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Rim-differentiation vs. mixture of constitutional isomers: A binding study between pillar[5]arene-based glycoclusters and lectins from pathogenic bacteria

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中国化学快报：英文版 2023年第2期34卷 214-218页

作者： Zhiping Liu Fanny Demontrond Anne Imberty Andrew C.-H.sue sébastien vidal Hongxia Zhao Tianjin Key Lab for Modern Drug Delivery and High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China Institut de Chimie et Biochimie Moléculaires et supramoléculaires Laboratoire de Chimie Organique 2-GlycochimieUMR 5246CNRSUniversitéClaude Bernard Lyon 1Universitéde LyonVilleurbanne 69622France CNRs Univ.Grenoble AlpesCERMAVGrenoble 38000France College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China CNRs Institut de Chimie des Substances NaturellesUniversitéParis-SaclayUPR 2301Gif-sur-Yvette 91198France

Macrocycle-based glycoclusters, on account of their promising anti-adhesive properties against bacteria,are potential therapeutic alternatives to classic antibiotics through the much less explored anti-adhesive strategy. In this study, a series of constitutionally-pure pentavalent glycoclusters was prepared by conjugating assorted azido-carbohydrates onto a penta-propargyl rim-differentiated pillar[5]arene(RD-P[5])scaffold through Cu(I)-catalyzed azide–alkyne cycloaddition “click” reactions. Their binding towards therapeutically relevant bacterial lectins, such as Lec A and Lec B from Pseudomonas aeruginosa and concanavalin A(Con A), were evaluated subsequently by isothermal titration calorimetric studies. Most of these isomerfree RD-P[5] pentavalent glycoclusters, except the fucosylated ones, display good affinities to ***, the dissociation constants observed are similar to those displayed by an analogous pentavalent glycocluster consisting of four P[5] constitutional isomers, in which the RD-P[5] component merely accounts for 7% in the mixture. Our results revealed that high constitutional purity is not essential for achieving effective multivalent interactions between P[5]-based glycoclusters and lectins, presumably as a result of the conformationally labile nature of the P[5] scaffold. This information provides valuable design principles for low-cost and facile syntheses of glycosylated P[5]s for biomedical applications.

关键词： Glycocluster Lectin Pillararene Multivalency Constitutional purity

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The impact of heterogeneity and pore network characteristics on single and multi-phase fluid propagation in complex porous media:An X-ray computed tomography study

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Petroleum science 2024年第3期21卷 1719-1738页

作者： shohreh Iraji Tales Rodrigues De Almeida Eddy Ruidiaz Munoz Mateus Basso Alexandre Campane vidal Department of Mechanical Engineering (FEM) State University of Campinas (UNICAMP) Department of Geology and Natural Resources Geosciences Institute (IG) State University of Campinas (UNICAMP) LRAP/COPPE/COPPETEC/UFRJ Center of Energy and Petroleum studies (CEPETRO) State University of Campinas (UNICAMP)

This study investigates the impact of pore network characteristics on fluid flow through complex and heterogeneous porous media, providing insights into the factors affecting fluid propagation in such systems. specifically, high-resolution or micro X-ray computed tomography(CT) imaging techniques were utilized to examine outcrop stromatolite samples of the Lagoa salgada, considered flow analogous to the Brazilian Pre-salt carbonate reservoirs. The petrophysical results comprised two distinct stromatolite depositional facies, the columnar and the fine-grained facies. By generating pore network model(PNM), the study quantified the relationship between key features of the porous system, including pore and throat radius, throat length, coordination number, shape factor, and pore volume. The study found that the less dense pore network of the columnar sample is typically characterized by larger pores and wider and longer throats but with a weaker connection of throats to pores. Both facies exhibited less variability in the radius of the pores and throats in comparison to throat length. Additionally, a series of core flooding experiments coupled with medical CT scanning was designed and conducted in the plug samples to assess flow propagation and saturation fields. The study revealed that the heterogeneity and presence of disconnected or dead-end pores significantly impacted the flow patterns and ***-phase flow patterns and oil saturation distribution reveal a preferential and heterogeneous displacement that mainly swept displaced fluid in some regions of plugs and bypassed it in others. The relation between saturation profiles, porosity profiles, and the number of fluid flow patterns for the samples was evident. Only for the columnar plug sample was the enhancement in recovery factor after shifting to lower salinity water injection(sB) observed.

