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Heuristics of node selection criteria to assess robustness of world airport network

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Chinese Journal of Aeronautics 2017年第4期30卷 1473-1480页

作者： Manel sORIA Oriol LORDAN Josmaría sALLAN Department of Physics Aeronautics Engineering Universitat Politecnica de Catalunya-BarcelonaTech Terrassa 08222 Spain Department of Management Universitat Politecnica de Catalunya-BarcelonaTech Terrassa 08222 Spain

The world airport network（WAN） is one of the networked infrastructures that shape today＇s economic and social activity, so its resilience against incidents affecting the WAN is an important problem. In this paper, the robustness of air route networks is extended by defining and testing several heuristics to define selection criteria to detect the critical nodes of the *** addition to heuristics based on genetic algorithms and simulated annealing, custom heuristics based on node damage and node betweenness are defined. The most effective heuristic is a multiattack heuristic combining both custom heuristics. Results obtained are of importance not only for advance in the understanding of the structure of complex networks, but also for critical node detection.

关键词： Adaptive strategy Air route networks Complex networks Intentional attacks Network robustness

Potential of RP-UHPLC-DAD-Ms for the qualitative and quantitative analysis of sofosbuvir in film coated tablets and profiling degradants

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Journal of Pharmaceutical Analysis 2017年第4期7卷 208-213页

作者： maría del mar Contreras Aránzazu Morales-soto Antonio segura-Carretero Javier Valverde Department of Analytical Chemistry Faculty of SciencesUniversity of GranadaAvenida Fuentenueva s/n18071 GranadaSpain Research and Development Functional Food Centre (CIDAF) Bioregión BuildingHealth Science Technological ParkAvda. Del Conocimiento s/n18016 GranadaSpain

sofosbuvir is one of the new direct-acting antiviral drugs against hepatitis C virus(HCV) infection. This drug has recently been launched into the market, and generic versions of the medication are expected to be produced by local drug producers in some countries. Therefore, new methods are required to control sofosbuvir in pharmaceuticals. In the present study, a new method based on reversed phase(RP)-ultra-high performance liquid chromatography(UHPLC) coupled to diode array detection(DAD) and mass spectrometry(Ms) was developed to facilitate the qualitative and quantitative analysis of sofosbuvir in film coated tablets. A wavelength of 260 nm was selected to perform a cost-effective quantification and the method showed adequate linearity,with an R^2 value of 0.9998, and acceptable values of accuracy(75%–102%) and precision(residual standard deviation s were 0.07 μg/mL and 0.36 μg/mL, ***, the use of high-resolution Ms enabled us to ensure the specificity, check impurities and better sensitivity. Therefore, this methodology promises to be suitable not only for the routine analysis of sofosbuvir in pharmaceutical dosage forms, but also for potential degradants.

关键词： Film coated tablets Mass spectrometry RP-UHPLC sofosbuvir

Local renin angiotensin system and sperm DNA fragmentation

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Asian Journal of Andrology 2022年第2期24卷 139-146页

作者： maría Victoria Aparicio Prieto maría Victoria Rodríguez Gallego Asier Valdivia Palacín Yosu Franco Iriarte Gotzone Hervás Barbara Enrique Echevarría Orella Luis Casis saenz Human Reproduction Unit Cruces University HospitalBarakaldo 48903Spain Human Reproduction Unit San Pedro HospitalLogroño 26006Spain Department of Physiology Faculty of Medicine and NursingUniversity of the Basque Country(UPV/EHU)Leioa 48940Spain Human Reproduction Unit Ruber International HospitalMadrid 28034Spain

The renin angiotensin system(RAs)appears to influence male fertility at multiple *** this work,we analyzed the relationship between the RAs and DNA *** male volunteers were divided into two groups(25 each):control(DNA fragmentation≤20%)and pathological(DNA fragmentation>20%)*** of five peptidases controlling RAs were measured fluorometrically:prolyl endopeptidase(which converts angiotensin[A]I and A II to A 1–7),neutral endopeptidase(NEP/CD10:A I to A 1–7),aminopeptidase N(APN/CD13:A III to A IV),aminopeptidase A(A II to A III)and aminopeptidase B(A III to A IV).Angiotensin-converting enzyme(A I to A II),APN/CD13 and NEP/CD10 were also assessed by semiquantitative cytometry and quantitative flow cytometry assays,as were the receptors of all RAs components:A II receptor type 1(AT1R),A II receptor type 2(AT2R),A IV receptor(AT4R or insulin-regulated aminopeptidase[IRAP]),(pro)renin receptor(PRR)and A 1–7 receptor or Mas receptor(MasR)None of the enzymes that regulate levels of RAs components,except for APN/CD13(decrease in fragmented cells),showed significant differences between both *** of RAs receptors revealed no significant differences in immunolabeling patterns between normozoospermic and fragmented *** of AT1R(94.3%normozoospermic vs 84.1%fragmented),AT4R(96.2%vs 95.3%)and MasR(97.4%vs 87.2%)was similar between the ***2R(87.4%normozoospermic vs 63.1%fragmented)and PRR(96.4%vs 48.2%)were higher in non-fragmented *** findings suggest that fragmented DNA spermatozoa have a lower capacity to respond to bioactive RAs peptides.

