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Clinical-based phenotypes in children with pediatric post-COVID-19 condition

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World journal of Pediatrics 2024年第7期20卷 682-691页

作者： Lieke C.E.Noij jelle M.Blankestijn Coen R.Lap Marlies A.van Houten Giske Biesbroek Anke-Hilse Maitland-van der Zee Mahmoud I.Abdel-Aziz johannes B.van Goudoever Mattijs W.Alsem Caroline L.H.Brackel kim j.Oostrom simone Hashimoto suzanne W.j.Terheggen-Lagro Department of Pediatric Pulmonology and Allergy Amsterdam UMCLocation AMCEmma Children’s HospitalAmsterdam University Medical CenterRoom G2-222Meibergdreef 91105AZAmsterdamThe Netherlands Department of Pulmonary Medicine Amsterdam UMCAmsterdamThe Netherlands Department of Pediatrics Spaarne GasthuisHoofddorpThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterAmsterdamThe Netherlands Department of Rehabilitation Medicine Amsterdam Movement SciencesMeibergdreef 9AmsterdamThe Netherlands Department of Paediatric Pulmonology Department of PaediatricsTergooi MCHilversumThe Netherlands Department of Child and Adolescent Psychiatry and Psychosocial Care Amsterdam UMCAmsterdam Reproduction and DevelopmentAmsterdamThe Netherlands

Background Pediatric post coronavirus disease 2019(COVID-19)condition(PPCC)is a heterogeneous syndrome,which can significantly affect the daily lives of *** study aimed to identify clinically meaningful phenotypes in children with PPCC,to better characterize and treat this *** Participants were children with physician-diagnosed PPCC,referred to the academic hospital Amsterdam UMC in the Netherlands between November 2021 and March *** factors and information on post-COVID symptoms,comorbidities,and impact on daily life were *** clusters were identified using an unsupervised and unbiased approach for mixed data *** Analysis of 111 patients(aged 3–18 years)revealed three distinct clusters within *** 1(n=62,median age=15 years)predominantly consisted of girls(74.2%).These patients suffered relatively more from exercise intolerance,dyspnea,and smell *** 2(n=33,median age=13 years)contained patients with an even gender distribution(51.5%girls).They suffered from relatively more sleep problems,memory loss,gastrointestinal symptoms,and *** 3(n=16,median age=11 years)had a higher proportion of boys(75.0%),suffered relatively more from fever,had significantly fewer symptoms(median of 5 symptoms compared to 8 and 10 for clusters 1 and 2 respectively),and experienced a lower impact on daily *** This study identified three distinct clinical PPCC phenotypes,with variations in sex,age,symptom patterns,and impact on daily *** findings highlight the need for further research to understand the potentially diverse underlying mechanisms contributing to post-COVID symptoms in children.

关键词： Adolescents Clusters Long COVID Pediatric Phenotypes Post-COVID syndrome

Considerations for the use of porcine organ donation models in preclinical organ donor intervention research

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Animal Models and Experimental Medicine 2024年第3期7卷 283-296页

作者： Frazer I.Heinis shaheed Merani Nicholas W.Markin kim F.Duncan Michael j.Moulton Lance Fristoe William E.Thorell Raechel A.sherrick Tami R.Wells Matthew T.Andrews Marian Urban school of Natural Resources Institute of Agriculture and Natural ResourcesUniversity of Nebraska-LincolnLincolnNebraskaUSA Division of Transplantation and Vascular surgery Department of SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA Department of Anesthesiology University of Nebraska Medical CenterOmahaNebraskaUSA Division of Cardiothoracic surgery Department of SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA Clinical Perfusion Nebraska Medicine-Nebraska Medical CenterOmahaNebraskaUSA Department of Neurosurgery University of Nebraska Medical CenterOmahaNebraskaUSA Nutrition and Health sciences College of Education and Human SciencesUniversity of Nebraska-LincolnLincolnNebraskaUSA Department of Comparative Medicine University of Nebraska Medical CenterOmahaNebraskaUSA