关键词： Pore network model Heterogeneous porous media Flow patterns Dead-end pores

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Interplay between mesenchymal stromal cells and the immune system after transplantation: implications for advanced cell therapy in the retina

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Neural Regeneration Research 2024年第3期19卷 542-547页

作者： María Norte-Muñoz David García-Bernal Diego García-Ayuso Manuel vidal-sanz Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la Salud30120 MurciaSpain Grupo de Investigación Trasplante Hematopoyético y Terapia celular Departamento de Bioquímica e Inmunología.Facultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la Salud30120 MurciaSpain

Advanced mesenchymal stromal cell-based therapies for neurodegenerative diseases are widely investigated in preclinical *** stromal cells are well positioned as therapeutics because they address the underlying mechanisms of neurodegeneration,namely trophic factor deprivation and *** studies have focused on the beneficial effects of mesenchymal stromal cell transplantation on neuronal survival or functional ***,little attention has been paid to the interaction between mesenchymal stromal cells and the host immune system due to the immunomodulatory properties of mesenchymal stromal cells and the long-held belief of the immunoprivileged status of the central nervous ***,we review the crosstalk between mesenchymal stromal cells and the immune system in general and in the context of the central nervous system,focusing on recent work in the retina and the importance of the type of transplantation.

关键词： adaptive immunity cell therapy central nervous system immune system innate immunity mesenchymal stromal cells neuroregeneration preclinical studies retina transplantation

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Investigation of pore geometry influence on fluid flow in heterogeneous porous media:A pore-scale study

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Energy Geoscience 2024年第1期5卷 72-88页

作者： Ramin soltanmohammadi shohreh Iraji Tales Rodrigues de Almeida Mateus Basso Eddy Ruidiaz Munoz Alexandre Campane vidal Ingram school of Engineering Texas State UniversitySan MarcosTX78666USA Department of Mechanical Engineering(FEM) State University of Campinas(UNICAMP)CampinasSP13083-855Brazil Department of Geology and Natural Resources Geosciences Institute(IG)State University of Campinas(UNICAMP)CampinasSP13083-855Brazil Center of Energy and Petroleum study(CEPETRO) State University of Campinas(UNICAMP)CampinasSP13083-855Brazil

Brazilian pre-salt reservoirs are renowned for their intricate pore networks and vuggy nature,posing significant challenges in modeling and simulating fluid flow within these carbonate *** possessing excellent petrophysical properties,such as high porosity and permeability,these reservoirs typically exhibit a notably low recovery factor,sometimes falling below 10%.Previous research has indicated that various enhanced oil recovery(EOR)methods,such as water alternating gas(WAG),can substantially augment the recovery factor in pre-salt reservoirs,resulting in improvements of up to 20%.Nevertheless,the fluid flow mechanism within Brazilian carbonate reservoirs,characterized by complex pore geometry,remains *** study examines the behavior of fluid flow in a similar heterogeneous porous material,utilizing a plug sample obtained from a vugular segment of a Brazilian stromatolite outcrop,known to share analogies with certain pre-salt *** conducted single-phase and multi-phase core flooding experiments,complemented by medical-CT scanning,to generate flow streamlines and evaluate the efficiency of water ***,micro-CT scanning of the core sample was performed,and two cross-sections from horizontal and vertical plates were *** cross-sections were then employed as geometries in a numerical simulator,enabling us to investigate the impact of pore geometry on fluid *** of the pore-scale modeling and experimental data unveiled that the presence of dead-end pores and vugs results in a significant portion of the fluid remaining stagnant within these ***,the injected fluid exhibits channeling-like behavior,leading to rapid breakthrough and low areal swept ***,the numerical simulation results demonstrated that,irrespective of the size of the dead-end regions,the pressure variation within the dead-end vugs and pores is *** the stromatolite's favorable petrophysica

