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Associated Factors to Poor Blood Pressure Control in Hypertensives Followed Up at the Campus University Hospital of Lome (Togo)

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World Journal of Cardiovascular Diseases 2024年第6期14卷 374-380页

作者： soulemane Pessinaba Yaovi Mignazonzon Afassinou Wiyao Dieudonné Kaziga Komlavi Yayehd Kolani Lamboni sélim bolarinwa Mohamed Kpélafia Ekpe Togbossi Akpe Adzodo Machihude Pio soodougoua Baragou Findibé Damorou Cardiology Department University Hospital of Campus Lome Togo Cardiology Department Sylvanus Olympio University Hospital Lome Togo Cardiology Department Kara University Hospital Kara Togo

Introduction: Hypertension is a real public health issue and its control is very difficult. We aim to determine the frequency of uncontrolled hypertension in hypertensive patients followed up as an outpatient at the campus university hospital of Lome (Togo) and to search for the associated factors. Methodology: The study was cross-sectional, descriptive and analytical, carried out from February (2022) to August 2022 in 260 hypertensive patients aged 22 years old, followed up (on an) as an outpatient for at least 3 months at the Lome University Hospital campus. A univariate then multivariate analysis were conducted in order to highlight the most common factors significantly linked to uncontrolled. Results: The mean age of hypertensives was 56.4 ± 12.7 years, the sex ratio (M/F) was 0.59. Prevalence of uncontrolled blood pressure was 42%. Associated Factors to poor blood pressure control in our study were age > 60 years (OR = 1.6 CI [1.17 - 2.50]), low socio-economic level (OR = 2.2 CI [1.96 - 4.33]), high cardiovascular risk level (OR = 3.1 CI [2.18 - 4.52]), non-adherence to regular blood pressure monitoring (OR = 3.3 CI [2.21 - 5.55]), low compliance to treatment (OR = 4.1 CI [2.33 - 6.76]) and a chronic renal failure (OR = 2.1 CI [1.21 - 3.10]). Conclusion: Nearly half of the hypertensives in our study had poorly controlled blood pressure by antihypertensive treatment medication. The factors of this poor control were age > 60 years, low socio-economic level, high or very high level of cardiovascular risk, low compliance to treatment, and renal failure.

关键词： Hypertension Poor Control Associated factors Togo

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single-cell and spatial omics:exploring hypothalamic heterogeneity

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Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong Lee su Bin lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

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Modulation effects of Cu modification and ligands (oxalate and borohydride) functionalization on Pt d-band center, upper d-band edge, and alloyed PtCe support acidity on semihydrogenation of acetylene

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Journal of Energy Chemistry 2022年第9期31卷 495-508,I0014页

作者： Olumide bolarinwa Ayodele International Iberian Nanotechnology Laboratory Braga 4715-330Portugal Department of Civil and Chemical Engineering University of Tennessee ChattanoogaTN 37403United States

The modulating effects of Cu modification and oxalate or borohydride ligands functionalization on the structure,catalyst d-band center(εd),upper d-band edge(εu),and acetylene partial hydrogenation of expediently synthesized Ce alloyed Pt supported catalysts were ***,a 5 wt%Pt alloyed Ce was synthesized via flame spray *** PtCe sample was further supported on zeolite Y,ZY,(PtCe/ZY)and copper modified ZY(PtCe/Cu-ZY).Furthermore,the PtCe was supported on two other oxalate and borohydride ligands functionalized copper modified ZY(PtCe/CuX-ZY and PtCe/CuB-ZY,respectively).The high-angle annular darkfield scanning transmission electron microscopy(HAADF/sTEM)data showed a reduction in the PtO average particle size from 2.65 nm in PtCeO_(2) to average 1.73,0.64,and 0.30 nm in PtCe/Cu-ZY,PtCe/CuX-ZY,and PtCe/CuB-ZY,which was corroborated by the electron energy-loss spectroscopy(EELs)results wherein nonhomogeneous mixing of elements was seen with segregated Pt clusters in the non-functionalized ***,both PtCe/CuX-ZY and PtCe/CuBZY samples showed near-perfect homogeneity with no distinct Pt *** measuredεu values for PtCe,PtCe/Cu-ZY,PtCe/CuX-ZY,and PtCe/CuB-ZY are+1.85,+0.40,-0.15,and-0.19 eV,*** positive values indicated strong metal-adsorbate bonding typical of large Pt sizes while the negative values indicated weak metal-adsorbate bonding due to highly downsized Pt *** ethylene yield(YC2H4)over the PtCe sample showed depletion as the reaction temperature increased,while it reflected maxima at 120℃ with 55.3%YC2H4 over PtCe/*** maxima shifted to 180℃ with enhanced YC2H4 of 71.4%in PtCe/*** the contrary,both PtCe/CuX-ZY and PtCe/CuB-ZY exhibited a monotonous increase in YC2H4 up to the maximum C_(2)H_(2)conversion with YC2H4 of 81.9%and 92.1%at 180 and 160℃,*** results showed that both the Cu modification and ligands functionalization were highly invaluable to enhance the properties and