关键词： DNA fragmentation local renin angiotensin system sperm fertility

Ear therapy and massage therapy in the elderly with dementia: a pilot study

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Journal of Traditional Chinese Medicine 2013年第4期33卷 461-467页

作者： Juan Rodríguez-Mansilla maría Victoria González-LópezArza Enrique Varela-Donoso Jesús Montanero-Fernández maría Jiménez-Palomares Elisa maria Garrido-Ardila Department of Medical-surgicalTherapy Medicine Faculty Extremadura University Department of Physical Medicine and Rehabilitation Medicine Faculty University Complutense Mathematics Department Medicine Faculty Extremadura University

OBJECTIVE: To assess the impact of massage versus ear acupuncture on behavior and participation in occupational therapy of dementia patients. METHODs: We performed a controlled, randomized longitudinal trial approved by the Bioethics Commission of the University of Extremadura. One hundred twenty elderly subjects with dementia institutionalized in residential homes in Extremadura (spain) received treatment based on massage and ear acupuncture over three months. Behavior alterations, sleep disturbance, and participation in rehabilitation and eating were assessed every month during the three months of intervention, and at one and two months of follow-up after the end of treatment. The assessment was performed through a structured questionnaire with closed format ques-tions done by an occupational therapist not involved in the study. REsULTs: There was a statistically significant positive effect of massage and ear acupuncture (Psured variables in the third month of intervention, which were maintained at two months after completing the treatment (PsION: Massage therapy and ear acupuncture can improve behavior and sleep disturbances, and increase the participation in eating and rehabilitation organized in residential homes, in dementia patients.

关键词： Activities of daily living Acupuncture ear Dementia Massage Aged

How Learning from Trauma Benefits the Obstetric Population?Damage Control surgery

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Maternal-Fetal Medicine 2023年第4期5卷 248-252页

作者： maría Fernanda Escobar Vidarte Daniela Nasner Albaro José Nieto-Calvache maría Paula Echavarría Javier Andrés Carvajal Department of Obstetrics and Gynecology High Complexity Obstetric UnitFundación Valle del LiliCali 760032Colombia Department of Obstetrics and Gynecology School of MedicineUniversidad IcesiCali 760032Colombia Clinical Research Center Fundación Valle del LiliCali 760032Colombia

The recent implementation of trauma-validated damage control strategies in severe postpartum hemorrhage proves the importance of interdisciplinary management in the obstetric *** hemorrhage control techniques and damage control surgery are clear examples of how learning from trauma can benefit the obstetric ***,most obstetric programs do not include training in this type of ***,it has been shown that these interventions are useful in the management of severe postpartum *** aim of this article is to introduce the application of damage control surgery principles in the management of massive obstetric *** propose to include appropriate training and the implementation of damage control surgery in obstetric management *** prompt application of damage control principles can be considered in patients with persistent hemodynamic instability despite control of the source of bleeding.

关键词： Postpartum hemorrhage Damage control Obstetric hemorrhage Critical care Maternal mortality

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西班牙梅里达古罗马狄安娜神庙区域更新设计

建筑遗产 2024年第1期 107-117页

作者： [西]何塞·马利亚·桑切斯·加西亚檀烨(译) 马德里理工大学马德里28040 不详

古罗马狄安娜神庙及其周边考古遗址是西班牙梅里达市最重要的区域之一,随着城市的发展,其周边场地被围墙围合,丧失了城市公共性。文章首先指出建筑师在古罗马狄安娜神庙区域更新项目中的首要目标,是重新利用古罗马时期遗留的广场空间,... 详细信息

古罗马狄安娜神庙及其周边考古遗址是西班牙梅里达市最重要的区域之一,随着城市的发展,其周边场地被围墙围合,丧失了城市公共性。文章首先指出建筑师在古罗马狄安娜神庙区域更新项目中的首要目标,是重新利用古罗马时期遗留的广场空间,在延续历史痕迹的同时重建城市公共空间;文章进一步从场地、几何形态和材料三方面详细分析了具体的设计策略,包括重整场地秩序,根据遗址和周边住宅情况新建“围廊建筑”,通过对“围廊建筑”层高、材料和细部构造的精心设计,与神庙对话,最终形成以神庙为中心的复合广场空间;新建建筑充分尊重历史遗产,满足当代功能,为城市创造了充满活力、灵活可变的公共空间。

关键词：古罗马狄安娜神庙围廊建筑场地几何材料更新考古遗产

Agglutination of Helicobacter pylori coccoids by lectins

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World Journal of Gastroenterology 2000年第2期6卷 202-209页

作者： mar mar khin Jie song Hua Han Cong Ng Torkel Wadstrm Bow Ho Departments of Microbiology Faculty of MedicineNational University of Singapore5Science Drive 2Singapore 117597Republic of Singapore Department of Medical Microbiology Lund UniversitySolvegatan 23S 223 62 LundSweden