关键词： Pore-scale modeling Pore geometry Flow streamlines Computational modeling Digital rock analysis

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Taurine: a promising nutraceutic in the prevention of retinal degeneration

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Neural Regeneration Research 2024年第3期19卷 606-610页

作者： Diego García-Ayuso Johnny Di Pierdomenico Ana Martínez-Vacas Manuel vidal-sanz serge Picaud María PVillegas-Pérez Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaEspaña sorbonne Université INSERMCNRSInstitut de la VisionParisFrance

Taurine is considered a non-essential amino acid because it is synthesized by most ***,dietary intake of taurine may be necessary to achieve the physiological levels required for the development,maintenance,and function of certain *** may be especially important for the *** concentration of taurine in the retina is higher than that in any other tissue in the body and taurine deficiency causes retinal oxidative stress,apoptosis,and degeneration of photoreceptors and retinal ganglion *** plasma taurine levels may also underlie retinal degeneration in humans and therefore,taurine administration could exert retinal neuroprotective *** has antioxidant,anti-apoptotic,immunomodulatory,and calcium homeostasis-regulatory *** review summarizes the role of taurine in retinal health and disease,where it appears that taurine may be a promising nutraceutical.

关键词： amino acid anti-inflammatory antioxidant gamma-aminobutyric acid nutraceutical photoreceptor degeneration retina retinitis pigmentosa taurine

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Mindfulness training in medical education as a means to improve resilience,empathy,and mental health in the medical profession

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World Journal of Psychiatry 2024年第4期14卷 489-493页

作者： Edison Iglesias de Oliveira vidal Luiz Fernando Alvarenga Ribeiro Marco Antonio de Carvalho-Filho Fernanda Bono Fukushima Internal Medicine Department Botucatu Medical SchoolSao Paulo State University(UNESP)Botucatu 18618-687SPBrazil Wenckebach Institute for Education and Training LEARN-Lifelong LearningEducation and Assessment Research NetworkUniversity Medical Center GroningenGroningen 9713AVGroningenNetherlands Assertiva Mindfulness Botucatu 18603-970SPBrazil surgical specialties and Anesthesiology Department Botucatu Medical SchoolSão Paulo State University(UNESP)Botucatu 18618-687SPBrazil

The high rates of depression,burnout,and increased risk of suicide among medical students,residents,and physicians in comparison with other careers signal a mental health crisis within our *** contend that this crisis coupled with the inadequate acquisition of interpersonal skills during medical education results from the interaction between a challenging environment and the mental capital of ***,we posit that mindfulness-based practices are instrumental for the development of major components of mental capital,such as resilience,flexibility of mind,and learning skills,while also serving as a pathway to enhance empathy,compassion,self-awareness,conflict resolution,and relational ***,the evidence base supporting the effectiveness of mindfulness-based interventions has been increasing over the years,and a growing number of medical schools have already integrated mindfulness into their *** we acknowledge that mindfulness is not a panacea for all educational and mental health problems in this field,we argue that there is currently an unprecedented opportunity to gather momentum,spread and study mindfulness-based programs in medical schools around the world as a way to address some longstanding shortcomings of the medical profession and the health and educational systems upon which it is rooted.

