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Green Chemical Engineering 2024年第4期5卷 473-482页

作者： Arunmozhiarasi Armugam Diane s.W.Lim siti Nurhanna Riduan shook Pui chan Jerome Asugan Yugen Zhang Institute of Bioengineering and Bioimaging Institute of sustainability for Chemicals Energy and Environment(ISCE2) Agency for Science Technology and Research (A*STAR) Diploma in Biomedical science School of Chemical and Life SciencesSingapore Polytechnic

Antimicrobial materials are a crucial component in eradicating and managing the spread of infectious *** are expected to act on a broad-spectrum of microbes, including emerging pathogens which could cause the next Disease X. Herein, we reassessed a series of antimicrobial imidazolium polymers on our shelves and uncovered extended functionality through dual modes of action. By redesigning their structures, a truly broadspectrum antimicrobial material with optimized activity against bacteria(G +ve, G-ve) and fungi, as well as enveloped and non-enveloped viruses was developed. We demonstrated that the imidazolium polymer exhibits dual modes of function against microbes: targeting the microbial membrane and binding DNA. The latter DNA binding affinity was found to be key against non-enveloped viruses. With this insight, we designed small molecule compounds that exhibited optimum broad-spectrum antimicrobial activity and excellent efficacy against EskAPE group of pathogens that are responsible for some of the deadliest nosocomial infections worldwide. Our results could also shed light on the design of broad-spectrum antimicrobial compounds against Disease X.

关键词： Broad-spectrum Antimicrobial Polyimidazolium structure-function Membrane active

Interplay of laser power and pore characteristics in selective laser melting of Zk60 magnesium alloys:A study based on in-situ monitoring and image analysis

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Journal of Magnesium and Alloys 2024年第4期12卷 1346-1366页

作者： Weijie Xie Hau-Chung Man Chi-Wai chan Department of Industrial and systems Engineering The Hong Kong Polytechnic UniversityHong KongChina school of Mechanical and Aerospace Engineering Queen’s UniversityBelfast BT95AHUK Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHong KongChina

This study offers significant insights into the multi-physics phenomena of the sLM process and the subsequent porosity characteristics of Zk60 Magnesium(Mg)***-speed in-situ monitoring was employed to visualise process signals in real-time,elucidating the dynamics of melt pools and vapour plumes under varying laser power conditions specifically between 40 W and 60 *** morphological analysis was performed using scanning-Electron Microscopy(sEM),demonstrating a critical correlation between laser power and pore *** laser power led to increased pore coverage,whereas a denser structure was observed at higher laser *** laser power influence on porosity was further confirmed via Optical Microscopy(OM)conducted on both top and cross-sectional surfaces of the *** increase in laser power resulted in a decrease in pore coverage and pore size,potentially leading to a denser printed part of Mg alloy.X-ray Computed Tomography(XCT)augmented these findings by providing a 3D volumetric representation of the sample internal structure,revealing an inverse relationship between laser power and overall pore *** laser power appeared to favour the formation of interconnected pores,while a reduction in interconnected pores and an increase in isolated pores were observed at higher *** interplay between melt pool size,vapour plume effects,and laser power was found to significantly influence the resulting porosity,indicating a need for effective management of these factors to optimise the sLM process of Mg alloys.

关键词： selective laser melting(sLM) Magnesium(Mg)alloys Biodegradable implants Porosity In-situ monitoring

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Multi-omic analyses identify mucosa bacteria and fecal metabolites associated with weight loss after fecal microbiota transplantation

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The Innovation 2022年第5期3卷 129-139页

作者： Fen Zhang Tao Zuo Yating Wan Zhilu Xu Chunpan Cheung Amy YLi Wenyi Zhu Whitney Tang Paul k.s.chan Francis k.L.chan siew C.Ng Department of Medicine and Therapeutics Institute of Digestive DiseaseState Key Laboratory of Digestive DiseasesLKS Institute of Health SciencesThe Chinese University of Hong KongHong Kong 999077China Microbiota I-Center(MagIC) Hong Kong 999077China Department of Microbiology The Chinese University of Hong KongHong Kong 999077China Center for Gut Microbiota Research Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China

