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Brain scarring in infants:immunological insights from a neonatal hypoxic-ischemic encephalopathy model

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Neural Regeneration Research 2025年第10期20卷 2909-2910页

作者： Pedro moreno Pimentel-Coelho Carlos Chagas Filho Biophysics Institute Federal University of Rio de JaneiroRio de JaneiroBrazil

Neonatal hypoxic-ischemic encephalopathy(HIE)is a significant cause of disability in *** brain function and accelerating neurological recovery may require a combination of neuroprotective and pro-regenerative treatments at different stages of *** the first hours after the neonatal insult are the most critical period for neuroprotection,the existence of secondary and tertiary mechanisms of brain injury offers the possibility of preventing delayed neurodegeneration in the subsequent days,weeks,or months(Levison et al.,2022).

关键词： neonatal protective hypoxic

The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： susana Mellado María JoséMorillo-Bargues Carla Perpiñá-Clérigues Francisco García-García Victoria moreno-Manzano Consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MsC-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and C–X3–C motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MsC-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma sobrado-Calvo Diana simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez JoséMCabrera-Maqueda Javier sierra Manuel Vidal-sanz María Teresa moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain Center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHCII) neuroprotection olfactory ensheathing glia retinal ganglion cells

Empirical mode decomposition of multiphase flows in porous media:characteristic scales and speed of convergence

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Petroleum science 2020年第1期17卷 153-167页

作者： Nicolás Echebarrena Pablo D.Mininni Gustavo A.moreno YPF-Technology EnsenadaBuenos AiresArgentina CONICET Buenos AiresArgentina Physics Department IFIBASchool of Exact and Natural SciencesUniversity of Buenos AiresCONICETUniversity Campus1428 Buenos AiresArgentina

We apply a proper orthogonal decomposition(POD)to data stemming from numerical simulations of a fingering instability in a multiphase flow passing through obstacles in a porous medium,to study water injection processes in the production of hydrocarbon *** show that the time evolution of a properly defined flow correlation length can be used to identify the onset of the fingering *** of characteristic lengths for each of the modes resulting from the POD provides further information on the dynamics of the ***,using numerical simulations with different viscosity ratios,we show that the convergence of the POD depends non-trivially on whether the fingering instability develops or *** result has implications on proposed methods to decrease the dimensionality of the problem by deriving reduced dynamical systems after truncating the system’s governing equations to a few POD modes.

关键词： Two-phase flow Empirical mode decomposition Viscous fingering Porous media

Patterns of trends in niveograph characteristics across the western United states from snow telemetry data

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Frontiers of Earth science 2020年第2期14卷 315-325页

作者： s.R.FAssNACHT J.I.LÓPEZ-moreno Ess-Watershed science Colorado State UniversityFort CollinsCO 80523-1472USA Cooperative Institute for Research in the Atmosphere Colorado State UniversityFort CollinsCO 80523-1375USA Natural Resources Ecology Laboratory Colorado State UniversityFort CollinsCO 80523-1499USA Instituto Pirenaico de Ecología CSICCampus de Aula Dei 50080Spain

The snowpack is changing across the globe,as the climate warms and *** used daily snow water equivalent(sWE)niveograph(time series of sWE)data from 458 snow telemetry(sNOTEL)stations for the period 1982 through *** indices based on amount,timing,time length,and rates were used to describe the annual temporal evolution in sWE accumulation and *** trends in these annual indices were computed over the time period for each station using the Theil-sen *** trends were then clustered into four groups to determine the spatial pattern of sWE *** and precipitation data were extracted from the PRIsM data set,due to the shorter time period of temperature measurement at the sNOTEL *** show that sNOTEL stations can be clustered in four clusters according to the observed trends in snow *** 1 stations are mostly located in the Eastern-and south-eastern most parts of the study area and they exhibit a generalized decrease in the indices related with peak sWE and snow *** stations recorded a negative trend in precipitation and an increase in *** 4 that is mostly restricted to the North and North-west of the study area shows an almost opposite pattern to cluster 1,due to months with positive trends and a more moderate increase of *** grouped in clusters 2 and 3 appear mixed with clusters 1 and 4,in general they show very little trends in the snow indices.

关键词： snow water equivalent cluster analysis sNOTEL

Individual and demographic responses of a marsh bird assemblage to habitat loss and subsequent restoration

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Avian Research 2020年第1期11卷 25-33页

作者： Ruben moreno-Opo Monticola Ornithological Group Faculty of BiologyUniversity Autonoma of MadridMadrid 28049Spain Deputy Directorate on Biodiversity Ministry for the Ecological TransitionMadrid 28071Spain

Background: The alteration and loss of habitats are two of the main threats that biodiversity conservation is cur?rently facing up to. The present study describes the effects of a perturbation and restoration in a reedbed habitat on a bird assemblage. We studied the bird community of a wetland of central spain between 1995 and 2009, during which time an anthropic perturbation altered the original structure of the habitat;subsequently, as a result of restoration works, the habitat returned to its original ***: We evaluated the effects on six population and physical parameters of the birds at three different phases of their life cycles(breeding, wintering and post?breeding migration seasons) before, during and after the habitat alteration. GLM was used to analyze the influence of three independent variables(year, perturbation phase and temperature).Results: The relative abundance and the species richness values decreased when habitat was altered, but then recovered as a result of the regeneration works. This pattern was the clearest amongst specialist species. Breeding success also declined during the perturbation phase and then increased;likewise, the sex ratio changed given that the proportion of male birds increased when habitat was altered. These results are discussed in relation to changes on availability of resources in altered habitats, to the adaptive mechanisms in the exploitation of ecological requirements and to the selection of optimum and sub?optimum habitats by generalist and specialist ***: Ecosystem restoration can favour the recovery of population indexes of specialist passerines, although it depends on the efficiency of the type of restoration activity performed and on the complexity of the habitat.

