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Hepatobiliary surgery and Nutrition 2022年第5期11卷 718-720页

作者： Charles de Ponthaud sébastien Gaujoux Department of Hepato-Biliary and Pancreatic surgery and Liver Transplantation AP-HPPitié-Salpêtrière HospitalParisFrance sorbonne University ParisFrance

This stepped-wedge cluster randomized study(1)included all pancreatectomies performed from 17 Dutch pancreatic surgery centers(all realizing>20 pancreaticoduodenectomies per year)over 22 *** aim was to demonstrate the value of an algorithm for the early diagnosis and management of postoperative *** algorithm determined when to do abdominal computed tomography(CT)scan,radiological drainage,start antibiotic treatment,and remove abdominal *** was calculated every day from postoperative day 3 to *** primary endpoint was a composite of bleeding that required invasive intervention,organ failure and 90-day mortality.

关键词： postoperative diagnosis remove

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Urine-derived stem/progenitor cells:A focus on their characterization and potential

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World Journal of stem Cells 2020年第10期12卷 1080-1096页

作者： Perrine Burdeyron sébastien Giraud Thierry Hauet Clara steichen INsERM U1082 IRTOMIT CHU de PoitiersPoitiers 86021France Facultéde Médecine et Pharmacie Universite de PoitiersPoitiers 86021France

Cell therapy,i.e.,the use of cells to repair an affected tissue or organ,is at the forefront of regenerative and personalized *** the multiple cell types that have been used for this purpose[including adult stem cells such as mesenchymal stem cells or pluripotent stem cells],urine-derived stem cells(UsCs)have aroused interest in the past *** display classical features of mesenchymal stem cells such as differentiation capacity and ***,they have the main advantage of being isolable from one sample of voided urine with a cheap and unpainful procedure,which is broadly applicable,whereas most adult stem cell types require invasive ***,UsCs can be differentiated into renal cell *** is of high interest for renal cell therapy-based regenerative *** review will firstly describe the isolation and characterization of *** will specifically present UsC phenotype,which is not an object of consensus in the literature,as well as detail their differentiation *** the second part of this review,we will present and discuss the main applications of *** include use as a substrate to generate human induced pluripotent stem cells,but we will deeply focus on the use of UsCs for cell therapy approaches with a detailed analysis depending on the targeted organ or ***,we will also focus on the applications that rely on the use of UsC-derived products such as microvesicles including exosomes,which is a strategy being increasingly *** the last section,we will discuss the remaining barriers and challenges in the field of UsC-based regenerative medicine.

关键词： Urine-derived stem cells Urine progenitor cells Exosomes Cell therapy Kidney injury and repair Regenerative medicine

sampled-Data Hamilton-Jacobi Reachability Based safe Motion Planning in Dynamic Environments

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Sampled-Data Hamilton-Jacobi Reachability Based Safe Motion ...

作者： sébastien KLEFF 上海交通大学

学位级别：硕士

随着机器人系统的广泛应用,如何在不确定条件下获取安全的运动轨迹是其面临的重要问题。传统鲁棒运动规划(Motion Planning,MP)不能保证机器人系统运行的性能和鲁棒安全性。对于具有不确定性,状态约束和安全性要求的系统,可达性分析是... 详细信息

