Rare Case of synchronous Presentation of Acute Myeloid Leukemia and Lung Cancer

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Journal of Cancer Therapy 2019年第6期10卷 471-475页

作者： K. J. sampath J. Pridvi A. Anil K. Ranjith L. swati s. Nishant Department of Pathology Care Hospitals Hitech city branch Hyderabad Telangana India Department of Oncology Care Hospitals Hitech city branch Hyderabad Telangana India Department of Pulmonology Care Hospitals Hitech city branch Hyderabad Telangana India

Background: There are very few publications on synchronous presentation of dual malignancies in the literature. Occurrence of second malignancy in a patient with a known malignant tumor is not uncommon, though synchronous primary malignancies are unusual. Case Presentation: A 77-year-old man was diagnosed elsewhere as squamous cell carcinoma of lung came to our oncology department for further management. He underwent bone marrow evaluation with the suspicious of metastasis in view of pancytopenia. On bone marrow evaluation, found to have prominence of blasts more than 20%, which were CD34 positive and CD117 positive and. Conclusion: Here we describe an unusual rare combination of synchronous presentation of acute myeloid leukemia and squamous cell carcinoma of lung.

关键词： synchronous Malignancy Lung Cancer Acute Myeloid Leukemia

Asiaticoside, a trisaccaride triterpene induces biochemical and molecular variations in brain of mice with parkinsonism

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Translational Neurodegeneration 2013年第1期2卷 164-173页

作者： Uvarajan sampath Vanisree Arambakkam Janardhanam Department of Biochemistry Indo-American CollegeCheyyarTamilnaduIndia Department of Biochemistry University of MadrasGuindy CampusChennaiTamilnaduIndia

Background:Parkinson’s disease characterized by oxidative stress and mitochondrial damage in the pars compacta of substantia nigra remains a challenge to manage with an added disadvantage of side effects of L-levo dopa,the standard drug used for ***,an alternative approach of utilizing natural components would be beneficial in the management of the *** present study was aimed to investigate the potential role of asiaticoside(As),a trisaccaride triterpene against1–methyl 4–phenyl 1,2,3,6 tetrahydropyridine(MPTP)-induced neurotoxicity in experimental ***:Mice were divided into 4 groups:Group I received vehicle saline,group II was treated with 20 mg/kg of body weight of MPTP(2 doses with 2 h intervals),group III received MPTP along with 50 mg/kg body weight of As for the 21 consecutive days starting from the day of MPTP *** IV received 50 mg/kg body weight of asiaticoside for the same period serving as drug *** were sacrificed at the end of experimental period and the striatum and midbrain samples were analyzed for enzyme assays,transmission electron microscopic(TEM)*** assay was performed to study the expression of GFAP to detect astrocyte,which are activated due to neuronal *** studies were carried out to quantify the expression of Bax and Bcl2,the molecular signatures that would provide clues of the extent of ***:The activities of enzymes were increased on As administration when compared with those of group II *** of Bax and Bcl2 along with GFAP did show significant variations(ps and the changes were found to be reversed significantly(psis also showed attenuated degenerative architecture on As *** mice which received As alone(drug control IV)did not show significant variation from that of the control ***

关键词： doses oxidative reversed

腹膜间皮细胞在小鼠子宫内膜细胞刺激腹腔微环境中作用

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中国病理生理杂志 2007年第9期23卷 1837-1841页

作者：曹绚杨炜敏宋明清杨冬梓 Parthasarathy sampath 中山大学第二附属医院妇产科广东广州510120 Emory大学医学院妇产科亚特兰大美国30322

目的:探讨腹腔微环境受子宫内膜细胞刺激改变中腹膜间皮细胞的作用及其对子宫内膜异位症发病机制的意义。方法:注射小鼠子宫内膜上皮和间质细胞入小鼠腹腔,酶联免疫吸附法(ELIsA)检测注射后4、24和72h时点腹腔冲洗液细胞因子MCP-1/JE、I... 详细信息