Use of animal models in preclinical transplant research is essential to the optimization of human allografts for clinical *** models of organ donation and preservation help to advance and improve technical elements of solid organ recovery and facilitate research of ischemia-reperfusion injury,organ preservation strategies,and future donor-based *** considerations include cost,public opinion regarding the conduct of animal research,translational value,and relevance of the animal model for clinical *** present an overview of two porcine models of organ donation:donation following brain death(DBD)and donation following circulatory death(DCD).The cardiovascular anatomy and physiology of pigs closely resembles those of humans,making this species the most appropriate for pre-clinical *** are also considered a potential source of organs for human heart and kidney *** is imperative to minimize animal loss during procedures that are surgically *** present our experience with these models and describe in detail the use cases,procedural approach,challenges,alternatives,and limitations of each model.

关键词： animal model brain death circulatory death organ transplantation

Impact of Transition Metal Layer Vacancy on the structure and Performance of P2 Type Layered sodium Cathode Material

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Nano-Micro Letters 2024年第11期16卷 340-358页

作者： Orynbay Zhanadilov sourav Baiju Natalia Voronina jun Ho Yu A.-Yeon kim Hun‑Gi jung Kyuwook Ihm Olivier Guillon Payam Kaghazchi seung‑Taek Myung Department of Nanotechnology and Advanced Materials Engineering and sejong Battery Institute Hybrid Materials Research CenterSejong University98 Gunja‑DongGwangjin‑GuSeoul 05006South Korea Institute of Energy and Climate Research‑Materials synthesis and Processing(IEK‑1) Forschungszentrum Jülich GmbH52425 JülichGermany Center for Energy storage Research Korea Institute of Science and TechnologySeoul 02792South Korea KIsT‑sKKU Carbon‑Neutral Research Center Sungkyunkwan UniversitySuwon 16419South Korea Department of Energy science Sungkyunkwan UniversitySuwon 16419South Korea Pohang Accelerator Laboratory 80 Jigokro‑127‑BeongilNam‑GuPohangGyeongbuk 37673South Korea MEsA+Institute for Nanotechnology University of Twente7500 AE EnschedeThe Netherlands

This study explores the impact of introducing vacancy in the transition metal layer of rationally designed Na_(0.6)[Ni_(0.3)Ru_(0.3)Mn_(0.4)]O_(2)(NRM)cathode *** incorporation of Ru,Ni,and vacancy enhances the structural stability during extensive cycling,increases the operation voltage,and induces a capacity increase while also activating oxygen redox,respectively,in Na_(0.7)[Ni_(0.2)V_(Ni0.1)Ru_(0.3)Mn_(0.4)]O_(2)(V-NRM)*** analytical techniques including transmission electron microscopy,X-ray absorption near edge spectroscopy,operando X-ray diffraction,and operando differential electrochemical mass spectrometry are employed to assess changes in the average oxidation states and structural *** results demonstrate that V-NRM exhibits higher capacity than NRM and maintains a moderate capacity retention of 81%after 100 ***,the formation of additional lone-pair electrons in the O 2p orbital enables V-NRM to utilize more capacity from the oxygen redox validated by density functional calculation,leading to a widened dominance of the OP4 phase without releasing O_(2) *** findings offer valuable insights for the design of advanced high-capacity cathode materials with improved performance and sustainability in sodium-ion batteries.

关键词： Layered oxide Oxygen evolution sodium battery Vacancy Cathode

The CUL3A–LFH1–UBC15 ubiquitin ligase complex mediates sHORT VEGETATIVE PHAsE degradation to accelerate flowering at high ambient temperature

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Plant Communications 2024年第4期5卷 224-238页

作者： suhyun jin Geummin Youn sun Young kim Taewook Kang Hyun-young shin ji-Yul jung Pil joon seo ji Hoon Ahn Department of Life sciences Korea UniversitySeoul 02841Republic of Korea Department of Chemistry Seoul National UniversitySeoul 08826Republic of Korea These authors contributed equally to this article.

