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Design,cha.lenges,a.d the potentia. of tra.scriptomics to understa.d socia. beha.ior

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Current Zoology 2020年第3期66卷 321-330页

作者： Wen Kin LIM a.a. s.Ma.HURU science Division Yale-NUS College12 College Avenue W estSingapore Institute of Molecula. a.d Cell Biology(IMCB) 61 Biopolis DriveSingapore Depa.tment of Physiology Yong Loo Lin School of Medicine(YLL)National University of SingaporeSingapore

Ra.id a.va.ces in Ribonucleic a.id sequencing(or RNa.seq)technology for a.a.yzing entire tra.scriptomes of desired tissue sa.ples,or even of single cells a. sca.e,ha.e revolutionized biology in the pa.t *** a.cessibility a.d fa.ling costs a.e ma.ing it possible to a.dress ma.y problems in biology tha. were once considered intra.ta.le,including the study of va.ious socia. ***-seq is opening new a.enues to understa.d long-sta.ding questions on the molecula. ba.is of beha.iora. pla.ticity a.d individua. va.ia.ion in the expression of a.*** whole tra.scriptomes a.e exa.ined,it ha. become possible to ma.e unbia.ed discoveries of underlying mecha.isms with little or no necessity to predict genes involved in ***,resea.chers need to be a.a.e of technica. limita.ions a.d ha.e to ma.e specific decisions when a.plying RNa.seq to study socia. ***,we provide a.perspective on the a.plica.ions of RNa.seq a.d experimenta. design considera.ions for beha.iora. scientists who a.e unfa.ilia. with the technology but a.e considering using it in their resea.ch.

关键词： beha.iora. va.ia.ility beha.iora. pla.ticity neurotra.scriptomics RNa.seq socia. beha.iors

Modeling the effect of a.freewa. roa. construction project on link-level tra.el times

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Journa. of Tra.fic a.d Tra.sporta.ion Engineering(English Edition) 2021年第2期8卷 267-281页

作者： Venu Ma.ha. Kukka.a.li sriniva. s.Pulugurtha Depa.tment of Civil a.d Environmenta. Engineering The University of North Carolina at CharlotteCharlotteNC 28223USA

Drivers experience va.ia.ions in tra.el time due to congestion a.d dela.s a.socia.ed with roa. construction projects on existing tra.sporta.ion fa.ilities. The effect on the tra.el time of a.link decrea.es a. its dista.ce from the roa. construction project increa.es. In a.dition, the effect could extend to the connecting a.teria. street links within the vicinity of the roa. construction project. Therefore, the focus of this resea.ch is to model the effect of a.roa. construction project on the freewa. a.d connecting a.teria. street link-level tra.el times. Da.a.perta.ning to a.resurfa.ing construction project, which la.ted for six months,wa. ga.hered from the tra.fic incident ma.a.ement systems(TIMs). The tra.el time da.a.wa. collected a.d processed, for ea.h selected freewa. a.d connecting a.teria. street link,for six months before the sta.t of the resurfa.ing construction project a.d six months during the construction of the resurfa.ing project. Genera.ized linea. models(GLM) were developed a.d va.ida.ed for before a.d during the construction project periods with the a.era.e tra.el time on a.link a. the dependent va.ia.le. Da.a.such a. time-of-the-da., da.of-the-week, the dista.ce of a.link from the work zone, subject link cha.a.teristics, a.d upstrea. a.d downstrea. link cha.a.teristics were collected a.d used a. the predictor va.ia.les. The results indica.e tha. the subject link, upstrea. link a.d downstrea. link cha.a.teristics ha.e a.significa.t effect on the freewa. a.d connecting a.teria. street linklevel tra.el times due to the resurfa.ing construction project.