关键词： Acetylene semihydrogenation Ethylene Pt d-band center Upper d-band edge

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Qualitative reappraisal of perspectives,prevalence,and management of family violence among the Yoruba people:a study of representatives of some Yoruba ethnic subgroups from Ile Ife

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Frontiers of Nursing 2020年第4期7卷 385-397页

作者： Omolola Irinoye Oluwasayo bolarinwa Ogunlade Department of Nursing science College of Health SciencesObafemi Awolowo UniversityIle Ife 220Nigeria Medical and Health services Obafemi Awolowo UniversityIle Ife 220Nigeria

Objective:The analysis of changing definitions and perspectives of violating behaviors within cultural contexts will inform the responses and interventions that will mostly reduce the occurrences of family ***:This study used focus group discussions of purposively selected participants to generate data that were analyzed using content with themes of definition,perspectives,prevalent forms,persons mostly affected,perpetrators,and management strategies among the Yoruba ***:There were multiple words and descriptions in the local Yoruba language for abuse and violence,but no single word for either of the two *** forms of family violence identified were verbal assaults from parents to children,among couples,siblings,physical assault of children by parents,physical assault of parents by children,neglect of children,parents,spouses mostly wives,sexual harassment,and sexual *** of wives and children was perceived to be increasing,occurring in one in four *** harassment and sexual violence were perceived to be rare,but the latter not an issue in marriage.A variant of sexual“touching”said to be tolerated with unmarried young people was identified as common among this ethnic *** and gender were dominant factors in the use of common forms of *** approaches were methods of management of family violence but perceived ***:This study concluded that family violence is a common phenomenon occurring among family ***,formal acceptable interventions that will be appropriate for this ethnic subgroup are required.

关键词： family violence qualitative reappraisal definition management Yoruba people

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Emissions of Er3+ and Yb3+ co-doped srZrO3 nanocrystals under near-infrared and near-ultraviolet excitations

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Journal of Advanced Ceramics 2020年第4期9卷 413-423页

作者： Hyeontae lim Juyeong lim soyoung Jang Y.s.Lee Department of Physics Soongsil UniversitySeoul06978Republic of Korea

In this study,the upconversion(UC)emissions of Er3+and Yb3+co-doped srZrO3 nanocrystals(NCs)were investigated in terms of the thermal annealing temperature and concentration of Er3+ions and compared with the emissions under a near-ultraviolet(near-UV)*** NCs were synthesized by the combustion method,and the as-synthesized NCs were post-annealed at high *** X-ray diffraction patterns revealed that the grain sizes and crystallinity degrees of the samples increased with increasing annealing *** photoluminescence spectra of our samples exhibited strong green and very weak red emissions with the near-UV excitation,originating from the f-f transitions in the Er3+***,under near-infrared(near-IR)excitation,we identified sizable visible emissions at 525,547,and 660 nm in our NCs,which indicated that the UC process successfully occurred in our *** UC emissions were maximized in the NCs with an Er3+concentration of 0.02 and thermal annealing at 1000°*** found that the intensity ratios of red to green emissions increased with increasing annealing *** discussed the differences in the emissions between near-UV and near-IR excitations.

关键词： Er3+and Yb3+co-doped srZrO3 upconversion downshifting nanocrystals combustion method annealing temperature

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Paleo-environmental conditions,paleoclimatic significance and effects of weathering on clay deposits in the Lower Benue Trough,*** approach

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Journal of Environmental & Earth sciences 2019年第2期1卷 18-30页

作者： A.T.bolarinwa s.O.Idakwo D.L.Bish Department of Geology University of IbadanIbadanNigeria Depatment of Earth sciences Kogi State UniversityP.M.B.1008AnyigbaKogi StateNigeria Department of Geological sciences Indiana UniversityBloomingtonIndianaU.S.A.

Combined methods for mineralogical identifications were used to characterise the clay deposits within the Lower Benue Trough of Nigeria to interpret paleo-environmental conditions,the paleoclimatic significance of the trough,and effects of weathering on the minerals as factors that favour its deposition/accumulation within the trough which host other important industrial minerals like coal,barite,limestone ***-sample random-powder XRD data and data for clay fractions deposited onto zero-background quartz plates were *** samples contained kaolinite,vermiculite,and traces of smectite,and the non-clay phases included quartz,microcline,and *** samples were unaffected after glycolation,confirming the absence of significant *** was characterized by the nature of its 10Åbasal peak with a width ofs very ***/TGA results support the presence of kaolinite,and the characteristic kaolinite O-H,Al-OH,si-OH and si-O-Al FTIR bands also confirmed its *** and book-like morphologies were observed under the sEM,typical of kaolinitic clay from in situ *** kaolinite abundance in these sediments is consistent with intense weathering of parent rocks rich in Al under wet/tropical paleo-climatic conditions with fresh and/or brackish water conditions in a continental *** variety of observed morphologies suggests that the deposits suffered more of chemical *** clay deposits in Lower Benue Trough are quartz-rich,kaolinitic and derived from the chemical weathering of Al-rich source rocks.