AIM To study the agglutination pattern ofHelicobacter pylori coccoid and spiral *** Assays of agglutination andagglutination inhibition were applied usingfifteen commercial *** strong agglutination was observedwith mannose-specific Concanavalin A(Con A),fucose-specific Tetragonolobus purpureas(Lotus A)and N-acetyl glucosamine-specificTriticum vulgaris(WGA)*** andfucose specific lectins were reactive with allstrains of *** coccoids as compared to *** carbohydrates,glycoproteinsand mucin were shown to inhibit ***-agglutination ***-treatment ofthe bacterial cells with formalin and sulphuricacid did not alter the agglutination patterns ***,sodium periodate treatment ofbacterial cells were shown to inhibitagglutination reaction with Con A,Lotus A andWGA *** the contrary,enzymatictreatment of coccoids and spirals did not showmarked inhibition of ***,heating of *** cells at 60℃ for 1 hour was shown toaugment the agglutination with all of the *** The considerable differences inlectin agglutination patterns seen among the twodifferentiated forms of *** might beattributable to the structural changes during theevents of morphological transformation,resulting in exposing or masking some of the sugar residues on the cell *** ofvarious sugar residues on the cell wall of thecoccoids may allow them to bind to differentcarbohydrate receptors on gastric mucus andepithelial *** coccoids with adherencecharacteristics like the spirals could aid in thepathogenic process of Helicobacter *** may probably lead to different clinicaloutcome of *** associated gastroduodenaldisease.

关键词： Helicobacter pylori coccoids lectin gastric mucosa

Multiple responses optimization in the development of a headspace gas chromatography method for the determination of residual solvents in pharmaceuticals

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Journal of Pharmaceutical Analysis 2015年第5期5卷 296-306页

作者： Carla M.Teglia Milagros Montemurro maría M.De Zan maría s.Cmara Laboratorio de Control de Calidad de Medicamentos Facultad de Bioquimica y Ciencias BiologicasUniversidad Nacional del Litoral

An efficient generic static headspace gas chromatography （HsGC） method was developed, optimized and validated for the routine determination of several residual solvents （Rs） in drug substance, using a strategy with two sets of calibration. Dimethylsulfoxide （DMsO） was selected as the sample diluent and internal standards were used to minimize signal variations due to the preparative step. A gas chroma- tograph from Agilent Model 6890 equipped with flame ionization detector （FID） and a DB-624 （30 m × 0.53 mm i.d., 3.00 μm film thickness） column was used. The inlet split ratio was 5：1. The influ- encing factors in the chromatographic separation of the analytes were determined through a fractional factorial experimental design. significant variables： the initial temperature （IT）, the final temperature （FT） of the oven and the carrier gas flow rate （F） were optimized using a central composite design. Response transformation and desirability function were applied to find out the optimal combination of the chromatographic variables to achieve an adequate resolution of the analytes and short analysis time. These conditions were 30 ℃ for IT, 158 ℃ for FT and 1.90 mL/min for F. The method was proven to be accurate, linear in a wide range and very sensitive for the analyzed solvents through a comprehensive validation according to the ICH guidelines.

关键词： Headspace gas chromatographyResidual solventsPharmaceuticalssurface response methodologyDesirabiliW function

Morphological and genetic differentiation in isolated populations of Mexican beech Fagus grandifolia ***

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Journal of Forestry Research 2021年第5期32卷 2169-2179页

作者： Dulce maría Galván-Hernández Pablo Octavio-Aguilar Luis Lazcano-Cruz Arturo sánchez-González Population Ecology Laboratory of the Biological Research Center Autonomous University of HidalgoKm 4.5 Pachuca-Tulancingo HighwayCP 42184 Mineral de La ReformaHidalgoMexico Genetic Laboratory of the Biological Research Center Autonomous University of HidalgoKm 4.5 Pachuca-Tulancingo HighwayCP 42184 Mineral de La ReformaHidalgoMexico

Mexican beech[Fagus grandifolia ***(martinez)***]is a subspecies endemic to the sierra Madre Oriental Mountains and considered endangered due to the low density of its populations and high degree of habitat fragmentation and environmental *** its morphological and genetic variation is associated with its ability to adapt to changes in environmental conditions,the objective of this study was to determine whether phenotypic and genotypic variation exist,and it relationships with population reduction *** four beech populations in the states of Hidalgo and Veracruz,we analyzed 11 morphological variables for leaves and 6 micros atellite *** morphological variables that to discriminate between populations were related to the size of the leaf,but a robust differentiation pattern was not found,given that independent groups of leaves were *** populations located closest to each other,had greater genetic variation and less genetic distance;populations in the extreme north and south had the lowest genetic *** differentiation among populations was associated with reduction in population *** the 3 localities in Hidalgo,recent bottlenecks were identified,and in Veracruz,an old bottleneck was *** in leaf morphology and genetic structure of Mexican beech populations could be the result of a combination of various geographical,climate and ecological factors.

关键词： Adaptation Bottleneck Genetic structure Leaf morphology Mexico sierra madre oriental