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Effect of liver regeneration after partial hepatectomy and ischemia-reperfusion on expression of growth factor receptors

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World Journal of Gastroenterology 2006年第24期12卷 3835-3840页

作者： P Baier G Wolf-Vorbeck s hempel UT Hopt E von Dobschuetz Department of General and Visceral surgery Albert-Ludwigs-University FreiburgGermany

瞄准：在肝新生在四不同生长因素受体的表示的时间功课上调查试验性的部分肝切除术和 normothermic ischemia-reperfusion 损坏的效果。这由于在刺激肝新生的生长因素的潜在的治疗学的使用是相关的。方法：为部分肝切除术(PH ) ， 80% ... 详细信息

瞄准：在肝新生在四不同生长因素受体的表示的时间功课上调查试验性的部分肝切除术和 normothermic ischemia-reperfusion 损坏的效果。这由于在刺激肝新生的生长因素的潜在的治疗学的使用是相关的。方法：为部分肝切除术(PH ) ， 80% 肝质量是在 sprague Dawley 老鼠的 resected。局部缺血和灌注(I/R ) 被门静脉和肝的动脉的吸藏为 15 min 导致。表皮的生长因素受体，肝的生长因素受体，成纤维细胞生长因素受体和瘤坏死因素 receptor-1 被免疫组织化学在损害以后分析直到 72 h。量的 RT-PCR 在最小的受体表示(24 h ) 的时间点被执行。结果：在免疫组织化学， EGFR， HGFR， FGFR 和 TNFR1 与一座山峰在部分肝切除术以后给双性人看了局面的动力学直到 12 h，在 24 h 以后的一个天底和另一弱增加直到 72 h。在肝新生期间，在局部缺血和灌注以后，受体表示更低；在在灌注以后的 24 h 的天底是一样。评估这个天底是否被 mRNA 抄写的缺乏引起，或由于一根柱子翻译规定， RT-PCR 在 24 h 并且与放松肝相比被执行。在每根探针，为受体有特定的 mRNA。EGFR， FGFR 和 TNFR1 mRNA 表示比在放松肝相等或低，在 I/R 以后的 HGFR 表示比在控制强壮。结论：部分至少由于 post-transcriptional 处理，在分析受体的表达式有一个天底在肝损伤以后的 24 h。因此，到在损坏以后的 stimulate 肝新生 24 h 的生长因素的治疗学的使用可能不是成功的。

关键词：肝切除术缺血再灌注损伤生长因子病理机制

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高技术工作团队的交互记忆系统及其效果

In vitro Response of Human Mesenchymal stromal Cells to Titanium Coated Peek Films and Their suitability for Magnetic Resonance Imaging

心理学 2006年第8期 271-280页

作者：张志学 Paul s.hempel 韩玉兰邱静

交互记忆系统近来被认为是影响工作团队绩效的重要特性之一。以往的研究局限于实验室样本或者由学生组成的临时团队，该研究从高技术企业中选取190个工作团队作为样本，考查了团队的交互记忆系统与团队中的其他现象之间的关系。研究除... 详细信息

交互记忆系统近来被认为是影响工作团队绩效的重要特性之一。以往的研究局限于实验室样本或者由学生组成的临时团队，该研究从高技术企业中选取190个工作团队作为样本，考查了团队的交互记忆系统与团队中的其他现象之间的关系。研究除了发现Lewis的量表中有两个题目不理想外，还发现交互记忆系统与团队成员之间的信任、合作性目标导向具有显著的正相关，同时交互记忆系统与团队的工作绩效和凝聚力也具有显著的关系。该文在检验团队层次的现象时，通过计算团队成员在相应变量上得分的一致性(r[，wg])来检查加总分析的合理性，这是从事团队层次的研究中需要遵循的方法。

关键词：交互记忆系统高技术企业团队绩效

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Journal of Materials science & Technology 2015年第5期31卷 427-436页

作者： Cindy Elschner Carolin Noack Carolin PreilBler Andreas Krause Ulrich scheler Ute hempel Leibniz-Institut fr Polymerforschung Dresden e.V. Hohe Str.601069 DresdenGermany CRTD/DFG-Center for Regenerative Therapies Dresden Fetscherstr.10501307 DresdenGermany Institut fr Physiologische Chemie Technische Universitt DresdenFiedlerstr.4201307 DresdenGermany NaMlab gGmbH Nthnitzer Str.6401187 DresdenGermany

Medical imaging is an important tool for the post-operative checkup of an accurate position of an implant as well as for monitoring the integration in the adjacent tissue that may influence the success of a medical ***,the possibility to use imaging methods is associated with the implant material and all the established metallic materials for surgery do not show a proper 'imaging compatibility'.The present study is a combined investigation of the in vitro response to human mesenchymal stromal cells（hMsC） and magnetic resonance imaging（MRI） compatibility of the potential material combination polyetheretherketone/titanium（PEEK/Ti） for medical *** of the advantageous imaging properties and the mechanical and chemical stability,PEEK becomes more and more an alternative to common metallic implant materials like titanium or ***,PEEK is a bioinert material having a limited ability for direct bone *** to its excellent biocompatibility,Ti was chosen as coating material to enhance the cellular *** result is a combination with advantageous properties:the magnetic susceptibility and elastic modulus close to bone,corrosion resistance and mechanical flexibility of PEEK and the excellent biocompatibility of *** appearance of metal-related artifact was discussed in electrical resistivity and magnetic ***,two titanium coatings have been investigated:a complete coating and a structured surface avoiding surface *** determine the in vitro biocompatibility,the cell responses were assessed in terms of the overall morphology of the hMsC and their cell area distribution,proliferation,osteogenic differentiation and mineral *** cellular stress was evaluated by the prostaglandin *** bonded materials both produced no disturbing artifacts in magnetic resonance *** to the pure PEEK material,the titanium coated specimens showed an enhanced biocompatibilit

关键词： Polyetheretherketone Titanium coating Biocompatibi

Modelling air change rate of naturally ventilated dairy buildings using response surface methodology and numerical simulation

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Building simulation 2021年第3期14卷 827-839页

作者： Qianying Yi Guoqiang Zhang Barbara Amon sabrina hempel David Janke Chayan Kumer saha Thomas Amon Department of Engineering Aarhus UniversitySkejby Nordlandsvej 3018200 AarhusDenmark Department of Engineering for Livestock Management Leibniz Institute for Agricultural Engineering and Bioeconomy(ATB)Max-Eyth-Allee 70014469 PotsdamGermany Department of Technology Assessment and substance Cycles Leibniz Institute for Agricultural Engineering and Bioeconomy(ATB)Max-Eyth-Allee 10014469 PotsdamGermany Faculty of Civil Engineering Architecture and Environmental EngineeringUniversity ofZielona GoraLicealna 9/965-417 Zielona GoraPoland Department of Farm Power and Machinery Bangladesh Agricultural UniversityBAU Main Road2202 MymensinghBangladesh Institute of Animal Hygiene and Environmental Health Department of Veterinary MedicineFree University BerlinRobert-von-Ostertag-Str.7-1314163 BerlinGermany

The air change rate(ACR)of naturally ventilated dairy buildings(NVDBs)plays an important part in the design and control of the ventilation system,as well as in the estimation of the gaseous emission *** objectives of this research were to model the ACR based on a quantitative investigation of the relationship between the ACR and its potential influencing factors,including the opening ratio(r),the building length to width ratio(a),the wind speed(U),and the wind direction(0).The investigations were performed using the response surface methodology integrated with the Box-Behnken design and Computational Fluid Dynamics(CFD)*** response surface models of the ACR of NVDBs were established for three opening ratio ranges of 5%-42.5%,42.5%-80%,and 5%-80%,*** was found that the selection of the opening ratio range had almost no effect on the developed response surface *** results showed that the ACR of NVDBs was not influenced by a,but was significantly affected by r,U,6,and interaction effects between every two of the three *** highest ACR was 6.7 s^(-1),6.0 s^(-1),and 4.0 s^(-1)when 0,U,and r was at their respective medium value while the rest parameters were at the highest values,indicating that the r played an important role in the value of *** was concluded that in the prediction of the ACR of a building,the influences of both individual and interactional effects of 0,U,and r should be considered.

关键词： emission estimation computational fluid dynamics Box-Behnken design response surface model

Risk and benefit from clinical trials in minors:Making the case for transparent and consistent publications

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Open Journal of Pediatrics 2013年第2期3卷 151-164页

作者： Andreas Dirk Henschel Lillian Geza Rothenberger Dominik schrey Joachim Gerβ Georg hempel Joachim Boos Department of Pharmaceutical and Medical Chemistry—Clinical Pharmacy University of MünsterMünsterGermany Department of Paediatric Haematology and Oncology University Children’s Hospital MünsterMünsterGermany Institute of Ethics and History in Medicine Center for MedicineSociety and PreventionUniversity of TuebingenGermany The Royal Marsden Hospital Department of Paediatric OncologySurreyUK Institute for Biostatistics and Clinical Research University of MuensterGermany Department of Pediatric Hematology and Oncology University Children’s HospitalMuenster Albert-Schweitzer-CampusMuensterGermany

Rationale, aim and objectives: The European (EU) regulation on medicinal products for pediatric use (EC 1901/2006), which became effective in 2007, aimed to stimulate the clinical testing of medications in minors in order to reduce off-label use. In consequence, the number of minors taking part in randomized controlled clinical trials (RCTs) is likely to increase. Clinical trials in minors require a complex methodological design, a careful consideration of risks and benefits and a high level of ethical reflection. Unfortunately, as to the quality of clinical trials and their publications in minors little is known. Therefore, we assessed published reports of randomized, controlled clinical trials in minors, focusing on a common disease (asthma) and a defined spectrum of lifethreatening diseases (malignant diseases). Method: In an exploratory design, we scanned the publications for methodological aspects as well as indicators of ethical soundness, e.g., statements that informed consent had been obtained before the start of the trial or that a Data and safety Monitoring Board ensured the patients’ safety during the trial. We also looked for passages reflecting the debate on equipoise or other forms of weighing risks and benefits. Results: We found that many of these aspects, which according to the scientific literature and generally acknowledged guidelines are essential to ensure good-quality trials and trial reports, were not considered in the publications analyzed. Conclusion: Therefore, we call for a more transparent and consistent presentation of the trials, especially of safety aspects, relying on a more critical and transparent ethical reflection.