关键词： Paleo-environmental conditions Al-rich source rocks Clay mineralogy Chemical weathering Lower Benue Trough

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Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

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Reducing costly falls after total knee arthroplasty

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World Journal of Orthopedics 2018年第10期9卷 198-202页

作者： surajudeen Adebola bolarinwa Wendy Novicoff Quanjun Cui Department of Orthopaedic surgery University of Virginia Health System

AIM To investigate whether adductor canal nerve block(ACB) reduces patient falls when compared to femoral nerve block(FNB) after total knee arthroplasty(TKA). METHODs We conducted an institutional review of all-cause falls after TKA from January 2013 to August 2016 using a quality improvement database. Our inclusion criteria were patients with diagnosis of primary knee osteoarthritis who underwent primary unilateral TKA with either a FNB or an ACB and sustained a fall during their hospitalization. We excluded patients who had revision TKA and extensor mechanism reconstruction. We also excluded patients with a history of post-traumatic arthritis, prior history of lower extremity fracture, history of neurological disease, or cerebrovascular disease. REsULTs A total of 834 patients had TKA with femoral nerve block and knee immobilizer(FNB + KI). Of those patients, 11(1.3%) experienced a fall during their hospital stay. In contrast, 791 patients had TKA with ACB. Of those patients, only one(0.13%) patient fall was recorded within this group. We used the Fisher's exact test to compare the differences between the two groups. The difference between the two groups achieves statistical significance(P = 0.006). We also found that 11 out of the 12 patients that fell had a right TKA procedure while one patient had a left TKA procedure. Nine out of twelve patients that fell were female, while only three patients were *** Given the reduction in the number of falls with ACB, it is recommended that ACB be considered the preferred analgesia for patients undergoing a TKA procedure.

关键词： Reducing falls Adductor canal nerve block Total knee arthroplasty Femoral nerve block Costly falls

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Rare-earth and trace elements and hydrogen and oxygen isotopic compositions of Cretaceous kaolinitic sediments from the Lower Benue Trough, Nigeria: provenance and paleoclimatic significance

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Acta Geochimica 2019年第3期38卷 350-363页

作者： Anthony T.bolarinwa sunday O.Idakwo David L.Bish Department of Geology University of Ibadan Department of Earth sciences Kogi State University Department of Geological sciences Indiana University

This study evaluated the Cretaceous(Campanian–Maastrichtian) kaolinitic sediments of the Ajali/Mamu and Enugu/Nkporo Formations from the Lower Benue Trough of Nigeria. A combined method of inductively coupled plasma–mass spectrometry and isotope ratio mass spectrometry was used to investigate trace and rareearth element geochemistry and hydrogen and oxygen isotopic compositions. These data were then used to infer the sediments' provenance and paleoclimatic conditions during their deposition. The sediments contained low concentrations of most trace elements, with the exceptions of Zr(651–1352 ppm), Ba(56–157 ppm), V(38–90 ppm),and sr(15.1–59.6 ppm). Average values of Co and Ni were1.5 and 0.7 ppm, respectively. Trace and rare earth element values were lower than corresponding values for upper continental crust and Post-Archean Australian shale, with the exception of Zr. The samples showed only slight light rare-earth enrichment and nearly flat heavy rare-earth depletion patterns, with negative Eu and Tm anomalies,typical of felsic sources. Geochemical parameters such as La/sc, Th/sc, and Th/Co ratios support that the kaolinitic sediments were derived from a felsic rock source, likely deposited in an oxic environment.^(18 )O values ranged from+ 15.4 to + 21.2% for the investigated samples, consistent with a residual material derived from chemicalweathering of felsic rock and redeposited in a sedimentary basin(typical values of + 19 to + 21.2%). While in the basin, the sediments experienced extended interactions with meteoric water enriched in d D and d16 O. However,the variation in d D and d16 O values for the investigated samples is attributed to the high temperature of formation(54–91 °C). The d D and d^(18 )O values suggest that the sediments, although obtained from different localities within the Lower Benue Trough, formed under similar hot,tropical climatic conditions.

关键词： Rare-earth and trace elements Oxygen/ hydrogen isotopic composition Kaolinitic sediments Lower Benue Trough Nigeria

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