Fecal microbiota transplantation(FMT)has shown promising results in animal models of obesity,while results in human studies are *** aimed to determine factors associated with weight loss after FMT in nine obese subjects using serial multi-omics analysis of the fecal and mucosal *** mucosal microbiome,fecal microbiome,and fecal metabolome showed individual clustering in each subject after *** colonic microbiome in patients showed more marked variance after FMT compared with the duodenal microbiome,characterized by an increased relative abundance of *** who lost weight after FMT sustained enrichment of Bifidobacterium bifidum and Alistipes onderdonkii in the duodenal,colonic mucosal,and fecal microbiome and increased levels of phosphopantothenate biosynthesis and fecal metabolite eicosapentaenoic acid(EPA),compared with those without weight *** levels of amino acid metabolism-associated were positively correlated with the fecal abundance of ***,and fatty acid metabolism-associated metabolites showed positive correlations with ***.

关键词： metabolism sustained weight

Dispersion effect of nano-structure pyrolytic carbon on mechanical,electrical,and microstructural characteristics of cement mortar composite

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International Journal of smart and Nano Materials 2024年第3期15卷 534-578页

作者： N.k.karthikeyan s.Elavenil school of Civil Engineering Vellore Institute of TechnologyChennaiIndia

In material science,converting waste into nanomaterials by green technologies highlights the interest in producing sus-tainable carbon nanomaterial(sCN).This study first-ever uti-lized tyre-char as a Nano-structure Pyrolytic Carbon(NsPC)to develop electrically conductive *** other car-bon nanomaterials,the efficiency of NsPC particle as an sCN in developing electrically conductive composites was investi-gated in terms of dispersion,mechanical,water absorption,electrical resistivity,and *** results of sedi-mentation and zeta potential(-19 mV)showed the excellent dispersion of NsPC particle in water with the combined effect of superplasticizer and *** compressive(40.37%)and flexural strength(10.76%)than that of plain cement mortar composite(CMC)is achieved with 2 wt.%and 1.5 wt.%of NsPC particle,*** water absorption rate and volume of permeable voids were reduced,exhibiting less *** percolation zone of AC and DC resis-tivity of NsPC composite ranges between 1 and 2 wt.%,and the established percolation threshold is at 2 wt.%.XRD analysis showed C-s-H formation consistently increased with curing age,and HR-sEM with EDAX analysis exhibits the dense micro-structure and well-distributed NsPC particle at the *** experimental outcomes significantly enhanced the relia-bility and provided a framework for tailoring NsPC particle as sCN for developing electrically conductive composite.

关键词： sustainable nanomaterial dispersion mechanical properties electrical resistivity microstructure analysis

Enhancing Multicriteria-Based Recommendations by Alleviating scalability and sparsity Issues Using Collaborative Denoising Autoencoder

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Computers, Materials & Continua 2024年第2期78卷 2269-2286页

作者： s.Abinaya k.Uttej kumar school of Computer science&Engineering Vellore Institute of TechnologyChennaiTamilnadu600127India

A Recommender system(Rs)is a crucial part of several firms,particularly those involved in *** conventional Rs,a user may only offer a single rating for an item-that is insufficient to perceive consumer ***,businesses in industries like e-learning and tourism enable customers to rate a product using a variety of factors to comprehend customers’*** the other hand,the collaborative filtering(CF)algorithm utilizing AutoEncoder(AE)is seen to be effective in identifying user-interested ***,the cost of these computations increases nonlinearly as the number of items and users *** triumph over the issues,a novel expanded stacked autoencoder(EsAE)with kernel Fuzzy C-Means Clustering(kFCM)technique is proposed with two *** the first phase of offline,the sparse multicriteria rating matrix is smoothened to a complete matrix by predicting the users’intact rating by the EsAE approach and users are clustered using the kFCM *** the next phase of online,the top-N recommendation prediction is made by the EsAE approach involving only the most similar user from multiple *** the EsAE_kFCM model upgrades the prediction accuracy of 98.2%in Top-N recommendation with a minimized recommendation generation *** experimental check on the Yahoo!Movies(YM)movie dataset and TripAdvisor(TA)travel dataset confirmed that the EsAE_kFCM model constantly outperforms conventional Rs algorithms on a variety of assessment measures.

