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Acta Pharmacologica sinica 2000年第9期21卷 11-15页

作者： s k mitra,u venkatesh udupa,s j sheshadri,m v venkataranganna,s gopumadhavan,s d anturlikar R&d Centre The Himalaya drug Company Bangalore-562 123 India R&d Centre The Himalaya drug Company Bangalore-562 123 India R&d Centre The Himalaya drug Company Bangalore-562 123 India R&d Centre The Himalaya drug Company Bangalore-562 123 India R&d Centre The Himalaya drug Company Bangalore-562 123 India R&d Centre The Himalaya drug Company Bangalore-562 123 India

AIm; To investigate the protective effect of Hd-03 in experimental cirrhosis following chronic intoxication with thioacetamide (TAA). mETHOds; The effect of Hd-03 (750 mg/kg po) was studied in rats following TAA-induced intoxication (50 mg/kg po) for a period of 90 d. Hd-03 was administered as an aqueous suspen-sion . Levels of biochemical markers indicative of hepa-totoxicity were assessed in serum and liver. Histopatho-logical evaluation of liver was also carried out to find out the protective effect of Hd-03 following TAA-induced chronic intoxication. REsuLTs; Administration of TAA at a dose of 50 mg/kg po for 90 d resulted in a sig-nificant derangement of serum [ serum glutamic pyruvate transaminase ( sGPT), serum glutamic oxaloacetate transaminase (sGOT) , alkaline phosphatase (ALP), al-bumin and bilirubin] and hepatic (triglycerides, protein, hydroxyproline, collagen and glycogen) biochemical pa-rameters. Histopathological evaluation of liver sections following TAA-intoxication showed necrosis and

关键词：草药医学 Hd-03 肝硬化

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Protective effect of Prostane in experimental prostatic hyperplasia in rats

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Asian journal of Andrology 1999年第4期1卷 175-179页

作者： s.k.mitra R.sundaram A.R.mohan s.gopumadhavan m.v.venkataranganna udupa venkatesha s.j.seshadri s.d.Autrulikar R&d Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 IndiaR&D Centre The Himalaya Drug Co. Makali Banalore 562-123 India

Aim: Prostane, a polyherbal formulation, was evaluated for its efficacy on 5α-reductase inhibition, α-adrenergic anta-gonistic activity and testosterone-induced prostatic hyperplasia. methods: 5α-reductase inhibition was evaluated usingrat prostate homogenate as an enzyme source. Adrenergic antagonistic activity was evaluated using isolated rat vas def-erens. Experimental prostatic hyperplasia was induced in rats by giving testosterone 3 rog/kg sc for 21 days. Re-sults: Prostane dose-dependently inhibited 5α-reductase activity and exhibited α-adrenergic antagonistic activity. Treat-ment with Prostane at 250, 500 and 750 mg/kg body wt, po for 21 days significantly reduced the prostatic weight, theepithelial height and the stromal proliferation in experimental prostatic hypertrophy. Conclusion: Prostane is effectivein the treatment of experimental prostatic hypertrophy in rats and may be passed on to clinical trials on benign prostatichypertrophy after necessary toxicological evaluations. (Asian j Androl 1999 dec; 1: 175-179)

关键词： Prostane BPH oxidoreductases adrenergic alpha-antagonists enzyme inhibitors prostate hyperplasia

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