随着机器人系统的广泛应用,如何在不确定条件下获取安全的运动轨迹是其面临的重要问题。传统鲁棒运动规划(Motion Planning,MP)不能保证机器人系统运行的性能和鲁棒安全性。对于具有不确定性,状态约束和安全性要求的系统,可达性分析是解决其控制问题的有效方法,但未被广泛应用到MP问题求解中。因此,本文基于可达性分析提出了一套系统的方法,用以解决不确定环境下的鲁棒MP问题。首先,本文进行了静态环境下MP问题的求解。离线部分,通过采样数据(sampled Data,sD)汉密尔顿-雅可比(Hamilton-Jacobi,HJ)可达性分析方法计算得到系统运动轨迹,然后基于递归算法将原始问题分解成为一系列微分博弈问题。在线部分,给出了一种具有鲁棒安全性和目标可达的反馈控制方法。第二,通过用时间维度对状态进行扩充,本文将上述方法在时变系统中进行了测试。第三,为了解决对抗性环境下的鲁棒MP问题,本文将上述算法引入到高维的联合状态空间下进行推理,并证明了在不失有效性的情况下,方法的维数灾可以通过向低维空间映射得到解决。第四,通过将算法转换到组态空间,我们讨论了其在非质点机器人系统中的应用。本文提出的方法都用仿真示例证明了有效性。特别地,我们以机器人手臂的追踪任务为例对算法进行了验证,该追踪任务要求机器人手臂在避免与移动的障碍物碰撞的情况下追踪移动目标。该仿真案例将之前讨论的所有方面结合到了同一场景,从而验证了本文提出算法的有效性、通用性和灵活性。最后,本文对基于可达性的鲁棒MP算法的研究进行了展望。

关键词：鲁棒运动规划可达性分析数据采样系统 Reach-Avoid博弈 Hamilton-Jacobi-Isaacs方程

Genetic characterization and potential molecular dissemination mechanism of tet(31) gene in Aeromonas caviae from an oxytetracycline wastewater treatment system

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Journal of Environmental sciences 2019年第2期31卷 259-266页

作者： Yanhong shi Zhe Tian sébastien Olivier Leclercq Hong Zhang Min Yang Yu Zhang state Key Laboratory of Environmental Aquatic Chemistry Research Centre for Eco-Environmental SciencesChinese Academy of Sciences University of Chinese Academy of sciences INRA UMR1282 Infectiology and Public Health Fran?ois Rabelais University UMR1282 Infectiology and Public Health

Recently, the rarely reported tet(31) tetracycline resistance determinant was commonly found in Aeromonas salmonicida, Gallibacterium anatis, and Oblitimonas alkaliphila isolated from farming animals and related environment. However, its distribution in other bacteria and potential molecular dissemination mechanism in environment are still unknown. The purpose of this study was to investigate the potential mechanism underlying dissemination of tet(31) by analysing the tet(31)-carrying fragments in A. caviae strains isolated from an aerobic biofilm reactor treating oxytetracycline bearing wastewater. Twenty-three A. caviae strains were screened for the tet(31) gene by polymerase chain reaction(PCR). Three strains(two harbouring tet(31), one not) were subjected to whole genome sequencing using the PacBio RsII platform. seventeen A. caviae strains carried the tet(31) gene and exhibited high resistance levels to oxytetracycline with minimum inhibitory concentrations(MICs)ranging from 256 to 512 mg/L. tet(31) was comprised of the transposon Tn6432 on the chromosome of A. caviae, and Tn6432 was also found in 15 additional tet(31)-positive A. caviae isolates by PCR. More important, Tn6432 was located on an integrative conjugative element(ICE)-like element, which could mediate the dissemination of the tet(31)-carrying transposon Tn6432 between bacteria. Comparative analysis demonstrated that Tn6432 homologs with the structure IsCR2-ΔphzF-tetR(31)-tet(31)-ΔglmM-sul2 were also carried by A. salmonicida, G. anatis, and O. alkaliphila, suggesting that this transposon can be transferred between species and even genera. This work provides the first report on the identification of the tet(31) gene in A. caviae, and will be helpful in exploring the dissemination mechanisms of tet(31) in water environment.