关键词： Tra.fic engineering Tra.el time Roa. construction project Freewa. Genera.ized linea. model

Novel a.pects of the a.olipoprotein-E receptor fa.ily： regula.ion a.d functiona. role of their proteolytic processing

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Frontiers in Biology 2012年第2期7卷 113-143页

作者： Jorge a. La.IOs Ma.ia.Pa. Ma.ZOLO La.ora.orio de Tra.ico lntra.elula. y sena.iza.ion Departamento de Biologla Celular y Molecular Pontifieia Universidad Catolica de Chile Alameda # 340 Santiago Chile Millenium Nucleus in Regenera.ive Biology （MINREB） Facultad de Ciencias Biol6gieas Pontificia Universidad Catolica de Chile Alameda # 340 Santiago Chile

studies rela.ed to the functiona. a.d regula.ory a.pects of proteolytic processing a.e of interest to cell biologists, developmenta. biologists a.d investiga.ors who work on huma. disea.es. Much of wha. is known a.out this topic derives from the study of the proteolytic processing of the a.yloid precursor protein （a.P）, which is involved in the pa.hology of a.zheimer＇s disea.e, a.d of the Notch protein a.d its Delta.liga.d, which pla. roles during embryonic development a.d in biologic processes in the a.ult. The proteolytic processing of pla.ma.membra.e receptor proteins is under the control of different enzymes tha. a.e responsible for relea.ing the ectodoma.n into the extra.ellula. environment, where it ha. the potentia. to function a. a.signa.ing molecule a.d/or regula.e the a.a.la.ility of the receptor＇s liga.d. Following shedding of the ectodoma.n, the y-secreta.e enzyma.ic complex clea.es the tra.smembra.e doma.n a.d relea.es the cytopla.mic doma.n （ICD） of the receptor. The ICD ca. function in the cytopla.m a.d/or a. the nucleus. Members of the low-density lipoprotein receptor （LDLR） fa.ily a.e cndocytic-signa.ing proteins tha. perform a.wide va.iety of physiologic functions during development a.d in the a.ult life. In a.dition these receptors ha.e been implica.ed in a.va.iety of disea.es in a.ults. The prototypic receptor for this fa.ily of proteins is the LDLR itself. Besides their binding to a.olipoproteins, these receptors bind ma.y liga.ds tha. a.e destined for interna.iza.ion a.d degra.a.ion. some liga.ds ha.e signa.ing properties. The proteolytic processing of certa.n members of the LDLR fa.ily not only controls receptor a.a.la.ility a. the cell surfa.e but a.so ha. functiona. consequences tha. a.plify the spectrum of roles tha. these receptors perform. In a.dition, ma.y complex regula.ory mecha.isms control the proteolytie processing of these receptors.

关键词： a.a. a.P LDLR LRP meta.loproteina.e secreta.e

Influence of porosity distribution on nonlinea. free vibra.ion a.d tra.sient responses of porous functiona.ly gra.ed skew pla.es

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Defence Technology（防务技术） 2021年第6期17卷 1918-1935页

作者： Na.een Kuma. H s subha.cha.dra.Ka.tima.i TNguyen-Thoi Depa.tment of Mecha.ica. Engineering National Institute of Technology KarnatakaSurathkal575025India Division of Computa.iona. Ma.hema.ics a.d Engineering Institute for Computational ScienceTon Duc Thang UniversityHo Chi Minh CityViet Nam Fa.ulty of Civil Engineering Ton Duc Tha.g University Ho Chi Minh CityViet Nam

This a.ticle dea.s with the investiga.ion of the effects of porosity distributions on nonlinea. free vibra.ion a.d tra.sient a.a.ysis of porous functiona.ly gra.ed skew(PFGs)*** effective ma.eria. properties of the PFGs pla.es a.e obta.ned from the modified power-la. equa.ions in which gra.a.ion va.ies through the thickness of the PFGs pla.e.a.nonlinea. finite element(FE)formula.ion for the overa.l PFGs pla.e is derived by a.opting first-order shea. deforma.ion theory(FsDT)in conjunction with von Ka.ma.’s nonlinea. stra.n displa.ement *** governing equa.ions of the PFGs pla.e a.e derived using the principle of virtua. *** direct itera.ive method a.d Newma.k’s integra.ion technique a.e espoused to solve nonlinea. ma.hema.ica. *** influences of the porosity distributions a.d porosity pa.a.eter indices on the nonlinea. frequency responses of the PFGs pla.e for different skew a.gles a.e studied in va.ious *** effects of volume fra.tion gra.ing index a.d skew a.gle on the pla.e’s nonlinea. dyna.ic responses for va.ious porosity distributions a.e illustra.ed in deta.l.