关键词： Clinical Trials Minors sIGN CONsORT Ethics

澳大利亚乔治布朗·达尔文植物园苏铁类植物资源收集与保护状况分析（英文）

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农业研究与应用 2017年第1期30卷 1-7页

作者：黄玉源 sharon Wilson Jane hempel 仲恺农业工程学院生命科学学院乔治布朗.达尔文植物园

本文对澳大利亚乔治布朗·达尔文植物园苏铁类植物资源的收集、保护状况等方面进行了调查研究,调查结果表明:由于植物园是坐落在野生苏铁的主要分布地之一,因此该植物园在收集和管理苏铁类植物资源方面具有优势,已经收集和种植了70多种... 详细信息

本文对澳大利亚乔治布朗·达尔文植物园苏铁类植物资源的收集、保护状况等方面进行了调查研究,调查结果表明:由于植物园是坐落在野生苏铁的主要分布地之一,因此该植物园在收集和管理苏铁类植物资源方面具有优势,已经收集和种植了70多种苏铁科和泽米铁科苏铁类植物,以及超过600多个苏铁植物植株。该植物园苏铁园建立于15年以前,种植的主要是澳大利亚本土分布的野生苏铁类植物,同时也种植有少量来自中国和其他国家的苏铁类植物。在植物园科技人员等全体职员的努力下,该植物园已经成为澳大利亚珍稀苏铁类植物资源重要的栖息地和保护地。本文对于植物园在苏铁植物资源的采集、栽培和管理的技术特点及优点进行了研究和分析,同时提出了一些建议。本研究对各地植物园在珍稀植物资源的收集和迁地保护等方面具有理论意义和实践的参考价值。

关键词：珍稀植物资源资源收集铁园植物植株迁地保护泽米 garden Australia cultivation ecology

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普里斯马-肖恩多夫休息站

世界建筑导报 2021年第5期36卷 52-52页

作者： Till schneider Jorg hempel(摄影) schneider+schumacher 不详

空间雕塑“棱镜”-德语中的棱镜-是为纪念施耐德和舒马赫对肖恩多夫市的贡献,展出于2019年Remstal花园展。四点六线的几何最小体设计聚焦于雷姆斯塔尔特别的自然景观,是观察、流连和凝视远方的好去处。为顺应自然规律,四面体形状的棱镜... 详细信息

空间雕塑“棱镜”-德语中的棱镜-是为纪念施耐德和舒马赫对肖恩多夫市的贡献,展出于2019年Remstal花园展。四点六线的几何最小体设计聚焦于雷姆斯塔尔特别的自然景观,是观察、流连和凝视远方的好去处。为顺应自然规律,四面体形状的棱镜体建在大片葡萄树线性结构的中间,堡垒底部上升一定角度,并采用集成材面板建造。景观两面设计截然不同:水平开口朝向山谷,可以望到肖恩多夫教堂。垂直的开口为入口处,面向葡萄园小路,斜坡和上方的树林。

关键词：舒马赫葡萄树线性结构多夫斯塔尔自然规律棱镜肖恩

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石油储罐内壁防静电涂料研究

涂料涂装与电镀 2005年第3期3卷 5-9页

作者：李荣俊林可湘吴国静曹晔海虹老人牌(中国)有限公司

通过对石油储罐静电危害性、防静电涂料导电原理及国内相关标准的扼要分析后,简要介绍海虹老人牌金属型、碳型及金属氧化物型三类防静电涂料特性及其配套体系。

关键词：石油储罐涂料研究防静电涂料内壁金属氧化物相关标准导电原理配套体系危害性金属型

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s+s法兰克福展馆

世界建筑导报 2021年第5期36卷 44-44页

作者： Till schneider Norbert Miguletz(摄影) Jorg hempel(摄影) Kirsten Bucher(摄影) schneider+schumacher 不详

对于临时展馆,法兰克福书展希望采用不同于以往的形式:作为建筑师,我们的任务是,一方面要创造一个500平方米的活动空间,另一方面要确保所建造的建筑物在每年的书展上保持可识别的标志性影响,这种影响至少持续十年。可持续性体现在各个方... 详细信息

对于临时展馆,法兰克福书展希望采用不同于以往的形式:作为建筑师,我们的任务是,一方面要创造一个500平方米的活动空间,另一方面要确保所建造的建筑物在每年的书展上保持可识别的标志性影响,这种影响至少持续十年。可持续性体现在各个方面,包括建筑的潜在使用方式、对不同位置的适应性、使用材料、快速组装和拆卸的优化结构、最小储物占地面积以及客户、规划者和承包商之间在整个开发过程中所秉承的可持续方法。

关键词：法兰克福书展优化结构占地面积规划者快速组装可持续性适应性