关键词： Habitat loss Land-use planning Marsh Restoration Ringing station Reedbed

Aerosol transmission of human pathogens:From miasmata to modern viral pandemics and their preservation potential in the Anthropocene record

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Geoscience Frontiers 2022年第6期13卷 210-223页

作者： Teresa moreno Wes Gibbons Institute of Environmental Assessment and Water Research IDAEA-CSIC08034 BarcelonaSpain Bimón Press Sitges08870 BarcelonaSpain

Ongoing uncertainty over the relative importance of aerosol transmission of COVID-19 is in part rooted in the history of medical science and our understanding of how epidemic diseases can spread through human populations. Ancient Greek medical theory held that such illnesses are transmitted by airborne pathogenic emanations containing particulate matter(“miasmata”). Notable Roman and medieval scholars such as Varro, Ibn al-Khatib and Fracastoro developed these ideas, combining them with early germ theory and the concept of contagion. A widely held but vaguely defined belief in toxic miasmatic mists as a dominant causative agent in disease propagation was overtaken by the science of 19th century microbiology and epidemiology, especially in the study of cholera, which was proven to be mainly transmitted by contaminated water. Airborne disease transmission came to be viewed as burdened by a dubious historical reputation and difficult to demonstrate convincingly. A breakthrough came with the classic mid-20th century work of Wells, Riley and Mills who proved how expiratory aerosols(their “droplet nuclei”)could transport still-infectious tuberculosis bacteria through ventilation systems. The topic of aerosol transmission of pathogenic respiratory diseases assumed a new dimension with the mid-late 20th century “Great Acceleration” of an increasingly hypermobile human population repeatedly infected by different strains of zoonotic viruses, and has taken centre stage this century in response to outbreaks of new respiratory infections that include coronaviruses. From a geoscience perspective, the consequences of pandemic-status diseases such as COVID-19, produced by viral pathogens utilising aerosols to infect a human population currently approaching 8 billion, are far-reaching and unprecedented. The obvious and sudden impacts on for example waste plastic production, water and air quality and atmospheric chemistry are accelerating human awareness of current environmental chal

关键词： COVID-19 History of epidemics Aerosol disease transmission Coronavirus Anthropocene record

Evaluation of drought indices to identify tolerant genotypes in common bean bush(Phaseolus vulgaris L.)

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Journal of Integrative Agriculture 2020年第1期19卷 99-107页

作者： Alefsi David sáNCHEZ-REINOsO Gustavo Adolfo LIGARRETO-moreno Hermann REsTREPO-DíAZ Departamento de Agronomía Universidad Nacional de Colombia

Drought is one of the major abiotic stresses often causing negative impacts on bean crops in the Andean region in Colombia. An experiment under the greenhouse conditions was carried out to assess the effect of a prolonged drought period(15 days) at two different phenological stages(vegetative or reproductive) on grain yield and yield components of five bush bean cultivars(ICA-Cerinza, Bachue, NUA35, Bianca, and Bacatá). Nine tolerance indices including stress susceptibility index(ssI), tolerance(TOL), mean productivity(MP), geometric mean productivity(GMP), stress tolerance index(sTI), yield stability index(YsI), yield index(YI), Harmonic mean(HM), and drought sensitivity index(DsI) were calculated based on grain yield under non-stressed(YP) and drought(Ys) conditions. Based on the different drought indices, genotypes ICA-Cerinza and NUA35 had the best performance under drought conditions in both studied phases, which reflected in a reduction of grain yield ~≤40%. The biplot analysis also showed a clear superiority of these two genotypes at both phenological stages. Results also showed that ssI was more effective to identify genotypes less affected by drought. The above results allowed us to conclude that ICA-Cerinza and NUA35 may be considered for agricultural areas where long periods of water deficit are expected and can be used in breeding programs for drought tolerance.

关键词： yield components selection indices correlation biplot analysis

An Approach to Design MIMO FO Controllers for Unstable Nonlinear Plants

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IEEE/CAA Journal of Automatica sinica 2016年第3期3卷 338-344页

作者： Arturo Rojas-moreno IEEE Department of Electrical Engineering Universidad de Ingenieriay Tecnologia (www.utec.edu.pe)

This paper develops an approach to control unstable nonlinear multi-inputs multi-output(MIMO) square plants using MIMO fractional order(FO) controllers. The controller design uses the linear time invariant(LTI) state space representation of the nonlinear model of the plant and the diagonal closedloop transfer matrix(TM) function to ensure decoupling between inputs. Each element of the obtained MIMO controller could be either a transfer function(TF) or a gain. A TF is associated in turn with its corresponding FO TF. For example, a D(Derivative) TF is related to a FO TF of the form Dδ, δ =[0, 1]. Two applications were performed to validate the developed approach via experimentation: control of the angular positions of a manipulator, and control of the car and arm positions of a translational manipulator.

关键词： Fractional calculus modeling of nonlinear sys-tem control of manipulator multivariable decoupling multivari-able nonlinear system