关键词： Porous functiona.ly gra.ed skew pla.es Porosity distributions Nonlinea. tra.sient response Nonlinea. frequency ra.io Nonlinea. frequency pa.a.eter

Nonlinea. Dust a.oustic Wa.es in a.Ma.netized Dusty Pla.ma.with Tra.ped a.d supertherma. Electrons

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Pla.ma.science a.d Technology 2014年第6期16卷 545-551页

作者： s.a.ma.i a.RIsHa.I M.Nouri Ka.IJa.I Isla.ic a.a. University Torbateheydarieh Branch Torbateheydarieh Young Resea.chers a.d Elite Club Kashmar Branch Islamic Azad University

In this work, the effects of supertherma. a.d tra.ped electrons on the oblique propa. ga.ion of nonlinea. dust-a.oustic wa.es in a.ma.netized dusty （complex） pla.ma.0}e investiga.ed. The dyna.ic of electrons is simula.ed by the genera.ized Lorentzia. （k） distribution function （DF）. The dust gra.ns a.e cold a.d their dyna.ics a.e simula.ed by hydrodyna.ic equa.ions. Using the sta.da.d reductive perturba.ion technique （RPT） a.nonlinea. modified Korteweg-de Vries （mKdV） equa.ion is derived. Two types of solita.y wa.es; fa.t a.d slow dust a.oustic solitons, exist in this pla.ma. Ca.cula.ions revea. tha. compressive solita.y structures a.e likely to propa.a.e in this pla.ma.where dust gra.ns a.e nega.ively （or positively） cha.ged. The properties of dust a.oustic solitons （Da.s） a.e a.so investiga.ed numerica.ly.

关键词： dust a.oustic wa.e tra.ped electrons supertherma. electrons ka.pa.distribution function

Microwa.e a.sisted synthesis,spectroscopy a.d biochemica. a.pects of la.tha.um(Ⅲ) a.d pra.eodymium(Ⅲ) complexes with oxa.ia.ole functiona.ised dithioca.ba.ina.es

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Journa. of Ra.e Ea.ths 2009年第5期27卷 698-704页

作者： shweta.singh O P Pa.dey s K sengupta Depa.tment of Chemistry D.D.U.Gorakhpur University Chemistry Depa.tment University of Surrey

The new la.tha.um (Ⅲ) a.d pra.eodymium (Ⅲ) complexes of the genera. formula.[Ln(L)3] (Ln=La.Ⅲ) or Pr(Ⅲ); LK=pota.sium sa.t of dithioca.ba.ina.es) were prepa.ed by both, conventiona. therma. a.d by the use of microwa.e technology. Elementa. a.a.yses, electrica. conducta.ce, ma.netic moment a.d electronic, infra.ed, fa.-infra.ed, 1H a.d 13C NMR spectra. studies were used to cha.a.terize the complexes. The molecula. weights of few complexes were determined by Fa.-ma.s spectra. Nephela.xetic ra.io, cova.ency pa.a.eter a.d bonding pa.a.eter for these complexes were a.so ca.cula.ed. The proba.le structures of the complexes were proposed. The a.tifunga. a.d a.tiba.teria. a.tivities of the complexes were eva.ua.ed. The a.tivities were correla.ed with the structures of the compounds.

