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Role of ischaemic preconditioning in liver regeneration following major liver resection and transplantation

World Journal of Gastroenterology 2007年第5期13卷 657-670页

作者： D Gomez s homer-vanniasinkam AM Graham KR Prasad Department of Hepatobiliary surgery and Transplantation St. James’s University Hospital United Kingdom Department of Vascular surgery Leeds General Infirmary Leeds United Kingdom Department of Biomedical sciences University of Bradford Bradford United Kingdom

Liver ischaemic preconditioning （IPC） is known to protect the liver from the detrimental effects of ischaemic-reperfusion injury （IRI）, which contributes significantly to the morbidity and mortality following major liver surgery. Recent studies have focused on the role of IPC in liver regeneration, the precise mechanism of which are not completely understood. This review discusses the current understanding of the mechanism of liver regeneration and the role of IPC in this setting. Relevant articles were reviewed from the published literature using the Medline database. The search was performed using the keywords ＂liver＂, ＂ischaemic reperfusion＇, ＂ischaemic preconditioning＂, ＂regeneration＂, ＂hepatectomy＂ and ＂transplantation＂. The underlying mechanism of liver regeneration is a complex process involving the interaction of cytokines, growth factors and the metabolic demand of the liver. IPC, through various mediators, promotes liver regeneration by up-regulating growth-promoting factors and suppresses growth-inhibiting factors as well as damaging stresses. The increased understanding of the cellular mechanisms involved in IPC will enable the development of alternative treatment modalities aimed at promoting liver regeneration following major liver resection and transplantation.

关键词： Liver regeneration Ischaemic reperfusion Lschaemic preconditioning Hepatectomy Transplantation

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Role of tissue microenvironment resident adipocytes in colon cancer

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World Journal of Gastroenterology 2017年第32期23卷 5829-5835页

作者： Maria Tabuso shervanthi homer-vanniasinkam Raghu Adya Ramesh P Arasaradnam Department of Gastro-enterology University Hospitals Coventry and Warwickshire Warwick Medical school University of Warwick Leeds Institute of Car-diovascular and Metabolic Medicine Faulty of Medicine and HealthUniversity of Leeds Division of surgical and Interventional sciences UCL Medical School Building Applied Biological and Experimental sciences University of Coventry

Colorectal cancer(CRC) is a multifactorial disease characterized by several genetic and epigenetic alterations occurring in epithelial cells. It is increasingly recognized that tumour progression is also regulated by tumour microenvironment(TME). The bidirectional cross-talk between tumour resident adipocytes and cancer cells within TME has been proposed as active contributor to carcinogenesis. Tumour resident adipocytes exhibit an activated phenotype characterized by increased secretion of pro-tumorigenic factors(angiogenic/inflammatory/immune) which contribute to cancer cell proliferation, invasion, neoangiogenesis, evasion of immune surveillance and therapy resistance. Furthermore, adipocytes represent a fuel rich source for increasing energy demand of rapidly proliferating tumour cells. Interestingly, a relationship between obesity and molecular variants in CRC has recently been identified. Whether adipose tissue promotes cancer progression in subsets of molecular phenotypes or whether local tissue adipocytes are involved in inactivation of tumour suppressor genes and/or activation of oncogenes still needs to be explored. This editorial highlights the major findings related to crosstalk between adipocytes and colon cancer cells and how local paracrine interactions may promote cancer progression. Furthermore, we provide future strategies in studying colonic TME which could provide insights in bidirectional cross-talk mechanisms between adipocytes and colonic epithelial cells. This could enable to decipher critical signalling pathways of both early colonic carcinogenesis and cancer progression.

关键词： Tumour resident adipocytes Dysfunctional adipocytes Adipose tissue Cancer cell-tumour resident adipocyte cross-talk Colon cancer microenvironment

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Adenoviral Vectors in Veterinary Vaccine Development: Potential for Further Development

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World Journal of Vaccines 2013年第3期3卷 111-121页

作者： Olasumbo L. Ndi Mary D. Barton Thiru vanniasinkam sansom Institute School of Pharmacy and Medical Sciences University of South Australia Adelaide Australia school of Biomedical sciences Charles Sturt University Wagga Wagga Australia.

Vaccines are an integral part of veterinary disease prevention. However there are still a significant number of veterinary diseases for which vaccines do not currently exist or where currently available vaccines do not provide adequate immunity. Adenoviruses have transitioned from tools for gene replacement therapy to bona fide vaccine delivery vehicles because of their ability to elicit potent cell-mediated and humoral responses making them ideal for use against viruses and other intracellular pathogens. Adenoviral vector based vaccines are likely to play a significant role in overcoming these problems in the future. However, this vector is under utilized in veterinary vaccine development at this time. This review focuses on adenoviral vector based vaccines developed to date and explores the potential for veterinary vaccine development based upon this platform: advantages and potential disadvantages of this technology are discussed as well as the potential for developing efficacious commercial veterinary adenoviral vector based vaccines.

关键词： Veterinary Vaccines Adenoviral Vector Adenoviral Vector Vaccine Vaccine Vector Immune Response

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