关键词： Mindfulness Medical education Mental capital Mental health Medical students Resilience

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Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto Gomez-Carballa Maria Jose Curras-Tuala sara Pischedda Miriam Cebey-Lopez Jose Gomez-Rial Irene Rivero-Cale Jacobo Pardo-seco Xabier Bello sandra Viz-Lasheras Antonio Justicia-Grande Julian Montoto-Louzao Alba Camino-Mera Isabel Ferreiros-vidal Maximo Fraga Jose RAntunez Rodolfo Gomez Federico Martinon-Torres Antonio salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-Es) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAs(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)***,the molecular mechanisms underlying HO remain poorly *** a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

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Debaryomyces hansenii supplementation in low fish meal diets promotes growth,modulates microbiota and enhances intestinal condition in juvenile marine fish

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Journal of Animal science and Biotechnology 2024年第1期15卷 253-276页

作者： Ignasi sanahuja Alberto Ruiz Joana P.Firmino Felipe E.Reyes-López Juan B.Ortiz-Delgado Eva Vallejos-vidal Lluis Tort Dariel Tovar-Ramírez Isabel M.Cerezo Miguel A.Moriñigo Carmen sarasquete Enric Gisbert Aquaculture Program Institute of Agrifood Research and Technology(IRTA)La Rapita 43540Spain Centro de Biotecnologia Acuicola Universidad de Santiago de ChileSantiagoChile Instituto de Ciencias Marinas de Andalucia(ICMAN-CsIC) Avda.Republica Saharaui no 2Campus Universitario Rio San PedroPuerto RealCadiz 11510Spain Nucleo de Investigaciones Aplicadas en Ciencias Veterinarias y Agronomicas Facultad de Medicina Veterinaria y AgronomiaUniversidad de Las AmericasSantiagoChile Department of Cell Biology Physiologyand ImmunologyUniversitat Autonoma de BarcelonaBarcelonaSpain Centro de Investigaciones Biologicas del Noroeste sC CIBNORLa PazMexico Department of Microbiology Instituto de Biotecnologia Y Desarrollo Azul(IBYDA)Faculty of SciencesUniversity of Malaga29010 MalagaSpain sCBI Bioinformatic UnitUniversity of Malaga29590 MalagaSpain

Background The development of a sustainable business model with social acceptance,makes necessary to develop new strategies to guarantee the growth,health,and well-being of farmed *** hansenii is a yeast species that can be used as a probiotic in aquaculture due to its capacity to i)promote cell proliferation and differen-tiation,ii)have immunostimulatory effects,iii)modulate gut microbiota,and/or iv)enhance the digestive *** provide inside into the effects of *** on juveniles of gilthead seabream(sparus aurata)condition,we inte-grated the evaluation of the main key performance indicators coupled with the integrative analysis of the intestine condition,through histological and microbiota state,and its transcriptomic *** After 70 days of a nutritional trial in which a diet with low levels of fishmeal(7%)was supplemented with 1.1%of ***(17.2×10^(5) CFU),an increase of ca.12%in somatic growth was observed together with an improve-ment in feed conversion in fish fed a yeast-supplemented *** terms of intestinal condition,this probiotic modu-lated gut microbiota without affecting the intestine cell organization,whereas an increase in the staining intensity of mucins rich in carboxylated and weakly sulphated glycoconjugates coupled with changes in the affinity for certain lectins were noted in goblet *** in microbiota were characterized by the reduction in abundance of several groups of Proteobacteria,especially those characterized as opportunistic *** microarrays-based transcrip-tomic analysis found 232 differential expressed genes in the anterior-mid intestine of ***,that were mostly related to metabolic,antioxidant,immune,and symbiotic *** Dietary administration of *** enhanced somatic growth and improved feed efficiency param-eters,results that were coupled to an improvement of intestinal condition as histochemical and transcriptomic tools *** probiotic ye

关键词： Debaryomyces hansenii Intestine condition Low fish meal diet Microbiota Transcriptomics Yeast probiotic

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A systematic Review of Cannabidiol Effects in Coronary syndromes: Challenges to Clinical Translation

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Journal of Biosciences and Medicines 2024年第4期12卷 246-263页