关键词： Recommender systems multicriteria rating collaborative filtering sparsity issue scalability issue stacked-autoencoder kernel Fuzzy C-Means Clustering

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子系统与系统稳定性的註(英文)

工程数学学报 1984年第2期 43-51页

作者： k.s.chan H.Tong Chinese University of Hong kong

本文讨论了非线性时间序列分析模型中,由k个子系统组成的系统的稳定性与子系统稳定性的关系,指出,如果子系统是正稳定的,系统未必是正稳定的。

关键词：数学学报

Emission colour tuning in kLnF_(4):Yb^(3+),Er^(3+)/Ho^(3+)phosphor

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Journal of Rare Earths 2024年第1期42卷 57-65,I0002页

作者： Janani k Gayathri E Vijayatha V Ramasubramanian s Thiyagarajan P Department of science and Humanities Nehru Institute of TechnologyKaliapuramThirumalayampalayamCoimbatoreIndia Department of sciences Amrita School of Physical SciencesAmrita Vishwa VidyapeethamCoimbatoreIndia Department of Physics Anna UniversityChennaiIndia

kLnF_(4):Yb^(3+),Er^(3+)/Ho^(3+)(Ln=Y,Yb,Gd)phosphors were prepared by solid-state reaction *** each of the Yb^(3+)/Er^(3+)and Yb^(3+)/Ho^(3+)co-doped phosphors independently,phase confirmation and morphological examination were accomplished using the X-ray diffraction technique and scanning electron microscope analysis.X-ray photoelectron spectroscopy analysis shows the charge state and existence of lanthanides and *** luminescence emissions of green and red colour were detected for the synthesized *** changes in the upconverted emission intensities and colour output pertaining to the change of the lanthanide host matrix along with dopants were investigated for the prepared *** the upconversion luminescence,erbium-doped samples exhibit a predominance of red emission while holmium-doped samples display a prevalence of green *** rare-earth Er/Ho doped kYbF4shows strong red emission compared to other ***_(4):Yb,Er/Ho exhibits relatively significant green upconve rsion emissions,while Yb,Er-doped kGdF_(4)host displays a 10-fold increase in green/red emission ratio with an increase in the input power of 20-780 *** photoluminescence studies and decay curve analysis were carried out using UV light excitation for the developed phosphors.A higher lifetime of 2.2 ms was measured for the downshifting red emission in the Ho doped kYbF_(4)*** study suggests a potential for colour tunability in the upconversion and downshifting emissions through host modifications to the fluoride phosphor.

关键词： Rare earths Energy transfer upconversion Downshifting Colour coordinates

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Quantitative and qualitative subgenomic RNA profiles of sARs-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin Ng Grace Lui Lowell Ling Agnes s.Y.Leung Chit Chow siaw shi Boon Wendy C.s.Ho Maggie Haitian Wang Renee Wan Yi chan Albert Martin Li David shu Cheong Hui Paul kay sheung chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club school of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The sARs-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus sARs-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq subgenomic RNA(sgRNA)

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工业型多重力分选机的扩大试验

有色矿冶 1992年第5期8卷 19-24页

作者： B.s.k.chan R.H.MOZLEY G.J.C.CHILDs 罗中平

本文介绍了用工业型多重力分选机(mGs)处理锡、铬铁矿、天青石和磁铁矿粉的扩大试验结果。结果表明,MGs能够获得优于传统设备的分选效果。

关键词：多重力选矿机重力选矿

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