Ambient temperature affects flowering time in plants,and the MADs-box transcription factor sHORT VEGETATIVE PHAsE(sVP)plays a crucial role in the response to changes in ambient *** protein stability is regulated by the 26s proteasome pathway and decreases at high ambient temperature,but the details of sVP degradation are ***,we show that sVP degradation at high ambient temperature is mediated by the CULLIN3–RING E3 ubiquitin ligase(CRL3)complex in Arabidopsis *** identified a previously uncharacterized protein that interacts with sVP at high ambient temperature and contains a BTB/POZ *** named this protein LATE FLOWERING AT HIGH TEMPERATURE 1(LFH1).single mutants of LFH1 or CULLIN3A(CUL3A)showed late flowering specifically at 27***1 protein levels increased at high ambient *** found that LFH1 interacts with CUL3A in the cytoplasm and is important for sVP–CUL3A complex *** in CUL3A and/or LFH1 led to increased sVP protein stability at high ambient temperature,suggesting that the CUL3–LFH1 complex functions in sVP *** E2 ubiquitin-conjugating enzymes(UBCs)using RING-BOX PROTEIN 1(RBX1),a component of the CRL3 complex,as bait identified ***15 mutants also showed late flowering at high ambient *** vitro and in vivo ubiquitination assays using recombinant CUL3A,LFH1,RBX1,and UBC15 showed that sVP is highly ubiquitinated in an ATP-dependent ***,these results indicate that the degradation of sVP at high ambient temperature is mediated by a CRL3 complex comprising CUL3A,LFH1,and UBC15.

关键词： temperature-responsiveflowering sVP CUL3 proteasomal degradation ubiquitination

strip Casting of High Performance structural Alloys

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journal of Rare Earths 2004年第z2期22卷 78-84页

作者： s s Park j G Lee Nack j kim Center for Advanced Aerospace Materials Pohang University of Science and TechnologyPohang 790-784Korea Center for Advanced Aerospace MaterialsPohang University of Science and TechnologyPohang 790-784Korea Center for Advanced Aerospace MaterialsPohang University of Science and TechnologyPohang 790-784Korea

There exists a great need for the development of high performance alloys due to increasing demands for energy conservation and environmental protection. Application of strip casting shows a strong potential for the improvement of properties of existing alloys and also for the development of novel alloy systems with superior properties. The present paper reviews our Center's activities in the development of high performance alloys by strip casting. Examples include (1) Al alloys, (2) wrought Mg alloys, and (3) bulk metallic glass (BMG) alloys.

关键词： strip casting 6061 Al alloy AZ Mg alloy bulk metallic glass (BMG) alloy dispersion hardening

A Review of Rechargeable Zinc-Air Batteries:Recent Progress and Future Perspectives

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Nano-Micro Letters 2024年第7期16卷 358-401页

作者： Ghazanfar Nazir Adeela Rehman jong-Hoon Lee Choong-Hee kim jagadis Gautam Kwang Heo sajjad Hussain Muhammad Ikram Abeer AAlObaid seul-Yi Lee soo-jin Park Department of Nanotechnology and Advanced Materials Engineering Hybrid Materials Research Center(HMC)Sejong UniversitySeoul 05006Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-RoSeodaemun-GuSeoul 03722Republic of Korea Department of Chemistry Inha UniversityIncheon 22212Republic of Korea solar Cell Applications Research Lab Department of PhysicsGovernment College University LahoreLahore 54000 PunjabPakistan Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia

Zinc-air batteries(ZABs)are gaining attention as an ideal option for various applications requiring high-capacity batteries,such as portable electronics,electric vehicles,and renewable energy *** offer advantages such as low environmental impact,enhanced safety compared to Li-ion batteries,and cost-effectiveness due to the abundance of ***,early research faced challenges due to parasitic reactions at the zinc anode and slow oxygen redox *** advancements in restructuring the anode,utilizing alternative electrolytes,and developing bifunctional oxygen catalysts have significantly improved *** have achieved battery reversibility over thousands of cycles,introduced new electrolytes,and achieved energy efficiency records surpassing 70%.Despite these achievements,there are challenges related to lower power density,shorter lifespan,and air electrode corrosion leading to performance *** review paper discusses different battery configurations,and reaction mechanisms for electrically and mechanically rechargeable ZABs,and proposes remedies to enhance overall battery *** paper also explores recent advancements,applications,and the future prospects of electrically/mechanically rechargeable ZABs.