目的:探讨腹腔微环境受子宫内膜细胞刺激改变中腹膜间皮细胞的作用及其对子宫内膜异位症发病机制的意义。方法:注射小鼠子宫内膜上皮和间质细胞入小鼠腹腔,酶联免疫吸附法(ELIsA)检测注射后4、24和72h时点腹腔冲洗液细胞因子MCP-1/JE、IL-1α和IL-6蛋白表达,同步逆转录-聚合酶链式反应技术(Real-Time RT-PCR)检测腹膜组织(主要含腹膜间皮细胞)和腹腔巨噬细胞的细胞因子MCP-1/JE、IL-1α和IL-6mRNA表达。结果:子宫内膜细胞刺激腹腔细胞因子蛋白含量迅速一过性升高,4h时点为表达高峰,腹膜细胞因子基因表达与腹腔液蛋白表达同步,腹腔巨噬细胞基因表达高峰滞后于腹腔液蛋白表达。子宫内膜上皮细胞刺激腹腔炎症反应作用强于间质细胞。结论:子宫内膜细胞刺激腹腔发生非特异性炎症反应,腹膜间皮细胞可能是其细胞因子效应的主要来源,提示腹膜在子宫内膜异位症中除作为病灶依附体外,还可能在腹腔微环境无菌性炎症反应中起重要作用。

关键词：子宫内膜异位症腹膜间皮细胞白细胞介素类单核细胞化学吸引蛋白质1

Prevalence, Aetiology, Maternal and Neonatal Outcome of Term Mothers with Anaemia, Presenting to a Tertiary Care Unit for Confinement in sri Lanka

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Advances in Reproductive sciences 2020年第4期8卷 221-233页

作者： Iresh Chaminda Kandauda sachini Lakmini Manatunga Kalana Maduwage Pushpa Manel Rathnayake sampath Tennakoon Chiran Thejana Gunathilake Department of Obstetrics and Gynaecology Faculty of Medicine University of Peradeniya Peradeniya Sri Lanka Department of Biochemistry Faculty of Medicine University of Peradeniya Peradeniya Sri Lanka Department of Pathology Faculty of Medicine University of Peradeniya Peradeniya Sri Lanka Department of Community Medicine Faculty of Medicine University of Peradeniya Peradeniya Sri Lanka

Objective: To describe the proportion of women presenting with undiagnosed anaemia at confinement and to explore associations between anaemia and socio economic factors, dietary pattern and compare maternal and neonat... 详细信息

strong>Objective:strong> To describe the proportion of women presenting with undiagnosed anaemia at confinement and to explore associations between anaemia and socio economic factors, dietary pattern and compare maternal and neonatal outcome among term mothers with anaemia compared to non-anaemic pregnant women at a tertiary care centre in sri Lanka. strong>Method:strong> A comparative cross-sectional study was performed by recruiting anaemic and non-anaemic term mothers who delivered at the Teaching Hospital Peradeniya during the period March 2018-March 2019. Pregnant mothers whose haemoglobin level was less than 10.5 g/dl were considered as anaemic and compared with the mothers whose haemoglobin level was above this level. With written consent, demographic data, etiological factors, maternal and neonatal outcomes of term mothers were evaluated by an interview and blood samples were withdrawn to carry out anaemia related investigations. strong>Results: strong>Among 2854 pregnancies, a total of 234 (8.19%) term pregnant mothers were anaemic and they were and compared with 199 non-anaemic mothers. Out of the anaemic mothers (Hb severe anaemia. Low monthly family income was significantly associated with the incidence of anaemia. Anaemia was also associated with low weekly consumption of red meat (OR 8.994;95% CI, 5.74 - 14.09, p s, 215 (67.44%) had low serum ferritin (st of them were diagnosed with iron deficiency anaemia (58.24%) (n = 113) based on haemoglobin. Most anaemic mothers had undergone elective caesarean section (46.26%) while vaginal deliveries (33.33%) were common among non-anamic group. strong>Conclusions: strong>A moderate prevalence of anaemia among term pregnant women in Peradeniya, sri Lanka was observed and was associated

关键词： Term Mothers Prevalence Anaemia Maternal Outcome Neonatal Outcome