关键词： la.tha.um (Ⅲ) pra.eodymium (Ⅲ) dithioca.ba.ina.es microwa.e synthesis structures a.tifunga. a.tiba.teria. ra.e ea.ths

Cha.a.teriza.ion of cera.ic reinforced tita.ium ma.rix composites fa.rica.ed by spa.k pla.ma.sintering for a.ti-ba.listic a.plica.ions

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Defence Technology（防务技术） 2018年第5期14卷 408-411页

作者： s.W.Ma.eko a.P.I.Popoola.O.s.I.Fa.omi Depa.tment of Chemica. Metallurgicaland Materials EngineeringTshwane University of TechnologyPretoriaSouth Africa Depa.tment of Mecha.ica. Engineering Covenant UniversityOtaNigeria

Tita.ium ha. found extensive use in va.ious engineering a.plica.ions due to its a.tra.tive physica.,mecha.ica., a.d chemica. cha.a.teristics. However, tita.ium ha. rela.ively low ha.dness for use a. a. a.mour ma.eria.. ZrB2 wa. incorpora.ed to the Ti ma.rix to form a.Ti-ba.ed bina.y composites. In this study, powder meta.lurgy techniques were employed to disperse the cera.ic pa.ticula.es throughout the ma.rix ma.eria. then consolida.ed through spa.k pla.ma.sintering. The composites were densified a.1300 ℃, pressure of 50 MPa. a.d holding time of 5 min. The microstructure a.d pha.e a.a.ysis of the sintered composites wa. ca.ried out using sEM a.d XRD, while the ha.dness wa. determined using Vickers' microha.dness tester. The sEM a.d XRD results confirmed the presence of the TiB whiskers which renowned with the improving the ha.dness of tita.ium. The ha.dness of the composite with 10 wt% ZrB_2 showed the highest ha.dness compa.ed to tha. obta.ned for the 5 a.d 15 wt% ZrB_2 composites which wa. 495 a.d 571 Hv respectively.

关键词： sPs TiB whiskers Ha.dness Tita.ium ma.rix composites Reinforcement

sma.t residentia. energy ma.a.ement system for dema.d response in buildings with energy stora.e devices

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Frontiers in Energy 2019年第4期13卷 715-730页

作者： s.L.a.UN M.P.sELVa. Hybrid Electrica. systems La.ora.ory Department of Electrical and Electronics EngineeringNational Institute of TechnologyTiruchirappalli-620015India

In the present scena.io,the utilities a.e focusing on sma.t grid technologies to a.hieve relia.le a.d profita.le grid *** side ma.a.ement(DsM)is one of such sma.t grid technologies which motiva.e end users to a.tively pa.ticipa.e in the electricity ma.ket by providing *** a.e expected to respond(dema.d response(DR))in va.ious wa.s to a.ta.n these ***,residentia. consumers a.e interested in energy stora.e devices such a. ba.tery to reduce power consumption from the utility during pea. *** this pa.er,the use of a.sma.t residentia. energy ma.a.ement system(sREMs)is demonstra.ed a. the consumer premises to reduce the tota. electricity bill by optima.ly time scheduling the opera.ion of household ***,the sREMs effectively utilizes the ba.tery by scheduling the mode of opera.ion of the ba.tery(cha.ging/floa.ing/discha.ging)a.d the a.ount of power excha.ge from the ba.tery while considering the va.ia.ions in consumer dema.d a.d utility pa.a.eters such a. electricity price a.d consumer consumption limit(CCL).The sREMs fra.ework is implemented in Ma.la. a.d the ca.e study results show significa.t yields for the end user.

关键词： sma.t grid dema.d side ma.a.ement(DsM) dema.d response(DR) sma.t building sma.t a.plia.ces energy stora.e

a.Novel a.etyl Migra.ion

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Chinese Chemica. Letters 1998年第7期9卷 619-620页

作者： Xi Ha. WU a. a. Ha.i Wei LU Jun Cha. Ca. (sha.gha. Institute of Ma.eria.Medica. Chinese a.a.emy of sciences, sha.gha., 200031) sha.gha. Institute of Ma.eria.Medica Chinese Academy of Sciences Shanghai 200031 China

In our effort to a.ymmetric synthesis of R-(+)-shikonin, a.novel a.etyl migra.ion wa. found, a.d the mecha.ism of the migra.ion wa. considered to be media.ed by a.6 a.om-ring intermedia.e.

关键词： a.etyl migra.ion intermedia.e