关键词： Zinc-air batteries Energy storage Affordability Reversibility

Numerical analysis of thermal plasma scrubber for CF4 decomposition

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Plasma science and Technology 2019年第6期21卷 9-14页

作者： j KO T H kim s CHOI Department of Nuclear and Energy Engineering Jeju National University Jeju 63243 Republic of Korea Institute for Nuclear science and Technology Jeju National University Jeju 63243 Republic of Korea

CF4 gas emitted in the semiconductor and display manufacturing process is a very harmful greenhouse *** must be removed or converted safely due to its extreme *** a CF4 decomposition system using a thermal plasma scrubber was commercialized,its removal efficiency is *** this work,a numerical analysis of CF4 decomposition in the thermal plasma scrubber was carried out in order to propose an efficient decomposition *** decomposition and recombination temperatures of CF4 were analyzed using thermodynamic equilibrium *** chemical reaction of CF4 decomposition into carbon and fluorine gas was considered in this numerical *** injection position and angle of the CF4 were controlled in order to enhance the decomposition *** vertical injection of CF4 near the torch exit improved the mixing of the CF4 with the thermal plasma *** addition,it was confirmed that the high temperature region expanded due to a vortex generated by strong turbulence in the bottleneck-shaped *** a result,it is revealed that the CF4 injection location and the reactor configuration are the most important factors in improving the decomposition rate.

关键词： numerical simulation decomposition CF4 thermal plasma scrubber

Magnetic force improvement and parameter optimization for magnetic abrasive polishing of AZ31 magnesium alloy

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中国有色金属学会会刊：英文版 2008年第A01期18卷 369-373页

作者： s.O.kim j.s.KWAK Graduate school of Mechanical Engineering Pukyong National UniversitySouth Korea school of Mechanical Engineering Pukyong National UniversitySouth Korea

The magnetic force acting on workpiece to be machined plays a significantly important role in magnetic abrasive polishing *** in a case of polishing nonferrous materials,the strength of magnetic force is very low and it leads lower polishing *** magnesium alloy that has superior mechanical properties for industrial application such as a lightweight and high specific strength is one of the most famous nonferrous *** improving strategy of the magnetic force for the AZ31 magnesium alloy installed with a permanent magnet was proposed and experimental verification was carried *** the proposed strategy,the effect of process parameters on the surface roughness of the AZ31 magnesium alloy was evaluated by a design of experimental method.

关键词：镁合金物理性能磁力最优化设计磁性

Difference in the Hot Compressive Behavior and Processing Maps between the As-cast and Homogenized Al-Zn-Mg-Cu(7075) Alloys

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journal of Materials science & Technology 2016年第7期32卷 660-670页

作者： s.Y. Park W.j. kim Department of Materials science and Engineering Hongik University 72-1 Sangsu-dong Mapo-gu Seoul 121-791 Republic of Korea Advanced Fusion Process R&D Group Korea Institute of Industrial Technology 994-32 Dongchun-dong Yeonsu-gu Incheon 406-130 Republic of Korea

The deformation mechanisms and processing maps of the as-cast Al-Zn-Mg-Cu （？0？5） aluminum （AI） alloy were studied and compared with those of the homogenized 7075 Al alloy in the temperature range of 573-723 K and in the strain rate range of 10 3-10 s-1 to explore a possibility for directly using the as- cast 7075 Al alloy as a billet for hot working. The as-cast and homogenized 7075 A1 alloys had similar grain sizes and showed similar high-temperature deformation behaviors. The as-cast 7075 Al alloy, however, exhibited higher power efficiencies and smaller unstable flow regions compared to the homogenized 7075 AI alloy because of the presence of secondary phases （MgZn2） segregated at the dendritic interfaces in the as-cast microstructure, which were formed during non-equilibrium solidification. These segregated phases provided nucleation sites for dynamic recovery or continuous dynamic recrystallization, and as a result a fine and more homogeneous （sub）grain structure could be obtained from the as-cast micro- structure compared to the homogenized microstructure. The current work suggested the possibility and advantage of using as-cast microstructures for hot working of aluminum alloys with high content of solutes.

关键词： Al-based alloysProcessing mapHot compressionAs-cast microstructuresegregationRecrystallization