作者： Mario E. Zuñiga-Ayala Alejandra Meaney-Martínez Alejandro Alcocer-Chauvet vidal Gonzalez-Coronado Nestor Rubio-Infante Gerardo Garcia-Rivas Department of Cardiology Instituto de Seguridad Social and Trabajadores del Estado (ISSSTE) Hospital Regional Primero de Octubre Mexico City Mexico Department of Interventional Cardiology Instituto de Seguridad Social y Trabajadores del Estado (ISSSTE) Hospital Regional Primero de Octubre Mexico City Mexico Instituto Tecnó logico de Monerrey Escuela de Medicina and Ciencias de la Salud C&#225tedra de Cardiolog&#237a and Medicina Vascular Monterrey Mexico

Background: Myocardial ischemia in addition to other several cardiac syndromes represent a pathological proinflammatory state alongside a complex cellular microenvironment that can be modified by using cannabinoids. Cannabidiol (CBD), a non-psychoactive compound of cannabis has been recently proposed as an immudomodulatory and cardioprotective drug. Objectives: In this systematic review we sought to clarify and summarize the clinical and preclinical evidence of potential benefit of the use of CBD in coronary syndromes. Methods: We conducted a systematic search and review according to the Preferred Reporting Items for systematic Reviews and Meta-Analyses (PRIsMA) and Review of Animal Data from Experimental studies (CAMARADEs) guidelines, in the electronic database from PubMed, Web of science and scopus up to April 2022 using predefined search terms. Pre-specified exclusion and inclusion criteria were considered, finally 11 articles were chosen to be included for this peer review. Results: Currently there are no good-quality clinical trials with the use of CBD in acute or chronic coronary syndromes. A total of 11 preclinical studies where prescreened and 5 demonstrated reproducible positive cardiovascular outcomes on in-vivo models treated with CBD. Mechanisms of CBD cardioprotection observed: 1) reduction in oxidative stress and inflammation, 2) activation of adenosine receptors and 3) increased expression of angiotensin type 2-receptor. Experimental models included ischemia/reperfusion injury, myocardial infarction, arrhythmias, and metabolic syndrome-like conditions. Conclusion: No clinical recommendation can be issued with the current evidence, on the use of CBD in acute and chronic coronary syndromes. Based on preclinical evidence, we considered there is enough evidence to propose the development of well-designed clinical trials that include CBD in the management of coronary syndromes.

关键词： Cannabis Cannabidiol Acute Coronary syndromes Myocardial Infarction Myocardial Ischemia and Oxidative stress

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Parking Availability Prediction with Coarse-Grained Human Mobility Data

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Computers, Materials & Continua 2022年第6期71卷 4355-4375页

作者： Aurora Gonzalez-vidal Fernando Terroso-sáenz Antonio skarmeta University of Murcia Murcia30003Spain Universidad Católica de Murcia(UCAM) Murcia30107Spain

Nowadays,the anticipation of parking-space demand is an instrumental service in order to reduce traffic congestion levels in urban *** purpose of our work is to study,design and develop a parking-availability predictor that extracts the knowledge from human mobility data,based on the anonymized human displacements of an urban area,and also from weather *** of the existing solutions for this prediction take as contextual data the current road-traffic state defined at very high temporal or spatial ***,access to this type of fine-grained location data is usually quite limited due to several economic or privacy-related *** overcome this limitation,our proposal uses urban areas that are defined at very low spatial and temporal *** conducted several experiments using three Artificial Neural Networks:Multilayer Perceptron,Gated Recurrent Units and bidirectional Long short Term Memory networks and we tested their suitability using different combinations of *** metrics are provided for the sake of comparison within our study and between other *** solution has been evaluated in a real-world testbed in the city of Murcia(spain)integrating an open human-mobility dataset showing high accuracy.A MAPE between 4%and 10%was reported in horizons of 1 to 3 h.

关键词： Parking space human mobility mining recurrent neural networks prediction

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