关键词： Aeromonas caviae tet(31) gene IsCR2 ICE-like element Wastewater

Hypoxia Is a Developmental Regulator in Plant Meristems

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Molecular Plant 2019年第11期12卷 1422-1424页

作者： Anne-Laure Le Gac Thomas laux signalling Research Centres BIOss and CIBss Faculty of BiologyUniversity of FreiburgSchanzlestrasse 179104 FreiburgGermany sino-German Joint Research Center on Agricultural Biology Shandong Agricultural UniversityTai'anShandongChina

Despite the presence of about 21%O2 in the atmosphere,organs of plants and mammals are inevitably subject to lower O2 tensions(pO2)due to high O2 demand in metabolic active cells and limited O2 transport *** humans,for example,the p O2 decreases from the ambient 21%(160 mm Hg)of the inhaled air to 2%-9%in the internal organs(Brahimi-Horn and Pouyssegur,2007).To cope with this limited oxygen supply,aerobic organisms have developed a variety of adaptive responses at cellular,tissue,and organismal levels(Bailey-serres et al.,2012).Although low O2 tensions are the normal conditions for organs,the ambient 21%O2 is usually referred to as normoxia and the lower internal concentrations as hypoxia(van Dongen and Licausi,2015).

关键词： Hypoxia Developmental Regulator ambient Plant Meristems

Fluid Flow Estimation with Multiscale Ensemble Filters Based on Motion Measurements Under Location Uncertainty

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Numerical Mathematics(Theory,Methods and Applications) 2013年第1期6卷 21-46页

作者： sébastien Beyou Thomas Corpetti sai Gorthi Etienne Mémin INRIA/FLUMINANCE 35042 Rennes CedexFrance CNRs/LETG-Rennes-Costel Campus Villejean Place du recteur Henri Le Moal CS *** Rennes cedexFrance Indian Institute of space science and Technology Valiamala P.O.Thiruvananthapuram–695547Kerala India

This paper proposes a novel multi-scale fluid flow data assimilation approach,which integrates and complements the advantages of a Bayesian sequential assimilationtechnique, the Weighted Ensemble Kalman filter (WEnKF) [27]. The data assimilation proposed in this work incorporates measurement brought by an efficient multiscalestochastic formulation of the well-known Lucas-Kanade (LK) estimator. This estimatorhas the great advantage to provide uncertainties associated to the motion measurements at different scales. The proposed assimilation scheme benefits from this multiscale uncertainty information and enables to enforce a physically plausible dynamicalconsistency of the estimated motion fields along the image sequence. Experimentalevaluations are presented on synthetic and real fluid flow sequences.

关键词： Data assimilation stochastic filter particle filters fluid motion estimation

Keggin-type H_4PVMo_(11)O_(40)-based catalysts for the isobutane selective oxidation

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science China Chemistry 2010年第9期53卷 2039-2046页

作者： PAUL sébastien sULTAN Manzoor BORDEs-RICHARD Elisabeth Université Lille Nord de France ECLilleUnité de Catalyse et de Chimie du Solide(UMR CNRS 8181)Cité Scientifique Université Lille Nord de France ENSCLUnité de Catalyse et de Chimie du Solide(UMR CNRS 8181)Cité Scientifique

Cesium heteropolysalts Cs3PMo12O40 and HCs3PVMo11O40 were synthesized by modifying the preparation conditions in order to get materials with a much higher surface area than the original Keggin-type heteropolyacids(H3PMo12O40 and H4PVMo11O40).These solids were used as carriers for the dispersion of H4PVMo11O40 heteropolyacid by the incipient wetness impregnation *** textural and structural properties of supports and catalysts were examined by scanning electron microscopy,N2 adsorption-desorption isotherms and Raman *** supported catalysts were studied before and after red/ox pretreatments by X-ray photoelectron spectroscopy,which showed that both the surface composition and oxidized to reduced species ratio depend on the used *** catalytic performances of these novel supported catalysts in the selective oxidation of isobutane to methacrylic acid and methacrolein were *** best catalytic properties were obtained when H4PVMo11O40 was supported on *** isobutane conversion and yield of the desired oxygenates increased along the unsupported H4PVMo11O40s3PMo12O40s3PVMo11O40 series.

关键词： cesium heteropolysalts supports supported H4PVMo11O40 red/ox XPs isobutane selective oxidation Keggin-type heteropolycompounds

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage